Johan Mattias Isaksson
Stillingsbeskrivelse
Leader of the UiT NMR lab, which is a node in the Norwegian NMR Platform (NNP) as well as the analytical platform SmallStruct.
Teaching, responsible for the courses: FAR-2301, FAR-3301, KJE-3303/8303.
Sailesh Maharjan,
Julie Marie Lesjø,
Johan Mattias Isaksson,
Kine Østnes Hansen,
Jeanette Hammer Andersen,
Espen Holst Hansen
m.fl.:
Parafenestella varangrensis sp. nov., a phomenin producing fungus from the Arctic
Marit Huizer,
Renate Døving Osvik,
Espen H. Hansen,
Terje Vasskog,
Jeanette Hammer Andersen,
Kim van Wezel
m.fl.:
Arctic Diatoms as a Source of Antibiofilm Compounds: Identification of Methyl 3-Hydroxyoctadecanoate and Pheophorbide a
Sailesh Maharjan,
Johan Mattias Isaksson,
Teppo Rämä,
Kine Østnes Hansen,
Jeanette Hammer Andersen,
Espen Holst Hansen
:
Marine-derived Acremonium strain prioritization using untargeted metabolomics approach for the identification of cytotoxic cyclic depsipeptides
Sailesh Maharjan,
Johan Mattias Isaksson,
Krupová Monika,
Teppo Rämä,
Kine Østnes Hansen,
Jeanette Hammer Andersen
m.fl.:
Metabolomics-Guided Discovery of Bipolarolides H−O, New Ophiobolin-Type Sesterterpenes with Antibacterial Activity from the Marine-Derived Fungus Uzbekistanica storfjordensis sp. nov.
Laura Schlüter,
Kine Østnes Hansen,
Johan Mattias Isaksson,
Jeanette Hammer Andersen,
Espen Holst Hansen,
Jörn Kalinowski
m.fl.:
Discovery of thiazostatin D/E using UPLC-HR-MS2-based metabolomics and σ-factor engineering of Actinoplanes sp. SE50/110
Birta Ravdna Alexandersen Sarre,
Olena Dobrovolska,
Patrik Lundström,
Diana Cornelia Turcu,
Tatiana Agback,
Øyvind Halskau
m.fl.:
Structural dynamics of human deoxyuridine 5’-triphosphate nucleotidohydrolase (dUTPase)
Philip Ben Rainsford,
Fredrik G. Rylandsholm,
Martin Jakubec,
Mitchell Silk,
Eric Juskewitz,
Johanna Ulrica Ericson
m.fl.:
Label-free measurement of antimicrobial peptide interactions with lipid vesicles and nanodiscs using microscale thermophoresis
Maxim Brilkov,
Martin Jakubec,
Victoria Stenbakk,
Terje Vasskog,
Tone Kristoffersen,
Jorunn Pauline Cavanagh
m.fl.:
Bacterial extracellular vesicles: towards realistic models for bacterial membranes in molecular interaction studies by surface plasmon resonance
Yannik Karl Heinz Schneider,
Anton Liaimer,
Johan Mattias Isaksson,
Oda Sofie Bye Wilhelmsen,
Jeanette Hammer Andersen,
Kine Østnes Hansen
m.fl.:
Four new suomilides isolated from the cyanobacterium Nostoc sp. KVJ20 and proposal of their biosynthetic origin
Fazlin Pheiffer,
Yannik Karl Heinz Schneider,
Espen Holst Hansen,
Jeanette Hammer Andersen,
Johan Mattias Isaksson,
Tobias Busche
m.fl.:
Bioassay-Guided Fractionation Leads to the Detection of Cholic Acid Generated by the Rare Thalassomonas sp.
