Bilde av Svineng, Gunbjørg
Foto: Gry Berntzen
Bilde av Svineng, Gunbjørg
Det helsevitenskapelige fakultet gunbjorg.svineng@uit.no +4777646757 41314428 +47-41314428 Tromsø MH2 L.08.324

Gunbjørg Svineng


Dekan

Stillingsbeskrivelse

Dekan Det helsevitenskapelige fakultet

Professor

https://orcid.org/0000-0002-5947-5647

 

 


  • Rabeia Almahmoudi, Abdelhakim Salem, Elin Synnøve Hadler-Olsen, Gunbjørg Svineng, Tuula Salo, Ahmed Al-Samadi :
    The effect of interleukin-17F on vasculogenic mimicry in oral tongue squamous cell carcinoma
    Cancer Science 2021 ARKIV / DOI
  • Sini Karinen, Krista Juurikka, Roosa Hujanen, Wafa Whabi, Elin Synnøve Hadler-Olsen, Gunbjørg Svineng m.fl.:
    Tumour cells express functional lymphatic endothelium-specific hyaluronan receptor in vitro and in vivo: Lymphatic mimicry promotes oral oncogenesis?
    Oncogenesis 2021 ARKIV / DOI
  • Synnøve Norvoll Magnussen, Jimita Prashant Toraskar, Elin Synnøve Hadler-Olsen, Tonje S. Steigedal, Gunbjørg Svineng :
    Nephronectin as a matrix effector in cancer
    Cancers 25. februar 2021 ARKIV / DOI
  • Synnøve Norvoll Magnussen, Jimita Prashant Toraskar, Imola Wilhelm, Janos Hasko, Stine Figenschau, Judit Molnar m.fl.:
    Nephronectin promotes breast cancer brain metastatic colonization via its integrin-binding domains
    Scientific Reports 2020 ARKIV / DOI
  • Rangita Dawadi, Nabin Malla, Beate Hegge, Imin Wushur, Eli Berg, Gunbjørg Svineng m.fl.:
    Molecular Interactions Stabilizing the Promatrix Metalloprotease-9·Serglycin Heteromer
    International Journal of Molecular Sciences 2020 ARKIV / DOI
  • Jimita Prashant Toraskar, Synnøve Norvoll Magnussen, Lars Hagen, Animesh Sharma, Linh Hoang, Geir Bjørkøy m.fl.:
    A Novel Truncated Form of Nephronectin Is Present in Small Extracellular Vesicles Isolated from 66cl4 Cells
    Journal of Proteome Research 01. februar 2019 ARKIV / FULLTEKST / DOI
  • Samantha Marie Solon-Biet, Victoria Carroll Cogger, Tamara Pulpitel, Devin Wahl, Ximonie Clark, Elena E. Bagley m.fl.:
    Branched-chain amino acids impact health and lifespan indirectly via amino acid balance and appetite control
    Nature Metabolism 2019 DOI
  • Jimita Prashant Toraskar, Synnøve Magnussen, Konika Chawla, Gunbjørg Svineng, Tonje S. Steigedal :
    Nephronectin mediates p38 MAPK‐induced cell viability via its integrin binding enhancer motif
    FEBS Open Bio 2018 ARKIV / DOI
  • Ingebrigt Sylte, Rangita Dawadi, Nabin Malla, Susannah von Hofsten, Tra-Mi Nguyen, Ann Iren Solli m.fl.:
    The selectivity of galardin and an azasugar-based hydroxamate compound for human Matrix metalloproteases and bacterial metalloproteases
    PLOS ONE 2018 ARKIV / DOI
  • Tonje S. Steigedal, Jimita Prashant Toraskar, Richard P. Redvers, Marit Valla, Synnøve Magnussen, Anna M. Bofin m.fl.:
    Nephronectin is Correlated with Poor Prognosis in Breast Cancer and Promotes Metastasis via its Integrin-Binding Motifs
    Neoplasia 2018 ARKIV / FULLTEKST / DOI
  • Pirjo Åström, Krista Juurikka, Elin Synnøve Hadler-Olsen, Gunbjørg Svineng, Nilva K. Cervigne, Ricardo D. Coletta m.fl.:
    The interplay of matrix metalloproteinase-8, transforming growth factor-β1 and vascular endothelial growth factor-C cooperatively contributes to the aggressiveness of oral tongue squamous cell carcinoma
    British Journal of Cancer 2017 ARKIV / DOI
  • Synnøve Magnussen, Elin Synnøve Hadler-Olsen, Daniela Elena Costea, Eli Berg, Cristiane de Albuquerque Cavalcanti Jacobsen, Bente Mortensen m.fl.:
    Cleavage of the urokinase receptor (uPAR) on oral cancer cells: Regulation by transforming growth factor - beta1 (TGF-beta1) and potential effects on migration and invasion
    BMC Cancer 2017 ARKIV / DOI
  • Oddveig G Rikardsen, Synnøve Magnussen, Gunbjørg Svineng, Elin Synnøve Hadler-Olsen, Lars Uhlin-Hansen, Sonja Eriksson Steigen :
    Plectin as a prognostic marker in non-metastatic oral squamous cell carcinoma
    BMC Oral Health 2015 ARKIV / DOI
  • Synnøve Magnussen, Elin Synnøve Hadler-Olsen, Nadezhda Latysheva, Emma Pirila, Sonja Eriksson Steigen, Robert Hanes m.fl.:
    Tumour Microenvironments Induce Expression of Urokinase Plasminogen Activator Receptor (uPAR) and Concomitant Activation of Gelatinolytic Enzymes
