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Bilde av Småbrekke, Lars
Bilde av Småbrekke, Lars
Professor. Forskningsgruppeleder. Samfunnsfarmasi. Klinisk farmasi og farmakoepidemiologi, forskningsgruppe lars.smabrekke@uit.no +4777645792 +4799249663 Her finner du meg

Lars Småbrekke

Stillingsbeskrivelse

Stillingen har undervisningsansvar for emnene Far-2101 og Far-3101, og jeg deltar i undervisning i flere andre emner på master og PhD-nivå.

Forskningen er rettet mot ulike aspekter relatert til legemiddelbruk, først og fremst antibiotika, og er i hovedsak basert på data fra befolkningsstudier, Legemiddelregisteret og data samlet fra klinisk praksis i sykehus.

  • Mohsen Gamal Saad Askar, Lars Småbrekke, Einar Jakobsen Holsbø, Lars Ailo Aslaksen Bongo, Kristian Svendsen :
    “Using network analysis modularity to group health code systems and decrease dimensionality in machine learning models”
    Exploratory Research in Clinical and Social Pharmacy (ERCSP) 2024 ARKIV / DOI
  • Beate Hennie Garcia, Katharina Kaino Omma, Lars Småbrekke, Jeanette Schultz Johansen, frode Skjold, Kjell Hermann Halvorsen :
    Investigating the impact of a pharmacist intervention on inappropriate prescribing practices at hospital admission and discharge in older patients: a secondary outcome analysis from a randomized controlled trial
    Therapeutic Advances in Drug Safety 2024 DOI
  • Eirin Guldsten Robinson, Hanna Gyllensten, Jeanette Schultz Johansen, Kjerstin Havnes, Anne Gerd Granås, Trine Strand Bergmo m.fl.:
    A Trial-Based Cost-Utility Analysis of a Medication Optimization Intervention Versus Standard Care in Older Adults
    Drugs & Aging 2023 ARKIV / DOI
  • Ann Helen Jakobsen, Lars Småbrekke, Timothy F. Chen, Kjell H. Halvorsen :
    Exploring stakeholders' perspectives on the quality of services provided through community pharmacies
    Research in Social and Administrative Pharmacy 2023 ARKIV / DOI
  • Trine Strand Bergmo, Vilde Sandsdalen, Unn Sollid Manskow, Lars Småbrekke, Marit Waaseth :
    Internet Use for Obtaining Medicine Information: Cross-sectional Survey
    JMIR Formative Research 2023 ARKIV / DOI
  • Niclas Peter Raffelsberger, Dorota Julia Buczek, Kristian Svendsen, Lars Småbrekke, Anna Kaarina Pöntinen, Iren Høyland Löhr m.fl.:
    Community carriage of ESBL-producing Escherichia coli and Klebsiella pneumoniae: a cross-sectional study of risk factors and comparative genomics of carriage and clinical isolates
    mSphere 2023 ARKIV / DOI
  • Dina Benedicte Berg Stensen, Lars Småbrekke, Karina Olsen, Guri Grimnes, Christopher Sivert Nielsen, Johanna U Ericson m.fl.:
    Circulating sex-steroids and Staphylococcus aureus nasal carriage in a general male population
    Epidemiology and Infection 2022 FULLTEKST / ARKIV / DOI
  • Therese von Hanno, Live Lund Hareide, Lars Småbrekke, Bente Morseth, Monica Sneve, Maja Gran Erke m.fl.:
    Macular Layer Thickness and Effect of BMI, Body Fat, and Traditional Cardiovascular Risk Factors: The Tromsø Study
    Investigative Ophthalmology and Visual Science 2022 ARKIV / DOI
  • Jeanette Schultz Johansen, Kjell H. Halvorsen, Kristian Svendsen, Kjerstin Havnes, Eirin Guldsten Robinson, Hilde Ljones Wetting m.fl.:
    Interdisciplinary collaboration across secondary and primary care to improve medication safety in the elderly (The IMMENSE study) – a randomized controlled trial
    BMC Health Services Research 2022 ARKIV / DOI
  • Mari Johannessen Walquist, Kristian Svendsen, Beate Hennie Garcia, Trine Strand Bergmo, Anne Elise Eggen, Kjell H. Halvorsen m.fl.:
    Self-reported medication information needs among medication users in a general population aged 40 years and above – the Tromsø study
    BMC Public Health 2022 ARKIV / DOI
  • Dina Benedicte Berg Stensen, Rafael Nozal Cañadas, Lars Småbrekke, Karina Olsen, Christopher Sivert Nielsen, Kristian Svendsen m.fl.:
    Social network analysis of Staphylococcus aureus carriage in a general youth population
    International Journal of Infectious Diseases 2022 ARKIV / FULLTEKST / DOI
  • Sigbjørn Svalestuen, Kristian Svendsen, Anne Elise Eggen, Lars Småbrekke :
    Association of area-level education with the regional growth trajectories of rates of antibacterial dispensing to patients under 3 years in Norway: a longitudinal retrospective study
    BMJ Open 2022 ARKIV / DOI
  • Niclas Peter Raffelsberger, Marit Andrea Klokkhammer Hetland, Kristian Svendsen, Lars Småbrekke, Iren Høyland Löhr, Lotte Andreassen m.fl.:
    Gastrointestinal carriage of Klebsiella pneumoniae in a general adult population: a cross-sectional study of risk factors and bacterial genomic diversity
    Gut microbes 2021 ARKIV / DOI
  • Sanna Beckstrøm, Kristian Svendsen, Lars Småbrekke :
    Antibacterial use by birth year and birth season in children 0-2 years in Norway
    Norsk Epidemiologi 2021 ARKIV / DOI
  • Dina Benedicte Berg Stensen, Lars Småbrekke, Karina Olsen, Guri Grimnes, Christopher Sivert Nielsen, Johanna U Ericson m.fl.:
    Circulating sex-steroids and Staphylococcus aureus nasal carriage in a general female population
    European Journal of Endocrinology (EJE) 2021 FULLTEKST / ARKIV / DOI
  • Kirsten Midttun Gravningen, Nigel Field, Hege Salvesen Blix, Anne Mette Asfeldt, Lars Småbrekke :
    Non-prescription purchase of antibiotics during travel abroad among a general adult population in Norway: Findings from the seventh Tromsø Study
    PLOS ONE 2020 ARKIV / DOI
  • Guttorm Raknes, Lars Småbrekke :
    No change in the consumption of thyroid hormones after starting low dose naltrexone (LDN): A quasi-experimental before-after study
    BMC Endocrine Disorders 2020 ARKIV / DOI
  • June Utnes Høgli, Beate Hennie Garcia, Kristian Svendsen, Vegard Skogen, Lars Småbrekke :
    Empirical prescribing of penicillin G/V reduces risk of readmission of hospitalized patients with community-acquired pneumonia in Norway: a retrospective observational study
    BMC Pulmonary Medicine 2020 ARKIV / DOI
  • Guttorm Raknes, Lars Småbrekke :
    Changes in the consumption of antiepileptics and psychotropic medicines after starting low dose naltrexone: A nation-wide register-based controlled before-after study
    Scientific Reports 2019 ARKIV / DOI
  • Ilya Nikolaevich Zykov, Niels Frimodt-Møller, Lars Småbrekke, Arnfinn Sundsfjord, Ørjan Samuelsen :
    Efficacy of mecillinam against clinical multidrug-resistant Escherichia coli in a murine urinary tract infection model
    International Journal of Antimicrobial Agents 02. november 2019 ARKIV / DOI
  • Dina Benedicte Berg Stensen, Lars Småbrekke, Karina Olsen, Guri Grimnes, Christopher Sivert Nielsen, Gunnar Skov Simonsen m.fl.:
    Hormonal contraceptive use and Staphylococcus aureus nasal and throat carriage in a Norwegian youth population
    PLOS ONE 2019 ARKIV / FULLTEKST / DOI
  • Guttorm Raknes, Lars Småbrekke :
    Low dose naltrexone: Effects on medication in rheumatoid and seropositive arthritis. A nationwide register-based controlled quasi-experimental before-after study
    PLOS ONE 2019 ARKIV / DOI
  • O D'Annibali, G Bonaldo, Monia Donati, Lars Småbrekke, Domenico Motola, A Vaccheri :
