Samuelsen, Ørjan
Professor
Christopher Frøhlich,
Vidar Sørum,
Nobuhiko Tokuriki,
Pål Jarle Johnsen,
Ørjan Samuelsen
:
Evolution of β-lactamase-mediated cefiderocol resistance
Kenneth Lindstedt,
Dorota Julia Buczek,
Torunn Annie Pedersen,
Erik Hjerde,
Niclas Peter Raffelsberger,
Yutaka Suzuki
m.fl.:
Detection of Klebsiella pneumoniae human gut carriage: a comparison of culture, qPCR, and whole metagenomic sequencing methods
Gut microbes 31. august 2022 DOI
Rebecca Ashley Gladstone,
Alan McNally,
Anna Kaarina Pöntinen,
Gerry Tonkin-Hill,
John A. Lees,
Kusti Onni Skytén
m.fl.:
Emergence and dissemination of antimicrobial resistance in Escherichia coli causing bloodstream infections in Norway in 2002–17: a nationwide, longitudinal, microbial population genomic study
Julia Kloos,
João A Gama,
Joachim Hegstad,
Ørjan Samuelsen,
Pål J Johnsen
:
Piggybacking on Niche Adaptation Improves the Maintenance of Multidrug-Resistance Plasmids
Niclas Peter Raffelsberger,
Marit Andrea Klokkhammer Hetland,
Kristian Svendsen,
Lars Småbrekke,
Iren Høyland Löhr,
Lotte Andreassen
m.fl.:
Gastrointestinal carriage of Klebsiella pneumoniae in a general adult population: a cross-sectional study of risk factors and bacterial genomic diversity
Supathep Tansirichaiya,
Richard N. Goodman,
Xinyu Guo,
Issra Bulgasim,
Ørjan Samuelsen,
Mohammed Al-Haroni
m.fl.:
Intracellular Transposition and Capture of Mobile Genetic Elements following Intercellular Conjugation of Multidrug Resistance Conjugative Plasmids from Clinical Enterobacteriaceae Isolates
Sergio Arredondo Alonso,
Anna Kaarina Pöntinen,
Francois Pierre Alexandre Cleon,
Rebecca Ashley Gladstone,
Anita C. Schürch,
Pål Jarle Johnsen
m.fl.:
A high-throughput multiplexing and selection strategy to complete bacterial genomes
Tommi Mäklin,
Teemu Kallonen,
Jarno Alanko,
Ørjan Samuelsen,
Kristin Hegstad,
Veli Mäkinen
m.fl.:
Bacterial genomic epidemiology with mixed samples
Jessin Janice,
Nicholas Agyepong,
Alex Owusu-Ofori,
Usha Govinden,
Sabiha Essack,
Ørjan Samuelsen
m.fl.:
Carbapenem resistance determinants acquired through novel chromosomal integrations in extensively drug-resistant pseudomonas aeruginosa
Aasmund Fostervold,
Marit Andrea Klokkhammer Hetland,
Ragna-Johanne Bakksjø,
Eva Bernhoff,
Kathryn E. Holt,
Ørjan Samuelsen
m.fl.:
A nationwide genomic study of clinical Klebsiella pneumoniae in
Norway 2001–15: introduction and spread of ESBLs facilitated by
clonal groups CG15 and CG307
Jonina Gudmundsdottir,
Elizabeth G. Aarag Fredheim,
Catharina I.M. Koumans,
Joachim Hegstad,
Po-Cheng Tang,
Dan I. Andersson
m.fl.:
The chemotherapeutic drug methotrexate selects for antibiotic resistance
Christopher Frøhlich,
João Alves Gama,
Klaus Harms,
Viivi H. A. Hirvonen,
Bjarte Aarmo Lund,
Marc W. van der Kamp
m.fl.:
Cryptic β-Lactamase Evolution Is Driven by Low β-Lactam Concentrations
Hanna-Kirsti S. Leiros,
Ane Molden Thomassen,
Ørjan Samuelsen,
Carl-Fredrik Flach,
Stathis D. Kotsakis,
Joakim Larsson
:
Structural insights into the enhanced carbapenemase
