Ann-Mari Holsæter
Førsteamanuensis
Stillingsbeskrivelse
Førsteamanuensis tilknyttet forskningsgruppen "Drug Transport and Delivery Research Group" siden Januar 2011.
Utdannet Cand Pharm ved UiT i 1999
Dr.Scient i legemiddelteknologi ved UiT i 2004
Arbeidet som QA Manager i ProBio AS og Biotec Pharmacon ASA i perioden 2006-2011
Jakob Tobias Lynnerup,
Jonas Borregaard Eriksen,
Annette Bauer-Brandl,
Ann Mari Holsæter,
Martin Brandl
:
Insight into the mechanism behind oral bioavailability-enhancement by nanosuspensions through combined dissolution/permeation studies
Ann Mari Holsæter,
Kristina Wizgird,
Iselin Karlsen,
Jeanette Frimand Hemmingsen,
Martin Brandl,
Natasa Skalko-Basnet
:
How docetaxel entrapment, vesicle size, zeta potential and stability change with liposome composition–A formulation screening study
Jostein Grip,
Erik Steene,
Rolf Einar Engstad,
Jeff Hart,
Andrea Bell,
Ingrid Skjæveland
m.fl.:
Development of a novel beta-glucan supplemented hydrogel spray formulation and wound healing efficacy in a db/db diabetic mouse model
May Wenche Jøraholmen,
Selenia Ternullo,
Ann Mari Holsæter,
Gøril Eide Flaten,
Natasa Skalko-Basnet
:
Advanced Drug Delivery Systems for Biologics
John Wiley & Sons 2021
Laura Schulte Werning,
Anjanah Murugaiah,
Bhupender Singh,
Mona Johannessen,
Rolf Einar Engstad,
Natasa Skalko-Basnet
m.fl.:
Multifunctional Nanofibrous Dressing with Antimicrobial and Anti-Inflammatory Properties Prepared by Needle-Free Electrospinning
Jennifer Cauzzo,
Mona Nystad,
Ann Mari Holsæter,
Purusotam Basnet,
Natasa Skalko-Basnet
:
Following the fate of dye-containing liposomes in vitro
Selenia Ternullo,
Laura Schulte Werning,
Ann Mari Holsæter,
Natasa Skalko-Basnet
:
Curcumin-In-Deformable Liposomes-In-ChitosanHydrogel as a Novel Wound Dressing
Selenia Ternullo,
Purusotam Basnet,
Ann Mari Holsæter,
Gøril Eide Flaten,
Louis de Weerd,
Natasa Skalko-Basnet
:
Deformable liposomes for skin therapy with human epidermal growth factor: The effect of liposomal surface charge
Jostein Grip,
Rolf Einar Engstad,
Ingrid Skjæveland,
Natasa Skalko-Basnet,
Johan Isaksson,
Purusotam Basnet
m.fl.:
Beta-glucan-loaded nanofiber dressing improves wound healing in diabetic mice
Ulrich Massing,
Sveinung Gaarden Ingebrigtsen,
Natasa Skalko-Basnet,
Ann Mari Holsæter
:
Dual Centrifugation - A Novel “in-vial” Liposome Processing Technique
Jostein Grip,
Rolf Einar Engstad,
Ingrid Skjærveland,
Natasa Skalko-Basnet,
Ann Mari Holsæter
:
Sprayable Carbopol hydrogel with soluble beta-1,3/1,6-glucan as an active ingredient for wound healing – Development and in-vivo evaluation
Selenia Ternullo,
Louis de Weerd,
Ann Mari Holsæter,
Gøril Eide Flaten,
Natasa Skalko-Basnet
:
Going skin deep: a direct comparison of penetration potential of lipid-based nanovesicles on the isolated perfused human skin flap model
Anders Øverbye,
Ann Mari Holsæter,
Markus Fusser,
Natasa Skalko-Basnet,
Tore Geir Iversen,
Maria Lyngaas Torgersen
m.fl.:
Ceramide-containing liposomes with doxorubicin: time and
cell-dependent effect of C6 and C12 ceramide
Sveinung Gaarden Ingebrigtsen,
Alena Didriksen,
Mona Johannessen,
Natasa Skalko-Basnet,
Ann Mari Holsæter
:
Old drug, new wrapping – A possible comeback for chloramphenicol?
Selenia Ternullo,
Louis de Weerd,
Gøril Eide Flaten,
Ann Mari Holsæter,
Natasa Skalko-Basnet
:
The isolated perfused human skin flap model: A missing link in skin penetration
studies?
