Legemiddelutvikling

Conference presentations

9) Dominik Ausbacher; Lindsey A. Lorenz; Darla M. Goeres; Philip S. Stewart ; Morten B. Strøm; Pia M. Vuorela; Adyary Fallarero. Antimicrobial β^2,2-amino acid derivatives eliminate Staphylococcus aureus biofilms by membrane disruption and biomass removal. DPhG Annual Meeting, Munich (2016).

8) Leena Hanski, Dominik Ausbacher; Morten B. Strøm; Pia M. Vuorela. Impact of β^2,2-amino acid derivatives, a novel class of Chlamydia pneumoniae inhibitors, on bronchial epithelium VEGF production. Conference on Lung and Respiratory Care, Manchester (2016).

7) Adyary Fallarero, Malena Skogman, Vânia Moreira, Suvi Manner, Dominik Ausbacher, Reko Leino, Morten B. Strøm, Jari Yli-Kauhaluoma, Pia M. Vuorela. The challenges of discovering new anti-biofilm probes from a high-throughput screening (HTS) perspective. Eurobiofilms 2013 - 3rd European Congress on Microbial Biofilms - Basic and Clinical Aspects, Ghent (2013).

6) Leena Pohjala, Dominik Ausbacher, Morten B. Strøm, Pia M. Vuorela. Inhibition of Chlamydia pneumoniae infectivity by β-amino acid derivatives mimicking cationic antimicrobial peptides. 7th meeting of the European society for Chlamydia research, Amsterdam (2012).

5) Dominik Ausbacher, Janni Kujala, Pia M. Vuorela, Morten B. Strøm, Adyary Fallarero. Control of Staphylococcus aureus biofilm with highly active β^2,2-amino acid derivatives. 3rd International Symposium on Antimicrobial Peptides, Lille (2012).

4) Dominik Ausbacher, Terkel Hansen, Gunbjørg Svineng, Morten B. Strøm. Mechanisms of cancer cell death induced by novel cationic β-peptidomimetics. 22nd American Peptide Symposium, San Diego (2011).

3) Terkel Hansen, Dominik Ausbacher, Martina Havelkova, Morten B. Strøm. Bactericidal activity of small β-peptidomimetics. 31. European Peptide Symposium, Copenhagen (2010).

2) Veronika Tørfoss, Dominik Ausbacher, Terkel Hansen, Martina Havelkova, Morten B. Strøm Anticancer activity of small cationic β-peptidomimetics. 31. European Peptide Symposium, Copenhagen (2010).

1) C. Becker, A. Ehmer, A. Maschke, A. Meindorfer, D. Ausbacher, J. Tessmar, T. Blunk, A. Goepferich. Influence of Micronisation of Proteins on the Properties of Lipid Microparticles for Controlled Release. DPhG Joint Meeting, Marburg (2006).

Publications

19) von Hofsten, S; Paulsen, M.H.; Magnussen, S.N.; Ausbacher, D.; Kranz, M.; Bayer, A.; Strøm, M.B., Berge, G. (2022).  The marine natural product mimi MPM‑1 is cytolytic and induces DAMP release from human cancer cell lines, Scientific Reports. 12:15586. DOI: 10.1038/s41598-022-19597-4

18) Paulsen, M.P.; Engqvist, M.; Ausbacher, D.; Anderssen T.; Langer, M.K.; Haug, T. Morello, G.R.;  Liikanen, L.E.; Blencke, H-M.; Isaksson, J.; Juskewitz, E. Bayer, A.; Strøm, M.B. (2021). Amphipathic Barbiturates as Mimics of Antimicrobial Peptides and the Marine Natural Products Eusynstyelamides with Activity against Multi-resistant Clinical Isolates, J. Med Chem. 64: 11395–11417. DOI: 10.1021/acs.jmedchem.1c00734

17) Eksteen, J. J.; Ausbacher, D.; Vasskog, T.; Rekdal, Ø.; Svendsen, J. S. M. (2020). Selective intracellular delivery of thiolated cargo to tumor and neovasculature cells using histidine-rich peptides as vectors. ACS Omega DOI: 10.1021/acsomega.9b00700

16) Paulsen, M.H.; Ausbacher, D.; Bayer, A.; Engqvist, M; Hansen, T.; Haug, T.; Anderssen, T.; Andersen, J.H.; Ericson Sollid J.U.; Strøm, M.B. (2019). Antimicrobial activity of amphipathic α, α-disubstituted β-amino amide derivatives against ESBL–CARBA producing multi-resistant bacteria; effect of halogenation, lipophilicity and cationic character. European Journal of Medicinal Chemistry. DOI: 10.1016/j.ejmech.2019.111671

