Dominik Ausbacher

Enhet: Institutt for farmasi



Conference presentations

9) Dominik Ausbacher; Lindsey A. Lorenz; Darla M. Goeres; Philip S. Stewart ; Morten B. Strøm; Pia M. Vuorela; Adyary Fallarero. Antimicrobial β2,2-amino acid derivatives eliminate Staphylococcus aureus biofilms by membrane disruption and biomass removal. DPhG Annual Meeting, Munich (2016).

8) Leena Hanski, Dominik Ausbacher; Morten B. Strøm; Pia M. Vuorela. Impact of β2,2-amino acid derivatives, a novel class of Chlamydia pneumoniae inhibitors, on bronchial epithelium VEGF production. Conference on Lung and Respiratory Care, Manchester (2016).

7) Adyary Fallarero, Malena Skogman, Vânia Moreira, Suvi Manner, Dominik Ausbacher, Reko Leino, Morten B. Strøm, Jari Yli-Kauhaluoma, Pia M. Vuorela. The challenges of discovering new anti-biofilm probes from a high-throughput screening (HTS) perspective. Eurobiofilms 2013 - 3rd European Congress on Microbial Biofilms - Basic and Clinical Aspects, Ghent (2013).

6) Leena Pohjala, Dominik Ausbacher, Morten B. Strøm, Pia M. Vuorela. Inhibition of Chlamydia pneumoniae infectivity by β-amino acid derivatives mimicking cationic antimicrobial peptides. 7th meeting of the European society for Chlamydia research, Amsterdam (2012).

5) Dominik Ausbacher, Janni Kujala, Pia M. Vuorela, Morten B. Strøm, Adyary Fallarero. Control of Staphylococcus aureus biofilm with highly active β2,2-amino acid derivatives. 3rd International Symposium on Antimicrobial Peptides, Lille (2012).

4) Dominik Ausbacher, Terkel Hansen, Gunbjørg Svineng, Morten B. Strøm. Mechanisms of cancer cell death induced by novel cationic β-peptidomimetics. 22nd American Peptide Symposium, San Diego (2011).

3) Terkel Hansen, Dominik Ausbacher, Martina Havelkova, Morten B. Strøm. Bactericidal activity of small β-peptidomimetics. 31. European Peptide Symposium, Copenhagen (2010).

2) Veronika Tørfoss, Dominik Ausbacher, Terkel Hansen, Martina Havelkova, Morten B. Strøm Anticancer activity of small cationic β-peptidomimetics. 31. European Peptide Symposium, Copenhagen (2010).

1) C. Becker, A. Ehmer, A. Maschke, A. Meindorfer, D. Ausbacher, J. Tessmar, T. Blunk, A. Goepferich. Influence of Micronisation of Proteins on the Properties of Lipid Microparticles for Controlled Release. DPhG Joint Meeting, Marburg (2006).



19) von Hofsten, S; Paulsen, M.H.; Magnussen, S.N.; Ausbacher, D.; Kranz, M.; Bayer, A.; Strøm, M.B., Berge, G. (2022).  The marine natural product mimi MPM‑1 is cytolytic and induces DAMP release from human cancer cell lines, Scientific Reports. 12:15586. DOI: 10.1038/s41598-022-19597-4

18) Paulsen, M.P.; Engqvist, M.; Ausbacher, D.; Anderssen T.; Langer, M.K.; Haug, T. Morello, G.R.;  Liikanen, L.E.; Blencke, H-M.; Isaksson, J.; Juskewitz, E. Bayer, A.; Strøm, M.B. (2021). Amphipathic Barbiturates as Mimics of Antimicrobial Peptides and the Marine Natural Products Eusynstyelamides with Activity against Multi-resistant Clinical Isolates, J. Med Chem. 64: 11395–11417. DOI: 10.1021/acs.jmedchem.1c00734

17) Eksteen, J. J.; Ausbacher, D.; Vasskog, T.; Rekdal, Ø.; Svendsen, J. S. M. (2020). Selective intracellular delivery of thiolated cargo to tumor and neovasculature cells using histidine-rich peptides as vectors. ACS Omega DOI: 10.1021/acsomega.9b00700

