Kristin Hegstad
Stillingsbeskrivelse
Bistilling som professor ved Forsningsgruppe for Vert-Mikrobe Interaksjoner ved Institutt for Medisinsk Biologi UiT
Hovedstilling som senior forsker ved Nasjonal kompetansetjeneste for påvisning av antibiotikaresistens (K-res) ved Avdeling for Mikrobiologi og Smittevern Universitetssykehuset Nord-Norge
Ingrid Maria Cecilia Rubin,
Vittal Prakash Ponraj,
Kasper Thystrup Karstensen,
Mikkel Lindegaard,
Kristin Hegstad,
Ana R. Freitas
m.fl.:
Virulence signature of the endemic vancomycin-resistant
Enterococcus faecium
clones in Denmark, 2015-2023
Theodor Anton Ross,
Jessin Janice,
Sergio Arredondo Alonso,
Iren Høyland Löhr,
Einar Holsbø,
Jukka Corander
m.fl.:
Enterococcus lactis is ecologically and genetically distinct from the major opportunistic pathogen Enterococcus faecium
Dagfinn Skaare,
Inger Lill Anthonisen,
Zecic Nermin,
Andrew John Jenkins,
Dominique Andree Yette Caugant,
Trond Egil Ranheim
m.fl.:
Genomic profiling of cefotaxime-resistant Haemophilus influenzae from Norway and Sweden reveals extensive expansion of virulent multidrug-resistant international clones
Stephen Dela Ahator,
Karoline Wenzl,
Kristin Hegstad,
Christian Stephan Lentz,
Mona Susan Johannessen
:
Comprehensive virulence profiling and evolutionary analysis of specificity determinants in Staphylococcus aureus two-component systems
Theresa Maria Wagner,
Anna Kaarina Pöntinen,
Carolin Fenzel,
Daniel Engi,
Jessin Janice,
Ana C. Almeida-Santos
m.fl.:
Interactions between commensal Enterococcus faecium and Enterococcus lactis and clinical isolates of Enterococcus faecium
Jeanette Slettnes Grunnvåg,
Kristin Hegstad,
Christian Stephan Lentz
:
Activity-based protein profiling of serine hydrolases and penicillin-binding proteins in Enterococcus faecium
Jonathan Hira,
Bhupender Singh,
Tirthankar Halder,
Anel Mahmutovic,
Clément Ajayi,
Arif Ahmed Sekh
m.fl.:
Single-cell phenotypic profiling and backtracing exposes and predicts clinically relevant subpopulations in isogenic Staphylococcus aureus communities
Stephen Dela Ahator,
Kristin Hegstad,
Christian Stephan Lentz,
Mona Susan Johannessen
:
Deciphering Staphylococcus aureus–host dynamics using dual activity-based protein profiling of ATP-interacting proteins
Theresa Wagner,
Jessin Janice,
Marc Schluz,
Susan Ballard,
Anders da Silva,
Geoffrey W Coombs
m.fl.:
Reversible vancomycin susceptibility within emerging ST1421 Enterococcus faecium strains is associated with rearranged vanA-gene clusters and increased vanA plasmid copy number
Theresa Maria Wagner,
Felipe Romero-Saavedra,
Diana Laverde,
Mona Susan Johannessen,
Johannes Hübner,
Kristin Hegstad
:
Enterococcal Membrane Vesicles as Vaccine Candidates
Guido Werner,
Natacha Couto,
Edward J. Feil,
Angela Novais,
Kristin Hegstad,
Benjamin P. Howden
m.fl.:
Taking hospital pathogen surveillance to the next level
Kristin Hegstad,
Anna Kaarina Pöntinen,
Jørgen Bjørnholt,
Else Quist Paulsen,
Arnfinn Ståle Sundsfjord
:
The first tigecycline resistant Enterococcus faecium in Norway was related to tigecycline exposure
Mushtaq al Rubaye,
Jessin Janice,
Jørgen Vildershøj Bjørnholt,
Oliver Kacelnik,
Bjørg C. Haldorsen,
Randi M. Nygaard
m.fl.:
The population structure of vancomycin-resistant and
-susceptible Enterococcus faecium in a low-prevalence
antimicrobial resistance setting is highly influenced by
circulating global hospital-associated clones
Mushtaq Talib Shawi al Rubaye,
Jessin Janice,
Jørgen Bjørnholt,
Iren Høyland Löhr,
Arnfinn Ståle Sundsfjord,
Kristin Hegstad
:
The first vanE-type vancomycin resistant Enterococcus faecalis isolates in Norway – phenotypic and molecular characteristics
Amalie Von Barner Tvedegaard Heim,
Jessin Janice,
Jørgen Bjørnholt,
Bjørn Tore Lunestad,
Kristin Hegstad,
Cecilie Smith Svanevik
:
Genomic insights into Enterococcus faecium isolates from marine bivalves highlight One Health concerns and healthcare linkages
Jessin Janice,
Theresa Maria Wagner,
Karina Olsen,
Joachim Hegstad,
Kristin Hegstad
:
Emergence of vancomycin-resistant enterococci from vancomycin-susceptible enterococci in hospitalized patients under antimicrobial therapy
Theresa Wagner,
Benjamin P Howden,
Arnfinn Sundsfjord,
Kristin Hegstad
:
Transiently silent acquired antimicrobial resistance: an emerging challenge in susceptibility testing
