No picture, placeholder image
No picture, placeholder image
Institutt for farmasi orjan.samuelsen@uit.no

Ørjan Samuelsen


Professor


  • Marius Linkevicius, Rémy A Bonnin, Erik Alm, Olov Svartström, Petra Apfalter, Rainer Hartl m.fl.:
    Rapid cross-border emergence of NDM-5-producing Escherichia coli in the European Union/European Economic Area, 2012 to June 2022
    Eurosurveillance 2023 ARKIV / DOI
  • Sergio Arredondo Alonso, Rebecca Ashley Gladstone, Anna Kaarina Pöntinen, João Alves Gama, Anita C. Schürch, Val F. Lanza m.fl.:
    Mge-cluster: a reference-free approach for typing bacterial plasmids
    NAR Genomics and Bioinformatics 2023 ARKIV / DOI
  • Jessica K Calland, Kaisa Haukka, Stephen W Kpordze, Atanyiwoen Brusah, Marta Corbella, Cristina Merla m.fl.:
    Population structure and antimicrobial resistance among Klebsiella isolates sampled from human, animal, and environmental sources in Ghana: a cross-sectional genomic One Health study
    Lancet Microbe 2023 DOI
  • Oskar Ljungquist, Bjørg Haldorsen, Anna Kaarina Pöntinen, Jessin Janice, Ellen Haldis Josefsen, Petter Elstrøm m.fl.:
    Nationwide, population-based observational study of the molecular epidemiology and temporal trend of carbapenemase-producing Enterobacterales in Norway, 2015 to 2021
    Eurosurveillance 2023 ARKIV / DOI
  • Greta Petazzoni, Greta Bellinzona, Cristina Merla, Marta Corbella, Vincenzina Monzillo, Ørjan Samuelsen m.fl.:
    The COVID-19 Pandemic Sparked off a Large-Scale Outbreak of Carbapenem-Resistant Acinetobacter baumannii from the Endemic Strains at an Italian Hospital
    Microbiology spectrum 2023 ARKIV / DOI
  • Niclas Peter Raffelsberger, Dorota Julia Buczek, Kristian Svendsen, Lars Småbrekke, Anna Kaarina Pöntinen, Iren Høyland Löhr m.fl.:
    Community carriage of ESBL-producing Escherichia coli and Klebsiella pneumoniae: a cross-sectional study of risk factors and comparative genomics of carriage and clinical isolates
    mSphere 2023 ARKIV / DOI
  • Paul Christoffer Lindemann, Torunn Pedersen, Dorthea Hagen Oma, Jessin Janice, Fredrik Grøvan, Ghantous Milad Chedid m.fl.:
    Intraregional hospital outbreak of OXA-244-producing Escherichia coli ST38 in Norway, 2020
    Eurosurveillance 2023 ARKIV / DOI
  • Sergio Arredondo Alonso, George Blundell-Hunter, Zuyi Fu, Rebecca Ashley Gladstone, Alfred Fillol-Salom, Jessica Loraine m.fl.:
    Evolutionary and functional history of the Escherichia coli K1 capsule
    Nature Communications 2023 ARKIV / DOI
  • Pete Kinross, Carlo Gagliotti, Hanna Merk, Diamantis Plachouras, Dominique L. Monnet, Liselotte Diaz Högberg m.fl.:
    Large increase in bloodstream infections with carbapenem-resistant Acinetobacter species during the first 2 years of the COVID-19 pandemic, EU/EEA, 2020 and 2021
    Eurosurveillance 2022 DOI
  • Tommi Mäklin, Harry Arthur Frank Wright Thorpe, Anna Kaarina Pöntinen, Rebecca Ashley Gladstone, Yan Shao, Maiju Pesonen m.fl.:
    Strong pathogen competition in neonatal gut colonisation
    Nature Communications 2022 ARKIV / DOI
  • Kenneth Lindstedt, Dorota Julia Buczek, Torunn Annie Pedersen, Erik Hjerde, Niclas Peter Raffelsberger, Yutaka Suzuki m.fl.:
    Detection of Klebsiella pneumoniae human gut carriage: a comparison of culture, qPCR, and whole metagenomic sequencing methods
    Gut microbes 31. august 2022 ARKIV / DOI
  • Aleksandra Jakovljev, Jan Egil Afset, Kjersti Haugum, Harald Otto Steinum, Torunn Gresdal Rønning, Ørjan Samuelsen m.fl.:
