Samuelsen, Ørjan

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  3. Ørjan Samuelsen

Through my positions as Professor II at the Microbial Pharmacology and Population Biology Research Group and as senior scientist at the Norwegian National Advisory Unit on Detection of Antimicrobial Resistance my research focuses broadly on the following topics molecular epidemiology, evaluation of diagnostic methods, biochemical and structural characterization of β-lactamases, development of β-lactamase inhibitors and the evolutionary aspects and transmission dynamics of resistance plasmids. 

  • Samuelsen, Ørjan; Toleman, MA; Hasseltvedt, Viggo H; Fuursted, K; Leegaard, Truls Michael; Walsh, TR; Sundsfjord, Arnfinn; Giske, CG. Molecular characterization of VIM-producing Klebsiella pneumoniae from Scandinavia reveals genetic relatedness with international clonal complexes encoding transferable multidrug resistance. Clinical Microbiology and Infection 2011; Volum 17 (12). ISSN 1198-743X.s 1811 - 1816.s doi: 10.1111/j.1469-0691.2011.03532.x.
  • Saradhi, Pardha; Leiros, Hanna-Kirsti S.; Ahmad, Rafi; Spencer, James; Leiros, Ingar; Walsh, Timothy R.; Sundsfjord, Arnfinn; Samuelsen, Ørjan. Structural and Computational Investigations of VIM-7: Insights into the Substrate Specificity of VIM Metallo-beta-Lactamases. Journal of Molecular Biology 2011; Volum 411 (1). ISSN 0022-2836.s 174 - 189.s doi: 10.1016/j.jmb.2011.05.035.
  • Karah, Nabil; Haldorsen, Bjørg; Hegstad, Kristin; Simonsen, Gunnar Skov; Sundsfjord, Arnfinn; Samuelsen, Ørjan. Species identification and molecular characterization of Acinetobacter spp. blood culture isolates from Norway. Journal of Antimicrobial Chemotherapy 2011; Volum 66 (4). ISSN 0305-7453.s 738 - 744.s doi: 10.1093/jac/dkq521.
  • Vading, M; Samuelsen, Ørjan; Haldorsen, Bjørg; Sundsfjord, Arnfinn; Giske, C.G.. Comparison of disk diffusion, Etest and VITEK2 for detection of carbapenemase-producing Klebsiella pneumoniae with the EUCAST and CLSI breakpoint systems. Clinical Microbiology and Infection 2011; Volum 17 (5). ISSN 1198-743X.s 668 - 674.s doi: 10.1111/j.1469-0691.2010.03299.x.
  • Samuelsen, Ørjan; Toleman, MA; Sundsfjord, Arnfinn; Rydberg, Johan; Leegaard, Truls Michael; Walder, M; Lia, Astrid; Ranheim, Trond Egil; Rajendra, Y; Hermansen, Nils Olav; Walsh, TR; Giske, CG. Molecular Epidemiology of Metallo-beta-Lactamase-Producing Pseudomonas aeruginosa Isolates from Norway and Sweden Shows Import of International Clones and Local Clonal Expansion. Antimicrobial Agents and Chemotherapy 2010; Volum 54 (1). ISSN 0066-4804.s 346 - 352.s doi: 10.1128/AAC.00824-09.
  • Samuelsen, Ørjan; Naseer, Umaer; Tofteland, Ståle; Skutlaberg, Dag Harald; Onken, Annette; Hjetland, Reidar; Sundsfjord, Arnfinn; Giske, Christian G.. Emergence of clonally related Klebsiella pneumoniae isolates of sequence type 258 producing plasmid-mediated KPC carbapenemase in Norway and Sweden. Journal of Antimicrobial Chemotherapy 2009; Volum 63 (4). ISSN 0305-7453.s 654 - 658.s doi: 10.1093/jac/dkp018.
  • Samuelsen, Ørjan; Åstrand, Ove Alexander Høgmoen; Frøhlich, Christopher; Heikal, Adam; Skagseth, Susann; Carlsen, Trine Josefine Olsen; Leiros, Hanna-Kirsti S.; Bayer, Annette; Schnaars, Christian; Kildahl-andersen, Geir; Lauksund, Silje; Finke, Sarah; Huber, Sandra; Gjøen, Tor; Andresen, Adriana Magalhaes Santos; Økstad, Ole Andreas; Rongved, Pål. ZN148 Is a Modular Synthetic Metallo-beta-Lactamase Inhibitor That Reverses Carbapenem Resistance in Gram-Negative Pathogens In Vivo. (data) Antimicrobial Agents and Chemotherapy 2020. ISSN 0066-4804.s doi: 10.1128/AAC.02415-19.

  • Kildahl-Andersen, Geir; Schnaars, Christian; Prandina, Anthony; Radix, Sylvie; Le Borgne, Marc; Jordheim, Lars Petter; Gjøen, Tor; Andresen, Adriana Magalhaes Santos; Lauksund, Silje; Fröhlich, Christopher; Samuelsen, Ørjan; Rongved, Pål; Åstrand, Ove Alexander Høgmoen. Synthesis and biological evaluation of zinc chelating compounds as metallo-β-lactamase inhibitors. MedChemComm 2019; Volum 10 (4). ISSN 2040-2503.s 528 - 537.s doi: 10.1039/c8md00578h.

  • Zykov, Ilya Nikolaevich; Frimodt-Møller, Niels; Småbrekke, Lars; Sundsfjord, Arnfinn; Samuelsen, Ørjan. Efficacy of mecillinam against clinical multidrug-resistant Escherichia coli in a murine urinary tract infection model. International Journal of Antimicrobial Agents 2019; Volum 55 (2). ISSN 0924-8579.s doi: 10.1016/j.ijantimicag.2019.11.008.

  • Elstrøm, Petter; Astrup, Elisabeth; Hegstad, Kristin; Samuelsen, Ørjan; Enger, Hege; Kacelnik, Oliver. The fight to keep resistance at bay, epidemiology of carbapenemase producing organisms (CPOs), vancomycin resistant enterococci (VRE) and methicillin resistant Staphylococcus aureus (MRSA) in Norway, 2006-2017. PLOS ONE 2019; Volum 14:e0211741 (2). ISSN 1932-6203.s 1 - 17.s doi: 10.1371/journal.pone.0211741.

  • Frøhlich, Christopher; Sørum, Vidar; Thomassen, Ane Molden; Johnsen, Pål Jarle; Leiros, Hanna-Kirsti S.; Samuelsen, Ørjan. OXA-48-Mediated Ceftazidime-Avibactam Resistance Is Associated with Evolutionary Trade-Offs. mSphere 2019; Volum 4 (2). ISSN 2379-5042.s doi: 10.1128/mSphere.00024-19.

  • Prandina, Anthony; Radix, Sylvie; Le Borgne, Marc; Jordheim, Lars Petter; Bousfiha, Zineb; Fröhlich, Christopher; Leiros, Hanna-Kirsti S.; Samuelsen, Ørjan; Frøvold, Espen; Rongved, Pål; Åstrand, Ove Alexander Høgmoen. Synthesis and biological evaluation of new dipicolylamine zinc chelators as metallo-β-lactamase inhibitors. Tetrahedron 2019; Volum 75 (11). ISSN 0040-4020.s 1525 - 1540.s doi: 10.1016/j.tet.2019.02.004.

  • Samuelsen, Ørjan; Hansen, Frank; Aasnæs, Bettina; Hasman, Henrik; Lund, Bjarte Aarmo; Leiros, Hanna-Kirsti S.; Lilje, Berit; James Peter, Jessin Janice; Jakobsen, Lotte; Littauer, Pia; Søes, Lillian M; Holzknecht, Barbara J.; Andersen, Leif P; Stegger, Marc; Andersen, Paal S.; Hammerum, Anette M.. Dissemination and Characteristics of a Novel Plasmid-Encoded Carbapenem-Hydrolyzing Class D β-Lactamase, OXA-436, Found in Isolates from Four Patients at Six Different Hospitals in Denmark. Antimicrobial Agents and Chemotherapy 2018; Volum 62 (1). ISSN 0066-4804.s doi: 10.1128/AAC.01260-17.

  • Taiaroa, George; Samuelsen, Ørjan; Kristensen, Tom; Økstad, Ole Andreas; Heikal, Adam. Complete Genome Sequence of Pseudomonas aeruginosa K34-7, a Carbapenem-Resistant Isolate of the High-Risk Sequence Type 233. Microbiology Resource Announcements (MRA) 2018; Volum 7 (4). ISSN 2169-8287.s 1 - 2.s doi: 10.1128/MRA.00886-18.

