Among the different evolutive forces, connectivity and local adaptation are two contrasting evolutionary forces highly influencing the population structure of a species above their distribution range. In my PhD I am stuttering the population structure of Cyclopterus lumpus looking at both connectivity and local adaptation in order to better define the different stocks of this species and predict the impact of translocation methods, domestication and climate change on its population structure.
My interest is to discover new bioactive molecules for drug discovery, mainly from marine bacteria. A crucial step in the discovery-process is the identification of known or unknown molecules which is heavily relying on HPLC-HR-MS2. Beside anti-cancer and other pharmaceutically relevant bioactivities, anti-bacterial activity and MoA is a strong interest of mine. Identified candidates are then isolated and their structure is elucidated by NMR. Another project I am working on delas with the screenig of marine rest-raw-material hydrolysates for new neutraceuticals to combat the metabolic syndrome.
At a glance:
Analytical and preparative Chemistry
Mass Spectrometry/ HR-MS and Ion mobillity spectroscopy (IMS), Metabolomics
Iliev, D. B, Jørgensen, S; Rode, ; Krasnov, A; Harneshaug, I. & J. B. Jørgensen(2009). CpG-induced secretion of MHCIIb from salmon (Salmo salar) APCs. Developmental & Comparative Immunology. Epub 19. August 2009.
Skjaeveland, I., Iliev, D. B., Strandskog, G.& J. B. Jørgensen (2009). Identification and characterization of TLR8 and MyD88 homologs in Atlantic salmon (Salmo salar). Developmental & Comparative Immunology 2009. 33: 1011-1017.
Skjæveland,I., D. B. Iliev, & J. B. Jørgensen(2009). Identification and characterization of TLR8 and MyD88 homologs in Atlantic salmon (Salmo salar.) Developmental & Comparative Immunology. 33: 1011-1017
Skjesol, A,. Aamo, T, M.N. Hegseth, Robertsen, B. & J.B. Jørgensen (2009). The interplay between infectious pancreatic necrosis virus (IPNV) and type I IFN. Inhibition of IFN signaling by IPNV proteins VP4 and VP5. Virus Research, 143, 53-60.
Hansen,TE, Puntervoll,P, SeternesOM & J B. Jørgensen (2008). Atlantic salmon possess three mitogen activated protein kinase kinase 6 papralogs responding differently to stress. FEBS Journal, 275 4887-4902.
Strandskog, G., Skjæveland, I. Ellingsen & J. B. Jørgensen(2008).Double-stranded RNA and CpG DNA induced immune responses in Atlantic salmon: Comparison and synergies. Vaccine, 26, 4704-4715.
Skjæveland,I., D. B. Iliev,J. Zou, T. Jørgensen & J. B. Jørgensen(2008). A TLR9 homolog that is up-regulated by IFN- in Atlantic salmon (Salmon salar).Developmental and Comparative Immunology, 32, 603-607.
Jørgensen, J. B, A. Johansen, M. N. Hegset, J. Zou,B. Robertsen, & C. J. Secombes (2007). A recombinant CSHE-214 cell line expressing an Mx1 promoter-reporter system responds to both type I and II interferon from salmonids and represents a versatile tool to study the IFN-system in teleost fish. Fish & Shellfish Immunology, 23, 1294-1303.
Røkenes,T. P., A. Skjesol & J.B. Jørgensen (2007). Intermolecular interactionsof infectious pancreas necrosis virus: capsid protein VP3 interacts with dsRNA and the RNA-dependent RNA polymerase VP1. Journal of Virology, 81, 6652-6663.
Hansen, T. E. & J.B. Jørgensen(2007). Cloning and characterisation of p38 MAP kinase from Atlantic salmon. A kinase important for regulating salmon TNF-2 and IL-1β expression. Molecular Immunology, 44, 3137-3146.
Strandskog, G. T. Ellingsen & J. B. Jørgensen(2007). Characterization of three distinct CpG oligonucleotide classes which differ in ability to induce IFNa/b activity and cell proliferation in Atlantic salmon (Salmo salar L.) leukocytes.Developmental and Comparative Immunology, 31, 39-51.
Pedersen, G. M., Johansen, A., Olsen, R. L. & J. B. Jørgensen (2006). Stimulation of anti-viral mechanisms in Atlantic salmon (Salmo salar) leukocytes: synergetic effects of cationic proteins and CpG ODN. Fish and Shellfish Immunology, 20, 203-518.
Johansen, A., Collett, E. B., Sandaker, B; Secombes, C. J.& Jørgensen, J. B. (2004). Quantification of Atlantic salmon type-I interferon using an Mx1 promoter reporter gene assay. Fish and Shellfish Immunology, 16,173-184.
Jørgensen, J. B., L.-H. Johansen, K. Steiro & A. Johansen (2003). CpG DNA induces protective antiviral immune responses in Atlantic salmon (Salmo salar L.). Journal of Virology, 77, 11471-1147.
Konferansen Frisk Fisk, Bergen, januar 2009: Stimulering av medfødt immunitet - en viktig strategi for nye generasjoner av vaksiner for fisk?
Europharmas Lofoten-seminar, Lofoten juni 2009: Toll-lignende reseptorer: Ny mulighet for økt kontroll av virusinfeksjoner.
10th International Congress of ISDCI, Charleston, South Carolina, USA. Theuse of CpG oligonucleotides as immunstimulants in fish.
Funksjonell genomforskning i Norge: Til å leve av - til å leve med? NRC, Fuge conference, Oslo, april 2003: Marin funksjonell genomforskning - hvordan sette Norge på verdenskartet?
Bioteknologi i primærnæringene - visjon og nytte, Biotechnology program arranged conference at Continental Hotel NRC SAS Hotell, Gardemoen, september 2002: DNA er mer enn gener, spesielle DNA-sekvenser øker motstandsevnen mot sykdom hos laks.
Invited speaker at the workshop" Non-specific defence mechanisms of fish". EAFP 9th International Conference on Diseases of Fish and Shellfish, Rhodes, Greece: The potential use of DNA oligonucleotides as immunostimulants.