    Antibacterial prescription in Italian preschool children: analysis of 7 years of data from the Emilia-Romagna region reimbursement database
    Journal of Antimicrobial Chemotherapy 01. august 2019 DOI
  • Cecilia S. Sambakunsi, Lars Småbrekke, Christine A. Varga, Vernon Solomon, John S. Mponda :
    Knowledge, attitudes and practices related to self-medication with antimicrobials in Lilongwe, Malawi
    Malawi Medical Journal 2019 ARKIV / DOI
  • Guttorm Raknes, Pia Simonsen, Lars Småbrekke :
    The effect of low-dose naltrexone on medication in inflammatory bowel disease: A quasi experimental before-and-after prescription database study
    Journal of Crohn's and Colitis 2018 ARKIV / DOI
  • Ilya Nikolaevich Zykov, Ørjan Samuelsen, Lotte Jakobsen, Lars Småbrekke, Dan I. Andersson, Arnfinn Sundsfjord m.fl.:
    Pharmacokinetics and pharmacodynamics of fosfomycin and its activity against extended-spectrum-lactamase-, plasmid-mediated AmpC-, and carbapenemase-producing escherichia coli in a murine urinary tract infection model
    Antimicrobial Agents and Chemotherapy 2018 ARKIV / DOI
  • Pål Haugen, Gunnar Skov Simonsen, Raul Primicerio, Anne-Sofie Furberg, Lars Småbrekke :
    Antibiotics to outpatients in Norway—Assessing effect of latitude and municipality population size using quantile regression in a cross-sectional study.
    Pharmaceutical statistics 2018 ARKIV / DOI
  • Bjørg Haldorsen, Christian G Giske, Dennis S Hansen, Kristjan Orri Helgason, Gunnar Kahlmeter, Iren Høyland Löhr m.fl.:
    Performance of the EUCAST disc diffusion method and two MIC methods in detection of Enterobacteriaceae with reduced susceptibility to meropenem: the NordicAST CPE study.
    Journal of Antimicrobial Chemotherapy 2018 ARKIV / DOI
  • Guttorm Raknes, Lars Småbrekke :
    Low dose naltrexone in multiple sclerosis: Effects on medication use. A quasi-experimental study
    PLOS ONE 2017 ARKIV / DOI
  • Guttorm Raknes, Lars Småbrekke :
    Low-dose naltrexone and opioid consumption: a drug utilization cohort study based on data from the Norwegian prescription database
    Pharmacoepidemiology and Drug Safety 2017 DOI
  • Guttorm Raknes, Lars Småbrekke :
    A sudden and unprecedented increase in low dose naltrexone (LDN) prescribing in Norway. Patient and prescriber characteristics, and dispense patterns. A drug utilization cohort study
    Pharmacoepidemiology and Drug Safety 2016 ARKIV / DOI
  • June Utnes Høgli, Beate Hennie Garcia, frode Skjold, Vegard Skogen, Lars Småbrekke :
    An audit and feedback intervention study increased adherence to antibiotic prescribing guidelines at a Norwegian hospital
    BMC Infectious Diseases 2016 SAMMENDRAG / FULLTEKST / ARKIV / DOI
  • Beate Hennie Garcia, Trude Giverhaug, June U. Høgli, Frode Skjold, Lars Småbrekke :
    A pharmacist-led follow-up program for patients with established coronary heart disease in North Norway – A randomized controlled trial [Programa farmacéutico de seguimiento para pacientes con enfermedad coronaria establecida en El Norte de Noruega – Ensayo controlado aleatorizado]
    Pharmacy Practice 2015 ARKIV / DOI
  • Ilya Nikolaevich Zykov, Arnfinn Sundsfjord, Lars Småbrekke, Ørjan Samuelsen :
    The antimicrobial activity of mecillinam, nitrofurantoin, temocillin and fosfomycin and comparative analysis of resistance patterns in a nationwide collection of ESBL-producing Escherichia coli in Norway 2010–2011
    Infectious Diseases 2015 DOI
  • Mauro Melis, Chiara Biagi, Lars Småbrekke, Francesco Nonino, Elena Buccellato, Monia Donati m.fl.:
    Drug-Induced Progressive Multifocal Leukoencephalopathy: A Comprehensive Analysis of the WHO Adverse Drug Reaction Database
    CNS Drugs 2015 DOI
  • June Utnes Høgli, Lars Småbrekke, Beate Garcia :
    MAT-CAP: A novel medication assessment tool to explore adherence to clinical practice guidelines in community-acquired pneumonia
    Pharmacoepidemiology and Drug Safety 2014 DOI
  • Mohsen Gamal Saad Askar, Masoud Tafavvoghi, Lars Småbrekke, Lars Ailo Bongo, Kristian Svendsen :
    Using machine learning methods to predict all-cause somatic hospitalizations in adults: A systematic review
    PLOS ONE 2024 DOI
  • Dina Benedicte Berg Stensen, Lars Småbrekke, Karina Olsen, Christopher Sivert Nielsen, Johanna Ericson Sollid, Gunnar Skov Simonsen m.fl.:
    Circulating sex-steroids and Staphylococcus aureus nasal carriage in a general population in Norway
    2021
  • Dina Benedicte Berg Stensen, Rafael A. Nozal Cañadas, Lars Småbrekke, Karina Olsen, Christopher Sivert Nielsen, Kristian Svendsen m.fl.:
    Social network analysis of Staphylococcus aureus carriage in a general youth population
    2021
  • Dina Benedicte Berg Stensen, Lars Småbrekke, Karina Olsen, Guri Grimnes, Christopher Sivert Nielsen, Johanna Ericson Sollid m.fl.:
    Circulating sex-steroids and Staphylococcus aureus nasal carriage in a general female population
    2021
  • Angela Lupattelli, Øystein Karlstad, Anders Engeland, Lars Småbrekke, Kristine Olsen, Aina Øvrebust m.fl.:
    The Norwegian Society for Pharmacoepidemiology
    Norsk Epidemiologi 2021 ARKIV / DOI
  • Ann Helen Jakobsen, Kjell H. Halvorsen, Lars Småbrekke :
    Forslag til kvalitetsindikatorer for primærapotek
    2019
  • Lyn Middleton, F Lampiao, Tomas F. Zimba, SM Muzime, Gunnar Skov Simonsen, Lars Småbrekke m.fl.:
    Sharing Knowledge Transforming Societies. The Norhed Programme 2013-2020
    African Minds 2019
  • Guttorm Raknes, Pia Simonsen, Lars Småbrekke :
    Erratum: The Effect of Low-Dose Naltrexone on Medication in Inflammatory Bowel Disease: A Quasi Experimental Before-and-After Prescription Database Study (Journal of Crohn's and Colitis DOI: 10.1093/ecco-jcc/jjy008)
    Journal of Crohn's and Colitis 2019 DOI
  • Kristian Svendsen, Øystein Karlstad, Lars Småbrekke :
    To the editor
    JAMA Internal Medicine 2018 DOI
  • Kristian Svendsen, Øystein Karlstad, Lars Småbrekke :
    Lower cancer incidence-warfarin effect or immortal time bias?
    JAMA Internal Medicine 2018 DOI
  • Martin Sørensen, Annette Kuehn, E.N. Clare Mills, Carol Ann Costello, Markus Ollert, Lars Småbrekke m.fl.:
    Cross-reactivity in fish allergy: A double-blind, placebo-controlled food-challenge trial
    Journal of Allergy and Clinical Immunology 2017 DOI
  • Dina Stensen, Lars Småbrekke, Karina Olsen, Guri Grimnes, Christopher Sivert Nielsen, Gunnar Skov Simonsen m.fl.:
    Hormonal contraceptive use and Staphylococcus aureus nasal and throat carriage in a Norwegian youth population. The Tromsø Study Fit Futures 2.
    2017
  • Kristian Svendsen, Håvard Wahl Kongsgård, Pål Haugen, Lars Småbrekke :
    Does travel time to pharmacies and general physicians influence the use of antibiotics in Norway?
    2016
  • Tone Ruud Engen, Beate Hennie Garcia, Kjell H. Halvorsen, Marit Waaseth, Lars Småbrekke, Hilde Ljones Wetting :
    Er det trygt å velge billigere resept-medisiner?
    22. januar 2015 DATA

    • De 50 siste resultatene fra Cristin vises på siden. Se alle arbeider i Cristin her →

    Forskningsinteresser

    Legemiddelbruk på individ- og populasjonsnivå, med hovedfokus på antibiotikabruk.