Theresa Maria Wagner,
Anna Kaarina Pöntinen,
Mushtaq T.S. AL Rubaye,
Arnfinn Ståle Sundsfjord,
Kristin Hegstad
:
Adaptive cell wall thickening in Enterococcus faecalis is associated with decreased vancomycin susceptibility
Helene Johannessen,
Inger Lill Anthonisen,
Nermin Zecic,
Kristin Hegstad,
Trond Egil Ranheim,
Dagfinn Skaare
:
Characterization and Fitness Cost of Tn7100, a Novel Integrative and Conjugative Element Conferring Multidrug Resistance in Haemophilus influenzae
Caillan Crowe-McAuliffe,
Victoriia Murina,
Kathryn Jane Turnbull,
Susanne Huch,
Marje Kasari,
Hiraku Takada
m.fl.:
Structural basis for PoxtA-mediated resistance to phenicol and oxazolidinone antibiotics
Sebastiaan J van Hal,
Rob J L Willems,
Theodore Gouliouris,
Susan A Ballard,
Teresa M Coque,
Anette M Hammerum
m.fl.:
The interplay between community and hospital Enterococcus faecium clones within health-care settings: a genomic analysis
Sebastiaan J. van Hal,
Rob J.L. Willems,
Theodore Gouliouris,
Susan A. Ballard,
Teresa M. Coque,
Anette M. Hammerum
m.fl.:
The global dissemination of hospital clones of Enterococcus faecium
Bishnu Joshi,
Bhupender Singh,
Aftab Nadeem,
Fatemeh Askarian,
Sun Nyunt Wai,
Mona Johannessen
m.fl.:
Transcriptome profiling of staphylococcus aureus associated extracellular vesicles reveals presence of small RNA-cargo
Monika Kumaraswamy,
Kamilla Wiull,
Bishnu Joshi,
George Sakoulas,
Armin Kousha,
Gustav Vaaje-Kolstad
m.fl.:
Bacterial membrane-derived vesicles attenuate vancomycin activity against methicillin-resistant staphylococcus aureus
Mushtaq T.S. Al-Rubaye,
Jessin Janice,
Jørgen Vildershøj Bjørnholt,
Aleksandra Jakovljev,
Maria Elisabeth Hultström,
Arnfinn Sundsfjord
m.fl.:
Novel genomic islands and a new vanD-subtype in the first sporadic VanD-type vancomycin resistant enterococci in Norway
Tommi Mäklin,
Teemu Kallonen,
Jarno Alanko,
Ørjan Samuelsen,
Kristin Hegstad,
Veli Mäkinen
m.fl.:
Bacterial genomic epidemiology with mixed samples
Theresa Wagner,
Jessin Janice,
Audun Sivertsen,
Ingegerd Sjögren,
Arnfinn Sundsfjord,
Kristin Hegstad
:
Alternative vanHAX promoters and increased vanA-plasmid copy number resurrect silenced glycopeptide resistance in Enterococcus faecium
Jonathan Hira,
Bhupender Singh,
Theresa Maria Wagner,
Kristin Hegstad,
Mona Susan Johannessen,
Christian Stephan Lentz
:
A high-throughput platform for phenotypic profiling of bacteria coupled to single cell-derived growth analysis
2023 ARKIV
Ingeborg Mathiesen,
Anna Kaarina Pöntinen,
Mona Johannessen,
Kristin Hegstad,
Theresa Wagner
:
Characterization of Putative Virulence Factors in Enterococcus faecium
2023 ARKIV
Ingeborg Mathiesen,
Theodor Anton Ross,
Anna Kaarina Pöntinen,
Einar Holsbø,
Michael Kampffmeyer,
Mona Johannessen
m.fl.:
Characterization of Putative Virulence Factors in Enterococcus faecium
2023 ARKIV
Theresa Wagner,
Anna Kaarina Pöntinen,
Carolin Kornelia Fenzel,
Daniel Engi,
Jessin Janice,
Ana Almeida-Santos
m.fl.:
Competition between commensal Enterococcus faecium and Enterococcus lactis and clinical isolates of E. faecium
2023 ARKIV
Kristin Hegstad
:
Linezolidresistens hos enterokokker – mekanismer og diagnostikk
2023 ARKIV
Carolin Kornelia Fenzel,
Anna K. Pöntinen,
Mona Johannessen,
Kristin Hegstad,
Theresa Wagner
:
Characterization of competition between commensal and clinical strains of Enterococcus faecium
2023 ARKIV
Espen Morten Viklem Eidum,
Theresa Maria Wagner,
Kristin Hegstad
:
Researchers develop potential vaccine against antibiotic-resistant enterococci
Trygve Grønning,
Kristin Hegstad,
Theresa Maria Wagner
:
Ny forskning kan stoppe fryktet sykehus-bakterie
Theresa Maria Wagner,
Jan Fredrik Frantzen,
Kristin Hegstad
:
Utvikler potensiell vaksine mot antibiotikaresistent sykehusbakterie
Jan Fredrik Frantzen,
Theresa Maria Wagner,
Kristin Hegstad
:
Utvikler potensiell vaksine mot hissig sykehusbakterie
Theresa Wagner,
Felipe Romero-Saavedra,
Diana Laverde,
Mona Johannessen,
Johannes Hübner,
Kristin Hegstad
:
Enterococcal Membrane Vesicles as Vaccine Candidates
2023 ARKIV
Amalie von BT Heim,
Bjørn Tore Lunestad,
Jessin Janice,
Jørgen Bjørnholt,
Kristin Hegstad,
Cecilie Smith Svanevik
:
Enterococci in marine bivalves from Norway – where do they come from and should we be concerned?
