Bilde av Fromm, Bastian
Bilde av Fromm, Bastian
Norges arktiske universitetsmuseum bastian.fromm@uit.no Tromsø

Bastian Fromm


Forsker


  • Kevin Peterson, Alan Beavan, Peter J Chabot, Mark A McPeek, Davide Pisani, Bastian Fromm m.fl.:
    MicroRNAs as Indicators into the Causes and Consequences of Whole-Genome Duplication Events
    Molecular Biology and Evolution (MBE) 2022 ARKIV / DOI
  • Ernesto Aparicio-Puerta, Cristina Gómez-Martín, Stavros Giannoukakos, José María Medina, Chantal Scheepbouwer, Adrián García-Moreno m.fl.:
    sRNAbench and sRNAtoolbox 2022 update: accurate miRNA and sncRNA profiling for model and non-model organisms
    Nucleic Acids Research (NAR) 2022 DOI
  • Bastian Fromm, Eirik Høye, Diana Domanska, Xiangfu Zhong, Ernesto Aparicio-Puerta, Vladimir Ovchinnikov m.fl.:
    MirGeneDB 2.1: toward a complete sampling of all major animal phyla
    Nucleic Acids Research (NAR) 2022 ARKIV / DOI
  • Bastian Fromm, Xiangfu Zhong, Marcel Tarbier, Marc R. Friedländer, Michael Hackenberg :
    The limits of human microRNA annotation have been met
    RNA: A publication of the RNA Society 2022 DOI
  • Eirik Høye, Bastian Fromm, Paul H.M. Böttger, Diana Domanska, Annette Torgunrud Kristensen, Christin Lund-Andersen m.fl.:
    A comprehensive framework for analysis of microRNA sequencing data in metastatic colorectal cancer
    NAR Cancer 14. januar 2022 ARKIV / DOI
  • Wenjing Kang, Bastian Fromm, Anna J. Houben, Eirik Høye, Daniela Bezdan, Carme Arnan m.fl.:
    MapToCleave: High-throughput profiling of microRNA biogenesis in living cells
    Cell reports 2021 ARKIV / DOI
  • Rui-Si Hu, Xiao-Xuan Zhang, Qiao-Ni Ma, Hany M Elsheika, Muhammad Ehsan, Quan Zhao m.fl.:
    Differential expression of microRNAs and tRNA fragments mediate the adaptation of the liver fluke Fasciola gigantica to its intermediate snail and definitive mammalian hosts
    International Journal of Parasitology 2021 DOI
  • Umberto Rosani, Enrico Bortoletto, Chang-Ming Bai, Beatriz Novoa, Antonio Figueras, Paola Venier m.fl.:
    Digging into bivalve miRNAomes: between conservation and innovation
    Philosophical Transactions of the Royal Society of London. Biological Sciences 2021 DOI
  • Baoqing Chen, Mihnea Paul Dragomir, Linda Fabris, Recep Bayraktar, Erik Knutsen, Xu Liu m.fl.:
    The long noncoding RNA CCAT2 induces chromosomal instability through BOP1-AURKB signaling
    Gastroenterology 2020 DOI
  • Christin Lund-Andersen, Sigve Nakken, Ståle Nygård, Bastian Fromm, Lars Birger Aasheim, Ben Davidson m.fl.:
    Integrative genomic analysis of peritoneal malignant mesothelioma: Understanding a case with extraordinary chemotherapy response
    Cold Spring Harbor Molecular Case Studies 2019 FULLTEKST / ARKIV / DOI
  • Eline P. Hansen, Bastian Fromm, Sidsel D. Andersen, Antonio Marcilla, Kasper L. Andersen, Anne Borup m.fl.:
    Exploration of extracellular vesicles from Ascaris suum provides evidence of parasite-host cross talk
    Journal of Extracellular Vesicles 2019 DOI
  • Bastian Fromm, Diana Ewa Domanska, Eirik Høye, Vladimir Ovchinnikov, Wenjing Kang, Ernesto Aparicio-Puerta m.fl.:
    MirGeneDB 2.0: the metazoan microRNA complement
    Nucleic Acids Research (NAR) 2019 ARKIV / DOI
  • James E. Tarver, Richard S. Taylor, Mark N. Puttick, Graeme T. Lloyd, Walker Pett, Bastian Fromm m.fl.:
    Well-annotated microRNAomes do not evidence pervasive miRNA loss
    Genome Biology and Evolution (GBE) 2018 DOI
  • Jon Bråte, Ralf Stefan Neumann, Bastian Fromm, Arthur Alexander Blørstad Haraldsen, James E. Tarver, Hiroshi Suga m.fl.:
    Unicellular origin of the animal microRNA machinery
    Current Biology 11. oktober 2018 DATA / ARKIV / DOI
  • Sinan Ugur Umu, Hilde Langseth, Cecilie Bucher-Johannessen, Bastian Fromm, Andreas Keller, Eckart Meese m.fl.:
    A comprehensive profile of circulating RNAs in human serum
    RNA Biology 2018 DOI
  • Vladimir Y. Ovchinnikov, Viatcheslav A Mordvinov, Bastian Fromm :
    Extreme conservation of miRNA complements in opisthorchiids
    Parasitology international 2017 DOI
  • Bernhard Egger, Lutz Bachmann, Bastian Fromm :
    Atp8 is in the ground pattern of flatworm mitochondrial genomes
    BMC Genomics 2017 ARKIV / FULLTEKST / DOI
  • Bastian Fromm, Vladimir Y. Ovchinnikov, Eirik Høye, Dolores Bernal, Michael Hackenberg, Antonio Marcilla :
    On the presence and immunoregulatory functions of extracellular microRNAs in the trematode Fasciola hepatica
    Parasite immunology (Print) 2017 DOI
  • Boris Simovski, Daniel Vodak, Sveinung Gundersen, Diana Ewa Domanska, Abdulrahman Azab, Lars Holden m.fl.:
    GSuite HyperBrowser: integrative analysis of dataset collections across the genome and epigenome
    GigaScience 27. april 2017 ARKIV / FULLTEKST / DOI
  • Alex Graudenzi, Claudia Cava, Gloria Bertoli, Bastian Fromm, Kjersti Flatmark, Giancarlo Mauri m.fl.:
    Pathway-based classification of breast cancer subtypes
    Frontiers in Bioscience 2017
  • Guillem Ylla, Bastian Fromm, Maria-Dolors Piulachs, Xavier Belles :
    The microRNA toolkit of insects