    Medlem i forskningsgruppe

    Clinical Pharmacy and Pharmacoepidemiology (IPSUM)   English content

    Medlem i prosjekt

    Quality indicators in community pharmacies The IMMENSE study The Tromsø Study Pharmacist-Physician collaboration in primary care

    CV

    Academic Curriculum Vitae for Lars Småbrekke

    Personal data and contact information
    Date of birth: 18.01.59

    Position: Professor

    Work address: Department of Pharmacy, UiT The Arctic University of Norway

    Phone: +4799249663 (cell) / +4777645792 (office)

    E-mail: lars.smabrekke@uit.no

    Research unique identifier: https://orcid.org/0000-0001-6474-3368

    UiT web-site: https://uit.no/ansatte/lars.smabrekke

    CRISTIN-ID: 55832

    Education
    2013 – 2014     Basic competency in Pedagogy in higher education, RESULT, UiT

    2009                 PhD. Faculty of Health Sciences, UiT https://munin.uit.no/handle/10037/2135

    1999                 Master in Public Health. Faculty of Health Sciences, UiT

    1985                 Candidatus Pharmaciae, UiO

    Current and previous positions
    2022 –  now   Prof. UiT The Arctic University of Norway, Department of Pharmacy

    2009 – 2021   A/Prof. UiT The Arctic University of Norway, Department of Pharmacy

    2008 – 2009   University scholarship (UiT The Arctic University of Norway)

    2004 – 2008   University Hospital North-Norway, Head of the regional drug information centre

    2003 ­– 2004   UiT The Arctic University of Norway (lecturer)

    1999 – 2003   University Hospital North-Norway, Head of the regional drug information centre

    1991-1999     Hospital Pharmacy, University Hospital North-Norway

    1986-1991         Hospital Pharmacy, Kirkenes Hospital, Norway

    Development of curricula

    2010 – 2012    Working group for the new BSc and MSc program in Pharmacy at UiT

    2012 – 2013    Revision of pharmacy education in Norway. (Head of the working group)

    2016                Profesjonsrådet. Head of national group establishing for learning outcomes in                                statistics in a 3+2 curriculum in pharmacy

     

    Boards and committees

    1994 – 1997    Interim board for establishing the pharmacy program at UiT

    1999 – 2004    External member. Board for the Department of Pharmacy

    Regional and national boards and committees

    1999 – 2000   Bivirkningsnemda (National board of adverse reactions to medicines)

    2008 – 2012   Blåreseptnemda (National board on reimbursement)

    2016 – now    Board member. The Regional Health Authority

    2010 – now    Board member. Norwegian Society of Pharmacoepidemiology

    Panels, workshops and conference organization

    2018     Critical thinking. Member of working group for the workshop (approx. 225 participants)

    2019     Conference on antibiotic stewardship and conservation in Africa.  Durban (South-Africa).               Organizing of the conference and chaired one afternoon session.

    2019    Critical thinking. Leader of the working group for the workshop. (approx. 275 participants)

    2020    Critical thinking. Member of working group for the workshop (approx. 225 participants)

    2023    NSPC. International Conference in Social Pharmacy. Member of working group

    Scientific evaluation committees
    2012     UiO. Position as A/Prof in community pharmacy

    2012     UiT The arctic university of Norway. Position as A/Prof in pharmacy practice

    2013     UiO. Position as A/Prof in community pharmacy

    2016     UiO. Position as Professor in community pharmacy

    2016     UiO. Position as A/Prof in community pharmacy

    2019     UiT The arctic university of Norway. Position as university lecturer

    2019     UKZN. Evaluation of PhD-thesis

    2022    NTNU. Exam for research line student

    Chronological list of publications
     1.       Rygnestad T, Småbrekke L, Nesje L, Talsethagen H, Rogne P, Myhr K, Bentzen I. Impact of improved treatment of sexually transmitted disease on HIV infection. Lancet. 1995 Oct 28;346(8983):1157

    2.      Simonsen T, Braathen P, Småbrekke L. Folsyre eller folinsyre som tilskudd ved samtidig behandling med metotrexat? Utposten. 1999;28:42-44

    3.      Endresen PC, Braathen P, Småbrekke L. Legemiddelbruk under graviditet. Utposten. 2000:29:45-46

    4.      Braathen P, Endresen PC, Småbrekke L, Ulvestad L. Ginko biloba, naturlegemiddel med mulig interaksjon med antitrombotiske midler. Utposten. 2000;29:32-33

    5.      Roland DDH, Schjøtt J, Småbrekke L, Westergren T. RELIS spørsmål og svar-database på internett. Utposten. 2001;30:38-39

    6.      Småbrekke L, Braathen P. Legemidler med laktose til pasienter med laktoseintoleranse? Tidsskr Nor Laegeforen. 2000 Aug 20;120(19):2303-4. Norwegian. PMID: 10997093

    7.      Småbrekke L. Stor skilnad i forbruksprofil mellom to universitetssykehus i Norge. Norsk Epidemiologi 2001;11: 61-5

    8.     Småbrekke L, Berild D, Giæver A, Myrbakk T, Fuskevåg A, Ericson JU, Flaegstad T, Olsvik O, Ringertz SH. Educational intervention for parents and healthcare providers leads to reduced antibiotic use in acute otitis media. Scand J Infect Dis. 2002;34(9):657-9. doi: 10.1080/00365540210147651. PMID: 12374355

    9.      Simonsen GS, Småbrekke L, Monnet DL, Sørensen TL, Møller JK, Kristinsson KG, Lagerqvist-Widh A, Torell E, Digranes A, Harthug S, Sundsfjord A. Prevalence of resistance to ampicillin, gentamicin and vancomycin in Enterococcus faecalis and Enterococcus faecium isolates from clinical specimens and use of antimicrobials in five Nordic hospitals. J Antimicrob Chemother 2003 Feb;51(2):323-31. doi: 10.1093/jac/dkg052. PMID: 12562698.6):X3. PMID: 33428587; PMCID: PMC7849480

    10.  Berild D, Småbrekke L, Halvorsen DS, Lelek M, Stahlsberg EM, Ringertz SH. Clostridium difficile infections related to antibiotic use and infection control facilities in two university hospitals. J Hosp Infect. 2003 Jul;54(3):202-6. doi: 10.1016/s0195-6701(03)00149-x. PMID: 12855235

    11.   Klingenberg C, Småbrekke L, Lier T, Flaegstad T. Validation of a simplified netilmicin dosage regimen in infants. Scand J Infect Dis. 2004;36(6-7):474-9. doi: 10.1080/00365540410020613. PMID: 15307571

    12.  Nordmo E, Småbrekke L. Kalseormedrue (Black cohosh) mot menopausale plager. Utposten 2005;34:42-43

    13.  Raknes G, Småbrekke L. Echinacea spp. (solhatt) og øvre luftveisinfeksjon. Tidsskr Nor Laegeforen. 2006 Oct 5;126(19):2526-7. Norwegian. PMID: 17028634

    14.  Vorren S, Småbrekke L. Reductil (sibutramin) og graviditet. Utposten 2008;37:44-45

    15.  Nordmo E, Småbrekke L. Melasma ved bruk av p-piller. NFT 2007: (5):12

    16.  Nordmo E, Småbrekke L. Interaksjon mellom metadon og valerianapreparater. NFT 2007; (10):10

    17.   Nordmo E, Småbrekke L. Nattlysolje mot atopisk eksem. NFT 2008; (3):11-12

    18.  Småbrekke L, Melbye H. Medikamentell behandling av akutt hoste. Tidsskr Nor Laegeforen. 2009 May 14;129(10):998-9. Norwegian. doi: 10.4045/tidsskr.08.0438. PMID: 19448753.

