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Bilde av Isaksson, Johan Mattias
Bilde av Isaksson, Johan Mattias
Førsteamanuensis Institutt for farmasi johan.isaksson@uit.no +4777644842 41354726 Her finner du meg

Johan Mattias Isaksson

Stillingsbeskrivelse

Responsible for the UiT NMR lab, which is a node in the Norwegian NMR Platform (NNP), and a WP leader of the DigiBiotics research project (DLN/RCN/UiT). I am also managing the analytical platform SmallStruct.

Teaching: FAR-2301, FAR-3301, KJE-3303/8303.

  • Birta Ravdna Alexandersen Sarre, Olena Dobrovolska, Patrik Lundström, Diana Cornelia Turcu, Tatiana Agback, Øyvind Halskau m.fl.:
    Structural dynamics of human deoxyuridine 5’-triphosphate nucleotidohydrolase (dUTPase)
    Scientific Reports 2024 ARKIV / DOI
  • Maxim Brilkov, Martin Jakubec, Victoria Stenbakk, Terje Vasskog, Tone Kristoffersen, Jorunn Pauline Cavanagh m.fl.:
    Bacterial extracellular vesicles: towards realistic models for bacterial membranes in molecular interaction studies by surface plasmon resonance
    Frontiers in Molecular Biosciences 2023 ARKIV / DOI
  • Philip Ben Rainsford, Fredrik G. Rylandsholm, Martin Jakubec, Mitchell Silk, Eric Juskewitz, Johanna Ulrica Ericson m.fl.:
    Label-free measurement of antimicrobial peptide interactions with lipid vesicles and nanodiscs using microscale thermophoresis
    Scientific Reports 2023 ARKIV / DOI
  • Yannik Karl Heinz Schneider, Anton Liaimer, Johan Mattias Isaksson, Oda Sofie Bye Wilhelmsen, Jeanette Hammer Andersen, Kine Østnes Hansen m.fl.:
    Four new suomilides isolated from the cyanobacterium Nostoc sp. KVJ20 and proposal of their biosynthetic origin
    Frontiers in Microbiology 2023 ARKIV / DOI
  • Sara Ullsten-Wahlund, Guillaume Petit, Johan Mattias Isaksson, Ida Kristine Østnes Hansen, Yannik Karl Heinz Schneider, Marte Jenssen m.fl.:
    Identification of New Purpuroine Analogues from the Arctic Echinodermata Pteraster militaris That Inhibit FLT3-ITD+ AML Cell Lines
    International Journal of Molecular Sciences 2022 ARKIV / DOI
  • Philip Ben Rainsford, Birta R. Sarre, Margherita Falavigna, Bjørn Olav Brandsdal, Gøril Eide Flaten, Martin Jakubec m.fl.:
    WIND-PVPA: Water/Ion NMR Detected PVPA to assess lipid barrier integrity in vitro through quantification of passive water- and ion transport
    Biochimica et Biophysica Acta - Biomembranes 2022 ARKIV / DOI
  • Eric Juskewitz, Ekaterina Mischenko, Vishesh Kumar Dubey, Marte Jenssen, Martin Jakubec, Philip Rainsford m.fl.:
    Lulworthinone: In Vitro Mode of Action Investigation of an Antibacterial Dimeric Naphthopyrone Isolated from a Marine Fungus
    Marine Drugs 2022 ARKIV / DOI
  • Fazlin Pheiffer, Yannik Karl Heinz Schneider, Espen Holst Hansen, Jeanette Hammer Andersen, Johan Mattias Isaksson, Tobias Busche m.fl.:
    Bioassay-Guided Fractionation Leads to the Detection of Cholic Acid Generated by the Rare Thalassomonas sp.
    Marine Drugs 2022 ARKIV / DOI
  • Venke Kristoffersen, Marte Jenssen, Heba Raid Jawad, Johan Isaksson, Espen Hansen, Teppo Rämä m.fl.:
    Two Novel Lyso-Ornithine Lipids Isolated from an Arctic Marine Lacinutrix sp. Bacterium
    Molecules 2021 ARKIV / DOI
  • Marianne Hagensen Paulsen, Magnus Engqvist, Dominik Ausbacher, Trude Anderssen, Manuel K- Langer, Tor Haug m.fl.:
