Tor Haug
Professor / akvamedisin
Manuel K Langer,
Ataur Rahman,
Hymonti Dey,
Trude Anderssen,
Hans-Matti Blencke,
Tor Haug
m.fl.:
Investigation of tetrasubstituted heterocycles reveals hydantoins as a promising scaffold for development of novel antimicrobials with membranolytic properties
European Journal of Medicinal Chemistry 2023 DOI
Hymonti Dey,
Danijela Simonovic,
Ingrid Sofie Norberg-Schulz Hagen,
Terje Vasskog,
Elizabeth G. Aarag Fredheim,
Hans-Matti Blencke
m.fl.:
Synthesis and Antimicrobial Activity of Short Analogues of the Marine Antimicrobial Peptide Turgencin A: Effects of SAR Optimizations, Cys-Cys Cyclization and Lipopeptide Modifications
Manuel K Langer,
Ataur Rahman,
Hymonti Dey,
Trude Anderssen,
Francesco Zilioli,
Tor Haug
m.fl.:
A concise SAR-analysis of antimicrobial cationic amphipathic barbiturates for an improved activity-toxicity profile
Marianne Hagensen Paulsen,
Magnus Engqvist,
Dominik Ausbacher,
Trude Anderssen,
Manuel K- Langer,
Tor Haug
m.fl.:
Amphipathic Barbiturates as Mimics of Antimicrobial Peptides and the Marine Natural Products Eusynstyelamides with Activity against Multi-resistant Clinical Isolates
Jonathan Hira,
Deanna Wolfson,
Aaron John Christian Andersen,
Tor Haug,
Klara Stensvåg
:
Autofluorescence mediated red spherulocyte sorting provides insights into the source of spinochromes in sea urchins
Ida Kristine Østnes Hansen,
Tomas Lövdahl,
Danijela Simonovic,
Kine Østnes Hansen,
Aaron John Christian Andersen,
hege Devold
m.fl.:
Antimicrobial activity of small synthetic peptides based on the marine peptide turgencin A: Prediction of antimicrobial peptide sequences in a natural peptide and strategy for optimization of potency
Ida Kristine Østnes Hansen,
Johan Isaksson,
Aaron G. Poth,
Kine Østnes Hansen,
Aaron John Christian Andersen,
Céline Sarah Marine Richard
m.fl.:
Isolation and characterization of antimicrobial peptides with unusual disulfide connectivity from the colonial ascidian Synoicum turgens
Runar Gjerp Solstad,
Cecilie Johansen,
Klara Stensvåg,
Morten B. Strøm,
Tor Haug
:
Structure‐activity relationship studies of shortened analogues of the antimicrobial peptide EeCentrocin 1 from the sea urchin Echinus esculentus
Marianne Hagensen Paulsen,
Dominik Ausbacher,
Annette Bayer,
Magnus Engqvist,
Terkel Hansen,
Tor Haug
m.fl.:
Antimicrobial activity of amphipathic α,α-disubstituted β-amino amide derivatives against ESBL–CARBA producing multi-resistant bacteria; effect of halogenation, lipophilicity and
cationic character
Marianne Hagensen Paulsen,
Eskil Andre Karlsen,
Dominik Ausbacher,
Trude Anderssen,
Annette Bayer,
Philipp Ochtrop
m.fl.:
An amphipathic cyclic tetrapeptide scaffold containing halogenated β2,2-amino acids with activity
against multi-resistant bacteria
Journal of Peptide Science 2018 DOI
Morten Kaare Moe,
Tor Haug,
Magne Olav Sydnes,
Sigmund Sperstad,
Chun Li,
Lena Christine Vaagsfjord
m.fl.:
Paralithocins, Antimicrobial Peptides with Unusual Disulfide Connectivity from the Red King Crab, Paralithodes camtschaticus
Elizaveta Igumnova,
Ekaterina Mishchenko,
Tor Haug,
Hans-Matti Blencke,
Johanna U Ericson Sollid,
Elizabeth Aarag
m.fl.:
Amphipathic sulfonamidobenzamides mimicking small antimicrobial marine natural products; investigation of antibacterial and anti-biofilm activity against antibiotic resistant clinical isolates.
