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  3. Lynn Butler
Bilde av Butler, Lynn
Bilde av Butler, Lynn
Translational Vascular Research Group lynn.m.butler@uit.no +4777625104 Tromsø MH L6.226

Lynn Butler

Førsteamanuesis

Stillingsbeskrivelse

Leader of the Translational Vascular Research Group

  • Fredrik Edfors, Maria Jesus Iglesias, Lynn Butler, Jacob Odeberg :
    Proteomics in thrombosis research
    Research and Practice in Thrombosis and Haemostasis (RPTH) 2022 ARKIV / DOI
  • Sandra Konrath, Reiner K. Mailer, Manu Beerens, Hanna Englert, Maike Frye, Piotr Kuta m.fl.:
    Intrinsic coagulation pathway-mediated thrombin generation in mouse whole blood
    Frontiers in Cardiovascular Medicine 2022 ARKIV / DOI
  • Marthe Norreen-Thorsen, Eike Christopher Struck, Sofia Maria Öling, Martin Zwahlen, Kalle Von Feilitzen, Jacob Odeberg m.fl.:
    A human adipose tissue cell-type transcriptome atlas
    Cell reports 2022 ARKIV / DOI
  • Misbah Razzaq, Maria Jesus Iglesias, Manal Ibrahim-Kosta, Louisa Goumidi, Omar Soukarieh, Carole Proust m.fl.:
    An artificial neural network approach integrating plasma proteomics and genetic data identifies PLXNA4 as a new susceptibility locus for pulmonary embolism
    Scientific Reports 2021 ARKIV / DOI
  • Max Karlsson, Zhang Cheng, Lorén Mear, Wen Zhong, Andreas Digre, Barbola Katona m.fl.:
    A single-cell type transcriptomics map of human tissues
    Science Advances 2021 ARKIV / DOI
  • Maria Jesus Iglesias, Larissa D. Kruse, Laura Sanchez-Rivera, Linnea Enge, Philip James Dusart, Mun-Gwan Hong m.fl.:
    Identification of Endothelial Proteins in Plasma Associated With Cardiovascular Risk Factors
    Arteriosclerosis, Thrombosis and Vascular Biology 2021 ARKIV / DOI
  • Reiner K. Mailer, Mikel Allende, Marco Heestermans, Michaela Schweizer, Carsten Deppermann, Maike Frye m.fl.:
    Xenotropic and polytropic retrovirus receptor 1 regulates procoagulant platelet polyphosphate
    Blood 2021 ARKIV / DOI
  • Marco Heestermans, Clement Naudin, Reiner K. Mailer, Sandra Konrath, Kristin Klaetschke, Anne Jämsä m.fl.:
    Identification of the factor XII contact activation site enables sensitive coagulation diagnostics
    Nature Communications 2021 ARKIV / DOI
  • Philip James Dusart, Björn M. Hallström, Thomas Renne, Jacob Olof Odeberg, Mathias Uhlén, Lynn Butler :
    A Systems-Based Map of Human Brain Cell-Type Enriched Genes and Malignancy-Associated Endothelial Changes
    Cell reports 2019 ARKIV / DOI

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    Forskningsinteresser

    The primary focus of the Translational Vascular Research group is the study of endothelial cells that line the inside of all blood vessels. These cells have many functions, such as providing an anti-thrombotic surface to prevent blood clotting and controlling leukocyte recruitment to tissue during inflammation. Our research is based around the identification of genes that are highly specifically expressed in endothelial cells (compared to other cell types) and the role of these genes in vascular function. Through this work, we identify potential plasma biomarker candidates for the clinical assessment of vascular health and risk stratification, diagnosis and prognosis of diseases of the cardiovascular system, such as venous and arterial thrombosis and COVID-19 complications.

    ORCID: https://orcid.org/0000-0002-2352-8217

    Medlem i forskningsgruppe

    Translational Vascular Research   English content

    Medlem i prosjekt

    Endothelial response to inflammation Uncharacterised endothelial cell gene function Plasma biomarkers for endothelial dysfunction Plasma biomarkers for COVID-19 vascular pathology

    CV

    Education and postdoctoral experience

    1998-01      Medical Science (B.Med.Sc Hons), Class 2.1. University of Birmingham, UK.                                        

    2001-05      Ph.D. Medicine. University of Birmingham, UK.                                        

    2008-11       Cancer Research UK Fellow, University of Birmingham, UK

    2005-08      British Heart Foundation Fellow, University of Birmingham, UK                      

    Academic positions

    2018-          Associate Professor: Dept. of Clinical Medicine, The Arctic University of Norway

                        Senior Researcher: Dept of Molecular Medicine and Surgery, Karolinska Institute, Sweden

                        Affiliation: Associated Investigator EMBL Centre for Molecular Medicine, Norway

    2014-17      Research Group Leader: Clinical Chemistry, University Medical Centre Hamburg, Germany 

                        Senior Researcher: Dept. Molecular Medicine and Surgery, Karolinska Institute

    2011-14      Assistant Professor: Dept. of Medicine, Karolinska Institute, Stockholm