    Scientific Reports 2016 DOI
  • Vilde Drageset Haakensen, Vegard Nygaard, Liliana Greger, Miriam Ragle Aure, Bastian Fromm, Ida Rashida Khan Bukholm m.fl.:
    Subtype-specific micro-RNA expression signatures in breast cancer progression
    International Journal of Cancer 2016 DOI
  • Lutz Bachmann, Bastian Fromm, Luciana Patella de Azambuja, Walter Boeger :
    The mitochondrial genome of the egg-laying flatworm Aglaiogyrodactylus forficulatus (Platyhelminthes: Monogenoidea)
    Parasites & Vectors 2016 DOI
  • João Ramalho-Carvalho, Bastian Fromm, Rui Henrique, Carmen Jerónimo :
    Deciphering the function of non-coding RNAs in prostate cancer
    Cancer Metastasis Review 2016 DOI
  • Kjersti Flatmark, Erik Ulvolden Høye, Bastian Fromm :
    microRNAs as cancer biomarkers
    Scandinavian Journal of Clinical and Laboratory Investigation 2016 DOI
  • Bastian Fromm, Tyler Billipp, Liam E. Peck, Morten Johansen, James E. Tarver, Benjamin L. King m.fl.:
    A Uniform System for the Annotation of Vertebrate microRNA Genes and the Evolution of the Human microRNAome
    Annual Review of Genetics 2015 DOI
  • Bastian Fromm, María Trelis, Michael Hackenberg, Fernando Cantalapiedra, Dolores Bernal, Antonio Marcilla :
    The revised microRNA complement of Fasciola hepatica reveals a plethora of overlooked microRNAs and evidence for enrichment of immuno-regulatory microRNAs in extracellular vesicles
    International Journal of Parasitology 2015 DOI
  • Christoph Hahn, Bastian Fromm, Lutz Bachmann :
    Comparative genomics of flatworms (Platyhelminthes) reveals shared genomic features of ecto- and endoparastic neodermata
    Genome Biology and Evolution (GBE) 2014 DOI
  • Bastian Fromm, Susann Burow, Christoph Hahn, Lutz Bachmann :
    MicroRNA loci support conspecificity of Gyrodactylus salaris and G. thymalli (Platyhelminthes: Monogenea)
    International Journal of Parasitology 2014 DOI
  • Bastian Fromm, Merete Molton Worren, Christoph Hahn, Johannes Eivind Hovig, Lutz Bachmann :
    Substantial loss of conserved and gain of novel microRNA families in flatworms
    Molecular Biology and Evolution (MBE) 2013 DOI
  • Bastian Fromm, Philip David Harris, Lutz Bachmann :
    MicroRNA preparations from individual monogenean Gyrodactylus salaris – a comparison of six commercially available totalRNA extraction kits
    BMC Research Notes 2011 DOI
  • Bastian Fromm, Arun H. Patil, Marc K. Halushka :
    A Novel Circulating MicroRNA for the Detection of Acute Myocarditis
    New England Journal of Medicine 2022 DOI
  • Bastian Fromm, Diana Domanska, Eirik Høye, Vladimir Ovchinnikov, Wenjing Kang, Ernesto Aparicio-Puerta m.fl.:
    Erratum: MirGeneDB 2.0: The metazoan microRNA complement (Nucleic Acids Research (2019) DOI: 10.1093/nar/gkz885)
    Nucleic Acids Research (NAR) 2020 DOI
  • Bastian Fromm, Wenjing Kang, Carlos Rovira, Alfonso Cayota, Kenneth W Witwer, Marc R. Friedländer m.fl.:
    Plant microRNAs in human sera are likely contaminants
    Journal of Nutritional Biochemistry 2019 DOI
  • Bastian Fromm, Juan Pablo Tosar, Yin Lu, Marc K. Halushka, Kenneth W. Witwer :
    Human and Cow Have Identical miR-21-5p and miR-30a-5p Sequences, Which Are Likely Unsuited to Study Dietary Uptake from Cow Milk
    Journal of Nutrition 2018 DOI
  • Marta Rodriguez, Cristina Bajo-Santos, Nina Pettersen Hessvik, Susanne Lorenz, Bastian Fromm, Viktor Berge m.fl.:
    Identification of non-invasive miRNAs biomarkers for prostate cancer by deep sequencing analysis of urinary exosomes
    Molecular Cancer 2017 DOI
  • Arthur Alexander Blørstad Haraldsen, Jon Bråte, Ralf Stefan Neumann, Bastian Fromm, Paul Eivind Grini, Kamran Shalchian-Tabrizi :
    Pre-metazoan origin of animal microRNAs
    2016
  • Bastian Fromm, Jutta Bachmann, Lutz Bachmann :
    Tilpassninger i arvematerialet hos parasittiske flatormer
    Naturen 2015
  • Bastian Fromm, Jutta Bachmann, Lutz Bachmann :
    Auf der Suche nach der genetischen Basis von Ekto- und Endoparasitismus der Plattwürmer
    Biologie in unserer Zeit 2015
  • Bastian Fromm, Merete Molton Worren, Christoph Hahn, Johannes Eivind Hovig, Lutz Bachmann :
    Evolution of Parasitism in Flatworms Is Accompanied by Substantial Loss of Conserved microRNA Families and Increase of Novel microRNAs
    2013
  • Bastian Fromm, Thomas D. Otto, Christoph Hahn, Philip David Harris, Lutz Bachmann :
    MiRCandRef a local assembly algorithm for description of microRNAs in non-genome organisms
    2012
  • Christoph Hahn, Philip David Harris, Bastian Fromm, Tor A. Bakke, Lutz Bachmann :
    Genomic insights into the evolution of the economically important monogenean flatworm Gyrodactylus salaris
    2012
  • Bastian Fromm, Lutz Bachmann, Philip David Harris :
    MicroRNA preparations from individual monogenean Gyrodactylus salaris – comparison of six commercially available “totalRNA” extraction kits
    2011
  • Bastian Fromm, Merete Molton Worren, Philip David Harris, Lutz Bachmann :
    The miRNA complement of Gyrodactylus salaris (Platyhelminthes, Monogenea)
    2011

