Maria Therese Ahlen
Stillingsbeskrivelse
Forskning og veiledning av studenter på bachelor, master og PhD nivå innen Immunologi.
Undervisning i immunologi for tannlege og medisinstudenter.
Tilknyttet Immunologisk forskningsgruppe UiT
Forsker ved Laboratoriemedisin og Nasjonal behandlingstjeneste for avanasert trombocyttimmunologi ved UNN www.unn.no/nnupi
Kontor: UNN Breivika, A10, Laboratoriemedisin, A2.1032
Vitenskapelige arbeidsområder
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Forskningsinteresser
Blodplateimmunologi
Forskning på ulike antistoff-medierte blodplatekomplikasjoner utføres i nært samarbeid med
Nasjonal behandlingstjeneste for avansert trombocyttimmunologi ved UNN.
T-cellereponser ved Føtal/neonatal alloimmun trombocytopeni
Identifisering av T-celler involvert i FNAIT
(Foto: Elisabeth Øvreberg)
Publikasjoner
2025
Improving prediction of fetal/neonatal intracranial hemorrhage in HPA-1a alloimmunized pregnancies to guide antenatal management: An observational cohort study. Ernstsen SL, Ahlen MT, Bertelsen EL, Kjeldsen-Kragh J, Husebekk A, Tiller H. Acta Obstet Gynecol Scand. 2025 Oct;104(10):1859-1868. doi: 10.1111/aogs.70031. Epub 2025 Aug 20. Original Research article.
Adding contrast to shed some light - A case of acute thrombocytopenia due to iohexol-dependent antibodies to glycoprotein IIb/IIIa. Lægreid IJ, Hald EM, Arsenovic MG, Ernstsen SL, Asplund Högelin K, Mørtberg TV, Ahlen MT. J Thromb Haemost. 2025 Oct 9:S1538-7836(25)00607-5. doi: 10.1016/j.jtha.2025.09.016. Online ahead of print. Original Research article.
Safety and Efficacy of Daratumumab in Immune Thrombocytopenia. Tsykunova G, Holme PA, Tran HTT Dr, Frederiksen H, Tjonnfjord E, Munthe LA, Drivet E, Kared H, Sørvoll IH, Ahlen MT, Mahevas M, Michel M, Bussel JB, Kuter DJ, Tvedt THA, Ghanima W. Blood Adv. 2025 Online ahead of print. doi: 10.1182/bloodadvances.2025017279. Original Research article.
Rising to the challenge: an international Delphi consensus study on fetal and neonatal alloimmune thrombocytopenia. Pothof R, van den Akker-van Marle EM, de Vos TW, Tiller H, Bussel JB, Ahlén MT, Curtis BR, Lopriore E, Verweij EJTJ, de Haas M; FNAIT modified Delphi expert group. Lancet Haematol. 2025 Apr;12(4):e304-e311. doi: 10.1016/S2352-3026(25)00029-8. Review
2024
Placenta-associated biomarkers and pregnancy outcome in HPA-1a alloimmunization: A prospective cohort study. Nedberg NH, Nystad M, Ahlen MT, Bertelsen EL, Guz K, Uhrynowska M, Dębska M, Gierszon A, Orzińska A, Husebekk A, Brojer E, Staff AC, Tiller H. Placenta. 2024. Dec;158:185-191. doi: 10.1016/j.placenta.2024.10.014. Original Research article.
Low Incidence of Anti-PF4/Heparin Antibodies in Patients with Acute Myelogenous Leukemia. Sørvoll IH, Lægreid IJ, Sollid T, Ahlen MT, Johansen S, Reikvam H. Mediterr J Hematol Infect Dis. 2024 Jul 1;16(1):e2024057. doi: 10.4084/MJHID.2024.057. Original Research article.
2023
Coucheron T, Uhrynowska M, Guz K, Orzińska A, Debska M, Gierszon A, Ahlen MT, Bertelsen EL, Berge G, Husebekk A, Brojer E, Tiller H. What's with the boys? Lower birth weight in boys from HPA-1a alloimmunized pregnancies - New insights from a large prospective screening study in Poland. J Reprod Immunol. 2023. 160:104168. doi: 10.1016/j.jri.2023.104168. Original Research article.
Ahlen MT, Bussel JB. Desialylation unmasks HPA-9B alloantibodies. Blood. 2023. 142(22):1853-1854. doi: 10.1182/blood.2023022495. Commentary.
Garabet L, Eriksson A, Tjønnfjord E, Cui XY, Olsen MK, Jacobsen HK, Jørgensen CT, Mathisen ÅB, Mowinckel MC, Ahlen MT, Sørvoll IH, Horvei KD, Ernstsen SL, Lægreid IJ, Stavik B, Holst R, Sandset PM, Ghanima W. SARS-CoV-2 vaccines are not associated with hypercoagulability in apparently healthy people. Res Pract Thromb Haemost. 2023 Jan;7(1):100002. doi: 10.1016/j.rpth.2022.100002 Original Research article.