Bioorganic & Medicinal Chemistry 2018 DOI
Christoffer Ågnes,
Ataur Rahman,
Hege Devold,
Klara Stensvåg,
Morten Bøhmer Strøm,
Tor Haug
:
Antibacterial and antibiofilm compounds in six marine invertebrates from Arctic and sub-Arctic Oceans
2023
Klara Stensvåg,
Tor Haug,
Gabriel Magno de Freitas Almeida,
Ida Kristine Østnes Hansen
:
Antibacterial natural products from the ocean - a promising source for future antiinfectives
2023 PROSJEKT
Ataur Rahman,
Manuel K Langer,
Hans-Matti Blencke,
Tor Haug,
Johanna U Ericson,
Morten B. Strøm
m.fl.:
Development of novel antimicrobial peptides: two classes with improved antimicrobial and antibiofilm activity
2023 PROSJEKT
Christoffer Ågnes,
Ataur Rahman,
hege Devold,
Klara Stensvåg,
Morten B. Strøm,
Tor Haug
:
Antibacterial and antibiofilm activity in Arctic and sub-Arctic marine benthic invertebrates
2023
Hymonti Dey,
Danijela Simonovic,
Ingrid Sofie Norberg-Schulz Hagen,
Terje Vasskog,
Elizabeth G. Aarag Fredheim,
Hans-Matti Blencke
m.fl.:
Antimicrobial activity and mode of action study of short cyclic analogues of the marine antimicrobial peptide Turgencin A
2023
Ataur Rahman,
Christoffer Ågnes,
Andrea Iselin Elvheim,
Ida Kristine Østnes Hansen,
Hans-Matti Blencke,
Bjarne Landfald
m.fl.:
Molecular characterization of marine bacteria and their potential as being antimicrobial producers: a pilot study using co-cultures
2023
Manuel K Langer,
Ataur Rahman,
Hymonti Dey,
Trude Anderssen,
Hans-Matti Blencke,
Tor Haug
m.fl.:
Tetrasubstituted hydantoins: Novel membranolytic antimicrobials
2023
Ida Kristine Østnes Hansen,
Tor Haug,
Klara Stensvåg,
Hans-Matti Blencke
:
Antimicrobial peptides from the Arctic ascidian Synoicum turgens
2022
Tor Haug
:
Isolation and characterization of antimicrobial peptides and alkaloids from marine invertebrates
2022
Tor Haug
:
How can antibacterial peptides become a new source for novel antibiotics?
2022
Ingrid Maribu,
Jan-Arne Arnesen,
Kjetil Elvevold,
Tor Haug
:
Chemical and Enzyme-Assisted Extraction of Fucoidan from
two Species of Brown Macroalgae (Ascophyllum nodosum
and Saccharina latissima)
2022 ARKIV
Ataur Rahman,
Christoffer Sivertsen,
Andrea Iselin Elvheim,
Ida Kristine Østnes Hansen,
Bjarne Landfald,
Tor Haug
m.fl.:
Antimicrobial compounds from Arctic and sub-Arctic marine bacteria and their potential against ESKAPE pathogens
2022
Ataur Rahman,
Andrea Iselin Elvheim,
Christoffer Ågnes,
Ida Kristine Østnes Hansen,
Bjarne Landfald,
Hans-Matti Blencke
m.fl.:
Antimicrobial and antibiofilm potential of marine bacteria
2022
Klara Stensvåg,
Ekaterina Mishchenko,
Hans-Matti Blencke,
Andrea Iselin Elvheim,
Christoffer Ågnes,
Ataur Rahman
m.fl.:
Health beneficial antimicrobials from marine natural Arctic and sub-Arctic resources
2022 PROSJEKT
Hymonti Dey,
Danijela Simonovic,
Ingrid Sofie Norberg-Schulz Hagen,
Terje Vasskog,
Elizabeth G. Aarag Fredheim,
Hans-Matti Blencke
m.fl.:
Antimicrobial Activity and Mode of Action Study of Short
Analogues of The Marine Antimicrobial Peptide Turgencin A
2022
Danijela Simonovic,
Hymonti Dey,
Natascha Johansen,
Trude Anderssen,
Terje Vasskog,
Elizabeth G. Aarag Fredheim
m.fl.:
Investigation of the antimicrobial activity and proteolytic stability
of the short analogues of the marine peptide EeCentrocin 1
2022
Nima Alinejad Chatli,
Morten B. Strøm,
Danijela Simonovic,
Tor Haug
:
Synthesis of linear and cyclic proline-rich analogues of the marine, antimicrobial peptides Hyasin 1 and Arasin 1
2022
Hymonti Dey,
Danijela Simonovic,
