Tor-Haug.JPG--Bredde--180px-
Tor-Haug.JPG--Bredde--180px-
Norges fiskerihøgskole tor.haug@uit.no +4777646071 913 55112 Tromsø NFH C 452

Tor Haug


Professor / akvamedisin


  • Manuel K Langer, Ataur Rahman, Hymonti Dey, Trude Anderssen, Francesco Zilioli, Tor Haug m.fl.:
    A concise SAR-analysis of antimicrobial cationic amphipathic barbiturates for an improved activity-toxicity profile
    European Journal of Medicinal Chemistry 2022 FULLTEKST / DATA / DOI
  • Marianne Hagensen Paulsen, Magnus Engqvist, Dominik Ausbacher, Trude Anderssen, Manuel K- Langer, Tor Haug m.fl.:
    Amphipathic Barbiturates as Mimics of Antimicrobial Peptides and the Marine Natural Products Eusynstyelamides with Activity against Multi-resistant Clinical Isolates
    Journal of Medicinal Chemistry 2021 ARKIV / DOI
  • Ida Kristine Østnes Hansen, Johan Isaksson, Aaron G. Poth, Kine Østnes Hansen, Aaron John Christian Andersen, Céline Sarah Marine Richard m.fl.:
    Isolation and characterization of antimicrobial peptides with unusual disulfide connectivity from the colonial ascidian Synoicum turgens
    Marine Drugs 2020 ARKIV / DOI
  • Ida Kristine Østnes Hansen, Tomas Lövdahl, Danijela Simonovic, Kine Østnes Hansen, Aaron John Christian Andersen, hege Devold m.fl.:
    Antimicrobial activity of small synthetic peptides based on the marine peptide turgencin A: Prediction of antimicrobial peptide sequences in a natural peptide and strategy for optimization of potency
    International Journal of Molecular Sciences 2020 ARKIV / DOI
  • Jonathan Hira, Deanna Wolfson, Aaron John Christian Andersen, Tor Haug, Klara Stensvåg :
    Autofluorescence mediated red spherulocyte sorting provides insights into the source of spinochromes in sea urchins
    Scientific Reports 2020 ARKIV / DOI
  • Runar Gjerp Solstad, Cecilie Johansen, Klara Stensvåg, Morten B. Strøm, Tor Haug :
    Structure‐activity relationship studies of shortened analogues of the antimicrobial peptide EeCentrocin 1 from the sea urchin Echinus esculentus
    Journal of Peptide Science 2019 ARKIV / DOI
  • Marianne Hagensen Paulsen, Dominik Ausbacher, Annette Bayer, Magnus Engqvist, Terkel Hansen, Tor Haug m.fl.:
    Antimicrobial activity of amphipathic α,α-disubstituted β-amino amide derivatives against ESBL–CARBA producing multi-resistant bacteria; effect of halogenation, lipophilicity and cationic character
    European Journal of Medicinal Chemistry 2019 ARKIV / DOI
  • Elizaveta Igumnova, Ekaterina Mishchenko, Tor Haug, Hans-Matti Blencke, Johanna U Ericson Sollid, Elizabeth Aarag m.fl.:
    Amphipathic sulfonamidobenzamides mimicking small antimicrobial marine natural products; investigation of antibacterial and anti-biofilm activity against antibiotic resistant clinical isolates.
    Bioorganic & Medicinal Chemistry 2018 DOI
  • Marianne Hagensen Paulsen, Eskil Andre Karlsen, Dominik Ausbacher, Trude Anderssen, Annette Bayer, Philipp Ochtrop m.fl.:
    An amphipathic cyclic tetrapeptide scaffold containing halogenated β2,2-amino acids with activity against multi-resistant bacteria
    Journal of Peptide Science 2018 DOI
  • Morten Kaare Moe, Tor Haug, Magne Olav Sydnes, Sigmund Sperstad, Chun Li, Lena Christine Vaagsfjord m.fl.:
    Paralithocins, Antimicrobial Peptides with Unusual Disulfide Connectivity from the Red King Crab, Paralithodes camtschaticus
    Journal of natural products 2018 ARKIV / DOI
  • Yulia A. Logashina, Runar Gjerp Solstad, Konstantin S. Mineev, Yuliya V. Korolkova, Irina V. Mosharova, Igor A. Dyachenko m.fl.:
    New Disulfide-Stabilized Fold Provides Sea Anemone Peptide to Exhibit Both Antimicrobial and TRPA1 Potentiating Properties
    Toxins 2017 ARKIV / DOI
  • Elizaveta Mikhailovna Igumnova, Ekaterina Mishchenko, Tor Haug, Hans-Matti Blencke, Johanna U Ericson Sollid, Elizabeth Aarag m.fl.:
    Synthesis and antimicrobial activity of small cationic amphipathic aminobenzamide marine natural product mimics and evaluation of relevance against clinical isolates including ESBL–CARBA producing multi-resistant bacteria
    Bioorganic & Medicinal Chemistry 2016 DOI
  • Nima Alinejad Chatli, Morten B. Strøm, Danijela Simonovic, Tor Haug :
    Synthesis of linear and cyclic proline-rich analogues of the marine, antimicrobial peptides Hyasin 1 and Arasin 1
    2022
  • Ida Kristine Østnes Hansen, Tor Haug, Klara Stensvåg, Hans-Matti Blencke :
    Antimicrobial peptides from the Arctic ascidian Synoicum turgens
    2022
  • Tor Haug :
    Isolation and characterization of antimicrobial peptides and alkaloids from marine invertebrates
    2022
  • Ataur Rahman, Christoffer Sivertsen, Andrea Iselin Elvheim, Ida Kristine Østnes Hansen, Bjarne Landfald, Tor Haug m.fl.:
    Antimicrobial compounds from Arctic and sub-Arctic marine bacteria and their potential against ESKAPE pathogens
    2022
  • Tor Haug :
    How can antibacterial peptides become a new source for novel antibiotics?
    2022
  • Ingrid Maribu, Jan-Arne Arnesen, Kjetil Elvevold, Tor Haug :
    Chemical and Enzyme-Assisted Extraction of Fucoidan from two Species of Brown Macroalgae (Ascophyllum nodosum and Saccharina latissima)
    2022 ARKIV
  • Danijela Simonovic, Hymonti Dey, Natascha Johansen, Trude Anderssen, Terje Vasskog, Elizabeth G. Aarag Fredheim m.fl.:
    Investigation of the antimicrobial activity and proteolytic stability of the short analogues of the marine peptide EeCentrocin 1
    2022
  • Hymonti Dey, Danijela Simonovic, Ingrid Sofie Norberg-Schulz Hagen, Terje Vasskog, Elizabeth G. Aarag Fredheim, Hans-Matti Blencke m.fl.:
    Antimicrobial Activity and Mode of Action Study of Short Analogues of The Marine Antimicrobial Peptide Turgencin A
    2022
  • Haakon Knutsen, Jonathan Hira, Tor Haug, Klara Stensvåg :
    Naphthoquinone pigments from the green sea urchin, Strongylocentrotus droebachiensis
    2021
  • Ingrid Maribu, Jan-Arne Arnesen, Kjetil Elvevold, Tor Haug :
    Chemical and Enzyme-Assisted Extraction of Fucoidan from two Species of Brown Macroalgae (Ascophyllum nodosum and Saccharina latissima)
    2021
  • Natascha Johansen, Danijela Simonovic, Tor Haug, Morten B. Strøm :
    Synthesis of analogues of the antimicrobial lead peptide P6 developed from the marine peptide EeCentrocin 1
    2021
  • Ingrid Norberg-Schulz Hagen, Danijela Simonovic, Tor Haug, Morten B. Strøm :
    Synthesis of short lipopeptide analogues of the marine, antimicrobial peptide Turgencin A
    2021
  • Danijela Simonovic, Hymonti Dey, Natascha Johansen, Trude Anderssen, Terje Vasskog, Elizabeth G. Aarag Fredheim m.fl.:
    Investigation of the antimicrobial activity and proteolytic stability of the short analogues of the marine peptide EeCentrocin 1
    2021
  • Hymonti Dey, Danijela Simonovic, Ingrid Sofie Norberg-Schulz Hagen, Terje Vasskog, Elizabeth G. Aarag Fredheim, Hans-Matti Blencke m.fl.:
    Antimicrobial activity and mode of action study of short analogues of the marine antimicrobial peptide Turgencin A
    2021
  • Jonathan Hira, Deanna Wolfson, Tor Haug, Klara Stensvåg :
    A simplified and robust method for isolating red spherule cells, and important immune cell of echinoderms
    2020
  • Pål Are Enbusk, Alice Marie Pedersen, Aaron John Christian Andersen, Ragnar Ludvig Olsen, Tor Haug, Klara Stensvåg :
    Hydrolysat fra raudåte (Calanus finmarchicus). Effekt av avsalting ved bruk av nanofilter
    2020
  • Ataur Rahman, Manuel Karl Langer, Hymonti Dey, Jonathan Hira, Ekaterina Mishchenko, Annette Bayer m.fl.:
    Novel antimicrobial and biofilm-inhibitors from marine resources
    2020
  • Emilie Kristensen, Frida Helen Broback, Christoffer Sivertsen, Karl-Erik Eilertsen, Tor Haug :
    Bioaktive forbindelser i brunalger
    2020
  • Jonathan Hira, Klara Stensvåg, Bjarne Landfald, Tor Haug :
