Group leader
Lynn ButlerProfessor (Group leader)
The primary focus of the Translational Vascular Research group is the study of endothelial cells that line the inside of all blood vessels. These cells have many functions, such as providing an anti-thrombotic surface to prevent blood clotting and controlling leukocyte recruitment to tissue during inflammation. Our research is based around the identification of genes that are highly specifically expressed in endothelial cells (compared to other cell types) and the role of these genes in vascular function. Through this work, we identify potential plasma biomarker candidates for the clinical assessment of vascular health and risk stratification, diagnosis and prognosis of diseases of the cardiovascular system, such as venous and arterial thrombosis and COVID-19 complications.
Öling S, Struck E, Norreen-Thorsen M, Zwahlen M, von Feilitzen K, Odeberg J, Pontén F, Lindskog C, Uhlén M, Dusart P, Butler LM (2024) A human stomach cell type transcriptome atlas. BMC Biology 22(1):36.
Struck EC, Dusart P, Belova T, Hsieh P, Kuijjer M, Butler LM (2024) Global transcriptome analysis reveals distinct phases of the endothelial response to tumour necrosis factor. Journal of Immunology 212(1):117-129
Iglesias MJ, Sanchez-Rivera L, Ibrahim-Kosta M, Naudin C, Munsch G, Goumidi L, Farm M, Smith P, Thibord F, Kral-Pointner JB, Hong MG, Suchon P, Germain M, Schottmaier W, Dusart P, Boland A, Kotol D, Edfors F, Koprulu M, Pietzner M, Langenberg C, Damrauer SM, Johnson AD, Klarin D, Smith NL, Smadja DM, Holmström M, Magnusson M, Silveira A, Uhlén M, Renné T, Martinez-Perez A, Emmerich J, Deleuze JF, Antovic J, Fernandez JMS, Assinger A, Schwenk JM, Andres JCS, Morange PE#, Butler LM#, Trégouët DA#, Odeberg J# (2023) Elevated plasma Complement Factor H Regulating Protein 5 is associated with venous thromboembolism. Nature Communications 14 3280
Englert H, Gøbel J, Khong D, Omidi M, Wolska N, Konrath S, Frye M, Mailer R, Beerns M, Gerwers J, Preston R, Odeberg J, Butler LM, Mass C, Stavrou E, Fuchs T, Renné T (2023) Targeting NETS using dual-active DNAse1 variants. Frontiers in Immunology 23:14:1181761
Konrath S, Mailer RK, Beerens M, Englert H, Frye M, Kuta P, Preston RSJ, Maas C, Butler LM, Roest M, de Laat B, Renne T (2022) Intrinsic coagulation pathway-mediated thrombin generation in mouse whole blood. Frontiers in Cardiovascular Medicine 28:9:1008410
Norreen-Thorsen M, Struck EC, Öling S, Zwahlen M, Von Feilitzen K, Odeberg J, Lindskog C, Pontén F, Uhlén M, Dusart PJ, Butler LM (2022) A human adipose transcriptome atlas. Cell Reports 40(2):111046
Iglesias MJ, Kruse LD, Sanchez-Rivera L, Enge L, Dusart P, Hong MG, Uhlén M, Renné T, Schwenk JM, Bergstrom G, Odeberg J, Butler LM (2021) Identification of endothelial proteins in plasma associated with cardiovascular risk factors. Arteriosclerosis Thrombosis Vascular Biology 41(12):2990-3004
Heestermans M, Naudin C, Mailer RK, Konrath S, Klaetschke K, Jamsa A, Frye M, Deppermann C, Pula G, Kuta P, Friese MA, Gelderblom M, Sickmann A, Preston RJS, Nofer J, Rose-John S, Butler LM, Salomon O, Stavrou E, Renné T (2021) Identification of the factor XII contact activation site enables sensitive coagulation diagnostics. Nature Communications 12:5596
Karlsson M, Zhang C, Méar L, Zhong W, Digre A, Katona B, Sjöstedt E, Butler LM, Odeberg J, Dusart P, Edfors F, Oksvold P, von Feilitzen K, Zwahlen M, Arif M, Altay O, Li X, Ozcan M, Mardonoglu A, Fagerberg L, Mulder J, Luo Y, Ponten F, Uhlén M, Lindskog C (2021) A single-cell transcriptomics map of human tissues. Science Advances 7(31) eabh2169
Razzaq M, Iglesias MJ, Ibrahim M, Goumidi L, Soukarieh O, Proust C, Roux M, Suchon P, Boland A, Daiain D, Olaso R, Butler L, Deleuze JF, Odeberg J, Morange PE, Tregouet DA (2021). An artificial neural network approach integrating plasma proteomics and genetic data identifies PLXNA4 as a new susceptibility locus for pulmonary embolism. Scientific Reports 11:14015
Dusart P, Hallström BM, Renné T, Odeberg J, Uhlén M, Butler LM (2019) A systems-based map of human brain cell-type enriched genes and malignancy-associated endothelial changes. Cell Reports 29(6) 1690-1706
Mailer RK, Allende M, Heestermans M, Schweizer, Fyre M, Oula G, Deppermann C, Odeberg J, Gelderblom M, Rose-John S, Sickmann A, Blankenberg S, Huber T, Kubisch C, Mass C, Gambaryan S, Firsov D, Stavrou W, Butler LM, Renné T (2019). Xenotropic and polytropic retrovirus receptor 1 regulates procoagulant platelet polyphosphate. Blood 2019004617
Ahmed, M, Gustafsson B, Aldi S, Dusart P, Egri G, Butler LM, Bone D, Dähne L, Hedin U, Caidahl K (2018) Molecular Imaging of a New Multimodal Microbubble for Adhesion Molecule Targeting. Cellular and Molecular Bioengineering 12,15-32
Dusart P, Fagerberg L, Perisic L, Civelek M, Struck E, Hedin U, Uhlén M, Trégouët DA, Renné T, Odeberg J, Butler LM (2018) A systems-approach reveals human nestin is an endothelial-enriched, angiogenesis-independent intermediate filament protein. Scientific Reports 8(1):14668
Gustafsson R, Renné T, Söderberg-Naucler C, Butler LM (2018) Human cytomegalovirus replication induces endothelial cell interleukin-11. Cytokine S1043-4666(18)30217-5
Bruzelius M, Iglesias MJ, Hong MG, Sanchez-Rivera L, Gyorgy B, Souto JC, Frånberg M, Fredolini C, Strawbridge RJ, Holmström M, Hamsten A, Uhlén M, Silveira A, Soria JM, Smadja DM, Butler LM, Schwenk JM, Morange PE, Trégouët DA, Odeberg J (2016). PDGFB, a new candidate plasma biomarker for venous thromboembolism: results from the VEREMA affinity proteomics study. Blood 128:e59-e66
Butler LM, Hallström BM, Fagerberg L, Pontén F, Uhlén M, Renné T, Odeberg J (2016). Analysis of body-wide unfractionated tissue data to identify a core human endothelial transcriptome. Cell Systems 3(3) 287-301
Labberton L, Kenne E, Long A, Nickel K, Di Gennaro A, Rigg R, Hernandez J, Butler L, Maas C, Stavrou E, Renné T (2016) Neutralizing blood-borne polyphosphate in vivo provides safe thromboprotection. Nature Communications doi:10.1038/ncomms12616