efficiency of OXA-655 compared to OXA-10
Catherine Ludden,
Felix Lötsch,
Erik Alm,
Narender Kumar,
Karin Johansson,
Barbara Albiger
m.fl.:
Cross-border spread of blaNDM-1- and blaOXA-48-positive Klebsiella pneumoniae: a European collaborative analysis of whole genome sequencing and epidemiological data, 2014 to 2019
Ørjan Samuelsen,
Ove Alexander Høgmoen Åstrand,
Christopher Frøhlich,
Adam Heikal,
Susann Skagseth,
Trine Josefine Olsen Carlsen
m.fl.:
ZN148 Is a Modular Synthetic Metallo-beta-Lactamase Inhibitor That Reverses Carbapenem Resistance in Gram-Negative Pathogens In Vivo
Joao Pedro Alves Gama,
Julia Maria Kloos,
Pål Jarle Johnsen,
Ørjan Samuelsen
:
Host dependent maintenance of a blaNDM-1-encoding plasmid in clinical Escherichia coli isolates
Christopher Frøhlich,
Vidar Sørum,
Sandra Huber,
Ørjan Samuelsen,
Fanny Berglund,
Erik Kristiansson
m.fl.:
Structural and biochemical characterization of the environmental MBLs MYO-1, ECV-1 and SHD-1
Torunn Annie Pedersen,
Marit Gjerde Tellevik,
Øyvind Kommedal,
Paul Christoffer Lindemann,
Sabrina John Moyo,
Jessin Janice James Peter
m.fl.:
Horizontal plasmid transfer among klebsiella pneumoniae isolates is the key factor for dissemination of extended-spectrum β-lactamases among children in Tanzania
Julia Maria Kloos,
Joao Pedro Alves Gama,
Pål Jarle Johnsen,
Ørjan Samuelsen
:
Host dependent maintenance of a blaNDM-1-encoding plasmid in clinical Escherichia coli isolates
Scientific Reports 2020 DOI
Ilya Nikolaevich Zykov,
Niels Frimodt-Møller,
Lars Småbrekke,
Arnfinn Sundsfjord,
Ørjan Samuelsen
:
Efficacy of mecillinam against clinical multidrug-resistant Escherichia coli in a murine urinary tract infection model
Petter Elstrøm,
Elisabeth Astrup,
Kristin Hegstad,
Ørjan Samuelsen,
Hege Enger,
Oliver Kacelnik
:
The fight to keep resistance at bay, epidemiology of carbapenemase producing organisms (CPOs), vancomycin resistant enterococci (VRE) and methicillin resistant Staphylococcus aureus (MRSA) in Norway, 2006-2017
Christopher Frøhlich,
Vidar Sørum,
Ane Molden Thomassen,
Pål Jarle Johnsen,
Hanna-Kirsti S. Leiros,
Ørjan Samuelsen
:
OXA-48-Mediated Ceftazidime-Avibactam Resistance Is Associated with Evolutionary Trade-Offs
Anthony Prandina,
Sylvie Radix,
Marc Le Borgne,
Lars Petter Jordheim,
Zineb Bousfiha,
Christopher Fröhlich
m.fl.:
Synthesis and biological evaluation of new dipicolylamine zinc chelators as metallo-β-lactamase inhibitors
Geir Kildahl-Andersen,
Christian Schnaars,
Anthony Prandina,
Sylvie Radix,
Marc Le Borgne,
Lars Petter Jordheim
m.fl.:
Synthesis and biological evaluation of zinc chelating compounds as metallo-β-lactamase inhibitors
MedChemComm 2019 DOI
Ørjan Samuelsen,
Frank Hansen,
Bettina Aasnæs,
Henrik Hasman,
Bjarte Aarmo Lund,
Hanna-Kirsti S. Leiros
m.fl.:
Dissemination and Characteristics of a Novel Plasmid-Encoded Carbapenem-Hydrolyzing Class D β-Lactamase, OXA-436, Found in Isolates from Four Patients at Six Different Hospitals in Denmark
Antimicrobial Agents and Chemotherapy 2018 DOI
