Jorunn Pauline Cavanagh


Førsteamanuensis ved Pediatrisk Forskningsgruppe

Stillingsbeskrivelse

Jeg jobber som førsteamanuensis ved Institutt for klinisk medisin, Forskningsgruppe for barne og ungdomshelse helse, Pediatrisk infeksjonsgruppe. Jeg har ansvar for veiledning og undervisning av studenter på bachelor, master og PhD nivå. Pediatrisk forskningsgruppe har flere prosjekter innen infeksjon, og har som mål å bedre diagnostikk og behandling av alvorlige infeksjoner hos barn.  


  • Ahmed Bargheet, Claus Andreas Klingenberg, Eirin Esaiassen, Erik Hjerde, Jorunn Pauline Cavanagh, Johan Bengtsson-Palme m.fl.:
    Development of early life gut resistome and mobilome across gestational ages and microbiota-modifying treatments
    EBioMedicine 2023 ARKIV / DOI
  • Runa Wolden, Kirill Ovchinnikov, Hermoine Jean Venter, Thomas Oftedal, Bao Dung Diep, Jorunn Pauline Cavanagh :
    The novel bacteriocin romsacin from Staphylococcus haemolyticus inhibits Gram-positive WHO priority pathogens
    Microbiology spectrum 2023 ARKIV / DOI
  • Maxim Brilkov, Martin Jakubec, Victoria Stenbakk, Terje Vasskog, Tone Kristoffersen, Jorunn Pauline Cavanagh m.fl.:
    Bacterial extracellular vesicles: towards realistic models for bacterial membranes in molecular interaction studies by surface plasmon resonance
    Frontiers in Molecular Biosciences 2023 ARKIV / DOI
  • Mattias Berglin, Jorunn Pauline Cavanagh, Josefin Seth Caous, Balmukund Thakkar, Jeddah Marie Vasquez, Wenche Gunvor B Stensen m.fl.:
    Flexible and Biocompatible Antifouling Polyurethane Surfaces Incorporating Tethered Antimicrobial Peptides through Click Reactions
    Macromolecular Bioscience 2023 ARKIV / DOI
  • Aline Bjerkhaug, Hildegunn Norbakken Granslo, Jorunn Pauline Cavanagh, Ina Isabella Høiland, Judith K Ludviksen, Corinna Lau m.fl.:
    Dual inhibition of complement C5 and CD14 attenuates inflammation in a cord blood model
    Pediatric Research 2023 FULLTEKST / DOI
  • Trym Thune Flygel, Dan Hameiri-Bowen, Victoria Simms, Sarah Rowland-Jones, Rashida Abbas Ferrand, Tsitsi Bandason m.fl.:
    Exhaled nitric oxide is associated with inflammatory biomarkers and risk of acute respiratory exacerbations in children with HIV-associated chronic lung disease
    HIV Medicine 2023 ARKIV / DOI
  • Anne Sofie Laulund, Franziska Angelika Schwartz, Lars Christophersen, Niels Høiby, John Sigurd Mjøen Svendsen, Wenche Gunvor Berg Stensen m.fl.:
    Lactoferricin-inspired peptide AMC-109 augments the effect of ciprofloxacin against Pseudomonas aeruginosa biofilm in chronic murine wounds
    Journal of Global Antimicrobial Resistance 2022 ARKIV / DOI
  • Christian Kranjec, Sofie Sagvaag Kristensen, Karolina Teresa Bartkiewicz, Mikkel Brønner, Jorunn P. Cavanagh, Aparna Srikantam m.fl.:
    A bacteriocin-based treatment option for Staphylococcus haemolyticus biofilms
    Scientific Reports 2021 ARKIV / DOI
  • Joakim Håkansson, Jorunn Pauline Cavanagh, Wenche Gunvor Berg Stensen, Bjarte Mortensen, John Sigurd Mjøen Svendsen, Johan Svenson :
    In vitro and in vivo antibacterial properties of peptide AMC-109 impregnated wound dressings and gels
    Journal of antibiotics (Tokyo. 1968) 2021 DOI
  • Vladimir Vimberg, Jorunn Pauline Cavanagh, Michaela Novotna, Jakub Lenart, Bich Nguyen Thi Ngoc, Jana Vesela m.fl.:
    Ribosome-Mediated Attenuation of vga(A) Expression Is Shaped by the Antibiotic Resistance Specificity of Vga(A) Protein Variants
    Antimicrobial Agents and Chemotherapy 2020 DOI
  • Maria Ronessen Pain, Runa Wolden, Daniel Jaén-Luchoro, Francisco Salvà-Serra, Beatriz Piñeiro Iglesias, Roger Karlsson m.fl.:
    Staphylococcus borealis sp. Nov., isolated from human skin and blood
    International Journal of Systematic and Evolutionary Microbiology 2020 ARKIV / DOI
  • Rasmus Goll, Peter Holger Johnsen, Erik Hjerde, Joseph Diab, Per Christian Valle, Frank Hilpüsch m.fl.:
    Effects of fecal microbiota transplantation in subjects with irritable bowel syndrome are mirrored by changes in gut microbiome
    Gut microbes 29. september 2020 ARKIV / DOI
  • Runa Wolden, Maria Pain, Roger Karlsson, Anders Karlsson, Elizabeth G. Aarag Fredheim, Jorunn Pauline Cavanagh :
    Identification of surface proteins in a clinical Staphylococcus haemolyticus isolate by bacterial surface shaving
    BMC Microbiology 2020 ARKIV / DOI
  • Jorunn Pauline Cavanagh, Fatemeh Askarian, Maria Pain, Jack-Ansgar Bruun, Ilona Urbarova, Sun Nyunt Wai m.fl.:
    Proteome profiling of secreted and membrane vesicle associated proteins of an invasive and a commensal Staphylococcus haemolyticus isolate.
    Data in Brief 2019 ARKIV / DOI
  • Maria Pain, Erik Hjerde, Claus Klingenberg, Jorunn Pauline Cavanagh :
    Comparative Genomic Analysis of Staphylococcus haemolyticus Reveals Key to Hospital Adaptation and Pathogenicity
    Frontiers in Microbiology 2019 ARKIV / DOI
  • Hildegunn Norbakken Granslo, Elizabeth Aarag, Eirin Esaiassen, Lars Christophersen, Peter Østrup Jensen, Tom Eirik Mollnes m.fl.:
    The synthetic antimicrobial peptide LTX21 induces inflammatory responses in a human whole blood model and a murine peritoneum model
    APMIS - Journal of Pathologiy, Microbiology and Immunology 2019 ARKIV / DOI
  • Trym Thune Flygel, Evgeniya Sovershaeva, Shantelle Classen-Weitz, Erik Hjerde, Kilaza S. Mwaikono, Jon Øyvind Odland m.fl.:
    Composition of Gut Microbiota of Children and Adolescents With Perinatal Human Immunodeficiency Virus Infection Taking Antiretroviral Therapy in Zimbabwe
    Journal of Infectious Diseases 2019 ARKIV / DOI
  • Vladimir Vimberg, Jorunn Pauline Cavanagh, Oldrich Benada, Olga Kofranova, Erik Hjerde, Leona Zieglerova m.fl.:
    Teicoplanin resistance in Staphylococcus haemolyticus is associated with mutations in histidine kinases VraS and WalK
    Diagnostic microbiology and infectious disease 2018 DOI
  • Eirin Esaiassen, Erik Hjerde, Jorunn Pauline Cavanagh, Tanja Pedersen, Jannicke Hanne Andresen, Siren Rettedal m.fl.:
    Effects of Probiotic Supplementation on the Gut Microbiota and Antibiotic Resistome Development in Preterm Infants
    Frontiers in pediatrics 2018 ARKIV / DOI
  • Jorunn Pauline Cavanagh, Maria Pain, Fatemeh Askarian, Jack-Ansgar Bruun, Ilona Urbarova, Sun Nyunt Wai m.fl.:
    Comparative exoproteome profiling of an invasive and a commensal Staphylococcus haemolyticus isolate
    Journal of Proteomics 2018 ARKIV / DOI
  • Fatemeh Askarian, John D. Lapek Jr., Mitesh Dongre, Chih-Ming Tsai, Monika Kumaraswamy, Armin Kousha m.fl.:
    Staphylococcus aureus Membrane-derived Vesicles Promote Bacterial Virulence and Confer Protective Immunity in Murine Infection Models
    Frontiers in Microbiology 2018 ARKIV / DOI