Ingrid Sofie Norberg-Schulz Hagen,
Terje Vasskog,
Elizabeth G. Aarag Fredheim,
Hans-Matti Blencke
m.fl.:
Antimicrobial activity and mode of action study of short analogues of the marine antimicrobial peptide Turgencin A
2021
Danijela Simonovic,
Hymonti Dey,
Natascha Johansen,
Trude Anderssen,
Terje Vasskog,
Elizabeth G. Aarag Fredheim
m.fl.:
Investigation of the antimicrobial activity and proteolytic stability of the short analogues of the marine peptide EeCentrocin 1
2021
Haakon Knutsen,
Jonathan Hira,
Tor Haug,
Klara Stensvåg
:
Naphthoquinone pigments from the green sea urchin, Strongylocentrotus droebachiensis
2021
Ingrid Maribu,
Jan-Arne Arnesen,
Kjetil Elvevold,
Tor Haug
:
Chemical and Enzyme-Assisted Extraction of Fucoidan from two Species of Brown Macroalgae (Ascophyllum nodosum and Saccharina latissima)
2021
Natascha Johansen,
Danijela Simonovic,
Tor Haug,
Morten B. Strøm
:
Synthesis of analogues of the antimicrobial lead peptide P6 developed from the marine peptide EeCentrocin 1
2021
Ingrid Norberg-Schulz Hagen,
Danijela Simonovic,
Tor Haug,
Morten B. Strøm
:
Synthesis of short lipopeptide analogues of the marine, antimicrobial peptide Turgencin A
2021
Ataur Rahman,
Manuel Karl Langer,
Hymonti Dey,
Jonathan Hira,
Ekaterina Mishchenko,
Annette Bayer
m.fl.:
Novel antimicrobial and biofilm-inhibitors from marine resources
2020
Pål Are Enbusk,
Alice Marie Pedersen,
Aaron John Christian Andersen,
Ragnar Ludvig Olsen,
Tor Haug,
Klara Stensvåg
:
Hydrolysat fra raudåte (Calanus finmarchicus). Effekt av avsalting ved bruk av nanofilter
2020
Emilie Kristensen,
Frida Helen Broback,
Christoffer Sivertsen,
Karl-Erik Eilertsen,
Tor Haug
:
Bioaktive forbindelser i brunalger
2020
Jonathan Hira,
Deanna Wolfson,
Tor Haug,
Klara Stensvåg
:
A simplified and robust method for isolating red spherule cells, and important immune cell of echinoderms
2020
Yulia A. Logashina,
Runar Gjerp Solstad,
Yuliya V. Korolkova,
Irina V. Mosharova,
Sergey A. Kozlov,
Klara Stensvåg
m.fl.:
Sea anemone peptide from Urticina eques potentiates the TRPA1 receptor and produces an antimicrobial effect
Toxicon 2019 DOI
Klara Stensvåg,
Morten Kaare Moe,
Tor Haug,
Magne Olav Sydnes,
Sigmund Sperstad,
Chun Li
m.fl.:
Paralithocins, Antimicrobial Peptides with Unusual Disulfide Connectivity from the Red King Crab, Paralithodes camtschaticus
2019
Sebastian Reidar Barriteau Siiri,
Tor Haug,
Klara Stensvåg,
Hans-Matti Blencke
:
Antimikrobielle forbindelser i sjøstjernen Asterias rubens og sjøpølsen Cucumaria frondosa
2019
Klara Stensvåg,
Jonathan Hira,
Ekaterina Mishchenko,
Hans-Matti Blencke,
Morten B. Strøm,
Bjarne Landfald
m.fl.:
Marine antimicrobial peptides – an inspiration for new compounds to fight bacteria
2019
Jonathan Hira,
Klara Stensvåg,
Bjarne Landfald,
Tor Haug
:
Host-pathogen interaction. Sea urchin (Strongylocentrotus droebachiensis) lesion syndrome and Vibrio bacteria
2019
Tomas Lövdahl,
Tor Haug,
Morten B. Strøm
:
Solid phase peptide synthesis and structure activity relationship study of a marine peptide from Synoicum turgens
2018
Klara Stensvåg,
Tor Haug,
Runar Gjerp Solstad,
Ekaterina Mishchenko,
Chun Li,
Hans-Matti Blencke
:
Bioactive compounds from marine resources
2017
Klara Stensvåg,
Tor Haug,
Ekaterina Mishchenko,
Hans-Matti Blencke
:
Marine natural resources – examples of health beneficial active components
2017
Ekaterina Mishchenko,
Hans-Matti Blencke,
Tor Haug,
Klara Stensvåg
:
Bioactive compounds from marine organisms in the High North - future antibiotics?