    PLOS ONE 2014 ARKIV / DOI
  • Synnøve Magnussen, Oddveig G Rikardsen, Elin Synnøve Hadler-Olsen, Lars Uhlin-Hansen, Sonja Eriksson Steigen, Gunbjørg Svineng :
    Urokinase Plasminogen Activator Receptor (uPAR) and Plasminogen Activator Inhibitor-1 (PAI-1) are potential predictive biomarkers in early stage Oral Squamous Cell Carcinomas (OSCC)
    PLOS ONE 07. juli 2014 ARKIV / DOI
  • Nabin Malla, Eli Berg, Achilleas D. Theocharis, Gunbjørg Svineng, Lars Uhlin-Hansen, Jan-Olof Winberg :
    Invitro reconstitution of complexes between pro-matrix metalloproteinase-9 and the proteoglycans serglycin and versican
    The FEBS Journal 2013 DOI
  • Chandra Sekhar Ravuri, Gunbjørg Svineng, nils-erik Huseby :
    Differential regulation of gamma-glutamyltransferase and glutamate cysteine ligase expression after mitochondrial uncoupling: gamma-glutamyltransferase is regulated in an Nrf2- and NF kappa B-independent manner
    Free radical research 2013 DOI
  • Bodil Irene Fadnes, Anne Husebekk, Gunbjørg Svineng, Øystein Rekdal, Masaki Yanagishita, Svein Olav Kolset m.fl.:
    The proteoglycan repertoire of lymphoid cells
    Glycoconjugate Journal 2012 ARKIV / DOI
  • Dominik Ausbacher, Gunbjørg Svineng, Terkel Hansen, Morten B. Strøm :
    Anticancer mechanisms of action of two small amphipathic beta(2,2)-amino acid derivatives derived from antimicrobial peptides
    Biochimica et Biophysica Acta - Biomembranes 19. juli 2012 DOI
  • Gunbjørg Svineng, Synnøve Magnussen, Elin Synnøve Hadler-Olsen :
    Plasmin and the plasminogen activator system in health and disease
    Walter de Gruyter (De Gruyter) 2012 DOI
  • Chandra Sekhar Ravuri, Gunbjørg Svineng, Serhiy Pankiv, nils-erik Huseby :
    Endogenous production of reactive oxygen species by the NADPH oxidase complexes is a determinant of gamma gamma-glutamyltransferase expression
    Free radical research 2011 DOI
  • Elin Synnøve Hadler-Olsen, Hilde Ljones, Chandra Sekhar Ravuri, Ahmad Omair, Oddveig G Rikardsen, Gunbjørg Svineng m.fl.:
    Organ specific regulation of tumour invasiveness and gelatinolytic activity at the invasive front
    European Journal of Cancer 2011 DOI
  • Hilde Ljones, Elin Synnøve Hadler-Olsen, Synnøve Magnussen, Oddveig G Rikardsen, sonja eriksson Steigen, elisabeth Sundkvist m.fl.:
    S100A4 Expression in Xenograft Tumors of human carcinoma cell lines is induced by the tumor microenvironment
    American Journal of Pathology 2011 DOI
  • Elin Synnøve Hadler-Olsen, Premasany Kanapathippillai, Eli Berg, Gunbjørg Svineng, Jan-Olof Winberg, Lars Uhlin-Hansen :
    Gelatin In Situ Zymography on Fixed, Paraffin-embedded Tissue: Zinc and Ethanol Fixation Preserve Enzyme Activity
    Journal of Histochemistry and Cytochemistry 2010 DOI
  • Elin Synnøve Hadler-Olsen, Hilde Ljones, Oddveig G Rikardsen, Sonja Eriksson Steigen, Premasany Kanapathippillai, Reidar Grenman m.fl.:
    Stromal impact on tumor growth and lymphangiogenesis in human carcinoma xenografts
    Virchows Archiv 2010 ARKIV / DOI
  • nils-erik Huseby, elisabeth Sundkvist, Gunbjørg Svineng :
    Glutathione and Sulfur Containing Amino Acids: Antioxidant and Conjugation Activities
    John Wiley & Sons 2009
  • Atle Noralf Larsen, Terese Solstad, Gunbjørg Svineng, Marit Seppola, Trond Ø. Jørgensen :
    Molecular characterisation of a goose-type lysozyme gene in Atlantic cod (Gadus morhua L.)
    Fish and Shellfish Immunology 2009 DOI
  • Renate Elenjord, Jasmine Blue Allen, Harald Thidemann Johansen, Harald T. Johansen, hanne Kildalsen, Gunbjørg Svineng m.fl.:
    Collagen I regulates matrix metalloproteinase-2 activation in osteosarcoma cells independent of S100A4
    The FEBS Journal 2009 DOI
  • Gunbjørg Svineng, Chandra Sekhar Ravuri, Oddveig G Rikardsen, Nils-Erik Huseby, Jan-Olof Winberg :
    The role of reactive oxygen species in integrin and matrix metalloproteinase expression and function
    Connective Tissue Research 2008 DOI
  • Eva Sjøttem, Cecilie Rekdal, Gunbjørg Svineng, Sylvia sagen Johnsen, Helle Bagterp Klenow, Rebecca dale Uglehus m.fl.:
    The ePHD protein SPBP interacts with TopBP1 and together they co-operate to stimulate Ets1-mediated transcription
    Nucleic Acids Research (NAR) 2007 DOI
  • Synnøve Magnussen, Jimita Prashant Toraskar, Imola Wilhelm, Janos Hasko, Stine Figenschau, Judith Molnar m.fl.:
    Nephronectin promotes breast cancer brain metastatic colonization via its integrin-binding domains
    2018
  • Synnøve Magnussen, Jimita Prashant Toraskar, Imola Wilhelm, Janos Hasko, Stine Figenschau, Judith Molnar m.fl.:
    Nephronectin (Npnt) promotes breast cancer brain metastasis via its integrin binding domains
    2017
  • Synnøve Magnussen, Imola Wilhelm, Janos Hasko, Judith Molnar, Marit Seppola, Elin Synnøve Hadler-Olsen m.fl.:
    The metastasis-promoting protein Nephronectin
    2016
  • Gunbjørg Svineng, Terje Steinar Larsen :
    Bli ekspert på menneskekroppen og få en trygg og viktig jobb!
    2015
  • Anna Maria Wirsing, Ann Iren Solli, Gunbjørg Svineng, Jan-Olof Winberg, Elin Synnøve Hadler-Olsen :
    Intracellular Matrix Metalloproteinase-2 in skeletal muscle: effect of glucose and oxidative stress
    2015
  • Anna Maria Wirsing, Ann Iren Solli, Gunbjørg Svineng, Jan-Olof Winberg, Elin Synnøve Hadler-Olsen :
    Intracellular Matrix Metalloproteinase-2 in skeletal muscle - a 3D skeletal muscle tissue engineering approach -
    2015
  • Tonje Strømmen Steigedal, Richard Redvers, Bedrich Eckhardt, John Michael Lamar, Judy Doherty, Richard O. Hynes m.fl.:
    The extracellular matrix protein Nephronectin (Npnt) promotes metastasis via its integrin binding domains
    2014
  • Tonje Steigedal, Gunbjørg Svineng, Richard Redvers, Bedrich Eckhardt, John M. Lamar, Judy Doherty m.fl.:
    Cellular interactions with the extracellular matrix of tumor microenvironment
    2013
  • Gunbjørg Svineng, Synnøve Magnussen, Elin Synnøve Hadler-Olsen, Nadezhda Latysheva, Emma Pirila, Sonja Eriksson Steigen m.fl.:
    Stromal induced expression of uPAR
    2013
  • Dominik Ausbacher, Terkel Hansen, Gunbjørg Svineng, Morten B. Strøm :
    Mechanisms of cancer cell death induced by two novel cationic beta-peptidomimetics
    Biopolymers 2011
  • Elin Synnøve Hadler-Olsen, Chandra Sekhar Ravuri, Hilde Ljones Wetting, Oddveig G Rikardsen, sonja eriksson Steigen, Gunbjørg Svineng m.fl.:
    Stromal Impact on Tumor Invasiveness and Gelatinolytic Activity at the Invasive Front
    2011
  • Richard Redvers, Gunbjørg Svineng, Bedrich Eckhardt, Normand Pouliot, Keith Stanley, Louis Reichardt m.fl.:
    The role of the extracellular matrix molecule Nephronectin/POEM in breast cancer metastasis
    2011
  • Dominik Ausbacher, Terkel Hansen, Gunbjørg Svineng, Morten B. Strøm :
    Mechanisms of cancer cell death induced by two novel cationic β-peptidomimetics
    2011
  • Elin Synnøve Hadler-Olsen, Chandra Sekhar Ravuri, Hilde Ljones, Oddveig G Rikardsen, sonja eriksson Steigen, Gunbjørg Svineng m.fl.:
    Organ specific stromal influence on tumor invasiveness and proteolytic activity at the invasive front
    European Journal of Cancer 2010 DOI
  • Elin Synnøve Hadler-Olsen, Hilde Ljones, O Rikardsen, sonja eriksson Steigen, Jan-Olof Winberg, Gunbjørg Svineng m.fl.:
    Stromal impact on tumor growth and lymphangiogenesis in human carcinoma xenografts
    APMIS - Journal of Pathologiy, Microbiology and Immunology 2010
  • Stian Sjøli, Olayiwola Adekoya, Yang Jiang, O Akselsen, VT Hansen, Gunbjørg Svineng m.fl.:
    Novel Inhibitors of Matrix Metalloprotease-9 and-14
    The FEBS Journal 2010
  • Atle Noralf Larsen, Ronny Helland, Gunbjørg Svineng, Trond Ø. Jørgensen :
    Identification, cloning and recombinant expression of a goose-type lysozyme from Atlantic cod (Gadus Morhua)
    2007
  • Chandra Sekhar Ravuri, Synnøve Magnussen, Jan-Olof Winberg, Nils-Erik Huseby, Gunbjørg Svineng :
    The effect of elevated levels of reactive oxygen species on oral squamous carcinoma cell adhesion and invasion
    2007
  • Gunbjørg Svineng :
    Genetic modifications of oral cancer cell lines
    2006
  • Eva Sjøttem, Helle Bagterp Klenow, Cecilie Rekdal, Gunbjørg Svineng, Sylvia Sagen Johnsen, Rebecca Dale Uglehus m.fl.:
    SPBP and TopBP1: Modulators of Androgen Receptor Activity
    2006

