Bilde av Hegstad, Kristin
Bilde av Hegstad, Kristin
Institutt for medisinsk biologi kristin.hegstad@uit.no +4777646351 97593783 Her finner du meg

Kristin Hegstad


Professor II

Stillingsbeskrivelse

Bistilling som professor ved Forsningsgruppe for Vert-Mikrobe Interaksjoner ved Institutt for Medisinsk Biologi UiT

Hovedstilling som senior forsker ved Nasjonal kompetansetjeneste for påvisning av antibiotikaresistens (K-res) ved Avdeling for Mikrobiologi og Smittevern Universitetssykehuset Nord-Norge 


  • Theresa Wagner, Benjamin P Howden, Arnfinn Sundsfjord, Kristin Hegstad :
    Transiently silent acquired antimicrobial resistance: an emerging challenge in susceptibility testing
    Journal of Antimicrobial Chemotherapy 2023 ARKIV / DOI
  • Theresa Wagner, Jessin Janice, Marc Schluz, Susan Ballard, Anders da Silva, Geoffrey W Coombs m.fl.:
    Reversible vancomycin susceptibility within emerging ST1421 Enterococcus faecium strains is associated with rearranged vanA-gene clusters and increased vanA plasmid copy number
    International Journal of Antimicrobial Agents 2023 ARKIV / DOI
  • Theresa Maria Wagner, Felipe Romero-Saavedra, Diana Laverde, Mona Susan Johannessen, Johannes Hübner, Kristin Hegstad :
    Enterococcal Membrane Vesicles as Vaccine Candidates
    International Journal of Molecular Sciences 2023 ARKIV / DOI
  • Guido Werner, Natacha Couto, Edward J. Feil, Angela Novais, Kristin Hegstad, Benjamin P. Howden m.fl.:
    Taking hospital pathogen surveillance to the next level
    Microbial Genomics 2023 ARKIV / DOI
  • Jessin Janice, Theresa Maria Wagner, Karina Olsen, Joachim Hegstad, Kristin Hegstad :
    Emergence of vancomycin-resistant enterococci from vancomycin-susceptible enterococci in hospitalized patients under antimicrobial therapy
    Journal of Global Antimicrobial Resistance 2023 ARKIV / DOI
  • Mushtaq Talib Shawi al Rubaye, Jessin Janice, Jørgen Bjørnholt, Iren Høyland Löhr, Arnfinn Ståle Sundsfjord, Kristin Hegstad :
    The first vanE-type vancomycin resistant Enterococcus faecalis isolates in Norway – phenotypic and molecular characteristics
    Journal of Global Antimicrobial Resistance 2023 ARKIV / DOI
  • Amalie Von Barner Tvedegaard Heim, Jessin Janice, Jørgen Bjørnholt, Bjørn Tore Lunestad, Kristin Hegstad, Cecilie Smith Svanevik :
    Genomic insights into Enterococcus faecium isolates from marine bivalves highlight One Health concerns and healthcare linkages
    Microbial Genomics 2023 ARKIV / DOI
  • Mushtaq al Rubaye, Jessin Janice, Jørgen Vildershøj Bjørnholt, Oliver Kacelnik, Bjørg C. Haldorsen, Randi M. Nygaard m.fl.:
    The population structure of vancomycin-resistant and -susceptible Enterococcus faecium in a low-prevalence antimicrobial resistance setting is highly influenced by circulating global hospital-associated clones
    Microbial Genomics 19. desember 2023 ARKIV / FULLTEKST / DOI
  • Kristin Hegstad, Anna Kaarina Pöntinen, Jørgen Bjørnholt, Else Quist Paulsen, Arnfinn Ståle Sundsfjord :
    The first tigecycline resistant Enterococcus faecium in Norway was related to tigecycline exposure
    Journal of Global Antimicrobial Resistance 2023 ARKIV / DOI
  • Caillan Crowe-McAuliffe, Victoriia Murina, Kathryn Jane Turnbull, Susanne Huch, Marje Kasari, Hiraku Takada m.fl.:
    Structural basis for PoxtA-mediated resistance to phenicol and oxazolidinone antibiotics
    Nature Communications 2022 ARKIV / DOI
  • Sebastiaan J van Hal, Rob J L Willems, Theodore Gouliouris, Susan A Ballard, Teresa M Coque, Anette M Hammerum m.fl.:
    The interplay between community and hospital Enterococcus faecium clones within health-care settings: a genomic analysis
    Lancet Microbe 2022 ARKIV / DOI
  • Helene Johannessen, Inger Lill Anthonisen, Nermin Zecic, Kristin Hegstad, Trond Egil Ranheim, Dagfinn Skaare :
    Characterization and Fitness Cost of Tn7100, a Novel Integrative and Conjugative Element Conferring Multidrug Resistance in Haemophilus influenzae