2022 ARKIV
Kristin Hegstad
:
Vancomycin variable resistant enterococci
2022 ARKIV
Kristin Hegstad
:
Tigesyklinresistens hos enterokokker i Norge
2022 ARKIV
Ingeborg Mathiesen,
Mona Johannessen,
Kristin Hegstad,
Theresa Wagner
:
Characterisation of putative virulence factors in Enterococcus faecium
2022 ARKIV
Theodor Anton Ross,
Anna Kaarina Pöntinen,
Jessin Janice,
Einar Holsbø,
Jukka Corander,
Kristin Hegstad
m.fl.:
Leveraging machine learning for finding novel putative virulence factors in Enterococcus faecium
2022 ARKIV
Ingeborg Mathiesen,
Mona Johannessen,
Kristin Hegstad,
Theresa Wagner
:
Characterisation of putative virulence factors in Enterococcus faecium
2022 ARKIV
Julie Kalveland,
Kristin Hegstad,
Torni Kristin Myrbakk
:
UNN-forskere oppdaget ny mekanisme for antibiotikaresistens
Theresa Wagner,
Jessin Janice James Peter,
Marc Schulz,
Susan A. Ballard,
Anders Goncalves da Silva,
Geoffrey W Coombs
m.fl.:
Australian vancomycin variable E. faecium ST1421 revert to resistance by the use of an alternative vanHAX promoter and increased vanA-plasmid copy number
2021 ARKIV
Bjørg C Haldorsen,
Erika Matuschek,
Jenny Åhman,
Gunnar Kahlmeter,
Arnfinn Sundsfjord,
Kristin Hegstad
:
Performance of the EUCAST disc diffusion method and gradient tests in detection of linezolid susceptibility in Enterococcus faecalis and Enterococcus faecium
2021 ARKIV
Theresa Wagner,
Kristin Hegstad
:
Transiently silenced acquired antimicrobial resistance – an increasing challenge in antimicrobial susceptibility testing
2021 ARKIV
Theresa Wagner,
Mona Johannessen,
Kristin Hegstad
:
Towards a vaccine based on enterococcal membrane vesicles
2020 ARKIV
Theresa Wagner,
Clement Ajayi,
Mona Johannessen,
Kristin Hegstad,
Gro Grimnes,
Ingrid Hemmingsen
:
Brukermøte 2020
2020 ARKIV
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Forskningsinteresser
Forskningsinteresser: Antimikrobiell resistens; Spredning av resistens - Mobile genetiske elementer og horisontal genoverføring - Mekanismer for antimikrobiell resistens - Deteksjon av antimikrobiell resistens - Nye virulens faktorer som target for å ufarliggjøre patogener - Membranvesikler
Medlem av Senter for Nye Antibakterielle Strategier (CANS)
For publikasjoner se: https://orcid.org/0000-0002-1314-0497
Medlem i forskningsgruppe
CV
Utdanning
- 2000: Dr. Scient. (PhD) i Medisinsk Mikrobiologi, Universitetet i Tromsø.
- 1995: Cand. Scient. i Marin bioteknologi/mikrobiologi, Universitetet i Tromsø.
Yrkespraksis
- 2004-: Forsker, Kompetansesenter for påvisning av antibiotika resistens, Universitetssykehuset Nord-Norge.
- 2017-: Professor II, Forskningsgruppe for Vert-mikrobe interaksjoner, Institutt for Medisinsk Biologi, UiT - Norges arktiske Universitet.
- 2008-2010 + 2015-2017: Seksjonsleder/daglig leder, Kompetansesenter for påvisning av antibiotika resistens, Universitetssykehuset Nord-Norge.
- 2006-2016: Førsteamanuensis II, Forskningsgruppe for Vert-Mikrobe Interasjoner, Universitetet i Tromsø.
- 2002-2004: Post Doktor, Avdeling for Mikrobiologi og Virologi, Universitetet i Tromsø.
- 2001-2002: Post Doktor, Unité des Agents Antibactériens, Institut Pasteur, Paris.