The Natural Products and Medicinal Chemistry Research Group focuses on marine natural products, medicinal chemistry, and bioanalytical chemistry. The group aims at developing novel lead compounds and formulations that can be used as future drug treatments for bacterial infections and cancer, which are diseases that affect thousands of people worldwide. The group's research also includes the development of novel -omics technology that can be used in diagnostic and personalized medicine (PM). The group uses advanced high-resolution LC-MS (liquid chromatography – mass spectrometry) in the fields of lipidomic and metabolomic to identify unique biomarkers for the development of novel diagnostic tools for disease detection and treatment. Overall, the Natural Products and Medicinal Chemistry Research Group aims at making a significant impact on society by developing new treatments for bacterial infections and cancer, as well as advancing diagnostic and personalized medicine through the use of -omics technology.
The group's Masters, PhD, and postdoc projects involve the synthesis of novel antimicrobial and anticancer peptides and peptidomimetics inspired by molecules from the sea (marine bioprospecting), investigations of bioactive molecules by NMR spectroscopy (nuclear magnetic resonance spectroscopy), inventive drug formulations, and lipidomic and metabolomic studies of clinical patient samples by high-resolution LC-MS.
Research focus natural products and medicinal chemistry:
Design and synthesis of peptides and peptidomimetics with antimicrobial, antibiofilm and anticancer activity, and inspired by antimicrobial peptides and marine natural products.
Lead-compound identification, structure activity-relationship studies, and mode-of-action studies.
The group has an automatic microwave assisted peptide synthesizer, and offers master and PhD projects in the field of amino acid, peptide and peptidomimetic synthesis together with biological studies in collaboration with external partners.
Research focus bioanalytical chemistry:
Lipidomic and metabolomic studies, and targeted quantification of small molecules from biological samples. The main focus of the lipidomic and metabolomic studies are investigations of clinical samples, including all steps from sample preparation to the understanding of biological relevance.
The research group is part of the Proteomics and Metabolomics Core Facility (PRiME) at UiT, and has access to UPLC-instruments with advanced low- and high-resolution mass spectrometers.
The group offers master and PhD projects in advanced analytical chemistry and in collaboration with external partners.
The research group has interdisciplinary projects within medicinal chemistry, bioanalytical chemistry, structure elucidation by NMR and MS, and drug formulation and delivery studies.
(Revised: October 23. 2023)
Julie Strømberg "Structure elucidation and bioactivity screening and optimization of disulfide rich peptides"
Marita Perez Syltern "Mapping antimicrobial resistance through a mass spectrometry based multi-omics approach"
Marit Huizer "AlgScaleUp - converting industrial greenhouse gases to valuable biomass"
Torbjørn Norberg Myhre "Trombolome - Development and application of a comprehensive digital archive of the Tromsø study metabolome"
Danijela Simonovic (2023) - Synthesis and structure-activity relationship studies of marine-derived antimicrobial peptides and small cyclic peptidomimetics. https://hdl.handle.net/10037/29375
Lorenz Göschl (2022) - Discovery and detection of phase-II metabolites of exogenous steroids in anti-doping analysis. https://hdl.handle.net/10037/24767
Joseph Diab (2020) - The Metabolome and Lipidome of Ulcerative Colitis. https://hdl.handle.net/10037/19449
Armin Schniers (2019) - The proteome of ulcerative colitis. https://hdl.handle.net/10037/15810
Stine Høgetveit Hansen (2023) - Synthetic Peptide Analogues of Turgencin A:
Optimization of Antibacterial Activity and Elucidation of Disulfide Connectivity by Sequential Alkylation and Mass Spectrometric Analysis
Magnus Andersland Antonsen (2023) - Mass Spectrometry Based Metabolomic and Lipidomic Analyses of Algal Biomass
Rasmus Pedersen (2023) -
Johannes Kristensen (2023) - Synthesis, bioactivity testing, and structure elucidation of antimicrobial peptide analogues derived from Synoicum Turgens
Johannes Frydenlund (2023) - Alterations in the metabolomic profile of Escherichia coli following experimental resistance evolution to ciprofloxacin
Gøril Laugsand (2023) - Using High-Resolution Mass Spectrometry to identify lipids in marine bacterial biomass
Bielul Haileab (2023) - Endringer i den metabolske profilen hos Escherichia coli ved utvikling av trimetoprimresistens
Agnethe Hansen Bæverud (2022) - Mass cultivation of the marine diatom Porosira glacialis: Method development and comparison of pigment composition in response to irradiance wavelength
Amalie Rebekka Nyborg (2022) - Isolation and characterization of secondary metabolites from Arctic, Marine Invertebrates
Kristine Haugland (2022) - Identification and semi-quantitative analysis of lipids in the diatom Porosira
Hemmingsen, L.M.; Giordani, B.; Paulsen, M.H.; Vanić, Ž.; Flaten, G.E.; Vitali, B.; Basnet, P.; Bayer, A.; Strøm, M.B.; Škalko-Basnet, N. Tailored anti-biofilm activity – Liposomal delivery for mimic of small antimicrobial peptide. Biomaterials Advances, 2023, 145, 213238, https://doi.org/10.1016/j.bioadv.2022.213238.
Dey, H., Simonovic, D., Norberg-Schulz Hagen, I., Vasskog, T., Fredheim, E.G.A., Blencke, H.-M., Anderssen, T., Strøm, M.B., Haug, T. Synthesis and Antimicrobial Activity of Short Analogues of the Marine Antimicrobial Peptide Turgencin A: Effects of SAR Optimizations, Cys-Cys Cyclization and Lipopeptide Modifications. International Journal of Molecular Sciences, 2022, 23(22), 13844. https://doi.org/10.3390/ijms232213844
Paulsen, M.H.; Engqvist, M.; Ausbacher, D.; Anderssen, T.; Langer, M.K.; Haug, T.; Morello, G.R.; Liikanen, L.E.; Blencke, H-.M.; Isaksson, J.; Juskewitz, E.; Bayer, A.; Strøm, M.B. Amphipathic Barbiturates as Mimics of Antimicrobial Peptides and the Marine Natural Products Eusynstyelamides with Activity against Multi-resistant Clinical Isolates. J. Med. Chem. 2021, 64, 11395. https://doi.org/10.1021/acs.jmedchem.1c00734
General approach to determine disulfide connectivity in cysteine-rich peptides by sequential alkylation on solid phase and mass spectrometry Analytical Chemistry 2016 DOI
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