Louise Roer,
Søren Overballe-Petersen,
Frank Hansen,
Kristian Schønning,
Mikala Wang,
Bent L Røder
m.fl.:
Escherichia coli Sequence Type 410 Is Causing New International High-Risk Clones
Christian Schnaars,
Geir kildahl-Andersen,
Anthony Prandina,
Roya Popal,
Sylvie Radix,
Marc Le Borgne
m.fl.:
Synthesis and preclinical evaluation of TPA-based zinc chelators as metallo-β-lactamase inhibitors
ACS Infectious Diseases 2018 DOI
George Taiaroa,
Ørjan Samuelsen,
Tom Kristensen,
Ole Andreas Økstad,
Adam Heikal
:
Complete Genome Sequence of Pseudomonas aeruginosa K34-7, a Carbapenem-Resistant Isolate of the High-Risk Sequence Type 233
Ilya Nikolaevich Zykov,
Ørjan Samuelsen,
Lotte Jakobsen,
Lars Småbrekke,
Dan I. Andersson,
Arnfinn Sundsfjord
m.fl.:
Pharmacokinetics and pharmacodynamics of fosfomycin and its activity against extended-spectrum-lactamase-, plasmid-mediated AmpC-, and carbapenemase-producing escherichia coli in a murine urinary tract infection model
Ellionor Rapp,
Ørjan Samuelsen,
Martin Sundqvist
:
Detection of carbapenemases with a newly developed commercial assay using Matrix Assisted Laser Desorption Ionization-Time of Flight
Bjørg Haldorsen,
Christian G Giske,
Dennis S Hansen,
Kristjan Orri Helgason,
Gunnar Kahlmeter,
Iren Høyland Löhr
m.fl.:
Performance of the EUCAST disc diffusion method and two MIC methods in detection of Enterobacteriaceae with reduced susceptibility to meropenem: the NordicAST CPE study.
Nicole L. Podnecky,
Elizabeth Aarag,
Julia Maria Kloos,
Vidar Sørum,
Raul Primicerio,
Adam Paul Roberts
m.fl.:
Conserved collateral antibiotic susceptibility networks in diverse clinical strains of Escherichia coli.
Torunn Annie Pedersen,
John Osei Sekyere,
Usha Govinden,
Krishnee Moodley,
Audun Sivertsen,
Ørjan Samuelsen
m.fl.:
Spread of plasmid-encoded NDM-1 and GES-5 carbapenemases among extensively drug-resistant and pandrug-resistant clinical enterobacteriaceae in durban, South Africa
Antimicrobial Agents and Chemotherapy 2018 DOI
Einar Sverre Berg,
Astrid Lousie Wester,
J Ahrenfeldt,
Solveig Sølverød Mo,
Jannice Schau Slettemeås,
Martin Steinbakk
m.fl.:
Norwegian patients and retail chicken meat share cephalosporin-resistant Escherichia coli and IncK/blaCMY-2 resistance plasmids
Clinical Microbiology and Infection (CMI) 2017 DOI
Ørjan Samuelsen,
Søren Overballe-Petersen,
Jørgen Bjørnholt,
Sylvain Brisse,
Michel Doumith,
Neil Woodford
m.fl.:
Molecular and epidemiological characterization of carbapenemase-producing Enterobacteriaceae in Norway, 2007 to 2014
Julia Maria Kloos,
Lea Jänisch,
Anna Kaarina Pöntinen,
Ørjan Samuelsen,
Pål Jarle Johnsen,
Jukka Corander
m.fl.:
Different metabolic proficiency among dominant ExPEC lineages
2022
Christopher Frøhlich,
Vidar Sørum,
Nobuhiko Tokuriki,
Ørjan Samuelsen
:
Evolution of ß-lactamase mediated cefiderocol resistance
2022
Bjørg Haldorsen,
Jessin Janice,
Ørjan Samuelsen
:
Evaluation of the Amplex eazyplex® SuperBug Acineto test for detection of acquired OXA and NDM carbapenemases in Acinetobacter spp.