Sveinung Gaarden Ingebrigtsen,
Natasa Skalko-Basnet,
Cristiane de Albuquerque Cavalcanti Jacobsen,
Ann Mari Holsæter
:
Successful co-encapsulation of benzoyl peroxide and chloramphenicol in liposomes by a novel manufacturing method - dual asymmetric centrifugation
Sveinung Gaarden Ingebrigtsen,
Natasa Skalko-Basnet,
Ann Mari Holsæter
:
Development and optimization of a new processing approach for manufacturing topical liposomes-in-hydrogel drug formulations by dual asymmetric centrifugation
Željka Vanić,
Ann Mari Holsæter,
Natasa Skalko-Basnet
:
(Phospho)lipid-based nanosystems for skin administration
Ann Mari Holsæter
:
Cancer and drug delivery
2023
Agnhild Johansen,
Kjersti Sellæg,
Synnøve Norvoll Magnussen,
May Wenche Jøraholmen,
Ann Mari Holsæter
:
Docetaxel liposomes – Can curcumin be co-entrapped and improve the in vitro cytotoxicity?
2023
Jakob T. Lynnerup,
Jonas B. Eriksen,
Ann Mari Holsæter,
Martin Brandl
:
The effect of nano-milling on dissolution/permeation of poorly soluble drug compounds
2022
Ann Mari Holsæter
:
Nærings-Ph.d. prosjekt for utvikling av nye sårprodukter ga etablering av forskning på nanofibre som legemiddelform i Norge
2022
Paul Gottschalk,
Ann Mari Holsæter
:
Optimierung der Herstellung von Liposomen mittels dualer
asymmetrischer Zentrifugation
2022
Laura Schulte Werning,
Natasa Skalko-Basnet,
Ann Mari Holsæter
:
Needle-free electrospinning of nanofibers with chloramphenicol-liposomes using the NanospiderTM
2022
Laura Schulte Werning,
Anjanah Murugaiah,
Natasa Skalko-Basnet,
Ann Mari Holsæter
:
In vitro testing of biocompatibility and anti-inflammatory activity of chloramphenicol loaded multifunctional nanofibers
2021
Ann Mari Holsæter
:
Ann Mari Holsæter: - Etikk må læres gjennom hele livet
01. mars 2021
Laura Schulte Werning,
Anjanah Murugaiah,
Natasa Skalko-Basnet,
Ann Mari Holsæter
:
Successful entrapment of chloramphenicol in electrospun nanofiber dressings
2021
Laura Schulte Werning,
Anjanah Murugaiah,
Natasa Skalko-Basnet,
Ann Mari Holsæter
:
Electrospinning of chloramphenicol-containing nanofibrous dressings for treatment of chronic wounds
2021 ARKIV
Jennifer Cauzzo,
Mona Nystad,
Ann Mari Holsæter,
Purusotam Basnet,
Natasa Skalko-Basnet
:
Dyes in Disguise: characterization of fluorescently labeled liposomes
2020 ARKIV
Jeanette Frimand Hemmingsen,
Martin Brandl,
Natasa Skalko-Basnet,
Ann Mari Holsæter
:
Design, preparation, characterization and stability of
docetaxel-containing liposomes
2020
Laura Schulte Werning,
Julie Wik Olaussen,
Natasa Skalko-Basnet,
Ann Mari Holsæter
:
Electrospinning chitosan-nanofibers using the needle-free Nanospider™ technology; Optimization of the polymer solution
2020
Ann Mari Holsæter,
Kristina Wizgird,
Natasa Skalko-Basnet
:
Docetaxel-liposomes prepared by dual centrifugation: effect of propylene glycol and lipid charge
2019
Jostein Grip,
Erik Steene,
Rolf Einar Engstad,
Ingrid Skjæveland,
Purusotam Basnet,
Natasa Skalko-Basnet
m.fl.:
Sprayable beta-glucan hydrogel as wound dressing: in vitro and in vivo evaluation
2019
Iselin Karlsen,
Natasa Skalko-Basnet,
Ann Mari Holsæter
:
Docetaxel Liposomes - A formulation Screening Study
2019 ARKIV
Jennifer Cauzzo,
Mona Nystad,
Ann Mari Holsæter,
Purusotam Basnet,
Natasa Skalko-Basnet
:
Liposome-cell interaction: following the fate of the nanocarrier
2019
Ann Mari Holsæter
:
Fokus på utnyttelse av digitale læringsressurser for økt fleksibilitet og kvalitet i undervisningen av de farmasøytiske laboratoriefagene
2019
Ann Mari Holsæter,
Jostein Grip,
Natasa Skalko-Basnet
:
Advanced wound dressing with beta-glucans: in vivo proof of nanofibers superiority
2018
Selenia Ternullo,
Louis de Weerd,
Ann Mari Holsæter,
Gøril Eide Flaten,
Natasa Skalko-Basnet
:
A Nano-Approach to Improve Local Skin Therapy: Isolated Perfused Human Skin Flap as a Tool in Optimization
2017
Ann Mari Holsæter
:
New activities related to liposomes
2017
Jostein Grip,
Rolf Einar Engstad,
Ingrid Skjæveland,
Natasa Skalko-Basnet,
Ann Mari Holsæter
:
Development of a novel wound healing spray: soluble beta-1,3/1,6-glucan as an active ingredient in Carbopol matrix in a db/db wound model
2017
Ann Mari Holsæter,
Sveinung Gaarden Ingebrigtsen,
Natasa Skalko-Basnet
:
Dermal Application of Chloramphenicol - The Effect of Liposomes and Chitosan Hydrogel Formulations on ex vivo Permeation and Antimicrobial Activity
2017 ARKIV
Ann Mari Holsæter
:
Vurdering av læring i laboratorieundervisning – et eksempel fra farmasiutdanningen
2017
Selenia Ternullo,
Louis de Weerd,
Gøril Eide Flaten,
Ann Mari Holsæter,
Natasa Skalko-Basnet
:
Isolated perfused human skin flap model: A novel tool to evaluate drug penetration through the skin
2016
Anders Øverbye,
Ann Mari Holsæter,
Natasa Skalko-Basnet,
Iversen Tore-Geir,
Maria Lyngaas Torgersen,
Tonje Sønstevold
m.fl.:
Biodegradable nanoparticles in cancer diagnosis and therapy (NANOCAN):Ceramide modulation of liposomal doxorubicin
2016
Ann Mari Holsæter
:
Preparation, characterization and in vitro testing of liposomes
2016
Selenia Ternullo,
Louis de Weerd,
Gøril Eide Flaten,
Ann Mari Holsæter,
Natasa Skalko-Basnet
:
Isolated perfused human skin flap model: a novel tool to evaluate drug penetration through the skin
2016
Selenia Ternullo,
Louis de Weerd,
Gøril Eide Flaten,
Ann Mari Holsæter,
Natasa Skalko-Basnet
:
Isolated perfused human skin flap model: a novel tool to evaluate drug penetration through the skin II
2016
Ann Mari Holsæter,
Natasa Skalko-Basnet
:
Liposomes as multi-functional delivery system in cancer therapy
2015
Sveinung Gaarden Ingebrigtsen,
Ivo Laidemäe,
Jukka Saarinen,
Clare J. Strachan,
Ann Mari Holsæter,
Natasa Skalko-Basnet
m.fl.:
Characterization of liposome-loaded nanofibers by coherent anti-Stokes Raman scattering microscopy and scanning white light interferometry
2015
Ann Mari Holsæter,
Natasa Skalko-Basnet
:
Multi-functional liposomes as delivery system in cancer therapy
2015
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Forskningsinteresser
Jeg har en allsidig forskningsbakgrunn innen fagfeltet legemiddelteknologi, hvor nanopartikler og da særlig liposomer, hydrogeler og nanofiber er de systemene jeg har jobbet mest med. Mange aktive substanser som indentifiseres som lovene legemiddelkandidater, men som p.g.a. lav løselighet, uønskede bivirkninger eller stabilitetesproblemer ikke når klinisk anvendelse, kan når de pakkes inn i en egnet formulering eller "nanocarrier" få utbedret disse begrensningene. Teknologiske plattformer som kan løse utfordringer i legemiddeltekologi med tanke på effektiv-, reproduserbar- og skalerbar fremstilling, og hvor jeg har opparbeidet meg spesiell ekspertise er;
- Dual (assymetric) centrifugation
- Elektrospinning
Strategier for effektiv og trygg legemiddelformulering inkluderer;
- Multifunksjonelle legemiddelformuleringer
- Målrettet opptak ("Targeting") - liposomer til injeksjon i kreftbehandling
- Lokal legemiddelbehandling - hydrogeler og nanofibre til bruk på hud og slimhinner
Undervisning
En viktig del av min stilling inkluderer undervisning og veiledning, og da primært av farmasistudenter. I tillegg til undervsining er også emneansvar og koordinering av undervisning inkludert eksamensarbeid og evaluering av emner en sentral del av denne jobben.
Jeg er kursansvarlig for emnene:
FAR-2402; Legemiddelformulering og biofarmasi
Underviser også i emnene:
FAR-2401; Basal legemiddelproduksjon
FAR-3911; Masteroppgave i farmasi (veileder)
FAR-3043: Advanced drug delivery systems in nanomedicine
FAR-8043; Nanomedicine and Nanotechnology