    19.  Klingenberg C, Småbrekke L, Døllner H, Simonsen GS. Peroral antibiotikabehandling av urinveisinfeksjon hos barn. Tidsskr Nor Laegeforen. 2009 Jun 25;129(13):1342-4. Norwegian. doi: 10.4045/tidsskr.09.0092. PMID: 19561661

    20. Nordmo E, Aronsen L, Wasland K, Småbrekke L, Vorren S. Severe apnea in an infant exposed to lamotrigine in breast milk. Ann Pharmacother. 2009 Nov;43(11):1893-7. doi: 10.1345/aph.1M254. Epub 2009 Oct 13. PMID: 19826099

    21.  Garcia BH, Småbrekke L, Trovik T, Giverhaug T. Application of the MAT-CHDSP to assess guideline adherence and therapy goal achievement in secondary prevention of coronary heart disease after percutaneous coronary intervention. Eur J Clin Pharmacol. 2013 Mar;69(3):703-9. doi: 10.1007/s00228-012-1402-7. Epub 2012 Sep 19. PMID: 22990329

    22. Høgli JU, Småbrekke L, Garcia BH. MAT-CAP: a novel medication assessment tool to explore adherence to clinical practice guidelines in community-acquired pneumonia. Pharmacoepidemiol Drug Saf. 2014 Sep;23(9):933-41. doi: 10.1002/pds.3640. Epub 2014 May 2. PMID: 24797586

    23. Garcia BH, Storli SL, Småbrekke L. A pharmacist-led follow-up program for patients with coronary heart disease in North Norway--a qualitative study exploring patient experiences. BMC Res Notes. 2014 Mar 29;7:197. doi: 10.1186/1756-0500-7-197. PMID: 24679131; PMCID: PMC3974183

    24. Garcia BH, Giverhaug T, Høgli JU, Skjold F, Småbrekke L. A pharmacist-led follow-up program for patients with established coronary heart disease in North Norway - a randomized controlled trial. Pharm Pract (Granada). 2015 Apr-Jun;13(2):575. doi: 10.18549/pharmpract.2015.02.575. Epub 2015 Jun 15. PMID: 26131047; PMCID: PMC4482847

    25. Melis M, Biagi C, Småbrekke L, Nonino F, Buccellato E, Donati M, Vaccheri A, Motola D. Drug-Induced Progressive Multifocal Leukoencephalopathy: A Comprehensive Analysis of the WHO Adverse Drug Reaction Database. CNS Drugs. 2015;29(10):879-91. doi: 10.1007/s40263-015-0286-3. PMID: 26507833

    26. Høgli JU, Garcia BH, Skjold F, Skogen V, Småbrekke L. An audit and feedback intervention study increased adherence to antibiotic prescribing guidelines at a Norwegian hospital. BMC Infect Dis. 2016 Feb 27;16:96. doi: 10.1186/s12879-016-1426-1. PMID: 26920549; PMCID: PMC4769530

    27.  Zykov IN, Sundsfjord A, Småbrekke L, Samuelsen Ø. The antimicrobial activity of mecillinam, nitrofurantoin, temocillin and fosfomycin and comparative analysis of resistance patterns in a nationwide collection of ESBL-producing Escherichia coli in Norway 2010-2011. Infect Dis (Lond). 2016 Feb;48(2):99-107. doi: 10.3109/23744235.2015.1087648. Epub 2015 Sep 28. PMID: 26414659

    28. Raknes G, Småbrekke L. A sudden and unprecedented increase in low dose naltrexone (LDN) prescribing in Norway. Patient and prescriber characteristics, and dispense patterns. A drug utilization cohort study. Pharmacoepidemiol Drug Saf. 2017 Feb;26(2):136-142. doi: 10.1002/pds.4110. Epub 2016 Sep 26. PMID: 27670755; PMCID: PMC5298009

    29. Raknes G, Småbrekke L. Low-dose naltrexone and opioid consumption: a drug utilization cohort study based on data from the Norwegian prescription database. Pharmacoepidemiol Drug Saf. 2017 Jun;26(6):685-693. doi: 10.1002/pds.4201. Epub 2017 Mar 29. PMID: 28370746; PMCID: PMC5485080

    30. Sørensen M, Kuehn A, Mills ENC, Costello CA, Ollert M, Småbrekke L, Primicerio R, Wickman M, Klingenberg C. Cross-reactivity in fish allergy: A double-blind, placebo-controlled food-challenge trial. J Allergy Clin Immunol 2017 Oct;140(4):1170-1172. doi: 10.1016/j.jaci.2017.03.043. Epub 2017 May 4. PMID: 28479332

    31.  Raknes G, Småbrekke L. Low dose naltrexone in multiple sclerosis: Effects on medication use. A quasi-experimental study. PLoS One 2017 Nov 3;12(11):e0187423. doi: 10.1371/journal.pone.0187423. PMID: 29099849; PMCID: PMC5669439

    32. Haugen P, Simonsen GS, Primicerio R, Furberg AS, Småbrekke L. Antibiotics to outpatients in Norway-Assessing effect of latitude and municipality population size using quantile regression in a cross-sectional study. Pharm Stat. 2018 Feb;17(1):4-11. doi: 10.1002/pst.1831. Epub 2017 Sep 29. PMID: 28961357

    33. Svendsen K, Karlstad Ø, Småbrekke L. Lower Cancer Incidence-Warfarin Effect or Immortal Time Bias? JAMA Intern Med. 2018 Apr 1;178(4):585. doi: 10.1001/jamainternmed.2018.0370. PMID: 29610882

    34. Zykov IN, Samuelsen Ø, Jakobsen L, Småbrekke L, Andersson DI, Sundsfjord A, Frimodt-Møller N. Pharmacokinetics and Pharmacodynamics of Fosfomycin and Its Activity against Extended-Spectrum-β-Lactamase-, Plasmid-Mediated AmpC-, and Carbapenemase-Producing Escherichia coli in a Murine Urinary Tract Infection Model. Antimicrob Agents Chemother. 2018 May 25;62(6):e02560-17. doi: 10.1128/AAC.02560-17. PMID: 29581117; PMCID: PMC5971609.