16) Paulsen, M.H.; Ausbacher, D.; Bayer, A.; Engqvist, M; Hansen, T.; Haug, T.; Anderssen, T.; Andersen, J.H.; Ericson Sollid J.U.; Strøm, M.B. (2019). Antimicrobial activity of amphipathic α, α-disubstituted β-amino amide derivatives against ESBL–CARBA producing multi-resistant bacteria; effect of halogenation, lipophilicity and cationic character. European Journal of Medicinal Chemistry. DOI: 10.1016/j.ejmech.2019.111671

15) Paulsen, M.H.; Karlsen, E.A.; Ausbacher, D.; Anderssen, T.; Bayer, A.; Ochtrop, P.; Hedberg, C.; Haug, T.; Ericson Sollid, J.U.; Strøm M.B. (2018). An amphipathic 13-membered cyclic tetrapeptide scaffold containing β2,2-amino acids with activity against multi-resistant bacteria. Journal of Peptide Science. DOI: 10.1002/psc.3117

14) Ausbacher, D; Lorenz, L.A.; Pitts, B.; Stewart, P.S.; Goeres, D.M. (2017). Paired methods to measure biofilm killing and removal: a case study with Penicillin G treatment of Staphylococcus aureus biofilm. Letters in Applied Microbiology. DOI: 10.1111/lam.12843.

13) Eksteen, J.J.; Ausbacher, D.; Simon-Santamaria, J.; Stiberg, T.; Cavalcanti-Jacobsen, C.; Wushur, I.; Svendsen, J.S.; Rekdal, Ø. (2016). Iterative design and in vivo Evaluation of an oncolytic antilymphoma peptide. Journal of Medicinal Chemistry. DOI: 10.1021/acs.jmedchem.6b00839.

12) Paulsen, M.H.; Engqvist, M.; Ausbacher, D.; Strøm, M. B.; Bayer, A. (2016). Efficient and scalable synthesis of α,α-­disubstituted β-amino amides. Organic and biomolecular chemistry . ISSN 1477-0520.s DOI: 10.1039/C6OB01219A.

11) Hanski, L.#; Ausbacher, D.#; Tiirola, T.M.; Strøm, M.B.; Vuorela, P.M. (2016). Amphipathic β2,2-amino acid derivatives suppress infectivity and Ddsrupt the intracellular replication cycle of Chlamydia pneumoniae. PLoS ONE, 11(6). DOI: 10.1371/journal.pone.0157306. #contributed equally

10) Sivertsen, A.; Tørfoss, V.; Isaksson, J.; Ausbacher, D.; Anderssen, T.; Brandsdal, B. O.; Havelkova, M.; Skjørholm, A. E.; Strøm M.B. (2013). Anticancer potency of small linear and cyclic tetrapeptides and pharmacokinetic investigations of peptide-binding to human serum albumin. J. Pept. Sci., 20: 279-291.

9) Ausbacher, D.; Fallarero, A.; Kujala, J.; Määttänen, A; Jouko, Peltonen; Strøm, M.B.; Vuorela, P.M. (2014). Staphylococcus aureus biofilm susceptibility to small and potent β2,2-amino acid derivatives. Biofouling, 30: 81-93. DOI: 10.1080/08927014.2013.847924

8) Ausbacher, D.; Svineng, G.; Hansen, T.; Strøm M.B. (2012). Anticancer mechanisms of action of two small amphipathic β2,2-amino acid derivatives derived from antimicrobial peptides. Biochimica et Biophysica Acta (BBA) - Biomembranes, 1818: 2917-2925. DOI: 10.1016/j.bbamem.2012.07.005

7) Hansen, T.; Ausbacher, D.; Zachariassen, Z.G.; Anderssen, T.; Havelkova, M.; Strøm M.B. (2012) Anticancer activity of small amphipathic β2,2-amino acid derivatives, European Journal of Medicinal Chemistry, 58: 22-29.

6) Tørfoss, V.; Isaksson, J.; Ausbacher, D.; Brandsdal, B. O.; Flaten, G. E.; Anderssen, T.; Cavalcanti-Jacobsen, C. de A.; Havelkova, M.; Nguyen, L. T.; Vogel, H. J.; Strøm, M. B. (2012) Improved anticancer potency by head-to-tail cyclisation of short cationic anticancer peptides containing a lipophilic β2,2-amino acid, Journal of Peptide Science, 18: 609-619.