  • Roer, Louise; Overballe-Petersen, Søren; Hansen, Frank; Schønning, Kristian; Wang, Mikala; Røder, Bent L; Hansen,, Dennis S; Justesen, Ulrik S; Andersen, Leif P; Fulgsang-Damgaard, David; Hopkins, Katie L; Woodford, Neil; Falgenhauer, Linda; Chakraborty, Trinad; Samuelsen, Ørjan; Sjöström, Karin; Johannesen, Thor B; Ng, Kim; Nielsen, Jens; Ethelberg, Steen; Stegger, Marc; Hammerum, Anette M.; Hasman, Henrik. Escherichia coli Sequence Type 410 Is Causing New International High-Risk Clones. mSphere 2018; Volum 3 (4). ISSN 2379-5042.s doi: 10.1128/mSphere.00337-18.

  • Schnaars, Christian; kildahl-Andersen, Geir; Prandina, Anthony; Popal, Roya; Radix, Sylvie; Le Borgne, Marc; Gjøen, Tor; Andresen, Adriana Magalhaes Santos; Heikal, Adam; Økstad, Ole Andreas Løchen; Fröhlich, Christopher; Samuelsen, Ørjan; Lauksund, Silje; Jordheim, Lars Petter; Rongved, Pål; Åstrand, Ove Alexander Høgmoen. Synthesis and preclinical evaluation of TPA-based zinc chelators as metallo-β-lactamase inhibitors. ACS Infectious Diseases 2018; Volum 4 (9). ISSN 2373-8227.s 1407 - 1422.s doi: 10.1021/acsinfecdis.8b00137.

  • Podnecky, Nicole L.; Aarag, Elizabeth; Kloos, Julia Maria; Sørum, Vidar; Primicerio, Raul; Roberts, Adam Paul; Rozen, Daniel E.; Samuelsen, Ørjan; Johnsen, Pål Jarle. Conserved collateral antibiotic susceptibility networks in diverse clinical strains of Escherichia coli.. Nature Communications 2018; Volum 9:3673. ISSN 2041-1723.s 1 - 11.s doi: 10.1038/s41467-018-06143-y.

  • Haldorsen, Bjørg; Giske, Christian G; Hansen, Dennis S; Helgason, Kristjan Orri; Kahlmeter, Gunnar; Löhr, Iren Høyland; Matuschek, Erika; Österblad, Monica; Rantakokko-Jalava, Kaisu; Wang, Mikala; Småbrekke, Lars; Samuelsen, Ørjan; Sundsfjord, Arnfinn. Performance of the EUCAST disc diffusion method and two MIC methods in detection of Enterobacteriaceae with reduced susceptibility to meropenem: the NordicAST CPE study.. Journal of Antimicrobial Chemotherapy 2018; Volum 73 (10). ISSN 0305-7453.s 2738 - 2747.s doi: 10.1093/jac/dky276.

  • Pedersen, Torunn Annie; Sekyere, John Osei; Govinden, Usha; Moodley, Krishnee; Sivertsen, Audun; Samuelsen, Ørjan; Essack, Sabiha Yusuk; Sundsfjord, Arnfinn. Spread of plasmid-encoded NDM-1 and GES-5 carbapenemases among extensively drug-resistant and pandrug-resistant clinical enterobacteriaceae in durban, South Africa. Antimicrobial Agents and Chemotherapy 2018; Volum 62 (5). ISSN 0066-4804.s doi: 10.1128/AAC.02178-17.

  • Zykov, Ilya Nikolaevich; Samuelsen, Ørjan; Jakobsen, Lotte; Småbrekke, Lars; Andersson, Dan I.; Sundsfjord, Arnfinn; Frimodt-Møller, Niels. Pharmacokinetics and pharmacodynamics of fosfomycin and its activity against extended-spectrum-lactamase-, plasmid-mediated AmpC-, and carbapenemase-producing escherichia coli in a murine urinary tract infection model. Antimicrobial Agents and Chemotherapy 2018; Volum 62 (6). ISSN 0066-4804.s doi: 10.1128/AAC.02560-17.

  • Rapp, Ellionor; Samuelsen, Ørjan; Sundqvist, Martin. Detection of carbapenemases with a newly developed commercial assay using Matrix Assisted Laser Desorption Ionization-Time of Flight. Journal of Microbiological Methods 2018; Volum 146. ISSN 0167-7012.s 37 - 39.s doi: 10.1016/j.mimet.2018.01.008.

  • Berg, Einar Sverre; Wester, Astrid Lousie; Ahrenfeldt, J; Mo, Solveig Sølverød; Slettemeås, Jannice Schau; Steinbakk, Martin; Samuelsen, Ørjan; Grude, Nils; Simonsen, Gunnar Skov; Löhr, Iren Høyland; Jørgensen, Silje; Tofteland, Ståle; Lund, O.; Dahle, Ulf R; Sunde, Marianne. Norwegian patients and retail chicken meat share cephalosporin-resistant Escherichia coli and IncK/blaCMY-2 resistance plasmids. Clinical Microbiology and Infection 2017; Volum 23 (6). ISSN 1198-743X.s 407.e9 - 407.e15.s doi: 10.1016/j.cmi.2016.12.035.

  • Samuelsen, Ørjan; Overballe-Petersen, Søren; Bjørnholt, Jørgen; Brisse, Sylvain; Doumith, Michel; Woodford, Neil; Hopkins, Katie L.; Aasnæs, Bettina; Haldorsen, Bjørg; Sundsfjord, Arnfinn. Molecular and epidemiological characterization of carbapenemase-producing Enterobacteriaceae in Norway, 2007 to 2014. (fulltekst) PLOS ONE 2017; Volum 12 (11). ISSN 1932-6203.s doi: 10.1371/journal.pone.0187832.

  • Knudsen, Per Kristian; Brandtzæg, Petter; Høiby, Ernst Arne; Bohlin, Jon; Samuelsen, Ørjan; Steinbakk, Martin; Abrahamsen, Tore G; Müller, Fredrik; Gammelsrud, Karianne Wiger. Impact of extensive antibiotic treatment on faecal carriage of antibiotic-resistant enterobacteria in children in a low resistance prevalence setting. (fulltekst) PLOS ONE 2017; Volum 12 (11). ISSN 1932-6203.s doi: 10.1371/journal.pone.0187618.

  • Skagseth, Susann; Christopeit, Tony; Akhter, Sundus; Bayer, Annette; Samuelsen, Ørjan; Leiros, Hanna-Kirsti S.. Structural insights into TMB-1 and the role of residues 119 and 228 in substrate and inhibitor binding. Antimicrobial Agents and Chemotherapy 2017; Volum 61:e02602-16 (8). ISSN 0066-4804.s 1 - 19.s doi: 10.1128/AAC.02602-16.

  • Charnock, Colin; Samuelsen, Ørjan; Nordlie, Anne-Lise; Hjeltnes, Bjarne. Use of a Commercially Available Microarray to Characterize Antibiotic-Resistant Clinical Isolates of Klebsiella pneumoniae. Current Microbiology 2017. ISSN 0343-8651.s 1 - 10.s doi: 10.1007/s00284-017-1361-4.

  • Ellington, Matthew J.; Ekelund, Oskar; Aarestrup, Frank Møller; Cantón, Rafael; Doumith, Michel; Giske, Christian G.; Grundman, Hajo; Hasman, Henrik; Holden, Matthew T.G.; Hopkins, Katie L.; Iredell, Jonathan R.; Kahlmeter, Gunnar; Köser, Claudio U.; MacGowan, Alasdair Peter; Mevius, Dik; Mulvey, Michael Richard; Naas, Thierry P.; Peto, Tim E.; Rolain, Jean-Marc; Samuelsen, Ørjan; Woodford, Neil. The role of whole genome sequencing in antimicrobial susceptibility testing of bacteria: report from the EUCAST Subcommittee. Clinical Microbiology and Infection 2017; Volum 23 (1). ISSN 1198-743X.s 2 - 22.s doi: 10.1016/j.cmi.2016.11.012.

  • Skagseth, Susann; Akhter, Sundus; Paulsen, Marianne H.; Zeeshan, Muhammad; Lauksund, Silje; Samuelsen, Ørjan; Leiros, Hanna-Kirsti S.; Bayer, Annette. Metallo-β-lactamase inhibitors by bioisosteric replacement: preparation, activity and binding. European Journal of Medicinal Chemistry 2017; Volum 135. ISSN 0223-5234.s 159 - 173.s doi: 10.1016/j.ejmech.2017.04.035.