    Amphipathic Barbiturates as Mimics of Antimicrobial Peptides and the Marine Natural Products Eusynstyelamides with Activity against Multi-resistant Clinical Isolates
    Journal of Medicinal Chemistry 2021 ARKIV / DOI
  • Marte Jenssen, Venke Kristoffersen, Kumar Motiram-Corral, Johan Isaksson, Teppo Rämä, Jeanette Hammer Andersen m.fl.:
    Chlovalicin B, a Chlorinated Sesquiterpene Isolated from the Marine Mushroom Digitatispora marina
    Molecules 2021 ARKIV / DOI
  • Marte Jenssen, Philip Rainsford, Eric Juskewitz, Jeanette Hammer Andersen, Espen Hansen, Johan Isaksson m.fl.:
    Lulworthinone, a New Dimeric Naphthopyrone From a Marine Fungus in the Family Lulworthiaceae With Antibacterial Activity Against Clinical Methicillin-Resistant Staphylococcus aureus Isolates
    Frontiers in Microbiology 2021 ARKIV / DOI
  • Ida Kristine Østnes Hansen, Johan Isaksson, Aaron G. Poth, Kine Østnes Hansen, Aaron John Christian Andersen, Céline Sarah Marine Richard m.fl.:
    Isolation and characterization of antimicrobial peptides with unusual disulfide connectivity from the colonial ascidian Synoicum turgens
    Marine Drugs 2020 ARKIV / DOI
  • Olena Dobrovolska, Maxim Brilkov, Noëlly Madeleine, Øyvind Ødegaard-Fougner, Øyvind Strømland, Stephen R. Martin m.fl.:
    The Arabidopsis (ASHH2) CW domain binds monomethylated K4 of the histone H3 tail through conformational selection
    The FEBS Journal 2020 ARKIV / DOI
  • Worku Dinku, Johan Isaksson, Fredrik G. Rylandsholm, Petr Bouř, Eva Brichtova, Sang Un Choi m.fl.:
    Anti-proliferative activity of a novel tricyclic triterpenoid acid from Commiphora africana resin against four human cancer cell lines
    Applied Biological Chemistry 2020 ARKIV / DOI
  • Yngve Guttormsen, Magnus John Espeland Fairhurst, Sunil Kumar Pandey, Johan Isaksson, Bengt Erik Haug, Annette Bayer :
    Total synthesis of phorbazole B
    Molecules 21. oktober 2020 ARKIV / PROSJEKT / DOI
  • Yannik Karl-Heinz Schneider, Marte Jenssen, Johan Isaksson, Kine Østnes Hansen, Jeanette Hammer Andersen, Espen Hansen :
    Bioactivity of Serratiochelin A, a Siderophore Isolated from a Co-Culture of Serratia sp. and Shewanella sp.
    Microorganisms 14. juli 2020 ARKIV / DOI
  • Ikenna E. Ndukwe, Yu-hong Lam, Sunil Kumar Pandey, Bengt Erik Haug, Annette Bayer, Edward C. Sherer m.fl.:
    Unequivocal structure confirmation of a breitfussin analog by anisotropic NMR measurements
    Chemical Science 21. september 2020 ARKIV / DOI
  • Aitor Moreno, Kine Østnes Hansen, Johan Isaksson :
    CSSF-CLIP-HSQMBC: measurement of heteronuclear coupling constants in severely crowded spectral regions
    RSC Advances 2019 ARKIV / DOI
  • Raja Priyanka Mary Michael Siranjeevi, Espen Hansen, Johan Isaksson, Jeanette hammer Andersen, Kine Østnes Hansen :
    Dendrobeaniamine A, a new alkaloid from the Arctic marine bryozoan Dendrobeania murrayana
    Natural Product Research 2019 ARKIV / DOI
  • Kine Østnes Hansen, Jeanette hammer Andersen, Annette Bayer, Sunil Kumar Pandey, Marianne Lorentzen, Kåre Bredeli Jørgensen m.fl.:
    Kinase chemodiversity from the Arctic: the breitfussins
    Journal of Medicinal Chemistry 2019 ARKIV / DOI
  • Yannik Karl-Heinz Schneider, Kine Østnes Hansen, Johan Isaksson, Sara Maria Ullsten-Wahlund, Espen Hansen, Jeanette Hammer Andersen :