5) Tørfoss, V.; Ausbacher, D.; Cavalcanti-Jacobsen, C.deA.; Hansen, T.; Brandsdal, B-.O.; Havelkova, M.; Strøm, M.B. (2011): Synthesis of anticancer heptapeptides containing a unique lipophilic β2,2-amino acid building block, Journal of Peptide Science 18: 170-176.

4) Hansen, T.; Ausbacher, D.; Flaten, G. E.; Havelkova, M.; Strøm, M. B.(2011): Synthesis of cationic antimicrobial β2,2-amino acid derivatives with potential for oral administration, Journal of Medicinal Chemistry 54: 858-868.

3) Hupfeld, S.; Moen, H. H.; Ausbacher, D.; Haas, H.; Brandl, M. (2010): Liposome fractionation and size analysis by asymmetrical flow field-flow fractionation/multi-angle light scattering: influence of ionic strength and osmotic pressure of the carrier liquid. Chemistry and Physics of Lipids 163: 141-147.

2) Hupfeld, S.; Ausbacher, D.; Brandl, M. (2009): Asymmetric flow field-flow fractionation of liposomes: 2. Concentration-detection and adsorptive loss phenomena. Journal of Separation Science 32: 3555-3561.

1) Hupfeld, S.; Ausbacher, D.; Brandl, M. (2009): Asymmetric flow field-flow fractionation of liposomes: optimization of fractionation variables. Journal of Separation Science 32: 1465-1470.



Strøm M.B., Bayer A., Engquvist M.S.O., Paulsen M.H., Ausbacher, D. (2018). Barbituric acid derivatives comprising cationic and lipophilic groups. US11072588B2/en


Personal overseas research grant of the Research Council of Norway (2014/15)

UiT transition grant for recruitment of young researchers (2012/13)

UiT mobility grant for research abroad (2011)

Travel grant of the Norwegian Pharmaceutical Society (2011)


Studies and Education

09/2015 - 02/2017
Postdoc, Faculty of Health Sciences, Natural Products and Medicinal Chemistry Research Group, Prof. M. B. Strøm, UiT-The Arctic University of Norway

03/2015 - 08/2015
Postdoc, Center for Biofilm Engineering, Standardized Biofilm Methods Laboratory, Assistant Prof. D. Goeres and Biofilm Control Laboratory, Prof. P.Stewart, Montana State University, Bozeman, USA

09/2014 - 02/2015
Postdoc, Faculty of Pharmacy, Division of Pharmaceutical Biosciences, Anti-infective Research Laboratory, Adjunct Prof. A. Fallarero and Prof. P. Vuorela, University of Helsinki, Finland

03/2013 - 08/2014
Postdoc, Faculty of Health Sciences, Natural Products and Medicinal Chemistry Research Group, Prof. M. B. Strøm, UiT-The Arctic University of Norway

11/2012 - 02/2013
Researcher, Faculty of Health Sciences, UiT-The Arctic University of Tromsø

PhD thesis defence: Biological activity of β2,2-amino acid derivatives derived from antimicrobial peptides- Investigations of Antimicrobial and Anticancer Activity and the Mechanisms of Action

11/2011 - 02/2012
Visiting PhD student, Pharmacutical Sciences Laboratory, Prof. P. Vuorela, Åbo Akademi University, Turku, Finland

10/2008 - 09/2012
Ph.D. student, Faculty of Health Sciences, Natural Products and Medicinal Chemistry Research Group Prof. M. B. Strøm, UiT-The Arctic University of Norway

07/2008 and 12/2012
Licensure for the profession as pharmacist in Germany and Norway

Diploma defence, A4F/MALS Analysis of Liposomes, Faculty of Biosciences, Department of Pharmaceutical Technology Prof. K. Mäder, University of Halle, Germany

05/2007 - 10/2007
Diploma student, Faculty of Health Sciences, Drug Transport and Delivery Research Group Prof. M. Brandl, UiT-The Arctic University of Norway

Second State Exam

First State Exam

10/2002 - 04/2007
Pharmacy studies, University of Regensburg, Germany

Karlsgymnasium Bad Reichenhall, University-entrance diploma



German (native)


Work experience

Researcher for Epitarget AS, Oslo

11/2007 - 04/2008
Pharmacist in practical training, Ahorn Apotheke, Regensburg

09/2006 - 10/2006
Aenova Sales Pharma - Dragenopharm-Apotheker Püschel GmbH & Co. KG, Tittmoning

07/2001 - 06/2002
Service in the mountain infantry batallion Berchtesgaden, Armed forces of Germany



Gøril Eide Flaten

Enhet: Institutt for farmasi


Sjekk ut mitt engelske personkort for mer informasjon og videopresentasjon av forskningen vår.