    Phenotypic and genotypic characterisation of thymine auxotrophy in Escherichia coli isolated from a patient with recurrent bloodstream infection
    PLOS ONE 2022 ARKIV / DOI
  • Vidar Sørum, Emma Lu Øynes, Anna Sollied Møller, Klaus Harms, Ørjan Samuelsen, Nicole L. Podnecky m.fl.:
    Evolutionary Instability of Collateral Susceptibility Networks in Ciprofloxacin-Resistant Clinical Escherichia coli Strains
    mBio 2022 ARKIV / DOI
  • Tommi Mäklin, Teemu Kallonen, Jarno Alanko, Ørjan Samuelsen, Kristin Hegstad, Veli Mäkinen m.fl.:
    Bacterial genomic epidemiology with mixed samples
    Microbial Genomics 2021 ARKIV / DOI
  • Jonina Gudmundsdottir, Elizabeth G. Aarag Fredheim, Catharina I.M. Koumans, Joachim Hegstad, Po-Cheng Tang, Dan I. Andersson m.fl.:
    The chemotherapeutic drug methotrexate selects for antibiotic resistance
    EBioMedicine 2021 ARKIV / DOI
  • Jessin Janice, Nicholas Agyepong, Alex Owusu-Ofori, Usha Govinden, Sabiha Essack, Ørjan Samuelsen m.fl.:
    Carbapenem resistance determinants acquired through novel chromosomal integrations in extensively drug-resistant pseudomonas aeruginosa
    Antimicrobial Agents and Chemotherapy 2021 ARKIV / DOI
  • Rebecca Ashley Gladstone, Alan McNally, Anna Kaarina Pöntinen, Gerry Tonkin-Hill, John A. Lees, Kusti Onni Skytén m.fl.:
    Emergence and dissemination of antimicrobial resistance in Escherichia coli causing bloodstream infections in Norway in 2002–17: a nationwide, longitudinal, microbial population genomic study
    Lancet Microbe 29. juni 2021 FULLTEKST / ARKIV / DOI
  • Niclas Peter Raffelsberger, Marit Andrea Klokkhammer Hetland, Kristian Svendsen, Lars Småbrekke, Iren Høyland Löhr, Lotte Andreassen m.fl.:
    Gastrointestinal carriage of Klebsiella pneumoniae in a general adult population: a cross-sectional study of risk factors and bacterial genomic diversity
    Gut microbes 2021 ARKIV / DOI
  • Julia Kloos, João A Gama, Joachim Hegstad, Ørjan Samuelsen, Pål J Johnsen :
    Piggybacking on Niche Adaptation Improves the Maintenance of Multidrug-Resistance Plasmids
    Molecular Biology and Evolution (MBE) 2021 ARKIV / DOI
  • Sergio Arredondo Alonso, Anna Kaarina Pöntinen, Francois Pierre Alexandre Cleon, Rebecca Ashley Gladstone, Anita C. Schürch, Pål Jarle Johnsen m.fl.:
    A high-throughput multiplexing and selection strategy to complete bacterial genomes
    GigaScience 2021 ARKIV / DOI
  • Supathep Tansirichaiya, Richard N. Goodman, Xinyu Guo, Issra Bulgasim, Ørjan Samuelsen, Mohammed Al-Haroni m.fl.:
    Intracellular Transposition and Capture of Mobile Genetic Elements following Intercellular Conjugation of Multidrug Resistance Conjugative Plasmids from Clinical Enterobacteriaceae Isolates
    Microbiology spectrum 2021 ARKIV / DOI
  • Aasmund Fostervold, Marit Andrea Klokkhammer Hetland, Ragna-Johanne Bakksjø, Eva Bernhoff, Kathryn E. Holt, Ørjan Samuelsen m.fl.:
    A nationwide genomic study of clinical Klebsiella pneumoniae in Norway 2001–15: introduction and spread of ESBLs facilitated by clonal groups CG15 and CG307
    Journal of Antimicrobial Chemotherapy 2021 ARKIV / DOI
  • Christopher Frøhlich, João Alves Gama, Klaus Harms, Viivi H. A. Hirvonen, Bjarte Aarmo Lund, Marc W. van der Kamp m.fl.:
    Cryptic β-Lactamase Evolution Is Driven by Low β-Lactam Concentrations
    mSphere 2021 ARKIV / DOI
  • Catherine Ludden, Felix Lötsch, Erik Alm, Narender Kumar, Karin Johansson, Barbara Albiger m.fl.:
    Cross-border spread of blaNDM-1- and blaOXA-48-positive Klebsiella pneumoniae: a European collaborative analysis of whole genome sequencing and epidemiological data, 2014 to 2019
    Eurosurveillance 2020 ARKIV / DOI
  • Joao Pedro Alves Gama, Julia Maria Kloos, Pål Jarle Johnsen, Ørjan Samuelsen :
    Host dependent maintenance of a blaNDM-1-encoding plasmid in clinical Escherichia coli isolates
    Scientific Reports 2020 ARKIV / DOI
  • Julia Maria Kloos, Joao Pedro Alves Gama, Pål Jarle Johnsen, Ørjan Samuelsen :
    Host dependent maintenance of a blaNDM-1-encoding plasmid in clinical Escherichia coli isolates
    Scientific Reports 2020 DOI
  • Torunn Annie Pedersen, Marit Gjerde Tellevik, Øyvind Kommedal, Paul Christoffer Lindemann, Sabrina John Moyo, Jessin Janice James Peter m.fl.:
    Horizontal plasmid transfer among klebsiella pneumoniae isolates is the key factor for dissemination of extended-spectrum β-lactamases among children in Tanzania
    mSphere 15. juli 2020 ARKIV / DOI
  • Hanna-Kirsti S. Leiros, Ane Molden Thomassen, Ørjan Samuelsen, Carl-Fredrik Flach, Stathis D. Kotsakis, Joakim Larsson :
    Structural insights into the enhanced carbapenemase efficiency of OXA-655 compared to OXA-10
    FEBS Open Bio 2020 ARKIV / FULLTEKST / DOI
  • Christopher Frøhlich, Vidar Sørum, Sandra Huber, Ørjan Samuelsen, Fanny Berglund, Erik Kristiansson m.fl.:
    Structural and biochemical characterization of the environmental MBLs MYO-1, ECV-1 and SHD-1
    Journal of Antimicrobial Chemotherapy 2020 ARKIV / DOI
  • Ørjan Samuelsen, Ove Alexander Høgmoen Åstrand, Christopher Frøhlich, Adam Heikal, Susann Skagseth, Trine Josefine Olsen Carlsen m.fl.:
    ZN148 Is a Modular Synthetic Metallo-beta-Lactamase Inhibitor That Reverses Carbapenem Resistance in Gram-Negative Pathogens In Vivo
    Antimicrobial Agents and Chemotherapy 2020 ARKIV / DATA / DOI
  • Christopher Frøhlich, Vidar Sørum, Ane Molden Thomassen, Pål Jarle Johnsen, Hanna-Kirsti S. Leiros, Ørjan Samuelsen :
    OXA-48-Mediated Ceftazidime-Avibactam Resistance Is Associated with Evolutionary Trade-Offs
    mSphere 2019 ARKIV / DOI
  • Petter Elstrøm, Elisabeth Astrup, Kristin Hegstad, Ørjan Samuelsen, Hege Enger, Oliver Kacelnik :
    The fight to keep resistance at bay, epidemiology of carbapenemase producing organisms (CPOs), vancomycin resistant enterococci (VRE) and methicillin resistant Staphylococcus aureus (MRSA) in Norway, 2006-2017
    PLOS ONE 2019 ARKIV / DOI
  • Anthony Prandina, Sylvie Radix, Marc Le Borgne, Lars Petter Jordheim, Zineb Bousfiha, Christopher Fröhlich m.fl.:
    Synthesis and biological evaluation of new dipicolylamine zinc chelators as metallo-β-lactamase inhibitors
    Tetrahedron 2019 ARKIV / DOI
  • Geir Kildahl-Andersen, Christian Schnaars, Anthony Prandina, Sylvie Radix, Marc Le Borgne, Lars Petter Jordheim m.fl.:
    Synthesis and biological evaluation of zinc chelating compounds as metallo-β-lactamase inhibitors
    MedChemComm 2019 DOI
  • Ilya Nikolaevich Zykov, Niels Frimodt-Møller, Lars Småbrekke, Arnfinn Sundsfjord, Ørjan Samuelsen :
    Efficacy of mecillinam against clinical multidrug-resistant Escherichia coli in a murine urinary tract infection model
    International Journal of Antimicrobial Agents 02. november 2019 ARKIV / DOI
  • Nicole L. Podnecky, Elizabeth Aarag, Julia Maria Kloos, Vidar Sørum, Raul Primicerio, Adam Paul Roberts m.fl.:
    Conserved collateral antibiotic susceptibility networks in diverse clinical strains of Escherichia coli.