    35.  Raknes G, Simonsen P, Småbrekke L. The Effect of Low-Dose Naltrexone on Medication in Inflammatory Bowel Disease: A Quasi Experimental Before-and-After Prescription Database Study. J Crohns Colitis. 2018 May 25;12(6):677-686. doi: 10.1093/ecco-jcc/jjy008

    36. Haldorsen B, Giske CG, Hansen DS, Helgason KO, Kahlmeter G, Löhr IH, Matuschek E, Österblad M, Rantakokko-Jalava K, Wang M, Småbrekke L, Samuelsen Ø, Sundsfjord A; NordicAST CPE Study Group. Performance of the EUCAST disc diffusion method and two MIC methods in detection of Enterobacteriaceae with reduced susceptibility to meropenem: the NordicAST CPE study. J Antimicrob Chemother. 2018 Oct 1;73(10):2738-2747. doi: 10.1093/jac/dky276

    37.  Stensen DB, Småbrekke L, Olsen K, Grimnes G, Nielsen CS, Simonsen GS, Sollid JUE, Furberg AS. Hormonal contraceptive use and Staphylococcus aureus nasal and throat carriage in a Norwegian youth population. PLoS One. 2019 Jul 5;14(7):e0218511. doi: 10.1371/journal.pone.0218511. PMID: 31276521; PMCID: PMC6611591

    38. D'Annibali O, Bonaldo G, Donati M, Småbrekke L, Motola D, Vaccheri A. Antibacterial prescription in Italian preschool children: analysis of 7 years of data from the Emilia-Romagna region reimbursement database. J Antimicrob Chemother. 2019 Aug 1;74(8):2434-2439. doi: 10.1093/jac/dkz153. PMID: 30993338

    39. Raknes G, Småbrekke L. Changes in the consumption of antiepileptics and psychotropic medicines after starting low dose naltrexone: A nation-wide register-based controlled before-after study. Sci Rep. 2019 Oct 21;9(1):15085.doi: 10.1038/s41598-019-51569-z. PMID: 31636347; PMCID: PMC6803623

    40. Sambakunsi CS, Småbrekke L, Varga CA, Solomon V, Mponda JS. Knowledge, attitudes and practices related to self-medication with antimicrobials in Lilongwe, Malawi. Malawi Med J. 2019 Dec;31(4):225-232. doi: 10.4314/mmj.v31i4.2. PMID: 32128032; PMCID: PMC7036431

    41.  Zykov IN, Frimodt-Møller N, Småbrekke L, Sundsfjord A, Samuelsen Ø. Efficacy of  mecillinam against clinical multidrug-resistant Escherichia coli in a murine urinary tract infection model. Int J Antimicrob Agents. 2020 Feb;55(2):105851. doi: 10.1016/j.ijantimicag.2019.11.008. Epub 2019 Nov 23. PMID: 31770624

    42. Middleton L, Lampiao, F, Zimba T, Muzime SN, Simonsen GS, Småbrekke L, Musaya J, Solomon V, Suleman F, Sundsfjord A, Essack S. (2019) Antimicrobial stewardship and concervancy in Africa. In Halvorsen T, Orgeret KS 6 Krøvel R (eds). Sharing knowledge, Transforming Societies: The Norhed Programme 2013-2020. pp. 68-82. ISBN 978-1-928502-00-5

    43. Høgli JU, Garcia BH, Svendsen K, Skogen V, Småbrekke L. Empirical prescribing of penicillin G/V reduces risk of readmission of hospitalized patients with community-acquired pneumonia in Norway: a retrospective observational study. BMC Pulm Med. 2020 Jun 15;20(1):169. doi: 10.1186/s12890-020-01188-6. PMID: 32539706; PMCID: PMC7294665.

    44. Gravningen K, Field N, Blix HS, Asfeldt AM, Småbrekke L. Non-prescription purchase of antibiotics during travel abroad among a general adult population in Norway: Findings from the seventh Tromsø Study. PLoS One. 2020 Feb 13;15(2):e0228792. doi: 10.1371/journal.pone.0228792. PMID: 32053671

    45. Raknes G, Småbrekke L. Low dose naltrexone: Effects on medication in rheumatoid and seropositive arthritis. A nationwide register-based controlled quasi-experimental before-after study. PLoS One. 2019 Oct 1;14(10):e0223545. 10.1371/journal.pone.0212460 PMID: 31574126

    46. Raknes G, Småbrekke L. No change in the consumption of thyroid hormones after starting low dose naltrexone (LDN): a quasi-experimental before-after study. BMC Endocr Disord. 2020 Oct 1;20(1):151. doi: 10.1186/s12902-020-00630-4. PMID: 33004044

    47.  Stensen DB, Småbrekke L, Olsen K, Grimnes G, Nielsen CS, Sollid JUE, Simonsen GS, Almås B, Furberg AS. Circulating sex-steroids and Staphylococcus aureus nasal carriage in a general female population. Eur J Endocrinol. 2021 Feb;184(2):337-346. doi: 10.1530/EJE-20-0877.

    48. Raffelsberger N, Hetland MAK, Svendsen K, Småbrekke L, Löhr IH, Andreassen LLE, Brisse S, Holt KE, Sundsfjord A, Samuelsen Ø, Gravningen K. Gastrointestinal carriage of Klebsiella pneumoniae in a general adult population: a cross-sectional study of risk factors and bacterial genomic diversity. Gut Microbes. 2021 Jan-Dec;13(1):1939599. doi: 10.1080/19490976.2021.1939599. PMID: 34182896; PMCID: PMC8244762.

    49. Beckstrøm S, Svendsen K, Småbrekke L. Antibacterial use by birth year and birth season in children 0-2 years in Norway. Norsk Epidemiologi 2021; 29: 35-43. DOI:10.5324/nje.v29il-2.4044

    50. Lupattelli A, Karlstad Ø, Engeland A, Småbrekke L, Olsen K, Øvrebust A, Waaseth, M.  The Norwegian Society for Pharmacoepidemiology. Norsk Epidemiologi 2021; 29(1-2). https://doi.org/10.5324/nje.v29i1-2.4039

    51.  Stensen DB, Småbrekke L, Olsen K, Grimnes G, Nielsen CS, Ericson JU, Simonsen GS, Almås B, Furberg AS. Circulating sex-steroids and Staphylococcus aureus nasal carriage in a general male population. Epidemiology&Infection 2022; 150: e93. https://doi.org/10.1017/S0950268822000735

    52. von Hanno T, Hareide LL, Småbrekke L, Morseth B, Sneve M, Erke MG, Mathiesen EB, Bertelsen G. Macular layer thickness and effect of BMI, body fat and traditional cardiovascular risk factors: The Tromsø study. IOVS 2022; 63(9):16  https://doi.org/10.1167/iovs.63.9.16

    53.  Stensen DB, Cañadas RAN, Småbrekke L, Olsen K, Nielsen CS, Svendsen K, Hanssen AM, Ericson JU, Simonsen GS, Bongo LA, Furberg AS. Social network analysis of Staphylococcus aureus carriage in a general youth population. Int J Infect Dis 2022;123: 200-209. doi: 10.1016/j.ijid.2022.08.018.

    54.  Johansen JS, Halvorsen KH, Svendsen K, Havnes K, Robinson EG, Wetting HL, Haustreis S, Småbrekke L, Kamycheva E, Garcia BH.BMC Health Serv Res 2022;22(1):1290. doi: 10.1186/s12913-022-08648-1.

    55.   Hoff Roland PD, Småbrekke L. Hostemidler – hva bør du vite? NFT 2022; 132:22

    56. Walquist MJ, Svendsen K, Garcia BH, Bergmo TS, Eggen AE, Halvorsen KH, Småbrekke L, Ringberg U, Lehnbom EC, Waaseth M. Self-reported information needs among medication users in a general populatioon aged 40 years and above – The Tromsø Study. BMC Public Health 2022;22(1):2182. doi: 10.1186/s12889-022-14573-z.

    57.  Svalestuen S, Svendsen K, Eggen AE, Småbrekke L. Association of area-level education with the regional growth trajectories of rates of antibacterial dispensing to patients under 3 years in Norway: a longitudinal retrospective study. BMJ Open  2022 Sep 8;12(9):e058491. doi: 10.1136/bmjopen-2021-058491.

    58. Bergmo TS, Sandsdalen V, Manskow US, Småbrekke L, Waaseth M. Internet Use for Obtaining Medicine Information: Cross-sectional Survey. JMIR Form Res. 2023 Feb 2;7:e40466. doi: 10.2196/40466.

    59. Jakobsen AH, Småbrekke L, Chen TF, Halvorsen KH. Exploring stakeholders' perspectives on the quality of services provided through community pharmacies. Res Social Adm Pharm. 2023 Sep;19(9):1307-1313. doi: 10.1016/j.sapharm.2023.05.015. Epub 2023 Jun 2.