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    Forskningsinteresser

    Finnes det en drivkraft for dyrelivets evolusjonen som forklarer livets enorme mangfoldet, og kan det også hjelpe oss å forstå den enorme suksessen til parasittiske arter som påvirker oss?

    Et underliggende og viktig trekk som går igjen i begge prosesser er små molekyler kalt mikroRNA. Etter at mikroRNA ble oppdaget for rundt 20 år siden, er de i dag de mest studerte molekylene noensinne, med mer enn 16.000 årlige publikasjoner. MikroRNA finnes i alle dyr og regulerer viktige biologiske prosesser. Deres primære funksjon er å gjøre små finjusteringer av gen-programmer. Imidlertid er mikroRNA-feltet, som følge av den enorme mengden publikasjoner, fullt av motstridende rapporter. Dette hindrer innsikt og forståelse av den underliggende biologien.

    Forskningen til Dr. Bastian Fromm har tidligere adressert dette med mikroRNA-gendatabasen MirGeneDB. Dette  har dermed lagt grunnlaget for å transformere mikroRNA-feltet fra et kvalitativt nivå til et kvantitativt nivå,  noe som gjør det mulig å stille helt nye, grunnleggende spørsmål.

    I dette TFS-prosjektet (MIRevolution) vil Dr. Fromm og hans gruppe bruke nye sekvenseringsmetoder, toppmoderne enkeltcelleeksperimenter. Prosjektet vil dra nytte av det unike biologiske mangfoldet i Tromsø, for å utdype forståelsen av dyre evolusjon, og spesielt parasitter. Ved bruk av mikroRNA vil viktige spørsmål innen systematikk og genregulering bli behandlet. Fromm Gruppen vil videre samarbeide med det ancient DNA-laboratoriet ved museet og museets samling. Dette tilrettelegger for å bruke mikroRNA i det helt nye forskningsfeltet paleotranscriptomics, som for første gang muliggjør genekspresjons studier i lenge dødt biologisk materiale.