  • Skagseth, Susann; Carlsen, Trine Josefine Olsen; Bjerga, Gro Elin Kjæreng; Spencer, James; Samuelsen, Ørjan; Leiros, Hanna-Kirsti S.. Role of residues W228 and Y233 in the structure and activity of metallo-β-lactamase GIM-1. Antimicrobial Agents and Chemotherapy 2016; Volum 60 (2). ISSN 0066-4804.s 990 - 1002.s doi: 10.1128/AAC.02017-15.

  • Di Luca, Maria Chiara; Sørum, Vidar; Starikova, Irina; Kloos, Julia Maria; Hülter, Nils Fredrik; Naseer, Mohammed Umaer; Johnsen, Pål Jarle; Samuelsen, Ørjan. Low biological cost of carbapenemase-encoding plasmids following transfer from Klebsiella pneumoniae to Escherichia coli. Journal of Antimicrobial Chemotherapy 2016; Volum 72 (1). ISSN 0305-7453.s 85 - 89.s doi: 10.1093/jac/dkw350.

  • Zykov, Ilya Nikolaevich; Sundsfjord, Arnfinn; Småbrekke, Lars; Samuelsen, Ørjan. The antimicrobial activity of mecillinam, nitrofurantoin, temocillin and fosfomycin and comparative analysis of resistance patterns in a nationwide collection of ESBL-producing Escherichia coli in Norway 2010–2011. Infectious Diseases 2015; Volum 48 (2). ISSN 2374-4235.s 99 - 107.s doi: 10.3109/23744235.2015.1087648.

  • Karah, Nabil; Samuelsen, Ørjan; Zarrilli, Raffaele; Sahl, Jason W.; Wai, Sun Nyunt; Uhlin, Bernt Eric. CRISPR-cas subtype I-Fb in acinetobacter baumannii: Evolution and utilization for strain subtyping. PLOS ONE 2015; Volum 10 (2). ISSN 1932-6203.s doi: 10.1371/journal.pone.0118205.

  • Leiros, Hanna-Kirsti S.; Edvardsen, Kine Susann Waade; Bjerga, Gro Elin Kjæreng; Samuelsen, Ørjan. Structural and biochemical characterization of VIM-26 shows that Leu224 has implications for the substrate specificity of VIM metallo-β-lactamases. The FEBS Journal 2015; Volum 282 (6). ISSN 1742-464X.s 1031 - 1042.s doi: 10.1111/febs.13200.

  • Moyo, Sabrina John; Haldorsen, Bjørg; Aboud, Said; Blomberg, Bjørn; Maselle, Samuel Y; Sundsfjord, Arnfinn; Langeland, Nina; Samuelsen, Ørjan. Identification of VIM-2-producing Pseudomonas aeruginosa from Tanzania is associated with sequence types 244 and 640 and the location of blaVIM-2 in a TniC integron. Antimicrobial Agents and Chemotherapy 2014; Volum 59 (1). ISSN 0066-4804.s 682 - 685.s doi: 10.1128/AAC.01436-13.

  • Haldorsen, Bjørg; Simonsen, Gunnar Skov; Sundsfjord, Arnfinn; Samuelsen, Ørjan. Increased prevalence of aminoglycoside resistance in clinical isolates of Escherichia coli and Klebsiella spp. in Norway is associated with the acquisition of AAC(3)-II and AAC(6')-Ib. Diagnostic microbiology and infectious disease 2014; Volum 78 (1). ISSN 0732-8893.s 66 - 69.s doi: 10.1016/j.diagmicrobio.2013.10.001.

  • Leiros, Hanna-Kirsti S.; Skagseth, Susann; Edvardsen, Kine Susann Waade; Lorentzen, Marit Sjo; Bjerga, Gro Elin Kjæreng; Leiros, Ingar; Samuelsen, Ørjan. His224 alters the R2 drug binding site and Phe218 influences the catalytic efficiency of the metallo-β-lactamase VIM-7. Antimicrobial Agents and Chemotherapy 2014; Volum 58 (8). ISSN 0066-4804.s 4826 - 4836.s doi: 10.1128/AAC.02735-13.

  • Jørgensen, Silje Bakken; Samuelsen, Ørjan; Sundsfjord, Arnfinn; Bhatti, Sidra Ahmad; Jørgensen, Ingvild Aalberg; Sivapathasundaram, Thusanth; Leegaard, Truls Michael. High prevalence of faecal carriage of ESBL-producing Enterobacteriaceae in Norwegian patients with gastroenteritis. Scandinavian Journal of Infectious Diseases 2014; Volum 46 (6). ISSN 0036-5548.s 462 - 465.s doi: 10.3109/00365548.2014.896031.

  • Tofteland, Ståle; Naseer, Mohammed Umaer; Lislevand, Jan Helge; Sundsfjord, Arnfinn; Samuelsen, Ørjan. A Long-Term Low-Frequency Hospital Outbreak of KPC-Producing Klebsiella pneumoniae Involving Intergenus Plasmid Diffusion and a Persisting Environmental Reservoir. PLOS ONE 2013; Volum 8 (3). ISSN 1932-6203.s doi: 10.1371/journal.pone.0059015.

  • Nijhuis, Roel; Samuelsen, Ørjan; Savelkoul, Paul; van Zwet, Anton. Evaluation of a new real-time PCR assay (Check-Direct CPE) for rapid detection of KPC, OXA-48, VIM, and NDM carbapenemases using spiked rectal swabs. Diagnostic microbiology and infectious disease 2013; Volum 77 (4). ISSN 0732-8893.s 316 - 320.s doi: 10.1016/j.diagmicrobio.2013.09.007.

  • Nilsen, Einar; Haldorsen, Bjørg; Sundsfjord, Arnfinn; Simonsen, Gunnar Skov; Ingebretsen, André; Naseer, Mohammed Umaer; Samuelsen, Ørjan. Large IncHI2-plasmids encode extended-spectrum beta-lactamases (ESBLs) in Enterobacter spp. bloodstream isolates, and support ESBL-transfer to Escherichia coli. Clinical Microbiology and Infection 2013; Volum 19 (11). ISSN 1198-743X.s E516 - E518.s doi: 10.1111/1469-0691.12274.

  • Borra, Naga Pardha Saradhi; Samuelsen, Ørjan; Spencer, James; Walsh, Timothy R.; Lorentzen, marit sjo; Leiros, Hanna-Kirsti S.. Crystal Structures of Pseudomonas aeruginosa GIM-1: Active-Site Plasticity in Metallo-beta-Lactamases. Antimicrobial Agents and Chemotherapy 2013; Volum 57 (2). ISSN 0066-4804.s 848 - 854.s doi: 10.1128/AAC.02227-12.

  • Saule, Mara; Samuelsen, Ørjan; Dumpis, Uga; Sundsfjord, Arnfinn; Karlsone, Aija; Balode, Arta; Miklasevics, Edvins; Karah, Nabil. Dissemination of a Carbapenem-Resistant Acinetobacter baumannii Strain Belonging to International Clone II/Sequence Type 2 and Harboring a Novel AbaR4-Like Resistance Island in Latvia. Antimicrobial Agents and Chemotherapy 2013; Volum 57 (2). ISSN 0066-4804.s 1069 - 1072.s doi: 10.1128/AAC.01783-12.

  • Starikova, Irina; Harms, Klaus; Haugen, Pål; Lunde, Tracy Munthali; Primicerio, Raul; Samuelsen, Ørjan; Nielsen, Kaare Magne; Johnsen, Pål Jarle. A Trade-off between the Fitness Cost of Functional Integrases and Long-trem stability of Integrons. (fulltekst) PLoS Pathogens 2012; Volum 8 (11). ISSN 1553-7366.s doi: 10.1371/journal.ppat.1003043.

  • Karah, Nabil; Sundsfjord, Arnfinn; Towner, Kevin; Samuelsen, Ørjan. Insights into the global molecular epidemiology of carbapenem non-susceptible clones of Acinetobacter baumannii. Drug resistance updates 2012; Volum 15 (4). ISSN 1368-7646.s 237 - 247.s doi: 10.1016/j.drup.2012.06.001.

  • Leiros, Hanna-Kirsti S.; Borra, Naga Pardha Saradhi; Brandsdal, Bjørn Olav; Edvardsen, Kine Susann Waade; Spencer, James; Walsh, Timothy R.; Samuelsen, Ørjan. Crystal Structure of the Mobile Metallo-beta-Lactamase AIM-1 from Pseudomonas aeruginosa: Insights into Antibiotic Binding and the Role of Gln157. Antimicrobial Agents and Chemotherapy 2012; Volum 56 (8). ISSN 0066-4804.s 4341 - 4353.s doi: 10.1128/AAC.00448-12.