Ann Mari Holsæter

Enhet: Institutt for farmasi


Forskningen hennes har fokus på avanserte legemiddelformuleringer, og forbedring av legemiddelterapi gjennom forbedring av legemidlenes opptak, stabilitet og/eller spesifisitet, med reduserte bivirkninger og økt effekt av behandling som mål. Hun har særlig ekspertise og interesse for liposomer, nanofibre og hydrogeler, anvendt alene eller i kombinasjon. Disse formuleringen er i hennes tilfelle i hovedsak fremstilt for topikal (huden, og sårbehandling) og systemisk administrasjon (injeksjonsmedisin), og da gjerne med antimikrobiell, anti-cancer eller immunstimmulerende effekt som mål. 

I forskningsgruppen har Ann Mari særlig ekspertise på teknologier som elektrospinning av nanofibre og bruk av "dual centrifugering" i fremstilling av nanopartikler, inkluderte liposomer. 


Arne O. Smalås

Enhet: Fakultet for naturvitenskap og teknologi

arne.smalas@uit.no +4777644070
  • Makromolekylers struktur og funksjon
  • Det molekylære opphav til enzymers kuldeadaptasjon
  • Utvikling av enzymer for anvendelse
  • Bioprospektering

Morten Bøhmer Strøm

Enhet: Institutt for farmasi


Professor, prodekan forskning og innovasjon

Morten B. Strøm er Prodekan forskning og innovasjon ved Det helsevitenskapelige fakultet. Han er professor i legemiddelkjemi ved Institutt for farmasi, Forskningsgruppe i naturstoff- og legemiddelkjemi. Forskningen hans omhandler utvikling av peptider og peptid etterligninger (peptidomimetika) med aktivitet mot resistente bakterier og med aktivitet mot kreftceller. Sammen med andre forskningsgrupper ved UiT studerer vi hvordan disse molekylene kan utvikles til å bli fremtidige legemidler og legemiddelformuleringer. Dette har gitt viktig erfaring innen innovasjon, patentering og kommersialisering.

Professor ved Forskningsgruppe i naturstoff- og legemiddelkjemi.


1) Design, synthesis and development of antimicrobial and anticancer peptides and peptidomimetics as lead-compounds for drug-development and investigation of pharmacophore models.

2) Design and synthesis of peptidomimetics and bioactive scaffolds for optimization of potency and pharmacokinetic properties.

3) Isolation and structural elucidation of marine bioactive compounds from Arctic and sub-Arctic marine invertebrates and synthesis of marine natural product mimics (marine bio-prospecting).

ORCID: https://orcid.org/0000-0003-1973-0778.