Journal of Global Antimicrobial Resistance 2021 DOI
João Alves Gama,
Julia Maria Kloos,
Joachim Hegstad,
Ørjan Samuelsen,
Pål Jarle Johnsen
:
Plasmid cost alleviation as a consequence of niche-adaptation
2021
Julia Maria Kloos,
João Alves Gama,
Joachim Hegstad,
Ørjan Samuelsen,
Pål Jarle Johnsen
:
Plasmid Cost Alleviation By Hitchhiking On Niche-adaptation
2021
Julia Maria Kloos,
Joao Pedro Alves Gama,
Joachim Hegstad,
Ørjan Samuelsen,
Pål Jarle Johnsen
:
E. coli Niche Adaptation Improves Plasmid Maintenance
2021
Christopher Frøhlich,
Hanna-Kirsti S. Leiros,
Pål Jarle Johnsen,
Ørjan Samuelsen
:
Sub-inhibitory concentrations of ceftazidime drive evolution of the OXA-48 carbapenemase
2019
Christopher Frøhlich,
Pål Jarle Johnsen,
Hanna-Kirsti Schrøder Leiros,
Ørjan Samuelsen
:
Evolution of OXA-48 under sub-MIC conditions
2019
Vidar Sørum,
Emma Lu Øynes,
Anna Møller,
Nicole L. Podnecky,
Sören Abel,
Ørjan Samuelsen
m.fl.:
Evolutionary stability of collateral susceptibility networks in clinical Escherichia coli strains
2019
Vidar Sørum,
Anna Sollied Møller,
Pål Jarle Johnsen,
Ørjan Samuelsen,
Sören Abel,
Nicole L. Podnecky
:
Evolutionary stability of collateral effects in ciprofloxacin resistant clinical Escherichia coli strains
2019
Vidar Sørum,
Anna Sollied Møller,
Sören Abel,
Ørjan Samuelsen,
Nicole L. Podnecky,
Pål Jarle Johnsen
:
Evolutionary stability of collateral effects in ciprofloxacin resistant clinical Escherichia coli strains
2019
Julia Maria Kloos,
Joao Pedro Alves Gama,
Ørjan Samuelsen,
Pål Jarle Johnsen
:
Klebsiella pneumoniae MDR-encoding plasmids in clinical isolates of uropathogenic Escherichia coli: plasmid-host co-evolution and its effect on fitness cost of plasmid-mediated resistance
2018
Julia Maria Kloos,
Joao Pedro Alves Gama,
Ørjan Samuelsen,
Pål Jarle Johnsen
:
Plasmid-host co-evolution of Klebsiella pneumoniae MDR-encoding plasmids in clinical isolates of uropathogenic Escherichia coli: effect on fitness cost of plasmid-mediated resistance
2018
Christopher Frøhlich,
Vidar Sørum,
Hanna-Kirsti S. Leiros,
Pål Jarle Johnsen,
Ørjan Samuelsen
:
Development of OXA-48 mediated ceftazidme-avibactam resistance is associated with an evolutionary trade-off
2018
Aleksandra Jakovljev,
Jan Egil Afset,
Kjersti Haugum,
Torunn Gresdal Rønning,
Harald Otto Steinum,
Ørjan Samuelsen
m.fl.:
"Escherichia coli sepsis: casus presentasjon med uvanlig resistensmønster"
2018
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Forskningsinteresser
Through my positions as Professor II at the Microbial Pharmacology and Population Biology Research Group and as senior scientist at the Norwegian National Advisory Unit on Detection of Antimicrobial Resistance my research focuses broadly on the following topics molecular epidemiology, evaluation of diagnostic methods, biochemical and structural characterization of β-lactamases, development of β-lactamase inhibitors and the evolutionary aspects and transmission dynamics of resistance plasmids.