  • El Salabi, Allaaeddin; Borra, Naga Pardha Saradhi; Toleman, Mark A.; Samuelsen, Ørjan; Walsh, Timothy R.. Genetic and Biochemical Characterization of a Novel Metallo-beta-Lactamase, TMB-1, from an Achromobacter xylosoxidans Strain Isolated in Tripoli, Libya. Antimicrobial Agents and Chemotherapy 2012; Volum 56 (5). ISSN 0066-4804.s 2241 - 2245.s doi: 10.1128/AAC.05640-11.

  • Hansen, Frank; Hammerum, Anette M.; Skov, Robert L; Giske, Christian G.; Sundsfjord, Arnfinn; Samuelsen, Ørjan. Evaluation of Rosco Neo-Sensitabs for phenotypic detection and subgrouping of ESBL-, AmpC- and carbapenemase-producing Enterobacteriaceae. Acta Pathologica, Microbiologica et Immunologica Scandinavica (APMIS) 2012; Volum 120 (9). ISSN 0903-4641.s 724 - 732.s doi: 10.1111/j.1600-0463.2012.02898.x.

  • Canton, Rafael; Akova, Murat; Carmeli, Yehuda; Giske, Christian; Glupczynski, Youri; Gniadkowski, Marek; Livermore, David M.; Miriagou, Vivi; Naas, Thiery; Rossolini, Gian Maria; Samuelsen, Ørjan; Seifert, Harald; Woodford, Neil; Nordmann, Patrice. Rapid evolution and spread of carbapenemases among Enterobacteriaceae in Europe. Clinical Microbiology and Infection 2012; Volum 18 (5). ISSN 1198-743X.s 413 - 431.s doi: 10.1111/j.1469-0691.2012.03821.x.

  • Naseer, Mohammed Umaer; Eriksen, Bjørn Odvar; Sundsfjord, Arnfinn; Samuelsen, Ørjan. Fecal colonization of VIM-1-producing Klebsiella pneumoniae and in vivo transfer of multidrug-resistant IncN plasmid in a renal transplant patient. Diagnostic microbiology and infectious disease 2012; Volum 72 (4). ISSN 0732-8893.s 363 - 366.s doi: 10.1016/j.diagmicrobio.2011.12.010.

  • Haldorsen, Bjørg; Samuelsen, Ørjan. Multiresistente Gram-negative bakterier - et økende globalt helseproblem. (fulltekst) Bioingeniøren 2012; Volum 47 (2). ISSN 0801-6828.s 16 - 21.

  • Karah, Nabil; Giske, Christian G.; Sundsfjord, Arnfinn; Samuelsen, Ørjan. A Diversity of OXA-Carbapenemases and Class 1 Integrons Among Carbapenem-Resistant Acinetobacter baumannii Clinical Isolates from Sweden Belonging to Different International Clonal Lineages. Microbial Drug Resistance 2011; Volum 17 (4). ISSN 1076-6294.s 545 - 549.s doi: 10.1089/mdr.2011.0089.

  • Samuelsen, Ørjan; Toleman, MA; Hasseltvedt, Viggo H; Fuursted, K; Leegaard, Truls Michael; Walsh, TR; Sundsfjord, Arnfinn; Giske, CG. Molecular characterization of VIM-producing Klebsiella pneumoniae from Scandinavia reveals genetic relatedness with international clonal complexes encoding transferable multidrug resistance. Clinical Microbiology and Infection 2011; Volum 17 (12). ISSN 1198-743X.s 1811 - 1816.s doi: 10.1111/j.1469-0691.2011.03532.x.

  • Seki, Liliane M.; Pereira, Polyana S.; de Souza, Maria da Penha A. H.; Conceicao, Magda de S.; Marques, Elizabeth A.; Porto, Carlos Oliveira; Colnago, Elvira Maria L.; Alves, Carlene de F. M.; Gomes, Deize; Assef, Ana Paula D. A. Carvalho; Samuelsen, Ørjan; Asensi, Marise D.. Molecular epidemiology of KPC-2-producing Klebsiella pneumoniae isolates in Brazil: the predominance of sequence type 437. Diagnostic microbiology and infectious disease 2011; Volum 70 (2). ISSN 0732-8893.s 274 - 277.s doi: 10.1016/j.diagmicrobio.2011.01.006.

  • Saradhi, Pardha; Leiros, Hanna-Kirsti S.; Ahmad, Rafi; Spencer, James; Leiros, Ingar; Walsh, Timothy R.; Sundsfjord, Arnfinn; Samuelsen, Ørjan. Structural and Computational Investigations of VIM-7: Insights into the Substrate Specificity of VIM Metallo-beta-Lactamases. Journal of Molecular Biology 2011; Volum 411 (1). ISSN 0022-2836.s 174 - 189.s doi: 10.1016/j.jmb.2011.05.035.

  • Karah, Nabil; Haldorsen, Bjørg; Hegstad, Kristin; Simonsen, Gunnar Skov; Sundsfjord, Arnfinn; Samuelsen, Ørjan. Species identification and molecular characterization of Acinetobacter spp. blood culture isolates from Norway. Journal of Antimicrobial Chemotherapy 2011; Volum 66 (4). ISSN 0305-7453.s 738 - 744.s doi: 10.1093/jac/dkq521.

  • Karah, Nabil; Haldorsen, Bjørg; Hermansen, Nils Olav; Tveten, Yngvar; Ragnhildstveit, Eivind; Skutlaberg, Dag Harald; Tofteland, Ståle; Sundsfjord, Arnfinn; Samuelsen, Ørjan. Emergence of OXA-carbapenemase- and 16S rRNA methylase-producing international clones of Acinetobacter baumannii in Norway. Journal of Medical Microbiology 2011; Volum 60 (4). ISSN 0022-2615.s 515 - 521.s doi: 10.1099/jmm.0.028340-0.

  • Vading, M; Samuelsen, Ørjan; Haldorsen, Bjørg; Sundsfjord, Arnfinn; Giske, C.G.. Comparison of disk diffusion, Etest and VITEK2 for detection of carbapenemase-producing Klebsiella pneumoniae with the EUCAST and CLSI breakpoint systems. Clinical Microbiology and Infection 2011; Volum 17 (5). ISSN 1198-743X.s 668 - 674.s doi: 10.1111/j.1469-0691.2010.03299.x.

  • Giske, C.G.; Gezelius, L; Samuelsen, Ørjan; Warner, M; Sundsfjord, Arnfinn; Woodford, N. A sensitive and specific phenotypic assay for detection of metallo-beta-lactamases and KPC in Klebsiella pneumoniae with the use of meropenem disks supplemented with aminophenylboronic acid, dipicolinic acid and cloxacillin. Clinical Microbiology and Infection 2011; Volum 17 (4). ISSN 1198-743X.s 552 - 556.s doi: 10.1111/j.1469-0691.2010.03294.x.

  • Samuelsen, Ørjan; Toleman, MA; Sundsfjord, Arnfinn; Rydberg, Johan; Leegaard, Truls Michael; Walder, M; Lia, Astrid; Ranheim, Trond Egil; Rajendra, Y; Hermansen, Nils Olav; Walsh, TR; Giske, CG. Molecular Epidemiology of Metallo-beta-Lactamase-Producing Pseudomonas aeruginosa Isolates from Norway and Sweden Shows Import of International Clones and Local Clonal Expansion. Antimicrobial Agents and Chemotherapy 2010; Volum 54 (1). ISSN 0066-4804.s 346 - 352.s doi: 10.1128/AAC.00824-09.

  • Karah, Nabil; Poirel, Laurent; Bengtsson, Stina; Sundqvist, Martin; Kahlmeter, Gunnar; Nordmann, Patrice; Sundsfjord, arnfinn; Samuelsen, Ørjan. Plasmid-mediated quinolone resistance determinants qnr and aac(6 ')-Ib-cr in Escherichia coli and Klebsiella spp. from Norway and Sweden. Diagnostic microbiology and infectious disease 2010; Volum 66 (4). ISSN 0732-8893.s 425 - 431.s doi: 10.1016/j.diagmicrobio.2009.12.004.

  • Samuelsen, Ørjan; Naseer, Umaer; Tofteland, Ståle; Skutlaberg, Dag Harald; Onken, Annette; Hjetland, Reidar; Sundsfjord, Arnfinn; Giske, Christian G.. Emergence of clonally related Klebsiella pneumoniae isolates of sequence type 258 producing plasmid-mediated KPC carbapenemase in Norway and Sweden. Journal of Antimicrobial Chemotherapy 2009; Volum 63 (4). ISSN 0305-7453.s 654 - 658.s doi: 10.1093/jac/dkp018.

