Lynn Butler

Twitter: @Endo_cells

Normal endothelial cell gene expression and function, and how these vary between different human organs

How endothelial dysfunction can influence the development of cardiovascular disease and thrombosis

EDUCATION

2001-2005       PhD: School of Clinical and Experimental Medicine, University of Birmingham, UK

                        Supervisor: Professor G.B. Nash            

1998-2001       B.Med.Sc (Medical Science) University of Birmingham, UK

CURRENT POSITIONS

2017 –             Senior Researcher, Clinical Chemistry, Department of Molecular Medicine and Surgery, Karolinska Institute, Sweden

2018 –              Associate Professor, K.G. Jebsen Thrombosis Research and Expertise Centre (TREC), Department of Clinical Medicine, The Arctic University of Norway, Tromsø

PREVIOUS POSITIONS

2014 – 2017     Research Group Leader, Institute for Clinical Chemistry and Laboratory Medicine, University Medical Centre Hamburg, Germany 

2014 – 2017     Researcher, Clinical Chemistry, Department of Molecular Medicine and Surgery, Karolinska Institute, Sweden

2011 – 2014    Assistant Professor, Department of Medicine, Karolinska Institute, Sweden

FELLOWSHIPS

2018 – 2021     Swedish Heart Lung Foundation Fellowship

2008 – 2011     Cancer Research UK post-doctoral research fellowship, School of Cancer Sciences, University of Birmingham, UK

2009                Wellcome Trust Knowledge Transfer Fellowship (MHH, Hannover, Germany)

2005 – 2008     British Hearth Foundation post-doctoral research fellowship, School of Clinical and Experimental Medicine, University of Birmingham, UK