15) Paulsen, M.H.; Karlsen, E.A.; Ausbacher, D.; Anderssen, T.; Bayer, A.; Ochtrop, P.; Hedberg, C.; Haug, T.; Ericson Sollid, J.U.; Strøm M.B. (2018). An amphipathic 13-membered cyclic tetrapeptide scaffold containing β^2,2-amino acids with activity against multi-resistant bacteria. Journal of Peptide Science. DOI: 10.1002/psc.3117

14) Ausbacher, D; Lorenz, L.A.; Pitts, B.; Stewart, P.S.; Goeres, D.M. (2017). Paired methods to measure biofilm killing and removal: a case study with Penicillin G treatment of Staphylococcus aureus biofilm. Letters in Applied Microbiology. DOI: 10.1111/lam.12843.

13) Eksteen, J.J.; Ausbacher, D.; Simon-Santamaria, J.; Stiberg, T.; Cavalcanti-Jacobsen, C.; Wushur, I.; Svendsen, J.S.; Rekdal, Ø. (2016). Iterative design and in vivo Evaluation of an oncolytic antilymphoma peptide. Journal of Medicinal Chemistry. DOI: 10.1021/acs.jmedchem.6b00839.

12) Paulsen, M.H.; Engqvist, M.; Ausbacher, D.; Strøm, M. B.; Bayer, A. (2016). Efficient and scalable synthesis of α,α-­disubstituted β-amino amides. Organic and biomolecular chemistry . ISSN 1477-0520.s DOI: 10.1039/C6OB01219A.

11) Hanski, L.^#; Ausbacher, D.^#; Tiirola, T.M.; Strøm, M.B.; Vuorela, P.M. (2016). Amphipathic β^2,2-amino acid derivatives suppress infectivity and Ddsrupt the intracellular replication cycle of Chlamydia pneumoniae. PLoS ONE, 11(6). DOI: 10.1371/journal.pone.0157306. ^#contributed equally

10) Sivertsen, A.; Tørfoss, V.; Isaksson, J.; Ausbacher, D.; Anderssen, T.; Brandsdal, B. O.; Havelkova, M.; Skjørholm, A. E.; Strøm M.B. (2013). Anticancer potency of small linear and cyclic tetrapeptides and pharmacokinetic investigations of peptide-binding to human serum albumin. J. Pept. Sci., 20: 279-291.

9) Ausbacher, D.; Fallarero, A.; Kujala, J.; Määttänen, A; Jouko, Peltonen; Strøm, M.B.; Vuorela, P.M. (2014). Staphylococcus aureus biofilm susceptibility to small and potent β^2,2-amino acid derivatives. Biofouling, 30: 81-93. DOI: 10.1080/08927014.2013.847924

8) Ausbacher, D.; Svineng, G.; Hansen, T.; Strøm M.B. (2012). Anticancer mechanisms of action of two small amphipathic β^2,2-amino acid derivatives derived from antimicrobial peptides. Biochimica et Biophysica Acta (BBA) - Biomembranes, 1818: 2917-2925. DOI: 10.1016/j.bbamem.2012.07.005

7) Hansen, T.; Ausbacher, D.; Zachariassen, Z.G.; Anderssen, T.; Havelkova, M.; Strøm M.B. (2012) Anticancer activity of small amphipathic β^2,2-amino acid derivatives, European Journal of Medicinal Chemistry, 58: 22-29.

6) Tørfoss, V.; Isaksson, J.; Ausbacher, D.; Brandsdal, B. O.; Flaten, G. E.; Anderssen, T.; Cavalcanti-Jacobsen, C. de A.; Havelkova, M.; Nguyen, L. T.; Vogel, H. J.; Strøm, M. B. (2012) Improved anticancer potency by head-to-tail cyclisation of short cationic anticancer peptides containing a lipophilic β^2,2-amino acid, Journal of Peptide Science, 18: 609-619.

5) Tørfoss, V.; Ausbacher, D.; Cavalcanti-Jacobsen, C.deA.; Hansen, T.; Brandsdal, B-.O.; Havelkova, M.; Strøm, M.B. (2011): Synthesis of anticancer heptapeptides containing a unique lipophilic β^2,2-amino acid building block, Journal of Peptide Science 18: 170-176.