    Anti-Bacterial Effect and Cytotoxicity Assessment of Lipid 430 Isolated from Algibacter sp.
    Molecules 2019 ARKIV / DOI
  • Venke Kristoffersen, Teppo Rämä, Johan Isaksson, Jeanette hammer Andersen, William H. Gerwick, Espen Hansen :
    Characterization of Rhamnolipids Produced by an Arctic Marine Bacterium from the Pseudomonas fluorescence Group
    Marine Drugs 2018 ARKIV / DOI
  • Kine Østnes Hanssen, Johan Isaksson, Eirin Glomsaker, Jeanette hammer Andersen, Espen Hansen :
    Ponasterone A and F, Ecdysteroids from the Arctic Bryozoan Alcyonidium gelatinosum
    Molecules 2018 ARKIV / DOI
  • Sundus Ahkter, Bjarte Aarmo Lund, Aya Ismael, Manuel Langer, Johan Isaksson, Tony Christopeit m.fl.:
    A focused fragment library targeting the antibiotic resistance enzyme - Oxacillinase-48: Synthesis, structural evaluation and inhibitor design
    European Journal of Medicinal Chemistry 2018 ARKIV / DOI
  • Bjarte Aarmo Lund, Ane Molden Thomassen, Birgit Helene Berg Nesheim, Trine Josefine Olsen Carlsen, Johan Isaksson, Tony Christopeit m.fl.:
    The biological assembly of OXA‐48 reveals a dimer interface with high charge complementarity and very high affinity
    The FEBS Journal 2018 DOI
  • Jostein Grip, Rolf Einar Engstad, Ingrid Skjæveland, Natasa Skalko-Basnet, Johan Isaksson, Purusotam Basnet m.fl.:
    Beta-glucan-loaded nanofiber dressing improves wound healing in diabetic mice
    European Journal of Pharmaceutical Sciences 2018 ARKIV / DOI
  • Raja Priyanka Mary Michael Siranjeevi, Kine Østnes Hanssen, Johan Isaksson, Jeanette hammer Andersen, Espen Hansen :
    A Novel Brominated Alkaloid Securidine A, Isolated from the Marine Bryozoan Securiflustra securifrons
    Molecules 2017 ARKIV / DOI
  • Kine Østnes Hansen, Johan Isaksson, Annette Bayer, Jostein a Johansen, Jeanette hammer Andersen, Espen Hansen :
    Securamine Derivatives from the Arctic Bryozoan Securiflustra securifrons
    Journal of natural products 2017 DOI
  • Marc Stierhof, Kine Hansen, Mukesh Sharma, Klaus Feussner, Karolina Subko, Fernando Fernàndez Diaz-Rullo m.fl.:
    New cytotoxic callipeltins from the Solomon Island marine sponge Asteropus sp.
    Tetrahedron 2016 DOI
  • Elisabeth Klungerbo Olsen, Kine Søderholm, Johan Isaksson, Jeanette hammer Andersen, Espen Hansen :
    Metabolomic Profiling Reveals the N-Acyl-Taurine Geodiataurine in Extracts from the Marine Sponge Geodia macandrewii (Bowerbank)
    Journal of natural products 2016 DOI
  • Ulli Rothweiler, Wenche Stensen, Bjørn Olav Brandsdal, Johan Isaksson, Frederick Alan Leeson, Richard Alan Engh m.fl.:
    Probing the ATP-Binding Pocket of Protein Kinase DYRK1A with Benzothiazole Fragment Molecules
    Journal of Medicinal Chemistry 2016 DOI
  • Johan Mattias Isaksson :
    Structural Dynamics Characterization of human dUTPase - a target in cancer
    2023
  • Maxim Brilkov, Jorunn Pauline Cavanagh, Johan Mattias Isaksson, Johanna E. Sollid, Gøril Eide Flaten :
    BACTERIALLY PRODUCED IN VITRO MEMBRANE MODEL SYSTEMS FROM RESISTANT- AND NON-RESISTANT CLINICAL ISOLATES
    2023
  • Philip Ben Rainsford, Maxim Brilkov, Finn Lillelund Aachmann, Gøril Eide Flaten, Johan Mattias Isaksson :
    NMR tube inserts for time-resolved spatial NMR
    2023