Eric Juskewitz,
Ekaterina Mischenko,
Vishesh Kumar Dubey,
Marte Jenssen,
Martin Jakubec,
Philip Rainsford
m.fl.:
Lulworthinone: In Vitro Mode of Action Investigation of an Antibacterial Dimeric Naphthopyrone Isolated from a Marine Fungus
Sara Ullsten-Wahlund,
Guillaume Petit,
Johan Mattias Isaksson,
Ida Kristine Østnes Hansen,
Yannik Karl Heinz Schneider,
Marte Jenssen
m.fl.:
Identification of New Purpuroine Analogues from the Arctic Echinodermata Pteraster militaris That Inhibit FLT3-ITD+ AML Cell Lines
Philip Ben Rainsford,
Birta R. Sarre,
Margherita Falavigna,
Bjørn Olav Brandsdal,
Gøril Eide Flaten,
Martin Jakubec
m.fl.:
WIND-PVPA: Water/Ion NMR Detected PVPA to assess lipid barrier integrity in vitro through quantification of passive water- and ion transport
Marte Jenssen,
Venke Kristoffersen,
Kumar Motiram-Corral,
Johan Isaksson,
Teppo Rämä,
Jeanette Hammer Andersen
m.fl.:
Chlovalicin B, a Chlorinated Sesquiterpene Isolated from the Marine Mushroom Digitatispora marina
Marte Jenssen,
Philip Rainsford,
Eric Juskewitz,
Jeanette Hammer Andersen,
Espen Hansen,
Johan Isaksson
m.fl.:
Lulworthinone, a New Dimeric Naphthopyrone From a Marine Fungus in the Family Lulworthiaceae With Antibacterial Activity Against Clinical Methicillin-Resistant Staphylococcus aureus Isolates
Marianne Hagensen Paulsen,
Magnus Engqvist,
Dominik Ausbacher,
Trude Anderssen,
Manuel K- Langer,
Tor Haug
m.fl.:
Amphipathic Barbiturates as Mimics of Antimicrobial Peptides and the Marine Natural Products Eusynstyelamides with Activity against Multi-resistant Clinical Isolates
Venke Kristoffersen,
Marte Jenssen,
Heba Raid Jawad,
Johan Isaksson,
Espen Hansen,
Teppo Rämä
m.fl.:
Two Novel Lyso-Ornithine Lipids Isolated from an Arctic Marine Lacinutrix sp. Bacterium
Worku Dinku,
Johan Isaksson,
Fredrik G. Rylandsholm,
Petr Bouř,
Eva Brichtova,
Sang Un Choi
m.fl.:
Anti-proliferative activity of a novel tricyclic triterpenoid acid from Commiphora africana resin against four human cancer cell lines
Olena Dobrovolska,
Maxim Brilkov,
Noëlly Madeleine,
Øyvind Ødegaard-Fougner,
Øyvind Strømland,
Stephen R. Martin
m.fl.:
The Arabidopsis (ASHH2) CW domain binds monomethylated K4 of the histone H3 tail through conformational selection
Yngve Guttormsen,
Magnus John Espeland Fairhurst,
Sunil Kumar Pandey,
Johan Isaksson,
Bengt Erik Haug,
Annette Bayer
:
Total synthesis of phorbazole B
Ida Kristine Østnes Hansen,
Johan Isaksson,
Aaron G. Poth,
Kine Østnes Hansen,
Aaron John Christian Andersen,
Céline Sarah Marine Richard
m.fl.:
Isolation and characterization of antimicrobial peptides with unusual disulfide connectivity from the colonial ascidian Synoicum turgens
Ikenna E. Ndukwe,
Yu-hong Lam,
Sunil Kumar Pandey,
Bengt Erik Haug,
Annette Bayer,
Edward C. Sherer
m.fl.:
Unequivocal structure confirmation of a breitfussin analog by anisotropic NMR measurements
Yannik Karl-Heinz Schneider,
Marte Jenssen,
Johan Isaksson,
Kine Østnes Hansen,
Jeanette Hammer Andersen,
Espen Hansen
:
Bioactivity of Serratiochelin A, a Siderophore Isolated from a Co-Culture of Serratia sp. and Shewanella sp.