  • Samuelsen, Ørjan; Buarø, Liselotte; Toleman, Mark A.; Giske, Christian G.; Hermansen, Nils Olav; Walsh, Timothy R; Sundsfjord, Arnfinn. The first metallo-beta-lactamase identified in Norway is associated with an tniC-class 1 integron in a Pseudomonas aeruginosa isolate of sequence type 233 imported from Ghana. Antimicrobial Agents and Chemotherapy 2009; Volum 53 (1). ISSN 0066-4804.s 331 - 332.

  • Källman, Owe; Giske, Christian G.; Samuelsen, Ørjan; Wretlind, Bengt; Kalin, Mats; Olsson-Liljequist, Barbro. Interplay of Efflux, Impermeability, and AmpC Activity Contributes to Cefuroxime Resistance in Clinical, Non-ESBL-Producing Isolates of Escherichia coli. Microbial Drug Resistance 2009; Volum 15 (2). ISSN 1076-6294.s 91 - 95.s doi: 10.1089/mdr.2009.0883.

  • Ganta, Sudhakar Reddy; Perumal, Senthil; Pagadala, Sundar Ram Reddy; Samuelsen, Ørjan; Spencer, James; Pratt, R.F.; Buynak, John D.. Approaches to the simultaneous inactivation of metallo- and serine-beta-lactamases. Bioorganic & Medicinal Chemistry Letters 2009; Volum 19 (6). ISSN 0960-894X.s 1618 - 1622.s doi: 10.1016/j.bmcl.2009.02.018.

  • Samuelsen, Ørjan; Buarø, Liselotte; Giske, Christian G.; Simonsen, Gunnar Skov; Aasnæs, Bettina; Sundsfjord, arnfinn. Evaluation of phenotypic tests for the detection of metallo-beta-lactamase-producing Pseudomonas aeruginosa in a low prevalence country. Journal of Antimicrobial Chemotherapy 2008; Volum 61. ISSN 0305-7453.s 827 - 830.s doi: 10.1093/jac/dkn016.

  • Samuelsen, Ørjan; Castanheira, Mariana; Walsh, Timothy R; Spencer, James. Kinetic characterization of VIM-7, a divergent member of the VIM metallo-beta-lactamase family. Antimicrobial Agents and Chemotherapy 2008; Volum 52 (8). ISSN 0066-4804.s 2905 - 2908.

  • Sundsfjord, Arnfinn; Simonsen, Gunnar Skov; Haldorsen, Bjørg; Lundblad, Eirik Wasmuth; Samuelsen, Ørjan. Bredspektrede betalaktamaser hos gramnegative stavbakterier. Tidsskrift for Den norske legeforening 2008; Volum 128 (23). ISSN 0029-2001.s 2741 - 2745.

  • Vik, Anders; Hedner, Erik; Charnock, Colin; Tangen, Linda; tangen, Linda W; Samuelsen, Ørjan; Larsson, Rolf; Bohlin, Lars; Gundersen, Lise-Lotte. Antimicrobial and cytotoxic activity of agelasine and agelasimine analogs. Bioorganic & Medicinal Chemistry 2007; Volum 15. ISSN 0968-0896.s doi: 10.1016/j.bmc.2007.03.08.

  • Vik, Anders; Hedner, Erik; Charnock, Colin; Samuelsen, Ørjan; Larsson, Rolf; Gundersen, Lise-Lotte; Bohlin, Lars. (+)-agelasine D: Improved synthesis and evaluation of antibacterial and cytotoxic activities. Journal of natural products 2006; Volum 69. ISSN 0163-3864.

  • Samuelsen, Ørjan; Haukland, Hanne; Kahl, BC; Von Eiff, C; Proctor, RA; Ulvatne, H; Sandvik, K; Vorland, Lars. Staphylococcus aureus small colony variants are resistant to the antimicrobial peptide lactoferricin B. Journal of Antimicrobial Chemotherapy 2005; Volum 56 (6). ISSN 0305-7453.s 1126 - 1129.

  • Samuelsen, Ørjan; Haukland, Hanne; Jenssen, Håvard; Kramer, M; Sandvik, K; Ulvatne, Hilde; Vorland, Lars. Induced resistance to the antimicrobial peptide lactoferricin B in Staphylococcus aureus. FEBS Letters 2005; Volum 579. ISSN 0014-5793.

  • Ulvatne, H.; Samuelsen, Ørjan; Haukland, Hanne; Kramer, M; Vorland, Lars. Lactoferricin B inhibits bacterial macromolecular synthesis in Escherichia coli and Bacillus subtilis. FEMS Microbiology Letters 2004; Volum 237. ISSN 0378-1097.s 377 - 384.

  • Ulvatne, Hilde; Haukland, Hanne Husom; Samuelsen, Ørjan; Kramer, Manuela; Vorland, Lars H.. Proteases in Escherichia coli and Staphylococcus aureus confer reduced susceptibility to lactoferricin B. Journal of Antimicrobial Chemotherapy 2002; Volum 50. ISSN 0305-7453.s 461 - 467.

  • Frøhlich, Christopher; Johnsen, Pål Jarle; Schrøder Leiros, Hanna-Kirsti; Samuelsen, Ørjan. Evolution of OXA-48 under sub-MIC conditions. 3rd Annual Meeting of the National Graduate School in Infection Biology and and Antimicrobials 2019-11-05 - 2019-11-06 2019.

  • Sørum, Vidar; Øynes, Emma Lu; Møller, Anna; Podnecky, Nicole L.; Abel, Sören; Samuelsen, Ørjan; Johnsen, Pål Jarle. Evolutionary stability of collateral susceptibility networks in clinical Escherichia coli strains. ECCMID 2019 2019-04-13 - 2019.

  • Frøhlich, Christopher; Leiros, Hanna-Kirsti S.; Johnsen, Pål Jarle; Samuelsen, Ørjan. Sub-inhibitory concentrations of ceftazidime drive evolution of the OXA-48 carbapenemase. ECCMID 2019 2019-04-13 - 2019-04-16 2019.

  • Kloos, Julia Maria; Alves Gama, Joao Pedro; Samuelsen, Ørjan; Johnsen, Pål Jarle. Plasmid-host co-evolution of Klebsiella pneumoniae MDR-encoding plasmids in clinical isolates of uropathogenic Escherichia coli: effect on fitness cost of plasmid-mediated resistance. IBA Annual Meeting 2018-11-08 - 2018.

  • Kloos, Julia Maria; Alves Gama, Joao Pedro; Samuelsen, Ørjan; Johnsen, Pål Jarle. Klebsiella pneumoniae MDR-encoding plasmids in clinical isolates of uropathogenic Escherichia coli: plasmid-host co-evolution and its effect on fitness cost of plasmid-mediated resistance. Plasmid Biology Symposium 2018-08-05 - 2018-08-10 2018.

  • Frøhlich, Christopher; Sørum, Vidar; Leiros, Hanna-Kirsti S.; Johnsen, Pål Jarle; Samuelsen, Ørjan. Development of OXA-48 mediated ceftazidme-avibactam resistance is associated with an evolutionary trade-off. ECCMID 2018-04-24 - 2018.

  • Jakovljev, Aleksandra; Afset, Jan Egil; Haugum, Kjersti; Rønning, Torunn Gresdal; Steinum, Harald Otto; Samuelsen, Ørjan; Gabrielsen, Christina. "Escherichia coli sepsis: casus presentasjon med uvanlig resistensmønster". Vårmøtet 2018 Norsk Forening for Medisinsk mikrobiologi 2018-05-31 - 2018-06-01 2018.

  • Heikal, Adam; Samuelsen, Ørjan; Kristensen, Tom; Økstad, Ole Andreas Løchen. Complete genome sequence of a multidrug-resistant, blaNDM-1-expressing Klebsiella pneumoniae K66-45 clinical isolate from Norway. Microbiology Resource Announcements (MRA) 2017; Volum 5:e00601 (27). ISSN 2169-8287.s 1 - 2.s doi: 10.1128/genomeA.00601-17.

  • Lund, Bjarte Aarmo; Leiros, Hanna-Kirsti S.; Bayer, Annette; Samuelsen, Ørjan; Christopeit, Tony. The OXA-class of β-lactamases. A structural view on antibiotic resistance. 2017 ISBN 978-82-8236-269-6.

  • Jakovljev, Aleksandra; Afset, Jan Egil; Haugum, Kjersti; Steinum, Harald Otto; Rønning, Torunn Gresdal; Samuelsen, Ørjan; Gabrielsen, Christina. Genetic basis of growth characteristics and trimethoprim-sulfamethoxazole susceptibility of thymine-dependent and thymine-independent serial blood culture isolates of Escherichia coli. 27th ECCMID 2017, 22-25 April, Vienna, Austria 2017-04-22 - 2017-04-25 2017.