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    Forskningsinteresser

    Tumorbiology

    Extracellular matrix degrading enzymes; uPAR and MMPs

    Cell adhesion molecules; Integrins

    Extracellular matrix proteins; Nephronectin

    Metastasis related proteins; S100A4


    Medlem i forskningsgruppe


    CV

    Instituttleder ved Institutt for medisinsk biologi, Det Helsevitenskapelige fakultet, fra 1.08.2017

    Forskningsopphold ved Sydney University, Charles Perkins Center or ANZAC Research Institute, Australia, 2016-2017.

    Forskningsgruppeleder Tumorbiologisk forskningsgruppe, 2015-2016.

    Forskningsopphold ved Peter MacCallum Cancer Centre, Melbourne, Australia, 2010-2011.

    Undervisningsansvarlig IMB, 2009-2016.

    Avdelingsleder Medisinsk biokjemi, IMB, 2006-2009. 

    Førsteamanuensis i medisinsk biokjemi, IMB fra 2005. 

    Forsker i Marin bioteknologi, Norges Fiskerihøyskole, 2004-2005.

    Postdoc. i Molekylær kreftforskning, Biokjemisk avdeling, IMB, lønnet av Kreftforeningen, 2001-2004. Prosjekt: SPBP 

    Doktorgrad i 1999 i Medicinsk Vetenskap fra Institutionen för Medicinsk Biokemi och Mikrobiologi, Medicinska fakultetet, Uppsala Universitet, Sverige.

    Cand.scient i 1993 i Molekylærbiologi ved Biokjemisk avdeling, Institutt for Medisinsk Biologi, UiT.


    MH2 L.08.324

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