    60. Raffelsberger N, Buczek DJ, Svendsen K, Småbrekke L, Pöntinen AK, Löhr IH, Andreassen LLE, Simonsen GS; Norwegian E. coli ESBL Study Group; Sundsfjord A, Gravningen K, Samuelsen Ø. Community carriage of ESBL-producing Escherichia coli and Klebsiella pneumoniae: a cross-sectional study of risk factors and comparative genomics of carriage and clinical isolates.

    Academic Curriculum Vitae for Lars Småbrekke

    Personal data and contact information
    Name:                             Lars Småbrekke

    Date of birth:                18.01.59

    Position:                         Professor

    Work address:              Department of Pharmacy, UiT The Arctic University of Norway

    Phone:                             +4799249663 (cell) / +4777645792 (office)

    E-mail:                            lars.smabrekke@uit.no

     

    Research unique identifier: https://orcid.org/0000-0001-6474-3368

    URL for UiT web-site: https://uit.no/ansatte/lars.smabrekke

    CRISTIN-ID: 55832

     

    Education
    2013 – 2014     Basic competency in Pedagogy in higher education, RESULT, UiT

    2009                  PhD. Faculty of Health Sciences, UiT

                                https://munin.uit.no/handle/10037/2135

    1999                   Master in Public Health. Faculty of Health Sciences, UiT

    1985                   Candidatus Pharmaciae, UiO

    Current and previous positions
    2022 –              Prof. UiT The Arctic University of Norway, Faculty of Health Sciences, Department of Pharmacy

    2009 – 2021   A/Prof. UiT The Arctic University of Norway, Faculty of Health Sciences, Department of Pharmacy

    2008 – 2009   University scholarship (UiT The Arctic University of Norway)

    2004 – 2008   University Hospital North-Norway, Head of the regional drug information centre

    2003 ­– 2004   UiT The Arctic University of Norway (lecturer)

    1999 – 2003   University Hospital North-Norway, Head of the regional drug information centre

    1991-1999     Hospital Pharmacy, University Hospital North-Norway

    1986-1991         Hospital Pharmacy, Kirkenes Hospital, Norway

    Boards and committees
     

    Development of curricula

    2010 – 2012    Working group for the new BSc and MSc program in Pharmacy at UiT

    2012 – 2013     Revision of pharmacy education in Norway. (Head of the working group)

    2016                   Profesjonsrådet. Head of national group establishing for learning outcomes in statistics in a 3+2 curriculum in pharmacy

     

    Boards and committees

    1994 – 1997    Interim board for establishing the pharmacy program at UiT

    1999 – 2004    External member. Board for the Department of Pharmacy

    1999 – 2000   Bivirkningsnemda (National board of adverse reactions to medicines)

    2008 – 2012   Blåreseptnemda (National board on reimbursement)

    2016 – now    Board member. The Regional Health Authority

    2010 – now     Board member. Norwegian Society of Pharmacoepidemiology

    Panels, workshops and conference organization
    2018     Critical thinking. Member of working group for the workshop (approx. 225 participants)

    2019     Conference on antibiotic stewardship and conservation in Africa.  Durban (South-Africa). Organizing of the conference and chaired one afternoon session.

    2019     Critical thinking. Leader of the working group for the workshop. (approx. 275 participants

    2020    Critical thinking. Member of working group for the workshop (approx. 225 participants)

    2023    NSPC. International Conference in Social Pharmacy

     

    Member of scientific evaluation committees
    2012     UiO. Position as A/Prof in community pharmacy

    2012     UiT The arctic university of Norway. Position as A/Prof in pharmacy practice

    2013     UiO. Position as A/Prof in community pharmacy

    2016     UiO. Position as Professor in community pharmacy

    2016     UiO. Position as A/Prof in community pharmacy

    2019     UiT The arctic university of Norway. Position as university lecturer

    2019     UKZN. Evaluation of PhD-thesis

    2022    NTNU. Evaluation of research line student

    2023    UiO. Evaluation of PhD thesis

    Chronological list of publications
    1.       Rygnestad T, Småbrekke L, Nesje L, Talsethagen H, Rogne P, Myhr K, Bentzen I. Impact of improved treatment of sexually transmitted disease on HIV infection. Lancet. 1995 Oct 28;346(8983):1157

    2.      Simonsen T, Braathen P, Småbrekke L. Folsyre eller folinsyre som tilskudd ved samtidig behandling med metotrexat? Utposten. 1999;28:42-44

    3.      Endresen PC, Braathen P, Småbrekke L. Legemiddelbruk under graviditet. Utposten. 2000:29:45-46

    4.      Braathen P, Endresen PC, Småbrekke L, Ulvestad L. Ginko biloba, naturlegemiddel med mulig interaksjon med antitrombotiske midler. Utposten. 2000;29:32-33

    5.      Roland DDH, Schjøtt J, Småbrekke L, Westergren T. RELIS spørsmål og svar-database på internett. Utposten. 2001;30:38-39

    6.      Småbrekke L, Braathen P. Legemidler med laktose til pasienter med laktoseintoleranse? Tidsskr Nor Laegeforen. 2000 Aug 20;120(19):2303-4. Norwegian. PMID: 10997093

    7.      Småbrekke L. Stor skilnad i forbruksprofil mellom to universitetssykehus i Norge. Norsk Epidemiologi 2001;11: 61-5

    8.     Småbrekke L, Berild D, Giæver A, Myrbakk T, Fuskevåg A, Ericson JU, Flaegstad T, Olsvik O, Ringertz SH. Educational intervention for parents and healthcare providers leads to reduced antibiotic use in acute otitis media. Scand J Infect Dis. 2002;34(9):657-9. doi: 10.1080/00365540210147651. PMID: 12374355

    9.      Simonsen GS, Småbrekke L, Monnet DL, Sørensen TL, Møller JK, Kristinsson KG, Lagerqvist-Widh A, Torell E, Digranes A, Harthug S, Sundsfjord A. Prevalence of resistance to ampicillin, gentamicin and vancomycin in Enterococcus faecalis and Enterococcus faecium isolates from clinical specimens and use of antimicrobials in five Nordic hospitals. J Antimicrob Chemother 2003 Feb;51(2):323-31. doi: 10.1093/jac/dkg052. PMID: 12562698.6):X3. PMID: 33428587; PMCID: PMC7849480

    10.  Berild D, Småbrekke L, Halvorsen DS, Lelek M, Stahlsberg EM, Ringertz SH. Clostridium difficile infections related to antibiotic use and infection control facilities in two university hospitals. J Hosp Infect. 2003 Jul;54(3):202-6. doi: 10.1016/s0195-6701(03)00149-x. PMID: 12855235

    11.   Klingenberg C, Småbrekke L, Lier T, Flaegstad T. Validation of a simplified netilmicin dosage regimen in infants. Scand J Infect Dis. 2004;36(6-7):474-9. doi: 10.1080/00365540410020613. PMID: 15307571

    12.  Nordmo E, Småbrekke L. Kalseormedrue (Black cohosh) mot menopausale plager. Utposten 2005;34:42-43

    13.  Raknes G, Småbrekke L. Echinacea spp. (solhatt) og øvre luftveisinfeksjon. Tidsskr Nor Laegeforen. 2006 Oct 5;126(19):2526-7. Norwegian. PMID: 17028634

    14.  Vorren S, Småbrekke L. Reductil (sibutramin) og graviditet. Utposten 2008;37:44-45

    15.  Nordmo E, Småbrekke L. Melasma ved bruk av p-piller. NFT 2007: (5):12

    16.  Nordmo E, Småbrekke L. Interaksjon mellom metadon og valerianapreparater. NFT 2007; (10):10

    17.   Nordmo E, Småbrekke L. Nattlysolje mot atopisk eksem. NFT 2008; (3):11-12

    18.  Småbrekke L, Melbye H. Medikamentell behandling av akutt hoste. Tidsskr Nor Laegeforen. 2009 May 14;129(10):998-9. Norwegian. doi: 10.4045/tidsskr.08.0438. PMID: 19448753.