Schultz NH, Søraas AVL, Sørvoll IH, Akkök ÇA, Vetlesen A, Bhamra JS, Ahlen MT, Holme PA, Aamodt AH, Skagen K, Skattør TH, Skjelland M, Wiedmann MK. Vaccine associated benign headache and cutaneous hemorrhage after ChAdOx1 nCoV-19 vaccine: A cohort study. J Stroke Cerebrovasc Dis. 2023 Jan;32(1):106860. doi: 10.1016/j.jstrokecerebrovasdis.2022.106860. Original Research article.
2022
Ernstsen SL, Ahlen MT, Johansen T, Bertelsen EL, Kjeldsen-Kragh J, Tiller H. Antenatal intravenous immunoglobulins in pregnancies at risk of fetal and neonatal alloimmune thrombocytopenia: comparison of neonatal outcome in treated and nontreated pregnancies. Am J Obstet Gynecol. 2022; S0002-9378(22)00325-8. Original Research article.
Kanack AJ, Laegreid IJ, Johansen S, Reikvam H, Ahlen MT, Padmanabhan A. Human papilloma virus vaccine and VITT antibody induction. Am J Hematol. 2022 Oct;97(10):E363-E364. doi: 10.1002/ajh.26659. Epub 2022 Aug 3.
Laegreid IJ, Olsen MI, Harr JI, Grønli RH, Mørtberg TV, Ernstsen SL, Ahlen MT. Acute drug-induced immune thrombocytopenia - A work of articaine. Transfusion. 2022 May;62(5):1142-1147. doi: 10.1111/trf.16858. Epub 2022 Mar 19.
Ueland T, Hausberg I, Mørtberg TV, Dahl TB, Lerum TV, Michelsen A, Ranheim T, Nezvalova Henriksen K, Dyrhol-Riise AM, Holme PA, Aaløkken TM, Skjønsberg OH, Barratt-Due A, Ahlén MT, Aukrust P, Halvorsen B. Anti-PF4/polyanion antibodies in COVID-19 patients are associated with disease severity and pulmonary pathology. Platelets. 2022 May 19;33(4):640-644. Original Research article.
Mørtberg TV, Zhi H, Vidarsson G, Foss S, Lissenberg-Thunnissen S, Wuhrer M, Michaelsen TE, Skogen B, Stuge TB, Andersen JT, Newman PJ, Ahlen MT. Prevention of Fetal/Neonatal Alloimmune Thrombocytopenia in Mice: Biochemical and Cell Biological Characterization of Isoforms of a Human Monoclonal Antibody. ImmunoHorizons. 2022; 6 (1) 90-103; Original Research article.
Johansen S, Laegreid IJ, Ernstsen SL, Azrakhsh NA, Kittang AO, Lindås R, Gjertsen BT, Vetti N, Mørtberg TV, Sørvoll IH, Holme PA, Ahlen MT, Reikvam H. Thrombosis and thrombocytopenia after HPV vaccination. J Thromb Haemost. 2022 Mar;20(3):700-704. doi: 10.1111/jth.15604. Epub 2021
2021
Ahlen MT. Fighting anti-CD36-mediated FNAIT. Blood. 2021 Nov 4;138(18):1650-1652. doi: 10.1182/blood.2021012454. Commentary.
Schultz NH, Sørvoll IH, Michelsen AE, Munthe LA, Lund-Johansen F, Ahlen MT, Wiedmann M, Aamodt AH, Skattør TH, Tjønnfjord GE, Holme PA Thrombosis and Thrombocytopenia after ChAdOx1 nCoV-19 Vaccination. N Engl J Med. 2021; 384(22):2124-2130. Brief report.
Newly discovered catastrophic antibody formation after the AstraZeneca vaccine. Lægreid IJ, Sørvoll IH, Ernstsen SL, Horvei KD, Hauglann S, Lund S, Grønli RH, Solbø C, Pedersen M, Ahlen MT. Tidsskr Nor Laegeforen. 2021 Apr 10;141. doi: 10.4045/tidsskr.21.0265.
Sørvoll IH, Horvei KD, Ernstsen SL, Laegreid IJ, Lund S, Grønli RH, Olsen MK, Jacobsen HK, Eriksson A, Halstensen AM, Tjønnfjord E, Ghanima W, Ahlen MT. An observational study to identify the prevalence of thrombocytopenia and anti-PF4/polyanion antibodies in Norwegian health care workers after COVID-19 vaccination. J Thromb Haemost. 2021; (7):1813-1818. Original Research article.