    Frontiers in Microbiology 2022 ARKIV / DOI
  • Mushtaq T.S. Al-Rubaye, Jessin Janice, Jørgen Vildershøj Bjørnholt, Aleksandra Jakovljev, Maria Elisabeth Hultström, Arnfinn Sundsfjord m.fl.:
    Novel genomic islands and a new vanD-subtype in the first sporadic VanD-type vancomycin resistant enterococci in Norway
    PLOS ONE 2021 ARKIV / DOI
  • Tommi Mäklin, Teemu Kallonen, Jarno Alanko, Ørjan Samuelsen, Kristin Hegstad, Veli Mäkinen m.fl.:
    Bacterial genomic epidemiology with mixed samples
    Microbial Genomics 2021 ARKIV / DOI
  • Sebastiaan J. van Hal, Rob J.L. Willems, Theodore Gouliouris, Susan A. Ballard, Teresa M. Coque, Anette M. Hammerum m.fl.:
    The global dissemination of hospital clones of Enterococcus faecium
    Genome Medicine 2021 ARKIV / DOI
  • Bishnu Joshi, Bhupender Singh, Aftab Nadeem, Fatemeh Askarian, Sun Nyunt Wai, Mona Johannessen m.fl.:
    Transcriptome profiling of staphylococcus aureus associated extracellular vesicles reveals presence of small RNA-cargo
    Frontiers in Molecular Biosciences 13. januar 2021 ARKIV / DOI
  • Monika Kumaraswamy, Kamilla Wiull, Bishnu Joshi, George Sakoulas, Armin Kousha, Gustav Vaaje-Kolstad m.fl.:
    Bacterial membrane-derived vesicles attenuate vancomycin activity against methicillin-resistant staphylococcus aureus
    Microorganisms 2021 ARKIV / DOI
  • Theresa Wagner, Jessin Janice, Audun Sivertsen, Ingegerd Sjögren, Arnfinn Sundsfjord, Kristin Hegstad :
    Alternative vanHAX promoters and increased vanA-plasmid copy number resurrect silenced glycopeptide resistance in Enterococcus faecium
    Journal of Antimicrobial Chemotherapy 2020 ARKIV / DOI
  • Kristin Hegstad, Haima Mylvaganam, Jessin Janice, Ellen Haldis Josefsen, Audun Sivertsen, Dagfinn Skaare :
    Role of Horizontal Gene Transfer in the Development of Multidrug Resistance in Haemophilus influenzae
    mSphere 2020 ARKIV / FULLTEKST / DOI
  • Petter Elstrøm, Elisabeth Astrup, Kristin Hegstad, Ørjan Samuelsen, Hege Enger, Oliver Kacelnik :
    The fight to keep resistance at bay, epidemiology of carbapenemase producing organisms (CPOs), vancomycin resistant enterococci (VRE) and methicillin resistant Staphylococcus aureus (MRSA) in Norway, 2006-2017
    PLOS ONE 2019 ARKIV / DOI
  • Theresa Wagner, Felipe Romero-Saavedra, Diana Laverde, Mona Johannessen, Johannes Hübner, Kristin Hegstad :
    Enterococcal Membrane Vesicles as Vaccine Candidates
    2023
  • Theresa Wagner, Anna Kaarina Pöntinen, Carolin Kornelia Fenzel, Daniel Engi, Jessin Janice, Ana Almeida-Santos m.fl.:
    Competition between commensal Enterococcus faecium and Enterococcus lactis and clinical isolates of E. faecium
    2023
  • Ingeborg Mathiesen, Anna Kaarina Pöntinen, Mona Johannessen, Kristin Hegstad, Theresa Wagner :
    Characterization of Putative Virulence Factors in Enterococcus faecium
    2023
  • Carolin Kornelia Fenzel, Anna K. Pöntinen, Mona Johannessen, Kristin Hegstad, Theresa Wagner :
    Characterization of competition between commensal and clinical strains of Enterococcus faecium​
    2023
  • Jonathan Hira, Bhupender Singh, Theresa Maria Wagner, Kristin Hegstad, Mona Susan Johannessen, Christian Stephan Lentz :
    A high-throughput platform for phenotypic profiling of bacteria coupled to single cell-derived growth analysis
    2023
  • Theresa Maria Wagner, Jan Fredrik Frantzen, Kristin Hegstad :
    Utvikler potensiell vaksine mot antibiotikaresistent sykehusbakterie
    NTB 2023 FULLTEKST
  • Trygve Grønning, Kristin Hegstad, Theresa Maria Wagner :
    Ny forskning kan stoppe fryktet sykehus-bakterie
    NRK Troms og Finmark 2023 FULLTEKST
  • Espen Morten Viklem Eidum, Theresa Maria Wagner, Kristin Hegstad :
    Researchers develop potential vaccine against antibiotic-resistant enterococci
    EurekAlert! 2023 FULLTEKST
  • Jan Fredrik Frantzen, Theresa Maria Wagner, Kristin Hegstad :