    19.  Klingenberg C, Småbrekke L, Døllner H, Simonsen GS. Peroral antibiotikabehandling av urinveisinfeksjon hos barn. Tidsskr Nor Laegeforen. 2009 Jun 25;129(13):1342-4. Norwegian. doi: 10.4045/tidsskr.09.0092. PMID: 19561661

    20. Nordmo E, Aronsen L, Wasland K, Småbrekke L, Vorren S. Severe apnea in an infant exposed to lamotrigine in breast milk. Ann Pharmacother. 2009 Nov;43(11):1893-7. doi: 10.1345/aph.1M254. Epub 2009 Oct 13. PMID: 19826099

    21.  Garcia BH, Småbrekke L, Trovik T, Giverhaug T. Application of the MAT-CHDSP to assess guideline adherence and therapy goal achievement in secondary prevention of coronary heart disease after percutaneous coronary intervention. Eur J Clin Pharmacol. 2013 Mar;69(3):703-9. doi: 10.1007/s00228-012-1402-7. Epub 2012 Sep 19. PMID: 22990329

    22. Høgli JU, Småbrekke L, Garcia BH. MAT-CAP: a novel medication assessment tool to explore adherence to clinical practice guidelines in community-acquired pneumonia. Pharmacoepidemiol Drug Saf. 2014 Sep;23(9):933-41. doi: 10.1002/pds.3640. Epub 2014 May 2. PMID: 24797586

    23. Garcia BH, Storli SL, Småbrekke L. A pharmacist-led follow-up program for patients with coronary heart disease in North Norway--a qualitative study exploring patient experiences. BMC Res Notes. 2014 Mar 29;7:197. doi: 10.1186/1756-0500-7-197. PMID: 24679131; PMCID: PMC3974183

    24. Garcia BH, Giverhaug T, Høgli JU, Skjold F, Småbrekke L. A pharmacist-led follow-up program for patients with established coronary heart disease in North Norway - a randomized controlled trial. Pharm Pract (Granada). 2015 Apr-Jun;13(2):575. doi: 10.18549/pharmpract.2015.02.575. Epub 2015 Jun 15. PMID: 26131047; PMCID: PMC4482847

    25. Melis M, Biagi C, Småbrekke L, Nonino F, Buccellato E, Donati M, Vaccheri A, Motola D. Drug-Induced Progressive Multifocal Leukoencephalopathy: A Comprehensive Analysis of the WHO Adverse Drug Reaction Database. CNS Drugs. 2015;29(10):879-91. doi: 10.1007/s40263-015-0286-3. PMID: 26507833

    26. Høgli JU, Garcia BH, Skjold F, Skogen V, Småbrekke L. An audit and feedback intervention study increased adherence to antibiotic prescribing guidelines at a Norwegian hospital. BMC Infect Dis. 2016 Feb 27;16:96. doi: 10.1186/s12879-016-1426-1. PMID: 26920549; PMCID: PMC4769530

    27.  Zykov IN, Sundsfjord A, Småbrekke L, Samuelsen Ø. The antimicrobial activity of mecillinam, nitrofurantoin, temocillin and fosfomycin and comparative analysis of resistance patterns in a nationwide collection of ESBL-producing Escherichia coli in Norway 2010-2011. Infect Dis (Lond). 2016 Feb;48(2):99-107. doi: 10.3109/23744235.2015.1087648. Epub 2015 Sep 28. PMID: 26414659

    28. Raknes G, Småbrekke L. A sudden and unprecedented increase in low dose naltrexone (LDN) prescribing in Norway. Patient and prescriber characteristics, and dispense patterns. A drug utilization cohort study. Pharmacoepidemiol Drug Saf. 2017 Feb;26(2):136-142. doi: 10.1002/pds.4110. Epub 2016 Sep 26. PMID: 27670755; PMCID: PMC5298009

    29. Raknes G, Småbrekke L. Low-dose naltrexone and opioid consumption: a drug utilization cohort study based on data from the Norwegian prescription database. Pharmacoepidemiol Drug Saf. 2017 Jun;26(6):685-693. doi: 10.1002/pds.4201. Epub 2017 Mar 29. PMID: 28370746; PMCID: PMC5485080

    30. Sørensen M, Kuehn A, Mills ENC, Costello CA, Ollert M, Småbrekke L, Primicerio R, Wickman M, Klingenberg C. Cross-reactivity in fish allergy: A double-blind, placebo-controlled food-challenge trial. J Allergy Clin Immunol 2017 Oct;140(4):1170-1172. doi: 10.1016/j.jaci.2017.03.043. Epub 2017 May 4. PMID: 28479332

    31.  Raknes G, Småbrekke L. Low dose naltrexone in multiple sclerosis: Effects on medication use. A quasi-experimental study. PLoS One 2017 Nov 3;12(11):e0187423. doi: 10.1371/journal.pone.0187423. PMID: 29099849; PMCID: PMC5669439

    32. Haugen P, Simonsen GS, Primicerio R, Furberg AS, Småbrekke L. Antibiotics to outpatients in Norway-Assessing effect of latitude and municipality population size using quantile regression in a cross-sectional study. Pharm Stat. 2018 Feb;17(1):4-11. doi: 10.1002/pst.1831. Epub 2017 Sep 29. PMID: 28961357

    33. Svendsen K, Karlstad Ø, Småbrekke L. Lower Cancer Incidence-Warfarin Effect or Immortal Time Bias? JAMA Intern Med. 2018 Apr 1;178(4):585. doi: 10.1001/jamainternmed.2018.0370. PMID: 29610882

    34. Zykov IN, Samuelsen Ø, Jakobsen L, Småbrekke L, Andersson DI, Sundsfjord A, Frimodt-Møller N. Pharmacokinetics and Pharmacodynamics of Fosfomycin and Its Activity against Extended-Spectrum-β-Lactamase-, Plasmid-Mediated AmpC-, and Carbapenemase-Producing Escherichia coli in a Murine Urinary Tract Infection Model. Antimicrob Agents Chemother. 2018 May 25;62(6):e02560-17. doi: 10.1128/AAC.02560-17. PMID: 29581117; PMCID: PMC5971609.

    35.  Raknes G, Simonsen P, Småbrekke L. The Effect of Low-Dose Naltrexone on Medication in Inflammatory Bowel Disease: A Quasi Experimental Before-and-After Prescription Database Study. J Crohns Colitis. 2018 May 25;12(6):677-686. doi: 10.1093/ecco-jcc/jjy008

    36. Haldorsen B, Giske CG, Hansen DS, Helgason KO, Kahlmeter G, Löhr IH, Matuschek E, Österblad M, Rantakokko-Jalava K, Wang M, Småbrekke L, Samuelsen Ø, Sundsfjord A; NordicAST CPE Study Group. Performance of the EUCAST disc diffusion method and two MIC methods in detection of Enterobacteriaceae with reduced susceptibility to meropenem: the NordicAST CPE study. J Antimicrob Chemother. 2018 Oct 1;73(10):2738-2747. doi: 10.1093/jac/dky276

    37.  Stensen DB, Småbrekke L, Olsen K, Grimnes G, Nielsen CS, Simonsen GS, Sollid JUE, Furberg AS. Hormonal contraceptive use and Staphylococcus aureus nasal and throat carriage in a Norwegian youth population. PLoS One. 2019 Jul 5;14(7):e0218511. doi: 10.1371/journal.pone.0218511. PMID: 31276521; PMCID: PMC6611591