Veiledning av PhD studenter

  1. 2000 – 2004: Biveileder for PhD Morten K. Moe - Tittel på PhD avhandling: ESI low-energy tandem MS characterisation of lipids modified by a novel derivatisation method. Finansiert av Norges Forskningsråd.
  2. 2007 – 2010: Biveileder for PhD Margey Tadesse - Tittel på PhD avhandling: Antimicrobial natural products from Arctic and sub-Arctic marine invertebrates. Finansiert av UiT.
  3. 2007 – 2011: Hovedveileder for PhD Terkel Hansen (cand. pharm.) - Tittel på PhD avhandling: Antimicrobial and anticancer beta-peptidomimetics – synthesis and biological evaluation of a new class of small and highly potent compounds. Finansiert av UiT.
  4. 2008 – 2012: Hovedveileder for PhD Dominik A. Ausbacher (cand. pharm.) - Tittel på PhD avhandling: Biological activity of β2,2-amino acid derivatives derived from antimicrobial peptides - Investigations of antimicrobial and anticancer activity and the mechanisms of action. Finansiert av UiT.
  5. 2008 – 2013: Hovedveileder for PhD Veronika Tørfoss (cand. pharm.) - Tittel på avhandling: Short anticancer peptides containing a lipophilic β2,2-amino acid - Synthesis and biological evaluation of linear and cyclic hepta-, hexa-, penta-, and tetrapeptides. Finansiert av Norges Forskningsråd (KOSK-II programmet).
  6. 2011 – 2015: Biveileder for PhD Elisabeth Klungerbo Olsen (cand. pharm.) - Tittel på avhandling: Bioprospecting of Arctic marine organisms. Finansiert av MabCent – SFI.
  7. 2011 – 2015: Hovedveileder for Elizaveta Mikhailovna Igumnova - Arbeidstittel: Chemical synthesis, isolation, and structural characterization of marine bioactive hit compounds. Finansiert av MabCent – SFI.
  8. 2011 – 2016: Biveileder for PhD Runar Gjerp Solstad - Tittel på avhandling: Discovery of antimicrobial peptides in two invertebrates, the sea anemone Urticina eques and the sea urchin chinus esculentus - Isolation, characterization and structure-activity relationship studies. Finansiert av UiT.
  9. 2012 – 2017: Hovedveileder for PhD Marianne Hagensen Paulsen - Tittel på avhandling: Synthetic mimics of antimicrobial peptides. Synthesis and biological studies of novel synthetic mimics of antimicrobial peptides. Finansiert av Norges Forskningsråd og UiT - "Fellesløftet".
  10. 2014 – 2017: Biveileder for PhD Thomas Aleksander Bakka (NTNU - Trondheim) - Tittel på avhandling: Synthesis and antimicrobial evaluation of small molecule amphiphiles derived from amphiphilic antimicrobial natural products. Finansiert av NTNU.
  11. 2018 – pågående prosjekt: Biveileder for Christoffer Ågnes Sivertsen (Fakultet for biovitenskap, fiskeri og økonomi - BFE, NFH UiT) - Arbeidstittel: Antibacterial and antibiofilm compounds in Arctic and sub-Arctic invertebrates. Finansiert av UiT - Norges arktiske universitet - "Tematiske satsninger" - AntifoMar.
  12. 2018 – 2022: Biveileder for PhD Manuel Karl Langer (Institutt for kjemi - IKJ, UiT) - Tittel på avhandling: Marine natural product inspired synthesis towards new antimicrobial and antifouling agents. Finansiert av UiT - Norges arktiske universitet - "Tematiske satsninger" - AntifoMar.
  13. 2019– pågående prosjekt: Biveileder for Hymonti Dey (Fakultet for biovitenskap, fiskeri og økonomi - BFE, NFH UiT) - Arbeidstittel: Bioactivity screening, mode-of-action (MoA) studies, and screening for mechanism of resistance development of novel antimicrobial peptides and peptidomimetics. Finansiert av UiT - Norges arktiske universitet - "Tematiske satsninger" - LEADScAMR.
  14. 2019 – 2023: Biveileder for PhD Susannah von Hofsten (Institutt for medisinsk biologi - IMB, UiT) - Tittel på avhandling: Anticancer activity of amphipathic barbiturates. Finansiert av UiT - Norges arktiske universitet.
  15. 2018 – 2023: Hovedveileder for PhD Danijela Simonovic (Institutt for farmasi - IFA, UiT) - Tittel på avhandling: Synthesis and structure-activity relationship studies of marine-derived antimicrobial peptides and small cyclic peptidomimetics. Finansiert av UiT - Norges arktiske universitet - "Tematiske satsninger" - LEADScAMR.
  16. 2019 – 2024: Biveileder for PhD Ataur Rahman (Fakultet for biovitenskap, fiskeri og økonomi - BFE, NFH UiT) - Tittel på avhandling: Bioactivity profiling and mode of action studies of antibacterial and antibiofilm agents of marine origin. Finansiert av UiT - Norges arktiske universitet - "Tematiske satsninger" - AntifoMar.

Veiledning av masterstudenter

Jeg har siden 2003 vært veileder for 31 mastergradsstudenter i farmasi / legemiddelkjemi / organisk kjemi.