    Host-pathogen interaction. Sea urchin (Strongylocentrotus droebachiensis) lesion syndrome and Vibrio bacteria
    2019
  • Klara Stensvåg, Morten Kaare Moe, Tor Haug, Magne Olav Sydnes, Sigmund Sperstad, Chun Li m.fl.:
    Paralithocins, Antimicrobial Peptides with Unusual Disulfide Connectivity from the Red King Crab, Paralithodes camtschaticus
    2019
  • Sebastian Reidar Barriteau Siiri, Tor Haug, Klara Stensvåg, Hans-Matti Blencke :
    Antimikrobielle forbindelser i sjøstjernen Asterias rubens og sjøpølsen Cucumaria frondosa
    2019
  • Yulia A. Logashina, Runar Gjerp Solstad, Yuliya V. Korolkova, Irina V. Mosharova, Sergey A. Kozlov, Klara Stensvåg m.fl.:
    Sea anemone peptide from Urticina eques potentiates the TRPA1 receptor and produces an antimicrobial effect
    Toxicon 2019 DOI
  • Klara Stensvåg, Jonathan Hira, Ekaterina Mishchenko, Hans-Matti Blencke, Morten B. Strøm, Bjarne Landfald m.fl.:
    Marine antimicrobial peptides – an inspiration for new compounds to fight bacteria
    2019
  • Tomas Lövdahl, Tor Haug, Morten B. Strøm :
    Solid phase peptide synthesis and structure activity relationship study of a marine peptide from Synoicum turgens
    2018
  • Ekaterina Mishchenko, Hans-Matti Blencke, Tor Haug, Klara Stensvåg :
    Bioactive compounds from marine organisms in the High North - future antibiotics?
    2017
  • Ekaterina Mishchenko, Johanna U Ericson Sollid, Hans-Matti Blencke, Tor Haug, Elizabeth Aarag, Klara Stensvåg :
    Antibacterial and Anti-biofilm Activity of Novel Marine Natural Product Mimics
    2017
  • Yulia A. Logashina, Runar Gjerp Solstad, Yuliya V. Korolkova, Irina V. Mosharova, Sergey A. Kozlov, Klara Stensvåg m.fl.:
    Sea anemone peptide from Urticina eques potentiates the TRPA1 receptor and produces an antimicrobial effect
    2017
  • Klara Stensvåg, Tor Haug, Ekaterina Mishchenko, Hans-Matti Blencke :
    Marine natural resources – examples of health beneficial active components
    2017
  • Klara Stensvåg, Tor Haug, Runar Gjerp Solstad, Ekaterina Mishchenko, Chun Li, Hans-Matti Blencke :
    Bioactive compounds from marine resources
    2017
  • Ekaterina Mishchenko, Elizaveta Igumnova, Johanna U Ericson Sollid, Hans-Matti Blencke, Reidunn Silje Lauksund, Tor Haug m.fl.:
    Antibacterial marine natural product mimics for treatment of infections.
    2017
  • Klara Stensvåg, Tor Haug, Ekaterina Mishchenko, Hans-Matti Blencke :
    Marine antimicrobial compounds and their potential as lead compounds for novel antibiotics
    2017
  • Lindsey Leigh Beecher Martinsen, Klara Stensvåg, Tor Haug :
    Antimikrobielle forbindelser i kongsnegl (Buccinum undatum) og neptunsnegl (Neptunea despecta)
    2017
  • Eskil André Karlsen, Marianne H. Paulsen, Tor Haug, Morten B. Strøm :
    Solid-phase peptide synthesis of antimicrobial peptide analogues of a marine peptide from Echinus esculentus and cyclic peptides with unnatural β2,2-amino acids incorporated
    2017
  • Lindsey Leigh Beecher Martinsen, Ida Kristine Hansen, Klara Stensvåg, Tor Haug :
    Antimicrobial peptides in the marine gastropod, Neptunea despecta.
    2017
  • Tor Haug, Runar Gjerp Solstad, Chun Li, Johan Isaksson, Jostein a Johansen, Johan Svenson m.fl.:
    Halogenated antimicrobial peptides from the red sea urchin, Echinus esculentus.
    2017
  • Ida Kristine Hansen, Kine Ø. Hanssen, Hans-Matti Blencke, Klara Stensvåg, Tor Haug :
    Antimicrobial peptides from Arctic ascidians
    2017
  • Runar Gjerp Solstad, Chun Li, Johan Isaksson, Jostein a Johansen, Johan Svenson, Klara Stensvåg m.fl.:
    Novel antimicrobial peptides EeCentrocins 1, 2 and EeStrongylocin 2 from the edible sea urchin Echinus esculentus have 6-Br-Trp post-translational modifications
    2016
  • Runar Gjerp Solstad, Hans-Matti Blencke, Ekaterina Mishchenko, Chun Li, Inger Rødum, Tor Haug m.fl.:
    Bioactive peptides from marine sources
    2016