    38. D'Annibali O, Bonaldo G, Donati M, Småbrekke L, Motola D, Vaccheri A. Antibacterial prescription in Italian preschool children: analysis of 7 years of data from the Emilia-Romagna region reimbursement database. J Antimicrob Chemother. 2019 Aug 1;74(8):2434-2439. doi: 10.1093/jac/dkz153. PMID: 30993338

    39. Raknes G, Småbrekke L. Changes in the consumption of antiepileptics and psychotropic medicines after starting low dose naltrexone: A nation-wide register-based controlled before-after study. Sci Rep. 2019 Oct 21;9(1):15085.doi: 10.1038/s41598-019-51569-z. PMID: 31636347; PMCID: PMC6803623

    40. Sambakunsi CS, Småbrekke L, Varga CA, Solomon V, Mponda JS. Knowledge, attitudes and practices related to self-medication with antimicrobials in Lilongwe, Malawi. Malawi Med J. 2019 Dec;31(4):225-232. doi: 10.4314/mmj.v31i4.2. PMID: 32128032; PMCID: PMC7036431

    41.  Zykov IN, Frimodt-Møller N, Småbrekke L, Sundsfjord A, Samuelsen Ø. Efficacy of  mecillinam against clinical multidrug-resistant Escherichia coli in a murine urinary tract infection model. Int J Antimicrob Agents. 2020 Feb;55(2):105851. doi: 10.1016/j.ijantimicag.2019.11.008. Epub 2019 Nov 23. PMID: 31770624

    42. Middleton L, Lampiao, F, Zimba T, Muzime SN, Simonsen GS, Småbrekke L, Musaya J, Solomon V, Suleman F, Sundsfjord A, Essack S. (2019) Antimicrobial stewardship and concervancy in Africa. In Halvorsen T, Orgeret KS 6 Krøvel R (eds). Sharing knowledge, Transforming Societies: The Norhed Programme 2013-2020. pp. 68-82. ISBN 978-1-928502-00-5

    43. Høgli JU, Garcia BH, Svendsen K, Skogen V, Småbrekke L. Empirical prescribing of penicillin G/V reduces risk of readmission of hospitalized patients with community-acquired pneumonia in Norway: a retrospective observational study. BMC Pulm Med. 2020 Jun 15;20(1):169. doi: 10.1186/s12890-020-01188-6. PMID: 32539706; PMCID: PMC7294665.

    44. Gravningen K, Field N, Blix HS, Asfeldt AM, Småbrekke L. Non-prescription purchase of antibiotics during travel abroad among a general adult population in Norway: Findings from the seventh Tromsø Study. PLoS One. 2020 Feb 13;15(2):e0228792. doi: 10.1371/journal.pone.0228792. PMID: 32053671

    45. Raknes G, Småbrekke L. Low dose naltrexone: Effects on medication in rheumatoid and seropositive arthritis. A nationwide register-based controlled quasi-experimental before-after study. PLoS One. 2019 Oct 1;14(10):e0223545. 10.1371/journal.pone.0212460 PMID: 31574126

    46. Raknes G, Småbrekke L. No change in the consumption of thyroid hormones after starting low dose naltrexone (LDN): a quasi-experimental before-after study. BMC Endocr Disord. 2020 Oct 1;20(1):151. doi: 10.1186/s12902-020-00630-4. PMID: 33004044

    47.  Stensen DB, Småbrekke L, Olsen K, Grimnes G, Nielsen CS, Sollid JUE, Simonsen GS, Almås B, Furberg AS. Circulating sex-steroids and Staphylococcus aureus nasal carriage in a general female population. Eur J Endocrinol. 2021 Feb;184(2):337-346. doi: 10.1530/EJE-20-0877.

    48. Raffelsberger N, Hetland MAK, Svendsen K, Småbrekke L, Löhr IH, Andreassen LLE, Brisse S, Holt KE, Sundsfjord A, Samuelsen Ø, Gravningen K. Gastrointestinal carriage of Klebsiella pneumoniae in a general adult population: a cross-sectional study of risk factors and bacterial genomic diversity. Gut Microbes. 2021 Jan-Dec;13(1):1939599. doi: 10.1080/19490976.2021.1939599. PMID: 34182896; PMCID: PMC8244762.

    49. Beckstrøm S, Svendsen K, Småbrekke L. Antibacterial use by birth year and birth season in children 0-2 years in Norway. Norsk Epidemiologi 2021; 29: 35-43. DOI:10.5324/nje.v29il-2.4044

    50. Lupattelli A, Karlstad Ø, Engeland A, Småbrekke L, Olsen K, Øvrebust A, Waaseth, M.  The Norwegian Society for Pharmacoepidemiology. Norsk Epidemiologi 2021; 29(1-2). https://doi.org/10.5324/nje.v29i1-2.4039

    51.  Stensen DB, Småbrekke L, Olsen K, Grimnes G, Nielsen CS, Ericson JU, Simonsen GS, Almås B, Furberg AS. Circulating sex-steroids and Staphylococcus aureus nasal carriage in a general male population. Epidemiology&Infection 2022; 150: e93. https://doi.org/10.1017/S0950268822000735

    52. von Hanno T, Hareide LL, Småbrekke L, Morseth B, Sneve M, Erke MG, Mathiesen EB, Bertelsen G. Macular layer thickness and effect of BMI, body fat and traditional cardiovascular risk factors: The Tromsø study. IOVS 2022; 63(9):16  https://doi.org/10.1167/iovs.63.9.16

    53.  Stensen DB, Cañadas RAN, Småbrekke L, Olsen K, Nielsen CS, Svendsen K, Hanssen AM, Ericson JU, Simonsen GS, Bongo LA, Furberg AS. Social network analysis of Staphylococcus aureus carriage in a general youth population. Int J Infect Dis 2022;123: 200-209. doi: 10.1016/j.ijid.2022.08.018.

    54.  Johansen JS, Halvorsen KH, Svendsen K, Havnes K, Robinson EG, Wetting HL, Haustreis S, Småbrekke L, Kamycheva E, Garcia BH.BMC Health Serv Res 2022;22(1):1290. doi: 10.1186/s12913-022-08648-1.

    55.   Hoff Roland PD, Småbrekke L. Hostemidler – hva bør du vite? NFT 2022; 132:22

    56. Walquist MJ, Svendsen K, Garcia BH, Bergmo TS, Eggen AE, Halvorsen KH, Småbrekke L, Ringberg U, Lehnbom EC, Waaseth M. Self-reported information needs among medication users in a general populatioon aged 40 years and above – The Tromsø Study. BMC Public Health 2022;22(1):2182. doi: 10.1186/s12889-022-14573-z.

    57.  Svalestuen S, Svendsen K, Eggen AE, Småbrekke L. Association of area-level education with the regional growth trajectories of rates of antibacterial dispensing to patients under 3 years in Norway: a longitudinal retrospective study. BMJ Open  2022 Sep 8;12(9):e058491. doi: 10.1136/bmjopen-2021-058491.

    58. Bergmo TS, Sandsdalen V, Manskow US, Småbrekke L, Waaseth M. Internet Use for Obtaining Medicine Information: Cross-sectional Survey. JMIR Form Res. 2023 Feb 2;7:e40466. doi: 10.2196/40466.

    59. Jakobsen AH, Småbrekke L, Chen TF, Halvorsen KH. Exploring stakeholders' perspectives on the quality of services provided through community pharmacies. Res Social Adm Pharm. 2023 Sep;19(9):1307-1313. doi: 10.1016/j.sapharm.2023.05.015. Epub 2023 Jun 2.

    60. Raffelsberger N, Buczek DJ, Svendsen K, Småbrekke L, Pöntinen AK, Löhr IH, Andreassen LLE, Simonsen GS; Norwegian E. coli ESBL Study Group; Sundsfjord A, Gravningen K, Samuelsen Ø. Community carriage of ESBL-producing Escherichia coli and Klebsiella pneumoniae: a cross-sectional study of risk factors and comparative genomics of carriage and clinical isolates.