  • Peter Holger Johnsen, Frank Hilpüsch, Jorunn Pauline Cavanagh, Ingrid Sande Leikanger, Caroline Kolstad, Per Christian Valle m.fl.:
    Faecal microbiota transplantation versus placebo for moderate-to-severe irritable bowel syndrome: a double-blind, randomised, placebo-controlled, parallel-group, single-centre trial
    The Lancet Gastroenterology and Hepatology 2017 DOI
  • Eirin Esaiassen, Erik Hjerde, Jorunn Pauline Cavanagh, Gunnar Skov Simonsen, Claus Klingenberg :
    Bifidobacterium bacteremia: Clinical characteristics and a genomic approach to assess pathogenicity
    Journal of Clinical Microbiology 2017 DOI
  • Caio Fernando de Oliveira, Jorunn Pauline Cavanagh, Elizabeth Aarag, Keli Cristine Reiter, Alexandre Rieger, Claus Klingenberg m.fl.:
    Coagulase-negative staphylococci in southern brazil: Looking toward its high diversity
    Revista da Sociedade Brasileira de Medicina Tropical 2016 ARKIV / DOI
  • Jorunn Pauline Cavanagh, Runa Wolden, Philipp Heise, Eirin Esaiassen, Claus Klingenberg, Elizabeth Aarag :
    Antimicrobial susceptibility and body site distribution of community isolates of coagulase-negative staphylococci
    APMIS - Journal of Pathologiy, Microbiology and Immunology 2016 ARKIV / DOI
  • Jorunn Pauline Cavanagh, Erik Hjerde, Matthew T.G. Holden, Tim Kahlke, Claus Klingenberg, Trond Flægstad m.fl.:
    Whole-genome sequencing reveals clonal expansion of multiresistant Staphylococcus heamolyticus in European hopsitals
    Journal of Antimicrobial Chemotherapy 2014 ARKIV / DOI
  • Jorunn Pauline Cavanagh, Hildegunn Norbakken Granslo, Elizabeth Aarag, L Christophersen, Peter Østrup Jensen, Kim Thomsen m.fl.:
    Efficacy of a synthetic antimicrobial peptidomimetic versus vancomycin in a Staphylococcus epidermidis device-related murine peritonitis model
    Journal of Antimicrobial Chemotherapy 2013 DOI
  • Jorunn Pauline Cavanagh, Claus Klingenberg, Anne-Merethe Hanssen, Elizabeth Aarag, Patrice Francois, Jaques Schrenzel m.fl.:
    Core genome conservation of Staphylococcus haemolyticus limits sequence based population structure analysis
    Journal of Microbiological Methods 2012 ARKIV / DOI
  • Kristina Flemming, Claus Klingenberg, Jorunn Pauline Cavanagh, Merethe vibeke Sletteng, Wenche Stensen, John Sigurd Svendsen m.fl.:
    High in vitro antimicrobial activity of synthetic antimicrobial peptidomimetics against staphylococcal biofilms
    Journal of Antimicrobial Chemotherapy 2009 DOI
  • Maxim Brilkov, Jorunn Pauline Cavanagh, Johan Mattias Isaksson, Johanna E. Sollid, Gøril Eide Flaten :
    BACTERIALLY PRODUCED IN VITRO MEMBRANE MODEL SYSTEMS FROM RESISTANT- AND NON-RESISTANT CLINICAL ISOLATES
    2023
  • Maxim Brilkov, Jorunn Pauline Cavanagh, Johan Mattias Isaksson, Johanna U Ericson :
    Outer-membrane vesicles as a bacterial membrane model to study interaction of antimicrobial peptides
    2023
  • Maxim Bril'kov, Jorunn Pauline Cavanagh, Johan Mattias Isaksson, Johanna U Ericson, Gøril Eide Flaten :
    Bacterially produced in vitro mambrane model systems from resistant- and non-resistant clinical isolates
    2022
  • Sofie Sagvaag Kristensen, Christian Kranjec, Karolina Teresa Bartkiewicz, Mikkel Brønner, Jorunn Pauline Cavanagh, Aparna Srikantam m.fl.:
    A bacteriocin‑based treatment option for Staphylococcus haemolyticus biofilms