  • Yannik Karl Heinz Schneider, Anton Liaimer, Johan Mattias Isaksson, Oda Sofie Bye Wilhelmsen, Jeanette Hammer Andersen, Kine Østnes Hansen m.fl.:
    Corrigendum: Four new suomilides isolated from the cyanobacterium Nostoc sp. KVJ20 and proposal of their biosynthetic origin (Frontiers in Microbiology, (2023), 14, (1130018), 10.3389/fmicb.2023.1130018)
    Frontiers in Microbiology 2023 DOI
  • Maxim Brilkov, Jorunn Pauline Cavanagh, Johan Mattias Isaksson, Johanna U Ericson :
    Outer-membrane vesicles as a bacterial membrane model to study interaction of antimicrobial peptides
    2023
  • Monika Krupova, Karolina Di Remigio Eikås, Johan Mattias Isaksson, Kenneth Ruud :
    Vibrational Circular Dichroism of Antimicrobial Peptides: What is Their Structure in Solution and in Membranes?
    2022
  • Philip Ben Rainsford, Johan Mattias Isaksson :
    Expanding the toolbox for the study of antimicrobial peptides
    UiT Norges arktiske universitet 2022
  • Maxim Bril'kov, Jorunn Pauline Cavanagh, Johan Mattias Isaksson, Johanna U Ericson, Gøril Eide Flaten :
    Bacterially produced in vitro mambrane model systems from resistant- and non-resistant clinical isolates
    2022
  • Johan Isaksson :
    CSSF-CLIP-HSQMBC: Measurement of heteronuclear coupling constants in severely crowded spectral regions
    2020
  • Johan Mattias Isaksson :
    CSSF-CLIP-HSQMBC
    2020
  • Priyanka Michael, Espen Hansen, Johan Isaksson, Jeanette hammer Andersen, Kine Østnes Hansen :
    Dendrobeaniamine A, a New Alkaloid from the Arctic Marine bryozoan Dendrobeania murrayana
    2019
  • Johan Isaksson :
    CSSF-CLIP-HSQMBC: Measurement of heteronuclear coupling constants in severely crowded spectral regions
    2019
  • Aitor Moreno, Kine Ø. Hanssen, Johan Isaksson :
    CSSF-CLIP-HSQMBC: Measurement of heteronuclear coupling constants in severely crowded spectral regions
    2019
  • Kine Ø. Hanssen, Jeanette hammer Andersen, Bert Klebl, Jan Eickhoff, Johan Isaksson, Espen Hansen :
    Novel kinase inhibitors from the Arctic marine hydrozoan Thuiaria breitfussi
    2019
  • Johan Isaksson, Birta Ravdna Sarre :
    “Dynamics characterization of dUTPase, a new target in cancer therapy”
    2018
  • Tor Haug, Runar Gjerp Solstad, Chun Li, Johan Isaksson, Jostein a Johansen, Johan Svenson m.fl.:
    Halogenated antimicrobial peptides from the red sea urchin, Echinus esculentus.
    2017
  • Marc Boomgaren, Birta Ravdna Sarre, Tor Arne Heim Andberg, Bjørn Olav Brandsdal, Johan Isaksson, Jørn H Hansen :
    Synthesis and exploration of a novel molecular scaffold for dUTPase inhibition: Aiming for new anticancer agents
    2017
  • Bjarte Aarmo Lund, Sundus Akhter, Yngve Guttormsen, Tony Christopeit, Johan Isaksson, Annette Bayer m.fl.:
    Structure-guided drug design for the antibiotic resistance enzyme OXA-48
    2016

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    CV

    2011- Research and NMR site management, Tromsø University, Norway
    2009

    PostDoc scientist for Prof. John Sigurd Svendsen in Organic chemistry (NMR), Tromsø University, Norway
    2005

    NMR Research scientist (pharmaceutic industry), Medivir AB, Sweden
    2005

    Ph.D. in Bioorganic chemistry (NMR), Uppsala University, Sweden
    1998 M.Sc. in Biomedical chemistry, Kalmar University, Sweden