Hege Lynum Pedersen
Stillingsbeskrivelse
Førsteamanuensis på RNA og molekylær patologi forskningsgruppe og studieprogramleder for master i biomedisin
Susannah von Hofsten,
Kristin Andreassen Fenton,
Hege Lynum Pedersen
:
Human and Murine Toll-like Receptor-Driven Disease in Systemic Lupus Erythematosus
Aud-Malin Karlsson Hovd,
Saba Nayar,
Charlotte G Smith,
Premasany Kanapathippilai,
Valentina Iannizzotto,
Francesca Barone
m.fl.:
Podoplanin expressing macrophages and their involvement in tertiary lymphoid structures in mouse models of Sjögren’s disease
Kristin Andreassen Fenton,
Hege Lynum Pedersen
:
Advanced methods and novel biomarkers in autoimmune diseases ‑ a review of the recent years progress in systemic lupus erythematosus
Luz P blanco,
Eduardo Patino-Martinez,
Shuichiro Nakabo,
Mingzeng Zhang,
Hege Lynum Pedersen,
Xinghao Wang
m.fl.:
Modulation of the itaconate pathway attenuates murine lupus
Arthritis & Rheumatology 2022 DOI
Luz P. Blanco,
Hege Lynum Pedersen,
Xinghao Wang,
Yaima L. Lightfoot,
Nickie Seto,
Carmelo Carmona-Rivera
m.fl.:
Improved Mitochondrial Metabolism and Reduced Inflammation Following Attenuation of Murine Lupus With Coenzyme Q10 Analog Idebenone
Arthritis & Rheumatology 2020 DOI
Seyed Esmaeil Dorraji,
Premasany Kanapathippillai,
Aud-Malin Karlsson Hovd,
Mikael Ryan Stenersrød,
Kjersti Daae Horvei,
anita Ursvik
m.fl.:
Kidney tertiary lymphoid structures in Lupus Nephritis develop into large interconnected networks and resemble lymph nodes in gene signature
Kristel Berg,
Hege Lynum Pedersen,
Ingar Leiros
:
Biochemical characterization of ferric uptake regulator (Fur) from Aliivibrio salmonicida. Mapping the DNA sequence specificity through binding studies and structural modelling
KA Fortner,
Luz P. Blanco,
I Buskiewicz,
N Huang,
PC Gibson,
DL Cook
m.fl.:
Targeting mitochondrial oxidative stress with MitoQ reduces NET formation and kidney disease in lupus-prone MRL-lpr mice.
X Wang,
Luz P. Blanco,
Carmelo Carmona-Rivera,
S Nakabo,
Hege Lynum Pedersen,
ZX Yu
m.fl.:
Gasdermin D modulates murine lupus and its associated organ damage
Arthritis & Rheumatology 2020 DOI
S Gupta,
S Nakabo,
Luz P. Blanco,
LJ O'Neil,
G Wigerblad,
RR Goel
m.fl.:
Sex differences in neutrophil biology modulate response to type I interferons and immunometabolism
Proceedings of the National Academy of Sciences of the United States of America (PNAS) 2020 DOI
Hege Lynum Pedersen,
Kjersti Daae Horvei,
Dhivya Thiyagarajan,
Gudrun Norby,
Natalya Seredkina,
Gabriella Moroni
m.fl.:
Lupus nephritis: low urinary DNase I levels reflect loss of
renal DNase I and may be utilized as a biomarker of
disease progression
Dhivya Thiyagarajan,
Hege Lynum Pedersen,
Natalya Seredkina,
Kjersti Daae Horvei,
Lorena Arranz,
Ramon Sonneveld
m.fl.:
IL-1β Promotes a New Function of DNase I as a Transcription Factor for the Fas Receptor Gene
Kjersti Daae Horvei,
Hege Lynum Pedersen,
Silje Fismen,
Dhivya Thiyagarajan,
Andrea Schneider,
Ole Petter Rekvig
m.fl.:
Lupus nephritis progression in FcγRIIB-/-yaa mice is associated with early development of glomerular electron dense deposits and loss of renal DNase I in severe disease.