  • Jakovljev, Aleksandra; Afset, Jan Egil; Haugum, Kjersti; Steinum, Harald Otto; Rønning Gresdal, Torunn; Samuelsen, Ørjan; Gabrielsen, Christina. Undersøkelse av det genetiske grunnlaget for fenotypiske forskjeller i vekstegenskaper og følsomhet overfor trimetoprim-sulfamethoxazole hos Escherichia coli isolert fra pasient med residiverende bakteriemiepisoder. Årskonferanse FHI 2016 2016-12-01 - 2016-12-02 2016.

  • Onarheim, Henning; BREKKE, RAGNVALD LJONES; Leiva, Rafael Alexander Mo; Oma, Dorthea Hagen; Kolstad, Helge; Samuelsen, Ørjan; Sundsfjord, Arnfinn; Mylvaganam, Haima. H. Onarheim og medarbeidere svarer. Tidsskrift for Den norske legeforening 2016; Volum 136 (17). ISSN 0029-2001.s 1424 - 1425.s doi: 10.4045/tidsskr.16.0755.

  • Di Luca, Maria Chiara; Skaare, Dagfinn; Aasnæs, Bettina; Sundsfjord, Arnfinn; Samuelsen, Ørjan. Identification of a novel IMI carbapenemase variant (IMI-9) in Enterobacter cloacae complex. International Journal of Antimicrobial Agents 2016; Volum 48 (6). ISSN 0924-8579.s 764 - 765.s doi: 10.1016/j.ijantimicag.2016.09.004.

  • Onarheim, Henning; Brekke, Ragnvald Ljones; Leiva, Rafael Alexander Mo; Oma, Dorthea Hagen; Kolstad, Helge; Samuelsen, Ørjan; Sundsfjord, Arnfinn; Mylvaganam, Haima. En kvinne med sepsis etter brannskade i Pakistan. Tidsskrift for Den norske legeforening 2016; Volum 136 (14). ISSN 0029-2001.s 1228 - 1232.

  • Skagseth, Susann; Samuelsen, Ørjan; Leiros, Hanna-Kirsti S.. The impact of residues 119 and 228 in the Tripoli metallo-beta-lactamase TMB-1 involved in resistance to beta-lactam antibiotics. 52nd Norwegian Biochemical Society Contact Meeting, Tromsø 2016-01-21 - 2016-01-24 2016.

  • Hegstad, Kristin; Samuelsen, Ørjan; Hegstad, Joachim; Sundsfjord, Arnfinn. Molecular methods for detection of antibacterial resistance genes: rationale and applications. Wolters Kluwer 2015 ISBN 978-1-4511-7675-9.s 408 - 449.

  • Åstrand, Ove Alexander Høgmoen; Leiros, Hanna-Kirsti S.; Samuelsen, Ørjan; Bayer, Annette; Rongved, Pål. Overcoming b-lactam resistance - A potential solution to multi-drug resistant bacteria. Organisk Kjemisk Vintermøte 2015 2015-01-08 - 2015-01-11 2015.

  • Berg, Einar Sverre; Wester, Astrid Lousie; Mo, Solveig Sølverød; Slettemeås, Jannice Schau; Steinbakk, Martin; Dahle, Ulf R; Samuelsen, Ørjan; Simonsen, Gunnar Skov; Löhr, Iren Høyland; Jørgensen, Silje; Sunde, Marianne. Highly similar cephalosporin resistant Escherichia coli and AmpC resistance plasmids found in both patients and poultry meat in Norway. ECCMID 2015-04-25 - 2015-04-28 2015.

  • Skagseth, Susann; Carlsen, Trine Josefine Olsen; Akhter, Sundus; Zeeshan, Muhammad; Åstrand, Ove Alexander Høgmoen; Bayer, Annette; Rongved, Pål; Samuelsen, Ørjan; Leiros, Hanna-Kirsti S.. The fight against metallo-beta-lactamases and antibiotic resistance. Annual BioStruct Conference, The National graduate school in structural biology 2015-09-27 - 2015-09-30 2015.

  • Skagseth, Susann; Carlsen, Trine Josefine Olsen; Akhter, Sundus; Zeeshan, Muhammad; Åstrand, Ove Alexander Høgmoen; Bayer, Annette; Rongved, Pål; Samuelsen, Ørjan; Leiros, Hanna-Kirsti S.. The fight against metallo-beta-lactamases and antibiotic resistance. BioStruct Open Day 2015-03-20 - 2015-03-20 2015.

  • Christopeit, Tony; Carlsen, Trine Josefine Olsen; Skagseth, Susann; Lund, Bjarte Aarmo; Samuelsen, Ørjan; Leiros, Hanna-Kirsti S.. Using fragment screening to identify novel starting points for potent inhibitors of metallo-beta-lactamase VIM-2. Fragments 2015: Fifth RSC-BMCS Fragment-based Drug Discovery meeting 2015-03-22 - 2015-03-22 2015.

  • Christopeit, Tony; Lund, Bjarte Aarmo; Carlsen, Trine Josefine Olsen; Skagseth, Susann; Samuelsen, Ørjan; Leiros, Hanna-Kirsti S.. Using Fragment Screening to Identify Novel Starting Points for Potent Carbapenemase Inhibitors. Interscience Conference of Antimicrobial Agents and Chemotherapy (ICAAC) 2015-09-17 - 2015-09-21 2015.

  • Paulsen, Marianne H.; Engqvist, Stig Olov Magnus; Samuelsen, Ørjan; Leiros, Hanna-Kirsti S.; Skagseth, Susann; Leszczak, Kinga; Akhter, Sundus; Bayer, Annette. Synthesis of potential metallo-beta-lactamase inhibitors. Organisk kjemisk vintermøte OKV29 2014-01-09 - 2014-01-12 2014.

  • Hansen, Frank; Hammerum, Anette M.; Skov, Robert; Haldorsen, Bjørg; Sundsfjord, Arnfinn; Samuelsen, Ørjan. Evaluation of the total MBL confirm kit (ROSCO) for detection of metallo-β-lactamases in Pseudomonas aeruginosa and Acinetobacter baumannii. Diagnostic microbiology and infectious disease 2014; Volum 79 (4). ISSN 0732-8893.s 486 - 488.s doi: 10.1016/j.diagmicrobio.2013.12.001.

  • Lund, Bjarte Aarmo; Bjerga, Gro Elin Kjæreng; Christopeit, Tony; Samuelsen, Ørjan; Leiros, Hanna-Kirsti S.. Structural view on antibiotic resistance. Fragment-based lead discovery for the inhibition of oxacillinases. 12th Beta-Lactamase Meeting 2014-06-28 - 2014-07-01 2014.

  • Lund, Bjarte Aarmo; Bjerga, Gro Elin Kjæreng; Christopeit, Tony; Samuelsen, Ørjan; Leiros, Hanna-Kirsti S.. Structural view on antibiotic resistance. Fragment-based lead discovery for the inhibition of oxacillinases. The 46th INTERNATIONAL SCHOOL OF CRYSTALLOGRAPHY 2014-05-30 - 2014-06-08 2014.

  • Christopeit, Tony; Carlsen, Trine Josefine Olsen; Skagseth, Susann; Lund, Bjarte Aarmo; Samuelsen, Ørjan; Leiros, Hanna-Kirsti S.. Characterization of substrate and inhibitor binding to different beta-lactamases using Surface Plasmon Resonance based biosensors. 12th Beta-Lactamase Meeting 2014-06-28 - 2014-07-01 2014.

  • Skagseth, Susann; Carlsen, Trine Josefine Olsen; Bjerga, Gro Elin Kjæreng; Bayer, Annette; Samuelsen, Ørjan; Leiros, Hanna-Kirsti S.. The importance of residue Trp228 and Tyr233 in the metallo-beta-lactamase GIM-1. 12th Beta-Lactamase Meeting 2014-06-28 - 2014-07-01 2014.

  • Nilsen, Einar; Haldorsen, Bjørg; Sundsfjord, Arnfinn; Simonsen, Gunnar Skov; Ingebretsen, André; Naseer, Mohammed Umaer; Samuelsen, Ørjan. Large IncHI2-plasmids encode extended-spectrum beta-lactamases (ESBLs) in Enterobacter spp. bloodstream isolates, and support ESBL-transfer to Escherichia coli. Clinical Microbiology and Infection 2013; Volum 19 (11). ISSN 1198-743X.s 1091 - 1091.