1. Dusart P, Hallström BM, Renné T, Odeberg J, Uhlén M, Butler LM* (2019) A systems-based map of human brain cell-type enriched genes and malignancy-associated endothelial changes. BioRxiv pre-print doi: https://doi.org/10.1101/528414
2. Ahmed, M, Gustafsson B, Aldi S, Dusart P, Egri G, Butler LM, Bone D, Dähne L, Hedin U, Caidahl K (2018) Molecular Imaging of a New Multimodal Microbubble for Adhesion Molecule Targeting Cellular and Molecular Bioengineering 12(1) 15-32
3. Dusart P, Fagerberg L, Perisic L, Civelek M, Struck E, Hedin U, Uhlén M, Trégouët DA, Renné T, Odeberg J, Butler LM (2018) A systems-approach reveals human nestin is an endothelial-enriched, angiogenesis-independent intermediate filament protein Scientific Reports 8(1):14668
4. Gustafsson R, Renné T, Söderberg-Naucler C, Butler LM (2018) Human cytomegalovirus replication induces endothelial cell interleukin-11. Cytokine S1043-4666(18)30217-5
5. Bruzelius M, Iglesias MJ, Hong MG, Sanchez-Rivera L, Gyorgy B, Souto JC, Frånberg M, Fredolini C, Strawbridge RJ, Holmström M, Hamsten A, Uhlén M, Silveira A, Soria JM, Smadja DM, Butler LM, Schwenk JM, Morange PE, Trégouët DA, Odeberg J (2016). PDGFB, a new candidate plasma biomarker for venous thromboembolism: results from the VEREMA affinity proteomics study. Blood 128:e59-e66
6. ­Butler LM, Hallström BM, Fagerberg L, Pontén F, Uhlén M, Renné T, Odeberg J (2016). Analysis of body-wide unfractionated tissue data to identify a core human endothelial transcriptome. Cell Systems 3(3) 287-301.
7. Labberton L, Kenne E, Long A, Nickel K, Di Gennaro A, Rigg R, Hernandez J, Butler L, Maas C, Stavrou E, Renné T (2016) Neutralizing blood-borne polyphosphate in vivo provides safe thromboprotection. Nature Communications doi:10.1038/ncomms12616
8. Gustafsson RKL, Jeffery HC, Yaiw KC, Wilhelmi V, Kostopoulou ON, Davoudi B, Afsar Rahbar A, Benard M, Renné T, Söderberg-Nauclér C, Butler LM (2015) Direct infection of primary endothelial cells with human cytomegalovirus prevents angiogenesis and migration. Journal of General Virology 96(12):3598-3612
9. Yaiw KC, Mohammad AA, Costa H, Taher C, Badrnya S, Assinger A, Wilhelmi V, Ananthaseshan S, Estekizadeh A, Davoudi B, Ovchinnikova O, Shlyakhto E, Rafnsson A, Khan Z, Butler L, Rahbar A, Pernow J, Söderberg-Nauclér C (2015) Human Cytomegalovirus Up-Regulates Endothelin Receptor Type B: Implication for Vasculopathies? Open Forum Infectious Diseases 2(4):ofv155
10. Sala-Cunill A, Björkqvist J, Senter R, Guilarte M, Cardona V, Labrador M, Nickel KF, Butler L, Luengo O, Kumar P, Labberton L, Long A, Di Gennaro A, Kenne E, Jämsä A, Krieger T, Schlüter H, Fuchs T, Flohr S, Hassiepen U, Cumin F, McCrea K, Maas C, Stavrou E, Renné T (2014) Activation of the plasma contact system in anaphylaxis – insight to severe mast cell-mediated allergic reactions. The Journal of Allergy and Clinical Immunology 135(4):1031-1043
11. Butler LM, Dzabic M, Jeffery HC, Bakker F, Rahbar A, Yaiw C, Religa P, Söderberg-Nauclér C (2014) Human cytomegalovirus inhibits renal cell erythropoietin production. Journal of the American Society of Nephrology (JASN) 25(8):1669-78.
12. Assinger A, Wang Y, Butler LM, Hansson GK, Yan ZQ, Söderberg-Nauclér C, Ketelhuth DFJ (2014) Apolipoprotein B100 danger-associated signal 1 triggers platelet activation and boosts platelet-leukocyte proinflammatory responses. Thrombosis and Haemostasis 112(2):332-41.
13. Assinger A, Kral J, Yaiw KC, Schrottmaier W, Kurzejamska E, Wang Y, Mohammad AA, Religa P, Rahbar A, Schabbauer G, Butler LM, Söderberg-Naucler C (2014) Human cytomegalovirus-platelet interaction triggers TLR2-dependent pro-inflammatory and pro-angiogenic responses. Arteriosclerosis, Thrombosis and Vascular Biology 34(4):801-9.
14. Yaiw KC, Mohammad AA, Taher C, Wilhelmi V, Davoudi B, Strååt K, Assinger A, Ovchinnikova O, Shlyakhto E, Rahbar A, Koutonguk O, Religa P, Butler L, Khan Z, Streblow D, Pernow J, Söderberg-Nauclér C (2014) Human cytomegalovirus induces upregulation of arginase II: possible implications for vasculopathies. Basic Research in Cardiology 109(2):401.
15. Jeffery HC, Söderberg-Nauclér C, Butler LM (2013) Human cytomegalovirus induces a biphasic inflammatory response in primary endothelial cells. Journal of Virology 87(11):6530-6535.