    Utvikler potensiell vaksine mot hissig sykehusbakterie
    www.forskning.no 2023 FULLTEKST
  • Kristin Hegstad :
    Linezolidresistens hos enterokokker – mekanismer og diagnostikk
    2023
  • Theresa Maria Wagner, Anna Kaarina Pöntinen, Mushtaq T.S. AL Rubaye, Arnfinn Ståle Sundsfjord, Kristin Hegstad :
    Adaptive cell wall thickening in Enterococcus faecalis is associated with decreased vancomycin susceptibility
    Clinical Microbiology and Infection (CMI) 2023 DOI
  • Ingeborg Mathiesen, Theodor Anton Ross, Anna Kaarina Pöntinen, Einar Holsbø, Michael Kampffmeyer, Mona Johannessen m.fl.:
    Characterization of Putative Virulence Factors in Enterococcus faecium
    2023
  • Julie Kalveland, Kristin Hegstad, Torni Kristin Myrbakk :
    UNN-forskere oppdaget ny mekanisme for antibiotikaresistens
    18. november 2022 FULLTEKST
  • Amalie von BT Heim, Bjørn Tore Lunestad, Jessin Janice, Jørgen Bjørnholt, Kristin Hegstad, Cecilie Smith Svanevik :
    Enterococci in marine bivalves from Norway – where do they come from and should we be concerned?
    2022
  • Kristin Hegstad :
    Vancomycin variable resistant enterococci
    2022
  • Kristin Hegstad :
    Tigesyklinresistens hos enterokokker i Norge
    2022
  • Ingeborg Mathiesen, Mona Johannessen, Kristin Hegstad, Theresa Wagner :
    Characterisation of putative virulence factors in Enterococcus faecium
    2022
  • Ingeborg Mathiesen, Mona Johannessen, Kristin Hegstad, Theresa Wagner :
    Characterisation of putative virulence factors in Enterococcus faecium
    2022
  • Theodor Anton Ross, Anna Kaarina Pöntinen, Jessin Janice, Einar Holsbø, Jukka Corander, Kristin Hegstad m.fl.:
    Leveraging machine learning for finding novel putative virulence factors in Enterococcus faecium
    2022
  • Bjørg C Haldorsen, Erika Matuschek, Jenny Åhman, Gunnar Kahlmeter, Arnfinn Sundsfjord, Kristin Hegstad :
    Performance of the EUCAST disc diffusion method and gradient tests in detection of linezolid susceptibility in Enterococcus faecalis and Enterococcus faecium
    2021
  • Theresa Wagner, Kristin Hegstad :
    Transiently silenced acquired antimicrobial resistance – an increasing challenge in antimicrobial susceptibility testing
    2021
  • Theresa Wagner, Jessin Janice James Peter, Marc Schulz, Susan A. Ballard, Anders Goncalves da Silva, Geoffrey W Coombs m.fl.:
    Australian vancomycin variable E. faecium ST1421 revert to resistance by the use of an alternative vanHAX promoter and increased vanA-plasmid copy number
    2021
  • Theresa Wagner, Mona Johannessen, Kristin Hegstad :
    Towards a vaccine based on enterococcal membrane vesicles
    2020
  • Theresa Wagner, Clement Ajayi, Mona Johannessen, Kristin Hegstad, Gro Grimnes, Ingrid Hemmingsen :
    Brukermøte 2020
    2020
  • Theresa Wagner, Clement Ajayi, Kristin Hegstad, Mona Johannessen, Gro Grimnes, Ingrid Hemmingsen :
    Brukermøte 2019
    2019
  • Bishnu Joshi, Sun Nyunt Wai, Mona Johannessen, Kristin Hegstad :
    Extracellular vesicle -associated small RNA released by Staphylococcus aureus (MSSA476) grown under stress condition
    2019
  • Theresa Wagner, Mona Johannessen, Kristin Hegstad :
    Investigating the immune response towards enterococcal membrane vesicles
    2019
  • Theresa Wagner, Jessin Janice, Audun Sivertsen, Ingegerd Sjögren, Arnfinn Sundsfjord, Kristin Hegstad :
    The bag of tricks of vancomycin variable enterococci: an alternative constitutive vanHAX-promoter, varying copy numbers and transferable resistance
    2019
  • Mushtaq Talib Shawi Al-Rubaye, Jessin Janice, Iren Høyland Löhr, Arnfinn Sundsfjord, Kristin Hegstad :
    THE FIRST VANE VANCOMYCIN RESISTANT ENTEROCOCCUS FAECALIS IN NORWAY
    2019
  • Mushtaq Talib Shawi Al-Rubaye, Jessin Janice, Jørgen Vildershøj Bjørnholt, Oliver Kacelink, Biørg C. Haldorsen, Randi M. Nygaard m.fl.:
    POPULATION STRUCTURE OF THE NORWEGIAN VANCOMYCIN RESISTANT AND SENSITIVE ENTEROCOCCI 2010-2015
    2019