2017
Ekaterina Mishchenko,
Elizaveta Igumnova,
Johanna U Ericson Sollid,
Hans-Matti Blencke,
Reidunn Silje Lauksund,
Tor Haug
m.fl.:
Antibacterial marine natural product mimics for treatment of infections.
2017
Tor Haug,
Runar Gjerp Solstad,
Chun Li,
Johan Isaksson,
Jostein a Johansen,
Johan Svenson
m.fl.:
Halogenated antimicrobial peptides from the red sea urchin, Echinus esculentus.
2017
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Publikasjoner utenom Cristin
Patents/patent applications
Tadesse, M., Strøm, M.B., Svenson, J., Jaspars, M., Stensvåg, K. & Haug, T. (2012). Bioactive alkaloids. International Patent Application, No. WO2011GB01359 (Publ. No. WO2012035305), filed 2011.09.16. 17 pages.
Stensvåg, K., Haug, T. , Li, C., Styrvold, O.B., Blencke, H.-M. & Paulsen, V. (2010). Novel polypeptides. United States Patent Application, No. 12/306,530 (publ. No. US20100093642 A1), filed 2010.04.15. 55 pages.
Stensvåg, K., Haug, T., Li, C., Styrvold, O.B., Blencke, H.-M. & Paulsen, V. (2009). Antimicrobial peptides. European Patent Application, No. 07768941.2 (publ. No. EP 2046811 B1), filed 2009.04.15. 74 pages.
Stensvåg, K., Haug, T. , Li, C., Styrvold, O.B., Blencke, H.-M. & Paulsen, V. (2008). Novel polypeptides. International Patent Application, No. WO2007NO00241 (Publ. No. WO2008002153), filed 2007.06.28. 84 pages.
Stensvåg, K., Haug, T. , Li, C. & Styrvold, O.B. (2006). Novel polypeptides. Norwegian Patent Application, No. NO20063056, filed 2006.06.30, 78 pages.
Haug, T. , Stensvåg, K., Styrvold, O.B., Sandsdalen, E. & Sperstad, S. (2005). Novel crustacean proline-rich peptides. International Patent Application, No. WO2005NO00151 (Publ. No. WO2005108576), filed 2005.05.06. 72 pages.
Haug, T. , Stensvåg, K., Styrvold, O.B. & Sandsdalen, E. (2004). Novel crustacean proline-rich peptides. Norwegian Patent Application, No. NO20041892, filed 2004.05.07, 44 pages.
Forskningsinteresser
Marine bioprospecting and drug discovery, with a focus on isolation and characterization of antimicrobial natural products.
Undervisning
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Bachelorgradskurs i bioteknologi: Marin bioteknologi 1 (Bio-2606), Marin bioprospektering (Bio-2607), Prosjektoppgave i marin bioteknologi (Bio-2610)
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Mastergradskurs i Fiskehelse: Farmakologi (Bio-3602)
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Veiledning av master- og doktorgradsstudenter