  • Haldorsen, Bjørg; Samuelsen, Ørjan; Sundsfjord, Arnfinn; Hegstad, Kristin. Agreement of the MIC Test Strip and Etest with microbroth dilution in glycopeptide susceptibility testing of Enterococcus sp. 23rd European Congress of Clinical Microbiology and Infectious Diseases 2013-04-27 - 2013-04-30 2013.

  • Samuelsen, Ørjan; Naseer, Mohammed Umaer; Karah, Nabil; Lindemann, Paul Christoffer; Leegaard, Truls Michael; Sundsfjord, Arnfinn; Kanestrøm, Anita. Identification of Enterobacteriaceae isolates with OXA-48 and coproduction of OXA-181 and NDM-1 in Norway. Journal of Antimicrobial Chemotherapy 2013; Volum 68 (7). ISSN 0305-7453.s 1682 - 1685.s doi: 10.1093/jac/dkt058.

  • Sundsfjord, Arnfinn; Samuelsen, Ørjan; Hegstad, Kristin; Haldorsen, Bjørg C. I førstelinjen mot resistente bakterier. Bioingeniøren 2012 (2). ISSN 0801-6828.s 12 - 14.

  • Dahle, Ulf R; Wester, Astrid Louise; Samuelsen, Ørjan; Sundsfjord, Arnfinn. Siste skanse for effektive antibiotika?. Tidsskrift for Den norske legeforening 2012; Volum 132. ISSN 0029-2001.s 1725 - 1726.s doi: 10.4045/tidsskr.12.0565.

  • Samuelsen, Ørjan; Thilesen, Carina; Heggelund, Lars; Vada, Anne N.; Kümmel, Angela; Sundsfjord, arnfinn. Identification of NDM-1-producing Enterobacteriaceae in Norway. Journal of Antimicrobial Chemotherapy 2011; Volum 66 (3). ISSN 0305-7453.s 670 - 672.s doi: 10.1093/jac/dkq483.

  • Tveten, Yngvar; Sarjomaa, Marjut Anneli; Skaare, Dagfinn; Grude, Nils; Samuelsen, Ørjan. Hvordan stoppe multiresidente bakterier?. Tidsskrift for Den norske legeforening 2011; Volum 7 (131). ISSN 0029-2001.s 698 - 700.s doi: 10.4045/tidsskr.10.0369.

  • Samuelsen, Ørjan. Resistance to the antimicrobial peptide lactoferricin B in Staphylococcus aureus. 2005 ISBN 82-7589-156-6.

  • Frøhlich, Christopher; Johnsen, Pål Jarle; Schrøder Leiros, Hanna-Kirsti; Samuelsen, Ørjan. Evolution of OXA-48 under sub-MIC conditions. 3rd Annual Meeting of the National Graduate School in Infection Biology and and Antimicrobials 2019-11-05 - 2019-11-06 2019.

  • Sørum, Vidar; Øynes, Emma Lu; Møller, Anna; Podnecky, Nicole L.; Abel, Sören; Samuelsen, Ørjan; Johnsen, Pål Jarle. Evolutionary stability of collateral susceptibility networks in clinical Escherichia coli strains. ECCMID 2019 2019-04-13 - 2019.

  • Frøhlich, Christopher; Leiros, Hanna-Kirsti S.; Johnsen, Pål Jarle; Samuelsen, Ørjan. Sub-inhibitory concentrations of ceftazidime drive evolution of the OXA-48 carbapenemase. ECCMID 2019 2019-04-13 - 2019-04-16 2019.

  • Kloos, Julia Maria; Alves Gama, Joao Pedro; Samuelsen, Ørjan; Johnsen, Pål Jarle. Plasmid-host co-evolution of Klebsiella pneumoniae MDR-encoding plasmids in clinical isolates of uropathogenic Escherichia coli: effect on fitness cost of plasmid-mediated resistance. IBA Annual Meeting 2018-11-08 - 2018.

  • Kloos, Julia Maria; Alves Gama, Joao Pedro; Samuelsen, Ørjan; Johnsen, Pål Jarle. Klebsiella pneumoniae MDR-encoding plasmids in clinical isolates of uropathogenic Escherichia coli: plasmid-host co-evolution and its effect on fitness cost of plasmid-mediated resistance. Plasmid Biology Symposium 2018-08-05 - 2018-08-10 2018.

  • Frøhlich, Christopher; Sørum, Vidar; Leiros, Hanna-Kirsti S.; Johnsen, Pål Jarle; Samuelsen, Ørjan. Development of OXA-48 mediated ceftazidme-avibactam resistance is associated with an evolutionary trade-off. ECCMID 2018-04-24 - 2018.

  • Jakovljev, Aleksandra; Afset, Jan Egil; Haugum, Kjersti; Rønning, Torunn Gresdal; Steinum, Harald Otto; Samuelsen, Ørjan; Gabrielsen, Christina. "Escherichia coli sepsis: casus presentasjon med uvanlig resistensmønster". Vårmøtet 2018 Norsk Forening for Medisinsk mikrobiologi 2018-05-31 - 2018-06-01 2018.

  • Heikal, Adam; Samuelsen, Ørjan; Kristensen, Tom; Økstad, Ole Andreas Løchen. Complete genome sequence of a multidrug-resistant, blaNDM-1-expressing Klebsiella pneumoniae K66-45 clinical isolate from Norway. Microbiology Resource Announcements (MRA) 2017; Volum 5:e00601 (27). ISSN 2169-8287.s 1 - 2.s doi: 10.1128/genomeA.00601-17.

  • Lund, Bjarte Aarmo; Leiros, Hanna-Kirsti S.; Bayer, Annette; Samuelsen, Ørjan; Christopeit, Tony. The OXA-class of β-lactamases. A structural view on antibiotic resistance. 2017 ISBN 978-82-8236-269-6.

  • Jakovljev, Aleksandra; Afset, Jan Egil; Haugum, Kjersti; Steinum, Harald Otto; Rønning, Torunn Gresdal; Samuelsen, Ørjan; Gabrielsen, Christina. Genetic basis of growth characteristics and trimethoprim-sulfamethoxazole susceptibility of thymine-dependent and thymine-independent serial blood culture isolates of Escherichia coli. 27th ECCMID 2017, 22-25 April, Vienna, Austria 2017-04-22 - 2017-04-25 2017.

  • Jakovljev, Aleksandra; Afset, Jan Egil; Haugum, Kjersti; Steinum, Harald Otto; Rønning Gresdal, Torunn; Samuelsen, Ørjan; Gabrielsen, Christina. Undersøkelse av det genetiske grunnlaget for fenotypiske forskjeller i vekstegenskaper og følsomhet overfor trimetoprim-sulfamethoxazole hos Escherichia coli isolert fra pasient med residiverende bakteriemiepisoder. Årskonferanse FHI 2016 2016-12-01 - 2016-12-02 2016.

  • Onarheim, Henning; BREKKE, RAGNVALD LJONES; Leiva, Rafael Alexander Mo; Oma, Dorthea Hagen; Kolstad, Helge; Samuelsen, Ørjan; Sundsfjord, Arnfinn; Mylvaganam, Haima. H. Onarheim og medarbeidere svarer. Tidsskrift for Den norske legeforening 2016; Volum 136 (17). ISSN 0029-2001.s 1424 - 1425.s doi: 10.4045/tidsskr.16.0755.

  • Di Luca, Maria Chiara; Skaare, Dagfinn; Aasnæs, Bettina; Sundsfjord, Arnfinn; Samuelsen, Ørjan. Identification of a novel IMI carbapenemase variant (IMI-9) in Enterobacter cloacae complex. International Journal of Antimicrobial Agents 2016; Volum 48 (6). ISSN 0924-8579.s 764 - 765.s doi: 10.1016/j.ijantimicag.2016.09.004.

  • Onarheim, Henning; Brekke, Ragnvald Ljones; Leiva, Rafael Alexander Mo; Oma, Dorthea Hagen; Kolstad, Helge; Samuelsen, Ørjan; Sundsfjord, Arnfinn; Mylvaganam, Haima. En kvinne med sepsis etter brannskade i Pakistan. Tidsskrift for Den norske legeforening 2016; Volum 136 (14). ISSN 0029-2001.s 1228 - 1232.

  • Skagseth, Susann; Samuelsen, Ørjan; Leiros, Hanna-Kirsti S.. The impact of residues 119 and 228 in the Tripoli metallo-beta-lactamase TMB-1 involved in resistance to beta-lactam antibiotics. 52nd Norwegian Biochemical Society Contact Meeting, Tromsø 2016-01-21 - 2016-01-24 2016.