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    Publikasjoner utenom Cristin

    Patents/patent applications

    Tadesse, M., Strøm, M.B., Svenson, J., Jaspars, M., Stensvåg, K. & Haug, T. (2012). Bioactive alkaloids. International Patent Application, No. WO2011GB01359 (Publ. No. WO2012035305), filed 2011.09.16. 17 pages.

    Stensvåg, K., Haug, T. , Li, C., Styrvold, O.B., Blencke, H.-M. & Paulsen, V. (2010). Novel polypeptides. United States Patent Application, No. 12/306,530 (publ. No. US20100093642 A1), filed 2010.04.15. 55 pages.

    Stensvåg, K., Haug, T., Li, C., Styrvold, O.B., Blencke, H.-M. & Paulsen, V. (2009). Antimicrobial peptides. European Patent Application, No. 07768941.2 (publ. No. EP 2046811 B1), filed 2009.04.15. 74 pages.

    Stensvåg, K., Haug, T. , Li, C., Styrvold, O.B., Blencke, H.-M. & Paulsen, V. (2008). Novel polypeptides. International Patent Application, No. WO2007NO00241 (Publ. No. WO2008002153), filed 2007.06.28. 84 pages.

    Stensvåg, K., Haug, T. , Li, C. & Styrvold, O.B. (2006). Novel polypeptides. Norwegian Patent Application, No. NO20063056, filed 2006.06.30, 78 pages.

    Haug, T. , Stensvåg, K., Styrvold, O.B., Sandsdalen, E. & Sperstad, S. (2005). Novel crustacean proline-rich peptides. International Patent Application, No. WO2005NO00151 (Publ. No. WO2005108576), filed 2005.05.06. 72 pages.

    Haug, T. , Stensvåg, K., Styrvold, O.B. & Sandsdalen, E. (2004). Novel crustacean proline-rich peptides. Norwegian Patent Application, No. NO20041892, filed 2004.05.07, 44 pages.


    Forskningsinteresser

    Marine bioprospecting and drug discovery, with a focus on isolation and characterization of antimicrobial natural products.

    Undervisning

    • Bachelorgradskurs i bioteknologi: Marin bioteknologi 1 (Bio-2606), Marin bioprospektering (Bio-2607), Prosjektoppgave i marin bioteknologi (Bio-2610)
    • Mastergradskurs i Fiskehelse: Farmakologi (Bio-3602) 
    • Veiledning av master- og doktorgradsstudenter

    Medlem i forskningsgruppe