    2021
  • Vladimir Vimberg, Jorunn Pauline Cavanagh, Michaela Novotna, Jakub Lenart, Bich Nguyen Thi Ngoc, Jana Vesela m.fl.:
    Erratum: Ribosome-mediated attenuation of vga(a) expression is shaped by the antibiotic resistance specificity of vga(A) protein variants
    Antimicrobial Agents and Chemotherapy 2021 DOI
  • Aline Bjerkhaug, Hildegunn Norbakken Granslo, Jorunn Pauline Cavanagh, Judith Anita Ludviksen, Tom Eirik Mollnes, Claus Klingenberg :
    Combined inhibition of CD14 and C5 in Escherichia coli and Group B streptococci induced inflammation in human cord blood.
    2020 DATA
  • Vladimir Vimberg, Radek Gažá, Zsolt Szűcs, Aniko Borbás, Pál Herczegh, Jorunn Pauline Cavanagh m.fl.:
    Fluorescence assay to predict activity of the glycopeptide antibiotics
    Journal of antibiotics (Tokyo. 1968) 2019 DOI
  • Runa Wolden, Maria Pain, Roger Karlsson, Anders Karlsson, Elizabeth G. Aarag Fredheim, Jorunn Pauline Cavanagh :
    Hunting new targets to prevent infections - A novel approach to bacterial surface shaving
    2019
  • Runa Wolden, Maria Pain, Roger Karlsson, Anders Karlsson, Elizabeth G. Aarag Fredheim, Jorunn Pauline Cavanagh :
    På jakt etter nye målsete for behandling av Staphylococcus haemolyticus-infeksjonar: Opp- regulering av sentrale virulens- og adhesjonsprotein hos S. haemolyticus ved kolonisering av humane keratinocyttar
    2019
  • Aline Bjerkhaug, Hildegunn Norbakken Granslo, Jorunn Pauline Cavanagh, Claus Klingenberg :
    JAKTEN PÅ ANTIBIOTIKAENS LILLE HJELPER
    Pingvinavisa 28. november 2019 DATA
  • Aline Bjerkhaug, Hildegunn Norbakken Granslo, Jorunn Pauline Cavanagh, Tom Eirik Mollnes, Claus Klingenberg :
    The method of combined inhibition of CD14 and C5 in Escherichia coli and Streptococcus agalactiae induced inflammation in human cord blood.
    2019
  • Hildegunn Norbakken Granslo, Elizabeth Aarag, Claus Andreas Klingenberg, Claus Moser, Eirin Esaiassen, Jorunn Pauline Cavanagh m.fl.:
    The synthetic antimicrobial peptide LTX21 induces inflammatory responses in an in vivo mouse peritonitis model and an ex vivo human whole blood model
    2017
  • Jorunn Pauline Cavanagh :
    Min doktorgrad. "Når snille bakterier blir slemme"
    2012
  • Jorunn Pauline Cavanagh :
    Forsker Grand Prix 2011
    2011

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    Forskningsinteresser


    Mitt forskningsfokus er på infeksjoner hos nyfødte, med spesielt fokus på infeksjoner forårsaket av koagulase negative stafylokokker, biofilm og antibiotika resistens. Vår hovedmålsetning er å finne nye behandlingsmetoder ved å identifisere virulensmekanismer hos Staphylococcus haemolyticus. I 2020 oppdaget vi en ny stafylokokkart, Staphylococcus borealis, vi forsker nå på hvilke infeksjoner denne hittil ubeskrevne bakterien gir. I 2023, startet vi prosjektet OPTIMIST prosjektet, der vi ønsker å se på årsaker til brystbetennelse. Studien vil forhåpentligvis resultere i bedre forebygging og behandling av brystbetennelse, som rammer omtrent 20% av ammende mødre.

    Undervisning

    Bidrar med forelesninger/seminarer FAR-2201 Immunologi og mikrobiologi, FAR-2204 Fysiologi og  ERN-3001 Epidemiologi, statistikk og forskningsmetode ved UiT. Veiledning av medisin forskerlinjestudenter,studenter på bachelor og master nivå, samt PhD kandidater.