16. Yaiw KC, Ovchinnikova O, Taher C, Mohammad AA, Davoudi B, Shlyakhto E, Rotar O, Konrady A, Wilhelmi V, Rahbar A, Butler L, Assinger A, Söderberg-Nauclér C (2013) High prevalence of human cytomegalovirus in carotid atherosclerotic plaques obtained from Russian patients undergoing carotid endarterectomy. Herpesviridae 14;4(1):3.
17. HC Jeffery, Wheat RL, Blackbourn DJ, Nash GB, Butler LM (2013) Infection and transmission dynamics of rKSHV.219 in primary endothelial cells. Journal of Virological Methods 193(1):251-9.
18. Fornara O, Odeberg J, Khan Z, Stragliotto G, Peredo I, Butler L, Söderberg-Naucler C (2013). Human cytomegalovirus particles directly suppress CD4 T-lymphocyte activation and proliferation. Immunobiology 218(8):1034-40.
19. Xu N, Meisgen F, Butler LM, Hag G, Xang XJ, Söderberg-Naucler C, Ståhle M, Pivarcsi A, Sonkoly E (2013). MicroRNA-31 is overexpressed in psoriasis and modulates inflammatory cytokine and chemokine production in keratinocytes via targeting serine/threonine kinase 40. Journal of Immunology 15(2):678-88.
20. Butler LM, Jeffery HC, Wheat RL, Nash GB, Blackbourn DJ (2012) Kaposi’s Sarcoma-associated herpesvirus inhibits expression and function of endothelial cell major histocompatibility complex class II via suppressor of cytokine signalling 3. Journal of Virology 86(13):7158-66.
21. Badrnya S, Butler LM, Söderberg-Naucler C, Volf I, Assinger A (2012). Platelets directly enhance neutrophil transmigration in response to oxidised low-density lipoprotein. Thrombosis and Haemostasis 108(4):719-29.
22. Butler LM, Jeffery HC, Wheat RL, Alkharsah KR, Schulz TF, Nash GB, Blackbourn DJ (2011) Kaposi’s sarcoma-associated herpesvirus infection of endothelial cells inhibits neutrophil recruitment through an interleukin 6 dependent mechanism: a new paradigm for viral immune evasion. Journal of Virology 85(14):7321-32.
23. Mutocheluh M, Hindle L, Areste C, Chanas S, Butler L, Lowry K, Shah K, Evans D, Blackbourn D (2011) Kaposi’s sarcoma-associated herpesvirus viral interferon regulatory factor-2 inhibits type 1 interferon signalling by targeting interferon-stimulated gene factor-3. Journal of General Virology 92(10):2394-8.
24. Durrington HJ, Upton PD, Hoer S, Boname J, Dunmore B, Yang J, Crilley TK, Butler LM, Blackbourn DJ, Nash GB, Lehner PJ, Morrell NW (2010) Identification of a lysosomal pathway regulating degradation of the bone morphogenetic protein receptor type-II. Journal of Biological Chemistry 285(48):37641-9.
25. Burton VJ, Butler LM, McGettrick HM, Stone PC, Savage CO, Rainger G. Ed, Nash GB (2010) Delay of migrating leukocytes by the basement membrane deposited by endothelial cells in long-term culture. Experimental Cell Research 317(3):276-92.
26. Butler LM, Rainger GE, Nash GB (2009) A role for the endothelial glycosaminoglycan hyaluronan in neutrophil recruitment by endothelial cells cultured for prolonged periods. Experimental Cell Research 315(19):3433-41.
27. Matharu NM, Butler LM, Rainger GE, Gosling P, Vohra RK, Nash GB. (2008) Mechanisms of the anti-inflammatory effects of hydroxyethyl starch demonstrated in a flow-based model of neutrophil recruitment by endothelial cells. Critical Care Medicine 36(5):1536-42.
28. Butler LM, Khan S, Rainger GE, Nash GB (2008) Effects of endothelial basement membrane on neutrophil adhesion and migration. Cellular Immunology 251(1):56-61.
29. Butler LM, Metson-Scott T, Felix J, Abhyankar A, Rainger G.E, Farndale R, Watson SP, Nash GB (2007) Sequential adhesion of platelets and leukocytes from flowing whole blood onto a collagen-coated surface: requirement for a GpVI-binding site in collagen. Thrombosis and Haemostasis 97(5):814-821.
30. Chakravorty SJ, McGettrick HM, Butler LM, Buckley CD, Rainger GE, Nash G (2006) An in vitro model for analysing neutrophil migration into and away from the sub-endothelial space: Roles of flow and CD31. Biorheology 43(1):71-82.
31. Butler LM, Rainger GE, Rahman M, Nash GB (2005) Prolonged culture of endothelial cells and deposition of basement membrane modify the recruitment of neutrophils. Experimental Cell Research 310(1):22-32.