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    Forskningsinteresser

    Forskningsinteresser: Antimikrobiell resistens; Spredning av resistens - Mobile genetiske elementer og horisontal genoverføring - Mekanismer for antimikrobiell resistens - Deteksjon av antimikrobiell resistens - Nye virulens faktorer som target for å ufarliggjøre patogener - Membranvesikler

    Medlem av Senter for Nye Antibakterielle Strategier (CANS

    For publikasjoner se: https://orcid.org/0000-0002-1314-0497 


    Medlem i forskningsgruppe


    CV

    Utdanning

    • 2000: Dr. Scient. (PhD) i Medisinsk Mikrobiologi, Universitetet i Tromsø.
    • 1995: Cand. Scient. i Marin bioteknologi/mikrobiologi, Universitetet i Tromsø.

    Yrkespraksis

    • 2004-: Forsker, Kompetansesenter for påvisning av antibiotika resistens, Universitetssykehuset Nord-Norge.
    • 2017-: Professor II, Forskningsgruppe for Vert-mikrobe interaksjoner, Institutt for Medisinsk Biologi, UiT - Norges arktiske Universitet.
    • 2008-2010 + 2015-2017: Seksjonsleder/daglig leder, Kompetansesenter for påvisning av antibiotika resistens, Universitetssykehuset Nord-Norge.
    • 2006-2016: Førsteamanuensis II, Forskningsgruppe for Vert-Mikrobe Interasjoner, Universitetet i Tromsø.
    • 2002-2004: Post Doktor, Avdeling for Mikrobiologi og Virologi, Universitetet i Tromsø.
    • 2001-2002: Post Doktor, Unité des Agents Antibactériens, Institut Pasteur, Paris.