Zhi H, Ahlen MT, Skogen B, Newman DK, Newman PJ. Preclinical evaluation of immunotherapeutic regimens for fetal/neonatal alloimmune thrombocytopenia. Blood Adv. 2021; 5(18):3552-3562. Original Research article.
Nazy I, Sachs UJ, Arnold DM, McKenzie SE, Choi P, Althaus K, Ahlen MT, Sharma R, Grace RF, Bakchoul T. Recommendations for the clinical and laboratory diagnosis of VITT against COVID-19: Communication from the ISTH SSC Subcommittee on Platelet Immunology. J Thromb Haemost. 2021 Jun;19(6):1585-1588.
2020
Ahlen MT, Heide G, Husebekk A, Skogen B, Kjeldsen‐Kragh J, Stuge TB. The prevalence of HPA‐1a alloimmunization and the potential risk of FNAIT depend on both the DRB3*01:01 allele and associated DR‐DQ haplotypes. Scand J Immunol. 2020; 92:e12890. Original Research article.
Kjeldsen-Kragh J, Ahlen MT. Foetal and neonatal alloimmune thrombocytopenia - The role of the HLA-DRB3*01:01 allele for HPA-1a-immunisation and foetal/neonatal outcome. Transfus Apher Sci. 2020 Feb;59(1):102707. Review.
Rasmussen TV, Ahlen MT. Murine models for studying treatment, prevention and pathogenesis of FNAIT. Transfus Apher Sci. 2020 Feb;59(1):102706. Review.
Tiller H, Ahlen MT, Akkök ÇA, Husebekk A. Fetal and neonatal alloimmune thrombocytopenia - The Norwegian management model. Transfus Apher Sci. 2020 Feb;59(1):102711
2018
Zhi H, Ahlen MT, Thinn, AM, Weiler, H, Curtis, BR., Skogen, B, Zhu, J, Newman, PJ. High-resolution mapping of the polyclonal immune response to the human platelet alloantigen HPA-1a (PlA1). Blood Advances, 2018: 2(21), 3001-3011. Original Research article.
Orzińska A, Guz K, Uhrynowska M, Dębska M, Mikula M, Ostrowski J, Ahlen MT, Husebekk A, Brojer E. Noninvasive prenatal HPA-1 typing in HPA-1a negative pregnancies selected in the Polish PREVFNAIT screening program. Transfusion. 2018 Nov;58(11):2705-2711.
2017
Tiller H, Husebekk A, Ahlen MT, Stuge TB, Skogen B. Current perspectives on fetal and neonatal alloimmune thrombocytopenia - increasing clinical concerns and new treatment opportunities. Int J Womens Health. 2017 Apr 19;9:223-234. Review.
Unraveling the role of maternal anti-HLA class I antibodies in fetal and neonatal thrombocytopenia-Antibody specificity analysis using epitope data. Dahl J, Refsum E, Ahlen MT, Egeland T, Jensen T, Viken MK, Stuge TB, Acharya G, Husebekk A, Skogen B, Tiller H. J Reprod Immunol. 2017 Aug;122:1-9. doi: 10.1016/j.jri.2017.06.003. Original Research article.
2016
Ahlen MT, Husebekk A, Killie IL, Skogen B, Stuge TB. T cell responses to Human Platelet Antigen-1a involve a unique form of indirect allorecognition. JCI Insight. 2016;1(14):e86558 Original research article.
Older
The DR7-DQ2 haplotype in a native Norwegian population. Heide G, Stuge TB, Skogen B, Husebekk A, Ahlen MT. Scand J Immunol. 2013 May;77(5):429-30. doi: 10.1111/sji.12031. Original research article.
Foetal/neonatal alloimmune thrombocytopenia in Egypt; human platelet antigen genotype frequencies and antibody detection and follow-up in pregnancies. Husebekk A, El Ekiaby M, Gorgy G, Killie MK, Uhlin-Hansen C, Salma W, Navarrete C, El Afandi M, Skogen B, Ahlen MT. Transfus Apher Sci. 2012 Dec;47(3):277-82. doi: 10.1016/j.transci.2012.04.001.
The development of severe neonatal alloimmune thrombocytopenia due to anti-HPA-1a antibodies is correlated to maternal ABO genotypes. Ahlen MT, Husebekk A, Killie MK, Kjeldsen-Kragh J, Olsson ML, Skogen B. Clin Dev Immunol. 2012;2012:156867. doi: 10.1155/2012/156867. Original research article.
Ahlen MT, Husebekk A, Killie MK, Skogen B and Stuge TB. T-cell responses associated with neonatal alloimmune thrombocytopenia: isolation of HPA-1a-specific, HLA-DRB3*0101-restricted CD4+ T cells. Blood. 2009 Apr 16;113(16):3838-44. Original research article.