4) Hansen, T.; Ausbacher, D.; Flaten, G. E.; Havelkova, M.; Strøm, M. B.(2011): Synthesis of cationic antimicrobial β^2,2-amino acid derivatives with potential for oral administration, Journal of Medicinal Chemistry 54: 858-868.

3) Hupfeld, S.; Moen, H. H.; Ausbacher, D.; Haas, H.; Brandl, M. (2010): Liposome fractionation and size analysis by asymmetrical flow field-flow fractionation/multi-angle light scattering: influence of ionic strength and osmotic pressure of the carrier liquid. Chemistry and Physics of Lipids 163: 141-147.

2) Hupfeld, S.; Ausbacher, D.; Brandl, M. (2009): Asymmetric flow field-flow fractionation of liposomes: 2. Concentration-detection and adsorptive loss phenomena. Journal of Separation Science 32: 3555-3561.

1) Hupfeld, S.; Ausbacher, D.; Brandl, M. (2009): Asymmetric flow field-flow fractionation of liposomes: optimization of fractionation variables. Journal of Separation Science 32: 1465-1470.

Patent

Strøm M.B., Bayer A., Engquvist M.S.O., Paulsen M.H., Ausbacher, D. (2018). Barbituric acid derivatives comprising cationic and lipophilic groups. US11072588B2/en

Stipends

Personal overseas research grant of the Research Council of Norway (2014/15)

UiT transition grant for recruitment of young researchers (2012/13)

UiT mobility grant for research abroad (2011)

Travel grant of the Norwegian Pharmaceutical Society (2011)

Studies and Education

09/2015 - 02/2017
Postdoc, Faculty of Health Sciences, Natural Products and Medicinal Chemistry Research Group, Prof. M. B. Strøm, UiT-The Arctic University of Norway

03/2015 - 08/2015
Postdoc, Center for Biofilm Engineering, Standardized Biofilm Methods Laboratory, Assistant Prof. D. Goeres and Biofilm Control Laboratory, Prof. P.Stewart, Montana State University, Bozeman, USA

09/2014 - 02/2015
Postdoc, Faculty of Pharmacy, Division of Pharmaceutical Biosciences, Anti-infective Research Laboratory, Adjunct Prof. A. Fallarero and Prof. P. Vuorela, University of Helsinki, Finland

03/2013 - 08/2014
Postdoc, Faculty of Health Sciences, Natural Products and Medicinal Chemistry Research Group, Prof. M. B. Strøm, UiT-The Arctic University of Norway

11/2012 - 02/2013
Researcher, Faculty of Health Sciences, UiT-The Arctic University of Tromsø

11/2012
PhD thesis defence: Biological activity of β2,2-amino acid derivatives derived from antimicrobial peptides- Investigations of Antimicrobial and Anticancer Activity and the Mechanisms of Action

11/2011 - 02/2012
Visiting PhD student, Pharmacutical Sciences Laboratory, Prof. P. Vuorela, Åbo Akademi University, Turku, Finland

10/2008 - 09/2012
Ph.D. student, Faculty of Health Sciences, Natural Products and Medicinal Chemistry Research Group Prof. M. B. Strøm, UiT-The Arctic University of Norway

07/2008 and 12/2012
Licensure for the profession as pharmacist in Germany and Norway

10/2007
Diploma defence, A4F/MALS Analysis of Liposomes, Faculty of Biosciences, Department of Pharmaceutical Technology Prof. K. Mäder, University of Halle, Germany

05/2007 - 10/2007
Diploma student, Faculty of Health Sciences, Drug Transport and Delivery Research Group Prof. M. Brandl, UiT-The Arctic University of Norway

04/2007
Second State Exam

08/2004
First State Exam

10/2002 - 04/2007
Pharmacy studies, University of Regensburg, Germany

06/2001
Karlsgymnasium Bad Reichenhall, University-entrance diploma

Languages

German (native)
English
Norwegian

Work experience

09/2008
Researcher for Epitarget AS, Oslo

11/2007 - 04/2008
Pharmacist in practical training, Ahorn Apotheke, Regensburg

09/2006 - 10/2006
Aenova Sales Pharma - Dragenopharm-Apotheker Püschel GmbH & Co. KG, Tittmoning

07/2001 - 06/2002
Service in the mountain infantry batallion Berchtesgaden, Armed forces of Germany