  • Hegstad, Kristin; Samuelsen, Ørjan; Hegstad, Joachim; Sundsfjord, Arnfinn. Molecular methods for detection of antibacterial resistance genes: rationale and applications. Wolters Kluwer 2015 ISBN 978-1-4511-7675-9.s 408 - 449.

  • Åstrand, Ove Alexander Høgmoen; Leiros, Hanna-Kirsti S.; Samuelsen, Ørjan; Bayer, Annette; Rongved, Pål. Overcoming b-lactam resistance - A potential solution to multi-drug resistant bacteria. Organisk Kjemisk Vintermøte 2015 2015-01-08 - 2015-01-11 2015.

  • Berg, Einar Sverre; Wester, Astrid Lousie; Mo, Solveig Sølverød; Slettemeås, Jannice Schau; Steinbakk, Martin; Dahle, Ulf R; Samuelsen, Ørjan; Simonsen, Gunnar Skov; Löhr, Iren Høyland; Jørgensen, Silje; Sunde, Marianne. Highly similar cephalosporin resistant Escherichia coli and AmpC resistance plasmids found in both patients and poultry meat in Norway. ECCMID 2015-04-25 - 2015-04-28 2015.

  • Skagseth, Susann; Carlsen, Trine Josefine Olsen; Akhter, Sundus; Zeeshan, Muhammad; Åstrand, Ove Alexander Høgmoen; Bayer, Annette; Rongved, Pål; Samuelsen, Ørjan; Leiros, Hanna-Kirsti S.. The fight against metallo-beta-lactamases and antibiotic resistance. Annual BioStruct Conference, The National graduate school in structural biology 2015-09-27 - 2015-09-30 2015.

  • Skagseth, Susann; Carlsen, Trine Josefine Olsen; Akhter, Sundus; Zeeshan, Muhammad; Åstrand, Ove Alexander Høgmoen; Bayer, Annette; Rongved, Pål; Samuelsen, Ørjan; Leiros, Hanna-Kirsti S.. The fight against metallo-beta-lactamases and antibiotic resistance. BioStruct Open Day 2015-03-20 - 2015-03-20 2015.

  • Christopeit, Tony; Carlsen, Trine Josefine Olsen; Skagseth, Susann; Lund, Bjarte Aarmo; Samuelsen, Ørjan; Leiros, Hanna-Kirsti S.. Using fragment screening to identify novel starting points for potent inhibitors of metallo-beta-lactamase VIM-2. Fragments 2015: Fifth RSC-BMCS Fragment-based Drug Discovery meeting 2015-03-22 - 2015-03-22 2015.

  • Christopeit, Tony; Lund, Bjarte Aarmo; Carlsen, Trine Josefine Olsen; Skagseth, Susann; Samuelsen, Ørjan; Leiros, Hanna-Kirsti S.. Using Fragment Screening to Identify Novel Starting Points for Potent Carbapenemase Inhibitors. Interscience Conference of Antimicrobial Agents and Chemotherapy (ICAAC) 2015-09-17 - 2015-09-21 2015.

  • Paulsen, Marianne H.; Engqvist, Stig Olov Magnus; Samuelsen, Ørjan; Leiros, Hanna-Kirsti S.; Skagseth, Susann; Leszczak, Kinga; Akhter, Sundus; Bayer, Annette. Synthesis of potential metallo-beta-lactamase inhibitors. Organisk kjemisk vintermøte OKV29 2014-01-09 - 2014-01-12 2014.

  • Hansen, Frank; Hammerum, Anette M.; Skov, Robert; Haldorsen, Bjørg; Sundsfjord, Arnfinn; Samuelsen, Ørjan. Evaluation of the total MBL confirm kit (ROSCO) for detection of metallo-β-lactamases in Pseudomonas aeruginosa and Acinetobacter baumannii. Diagnostic microbiology and infectious disease 2014; Volum 79 (4). ISSN 0732-8893.s 486 - 488.s doi: 10.1016/j.diagmicrobio.2013.12.001.

  • Lund, Bjarte Aarmo; Bjerga, Gro Elin Kjæreng; Christopeit, Tony; Samuelsen, Ørjan; Leiros, Hanna-Kirsti S.. Structural view on antibiotic resistance. Fragment-based lead discovery for the inhibition of oxacillinases. 12th Beta-Lactamase Meeting 2014-06-28 - 2014-07-01 2014.

  • Lund, Bjarte Aarmo; Bjerga, Gro Elin Kjæreng; Christopeit, Tony; Samuelsen, Ørjan; Leiros, Hanna-Kirsti S.. Structural view on antibiotic resistance. Fragment-based lead discovery for the inhibition of oxacillinases. The 46th INTERNATIONAL SCHOOL OF CRYSTALLOGRAPHY 2014-05-30 - 2014-06-08 2014.

  • Christopeit, Tony; Carlsen, Trine Josefine Olsen; Skagseth, Susann; Lund, Bjarte Aarmo; Samuelsen, Ørjan; Leiros, Hanna-Kirsti S.. Characterization of substrate and inhibitor binding to different beta-lactamases using Surface Plasmon Resonance based biosensors. 12th Beta-Lactamase Meeting 2014-06-28 - 2014-07-01 2014.

  • Skagseth, Susann; Carlsen, Trine Josefine Olsen; Bjerga, Gro Elin Kjæreng; Bayer, Annette; Samuelsen, Ørjan; Leiros, Hanna-Kirsti S.. The importance of residue Trp228 and Tyr233 in the metallo-beta-lactamase GIM-1. 12th Beta-Lactamase Meeting 2014-06-28 - 2014-07-01 2014.

  • Nilsen, Einar; Haldorsen, Bjørg; Sundsfjord, Arnfinn; Simonsen, Gunnar Skov; Ingebretsen, André; Naseer, Mohammed Umaer; Samuelsen, Ørjan. Large IncHI2-plasmids encode extended-spectrum beta-lactamases (ESBLs) in Enterobacter spp. bloodstream isolates, and support ESBL-transfer to Escherichia coli. Clinical Microbiology and Infection 2013; Volum 19 (11). ISSN 1198-743X.s 1091 - 1091.

  • Haldorsen, Bjørg; Samuelsen, Ørjan; Sundsfjord, Arnfinn; Hegstad, Kristin. Agreement of the MIC Test Strip and Etest with microbroth dilution in glycopeptide susceptibility testing of Enterococcus sp. 23rd European Congress of Clinical Microbiology and Infectious Diseases 2013-04-27 - 2013-04-30 2013.

  • Samuelsen, Ørjan; Naseer, Mohammed Umaer; Karah, Nabil; Lindemann, Paul Christoffer; Leegaard, Truls Michael; Sundsfjord, Arnfinn; Kanestrøm, Anita. Identification of Enterobacteriaceae isolates with OXA-48 and coproduction of OXA-181 and NDM-1 in Norway. Journal of Antimicrobial Chemotherapy 2013; Volum 68 (7). ISSN 0305-7453.s 1682 - 1685.s doi: 10.1093/jac/dkt058.

  • Sundsfjord, Arnfinn; Samuelsen, Ørjan; Hegstad, Kristin; Haldorsen, Bjørg C. I førstelinjen mot resistente bakterier. Bioingeniøren 2012 (2). ISSN 0801-6828.s 12 - 14.

  • Dahle, Ulf R; Wester, Astrid Louise; Samuelsen, Ørjan; Sundsfjord, Arnfinn. Siste skanse for effektive antibiotika?. Tidsskrift for Den norske legeforening 2012; Volum 132. ISSN 0029-2001.s 1725 - 1726.s doi: 10.4045/tidsskr.12.0565.

  • Samuelsen, Ørjan; Thilesen, Carina; Heggelund, Lars; Vada, Anne N.; Kümmel, Angela; Sundsfjord, arnfinn. Identification of NDM-1-producing Enterobacteriaceae in Norway. Journal of Antimicrobial Chemotherapy 2011; Volum 66 (3). ISSN 0305-7453.s 670 - 672.s doi: 10.1093/jac/dkq483.

  • Tveten, Yngvar; Sarjomaa, Marjut Anneli; Skaare, Dagfinn; Grude, Nils; Samuelsen, Ørjan. Hvordan stoppe multiresidente bakterier?. Tidsskrift for Den norske legeforening 2011; Volum 7 (131). ISSN 0029-2001.s 698 - 700.s doi: 10.4045/tidsskr.10.0369.

  • Samuelsen, Ørjan. Resistance to the antimicrobial peptide lactoferricin B in Staphylococcus aureus. 2005 ISBN 82-7589-156-6.

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