Ole Petter Rekvig,
Dhivya Thiyagarajan,
Hege Lynum Pedersen,
Kjersti Daae Horvei,
Natalya Seredkina
:
Future perspectives on pathogenesis of Lupus Nephritis: facts, problems, and potential causal therapy modalities
American Journal of Pathology 2016 DOI
Hege Lynum Pedersen,
Kjersti Daae Horvei,
Dhivya Thiyagarajan,
Natalya Seredkina,
Ole Petter Rekvig
:
Murine and human lupus nephritis: pathogenic mechanisms and theoretical strategies for therapy
Seminars in Nephrology 2015 DOI
Hege Lynum Pedersen,
Kenneth Johnson,
Colin McVey,
Ingar Leiros,
Elin Moe
:
Structure determination of uracil-DNA N-glycosylase from Deinococcus radiodurans in complex with DNA
Adele Kim Williamson,
Hege Lynum Pedersen
:
Recombinant expression and purification of an ATP-dependent DNA ligase from Aliivibrio salmonicida
Protein Expression and Purification 2014 DOI
Rafi Ahmad,
Geir Åsmund Hansen,
Hilde Hansen,
Erik Hjerde,
hege lynum Pedersen,
steinar Paulsen
m.fl.:
Prediction, microarray and northern blot analyses identify new intergenic small RNAs in aliivibrio salmonicida
Journal of Molecular Microbiology and Biotechnology 28. desember 2012 DOI
hege lynum Pedersen,
Rafi Ahmad,
EK Riise,
Hanna-Kirsti S. Leiros,
Stefan Hauglid,
S Espelid
m.fl.:
Experimental and computational characterization of the ferric uptake regulator from Aliivibrio salmonicida (Vibrio salmonicida)
Journal of Microbiology 2010 DOI
hege lynum Pedersen,
erik Hjerde,
steinar Paulsen,
Hilde Hansen,
Lotte Olsen,
Sunniva Katharina Thode
m.fl.:
Global responses of Aliivibrio salmonicida to hydrogen peroxide as revealed by microarray analysis
Marine Genomics 2010 DOI
hege lynum Pedersen,
Nils Peder Willassen,
Ingar Leiros
:
The first structure of a cold-adapted superoxide dismutase (SOD): biochemical and structural characterization of iron SOD from Aliivibrio salmonicida
Acta Crystallographica. Section F : Structural Biology and Crystallization Communications 2009 DOI
Kristin Andreassen Fenton,
Hege Lynum Pedersen
:
Characterising tertiary lymphoid structures in lupus-prone mice
Research Features Magazine 05. mai 2021 DOI
Hege Lynum Pedersen,
Luz P. Blanco,
Xinghao Wang,
Vance Holt,
Mariana J. Kaplan
:
White blood cell metabolism in human SLE
2019
Luz P. Blanco,
Hege Lynum Pedersen,
Yaima L. Lightfoot,
Nickie Seto,
Carmelo Carmona-Rivera,
Yudong Liu
m.fl.:
The coenzyme Q10 analog idebenone ameliorates murine lupus
2019
Hege Lynum Pedersen,
Kjersti Daae Horvei,
Dhivya Thiyagarajan,
Gudrun Norby,
Natalya Seredkina,
Gabriella Moroni
m.fl.:
LUPUS NEPHRITIS: SEVERELY REDUCED URINARY DNASE I LEVELS REFLECT LOSS OF RENAL DNASE I, DISEASE PROGRESSION AND MAY REDUCE THE NEED FOR RENAL BIOPSIES
2018
Hege Lynum Pedersen
:
Lupus nefritt i mus og mennesker - hva har vi lært, og er det muligheter for terapi?
Revmatologi BestPractice 2016
Hege Lynum Pedersen
:
MARZymes - Marine enzymes from the Arctic region
2013
Adele Kim Williamson,
Bjørn Altermark,
hege lynum Pedersen,
Gro Elin Kjæreng Bjerga,
Marcin Miroslaw Pierechod,
Nils Peder Willassen
m.fl.:
Discovery of Cold-active Enzymes from the Marine Arctic Environment
2013
hege lynum Pedersen,
Bjørn Altermark,
Erik Hjerde,
Adele Kim Williamson,
Marcin Miroslaw Pierechod,
Gro Elin Kjæreng Bjerga
m.fl.:
Genome Sequencing of Bacteria Isolated from the Arctic Marine Environment
2013
Adele Kim Williamson,
Bjørn Altermark,
Marcin Miroslaw Pierechod,
Gro Elin Kjæreng Bjerga,
hege lynum Pedersen,
Concetta De Santi
m.fl.:
Hot Investigations into Cold-Sourced Enzymes
2013
Hege Lynum Pedersen
:
Stress responses in Aliivibrio salmonicida
2010
Hege Lynum Pedersen,
Laila Niiranen,
Kjersti Lian,
Aili Sarre,
Joanna Timmins,
Sean McSweeney
m.fl.:
Protein interaction studies of BER proteins from the extreme radiation resistant bacterium Deinococcus radiodurans
2010
Laila Niiranen,
Hege Lynum Pedersen,
Kjersti Lien,
Aili Sarre,
Joanna Timmins,
S McSweeney
m.fl.:
Identification of novel interaction partners for DNA glycosylases in the extreme radiation resistant bacterium Deinococcus radiodurans
2009
Hege Lynum Pedersen
:
Oxidative stress and iron limitation in Aliivibrio
salmonicida
Expression profiling, and molecular characterisation of
FeSOD and Fur
UiT Norges arktiske universitet 2009
Hege Lynum Pedersen,
Ellen Kristin Riise,
Arne O. Smalås,
Nils Peder Willassen
:
Oxidative stress in Vibrio salmonicida
2006
Inger Liv Uttakleiv Ræder,
hege lynum Pedersen,
steinar Paulsen,
Trond Jørgensen,
Nils Peder Willassen,
Arne Oskar Smalås
:
Proteomic studies of Vibrio Salmonicida
2005
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Forskningsinteresser
Read more about the research projects at the home page of RAMP research group
I work as an Assoociate Professor. My research interests are in immunology and protein research. I work with the autoimmune disease Systemic Lupus Erythematosus (SLE), and my focus has been mainly related to new biomarkers and treatment of this disease.
We aim to develop new therapeutic tools and ways to monitor the disease based on novel and precise knowledge of the disease initiation and development. Since the expression of both DNase I and neutrophil extracellular traps (NETs) are abnormal in SLE, we hypothesize that they can be utilized in therapy and as biomarkers. To explore this, we will investigate the expression pattern and regulation of DNase I and NETs.
Undervisning
MBI-1105, basal biokjemi
- Forelesniger og seminarer i enzymologi
ODO-2008
- Forelesninger, seminarer og case i immunologi
MBI-3911
- Emneansvarlig