    Nature Communications 10. september 2018 ARKIV / DOI
  • Marit Hetland, Mia Angelique Winkler, Thomas D Stanton, Ryan R. Wick, Margaret MC Lam, Aasmund Fostervold m.fl.:
    Klebsiella pneumoniae ecology and antimicrobial resistance in a One Health perspective
    2023
  • Julia Maria Kloos, Lea Jänisch, Anna Kaarina Pöntinen, Ørjan Samuelsen, Pål Jarle Johnsen, Jukka Corander m.fl.:
    Different metabolic proficiency among dominant ExPEC lineages
    2022
  • Christopher Frøhlich, Vidar Sørum, Nobuhiko Tokuriki, Ørjan Samuelsen :
    Evolution of ß-lactamase mediated cefiderocol resistance
    2022
  • Pål Jarle Johnsen, Elizabeth G Aarag Fredheim, Ørjan Samuelsen, Klaus Harms :
    The role of drugs used in cancer chemotherapy as drivers of antibiotic resistance evolution in Escherichia coli
    2022
  • Rebecca Ashley Gladstone, Alan McNally, Pål Jarle Johnsen, Ørjan Samuelsen, Jukka Corander :
    Antimicrobial resistance genes and clonal success in Escherichia coli isolates causing bloodstream infection – Authors’ reply
    Lancet Microbe 2021 DOI
  • Bjørg Haldorsen, Jessin Janice, Ørjan Samuelsen :
    Evaluation of the Amplex eazyplex® SuperBug Acineto test for detection of acquired OXA and NDM carbapenemases in Acinetobacter spp.
    Journal of Global Antimicrobial Resistance 2021 DOI
  • João Alves Gama, Julia Maria Kloos, Joachim Hegstad, Ørjan Samuelsen, Pål Jarle Johnsen :
    Plasmid cost alleviation as a consequence of niche-adaptation
    2021
  • Julia Maria Kloos, João Alves Gama, Joachim Hegstad, Ørjan Samuelsen, Pål Jarle Johnsen :
    Plasmid Cost Alleviation By Hitchhiking On Niche-adaptation
    2021
  • Julia Maria Kloos, Joao Pedro Alves Gama, Joachim Hegstad, Ørjan Samuelsen, Pål Jarle Johnsen :
    E. coli Niche Adaptation Improves Plasmid Maintenance
    2021
  • Christopher Frøhlich, Hanna-Kirsti S. Leiros, Pål Jarle Johnsen, Ørjan Samuelsen :
    Sub-inhibitory concentrations of ceftazidime drive evolution of the OXA-48 carbapenemase
    2019
  • Christopher Frøhlich, Pål Jarle Johnsen, Hanna-Kirsti Schrøder Leiros, Ørjan Samuelsen :
    Evolution of OXA-48 under sub-MIC conditions
    2019
  • Vidar Sørum, Anna Sollied Møller, Pål Jarle Johnsen, Ørjan Samuelsen, Sören Abel, Nicole L. Podnecky :
    Evolutionary stability of collateral effects in ciprofloxacin resistant clinical Escherichia coli strains
    2019
  • Vidar Sørum, Anna Sollied Møller, Sören Abel, Ørjan Samuelsen, Nicole L. Podnecky, Pål Jarle Johnsen :
    Evolutionary stability of collateral effects in ciprofloxacin resistant clinical Escherichia coli strains
    2019
  • Vidar Sørum, Emma Lu Øynes, Anna Møller, Nicole L. Podnecky, Sören Abel, Ørjan Samuelsen m.fl.:
    Evolutionary stability of collateral susceptibility networks in clinical Escherichia coli strains
    2019

  • De 50 siste resultatene fra Cristin vises på siden. Se alle arbeider i Cristin her →


    Forskningsinteresser

    Through my positions as Professor II at the Microbial Pharmacology and Population Biology Research Group and as senior scientist at the Norwegian National Advisory Unit on Detection of Antimicrobial Resistance my research focuses broadly on the following topics molecular epidemiology, evaluation of diagnostic methods, biochemical and structural characterization of β-lactamases, development of β-lactamase inhibitors and the evolutionary aspects and transmission dynamics of resistance plasmids.