Raja Priyanka Mary Michael Siranjeevi,
Espen Hansen,
Johan Isaksson,
Jeanette hammer Andersen,
Kine Østnes Hansen
:
Dendrobeaniamine A, a new alkaloid from the Arctic marine bryozoan Dendrobeania murrayana
Kine Østnes Hansen,
Jeanette hammer Andersen,
Annette Bayer,
Sunil Kumar Pandey,
Marianne Lorentzen,
Kåre Bredeli Jørgensen
m.fl.:
Kinase chemodiversity from the Arctic: the breitfussins
Yannik Karl-Heinz Schneider,
Kine Østnes Hansen,
Johan Isaksson,
Sara Maria Ullsten-Wahlund,
Espen Hansen,
Jeanette Hammer Andersen
:
Anti-Bacterial Effect and Cytotoxicity Assessment of Lipid 430 Isolated from Algibacter sp.
Aitor Moreno,
Kine Østnes Hansen,
Johan Isaksson
:
CSSF-CLIP-HSQMBC: measurement of heteronuclear coupling constants in severely crowded spectral regions
Venke Kristoffersen,
Teppo Rämä,
Johan Isaksson,
Jeanette hammer Andersen,
William H. Gerwick,
Espen Hansen
:
Characterization of Rhamnolipids Produced by an Arctic Marine Bacterium from the Pseudomonas fluorescence Group
Kine Østnes Hanssen,
Johan Isaksson,
Eirin Glomsaker,
Jeanette hammer Andersen,
Espen Hansen
:
Ponasterone A and F, Ecdysteroids from the Arctic Bryozoan Alcyonidium gelatinosum
Jostein Grip,
Rolf Einar Engstad,
Ingrid Skjæveland,
Natasa Skalko-Basnet,
Johan Isaksson,
Purusotam Basnet
m.fl.:
Beta-glucan-loaded nanofiber dressing improves wound healing in diabetic mice
Sundus Akhter,
Bjarte Aarmo Lund,
Aya Ismael,
Manuel K Langer,
Johan Mattias Isaksson,
Tony Christopeit
m.fl.:
A focused fragment library targeting the antibiotic resistance enzyme - Oxacillinase-48: Synthesis, structural evaluation and inhibitor design
Sundus Ahkter,
Bjarte Aarmo Lund,
Aya Ismael,
Manuel Langer,
Johan Isaksson,
Tony Christopeit
m.fl.:
A focused fragment library targeting the antibiotic resistance enzyme - Oxacillinase-48: Synthesis, structural evaluation and inhibitor design
Bjarte Aarmo Lund,
Ane Molden Thomassen,
Birgit Helene Berg Nesheim,
Trine Josefine Olsen Carlsen,
Johan Isaksson,
Tony Christopeit
m.fl.:
The biological assembly of OXA‐48 reveals a dimer interface with high charge complementarity and very high affinity
Raja Priyanka Mary Michael Siranjeevi,
Kine Østnes Hanssen,
Johan Isaksson,
Jeanette hammer Andersen,
Espen Hansen
:
A Novel Brominated Alkaloid Securidine A, Isolated from the Marine Bryozoan Securiflustra securifrons
Kine Østnes Hansen,
Johan Isaksson,
Annette Bayer,
Jostein a Johansen,
Jeanette hammer Andersen,
Espen Hansen
:
Securamine Derivatives from the Arctic Bryozoan Securiflustra securifrons
Maxim Brilkov,
Jorunn Pauline Cavanagh,
Johan Mattias Isaksson,
Johanna U Ericson
:
Outer-membrane vesicles as a bacterial membrane model to study interaction of antimicrobial peptides
2023 ARKIV
Yannik Karl Heinz Schneider,
Anton Liaimer,
Johan Mattias Isaksson,
Oda Sofie Bye Wilhelmsen,
Jeanette Hammer Andersen,
Kine Østnes Hansen
m.fl.:
Corrigendum: Four new suomilides isolated from the cyanobacterium Nostoc sp. KVJ20 and proposal of their biosynthetic origin (Frontiers in Microbiology, (2023), 14, (1130018), 10.3389/fmicb.2023.1130018)
Johan Mattias Isaksson
:
Structural Dynamics Characterization of human dUTPase - a target in cancer
2023 ARKIV
Philip Ben Rainsford,
Maxim Brilkov,
Finn Lillelund Aachmann,
Gøril Eide Flaten,
Johan Mattias Isaksson
:
NMR tube inserts for time-resolved spatial NMR
2023 ARKIV
Maxim Brilkov,
Jorunn Pauline Cavanagh,
Johan Mattias Isaksson,
Johanna E. Sollid,
Gøril Eide Flaten
:
BACTERIALLY PRODUCED IN VITRO MEMBRANE MODEL SYSTEMS FROM RESISTANT- AND NON-RESISTANT CLINICAL ISOLATES
2023 ARKIV
Maxim Bril'kov,
Jorunn Pauline Cavanagh,
Johan Mattias Isaksson,
Johanna U Ericson,
Gøril Eide Flaten
:
Bacterially produced in vitro mambrane model systems from resistant- and non-resistant clinical isolates
2022 ARKIV
Monika Krupova,
Karolina Di Remigio Eikås,
Johan Mattias Isaksson,
Kenneth Ruud
:
Vibrational Circular Dichroism of Antimicrobial Peptides: What is Their Structure in Solution and in Membranes?
2022 ARKIV
Philip Ben Rainsford,
Johan Mattias Isaksson
:
Expanding the toolbox for the study of antimicrobial peptides
UiT Norges arktiske universitet 02. juni 2022 ARKIV
Johan Mattias Isaksson
:
CSSF-CLIP-HSQMBC
2020 ARKIV
Johan Isaksson
:
CSSF-CLIP-HSQMBC: Measurement of heteronuclear coupling constants in severely crowded spectral regions
2020 ARKIV
Priyanka Michael,
Espen Hansen,
Johan Isaksson,
Jeanette hammer Andersen,
Kine Østnes Hansen
:
Dendrobeaniamine A, a New Alkaloid from the Arctic Marine bryozoan Dendrobeania murrayana
2019 ARKIV
Kine Ø. Hanssen,
Jeanette hammer Andersen,
Bert Klebl,
Jan Eickhoff,
Johan Isaksson,
Espen Hansen
:
Novel kinase inhibitors from the Arctic marine hydrozoan Thuiaria breitfussi
2019 ARKIV
Aitor Moreno,
Kine Ø. Hanssen,
Johan Isaksson
:
CSSF-CLIP-HSQMBC: Measurement of heteronuclear coupling constants in severely crowded spectral regions
2019 ARKIV
Johan Isaksson
:
CSSF-CLIP-HSQMBC: Measurement of heteronuclear coupling constants in severely crowded spectral regions
2019 ARKIV
Johan Isaksson,
Birta Ravdna Sarre
:
“Dynamics characterization of dUTPase, a new target in cancer therapy”
2018 ARKIV
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Forskningsinteresser
See english page.
Undervisning
Course responsible for the courses: Medicinal chemistry (FAR-2301), Advanced pharmaceutical chemistry (FAR-3301) and and NMR Spectroscopy (KJE-3303/8303).
Medlem i forskningsgruppe
CV
Aug 2022-today Professor in the Natural Products and Medicinal Chemistry Group, Department of Pharmacy, University of Tromsø The Arctic University of Norway (UiT), Norway (80%)
Aug 2022-Aug 2024 Assoc. Professor in the Natural Products and Medicinal Chemistry Group, Department of Pharmacy, University of Tromsø The Arctic University of Norway (UiT), Norway (80%)
Aug 2022-today Senior researcher, leader of the UiT NMR laboratory and the Tromsø Norwegian NMR Platform (NNP) node, manager of the SmallStruct platform, Department of Chemistry, UiT, Norway (20%)
Feb 2011-Jul 2022 Senior researcher, leader of the UiT NMR laboratory, manager of the SmallStruct platform, Department of Chemistry, UiT, Norway
Feb 2009-Jan 2011 Postdoc with Prof. John Sigurd Svendsen/NMR management, Dept. Chemistry, UiT, Norway
Oct 2005-Jan 2009 Research scientist, NMR, Medivir AB (http://medivir.com), Stockholm, Sweden