Selected publications
FNAIT and platelet immunology
What's with the boys? Lower birth weight in boys from HPA-1a alloimmunized pregnancies - New insights from a large prospective screening study in Poland. Coucheron T, Uhrynowska M, Guz K, Orzińska A, Debska M, Gierszon A, Ahlen MT, Bertelsen EL, Berge G, Husebekk A, Brojer E, Tiller H. J Reprod Immunol. 2023;160:104168. https://doi.org/10.1016/j.jri.2023.104168
Antenatal intravenous immunoglobulins in pregnancies at risk of fetal and neonatal alloimmune thrombocytopenia: comparison of neonatal outcome in treated and nontreated pregnancies. Ernstsen SL, Ahlen MT, Johansen T, Bertelsen EL, Kjeldsen-Kragh J, Tiller H. Am J Obstet Gynecol. 2022;227(3):506.e12. https://doi.org/10.1016/j.ajog.2022.04.044
Prevention of Fetal/Neonatal Alloimmune Thrombocytopenia in Mice: Biochemical and Cell Biological Characterization of Isoforms of a Human Monoclonal Antibody. Mortberg TV, Zhi H, Vidarsson G, Foss S, Lissenberg-Thunnissen S, Wuhrer M, Michaelsen TE, Skogen B, Stuge TB, Andersen JT, Newman PJ, Ahlen MT. Immunohorizons. 2022;6:90-103 https://doi.org/10.4049/immunohorizons.2100097
Acute drug-induced immune thrombocytopenia - A work of articaine. Laegreid IJ, Olsen MI, Harr JI, Grønli RH, Mørtberg TV, Ernstsen SL, Ahlen MT. Transfusion. 2022;62(5):1142-1147. https://doi.org/10.1111/trf.16858
Thrombosis and thrombocytopenia after HPV vaccination. Johansen S, Laegreid IJ, Ernstsen SL, Azrakhsh NA, Kittang AO, Lindås R, Gjertsen BT, Vetti N, Mørtberg TV, Sørvoll IH, Holme PA, Ahlen MT, Reikvam H. J Thromb Haemost. 2022;20(3):700-704. https://doi.org/10.1111/jth.15604
An observational study to identify the prevalence of thrombocytopenia and anti-PF4/polyanion antibodies in Norwegian health care workers after COVID-19 vaccination. Sørvoll IH, Horvei KD, Ernstsen SL, Laegreid IJ, Lund S, Grønli RH, Olsen MK, Jacobsen HK, Eriksson A, Halstensen AM, Tjønnfjord E, Ghanima W, Ahlen MT. J Thromb Haemost. 2021;19(7):1813-1818. https://doi.org/10.1111/jth.15352
Platelet alloimmunization is associated with low grade chronic histiocytic intervillositis - A new link to a rare placental lesion? Nedberg NH, Turowski G, Guz 3, Przytuła E, Uhrynowska M, Roald B, Husebekk A, Sitras V, Nystad M, Dębska M, Brojer E, Tiller H. Placenta. 2021;1:112:89-96. https://doi.org/10.1016/j.placenta.2021.07.291
Preclinical evaluation of immunotherapeutic regimens for fetal/neonatal alloimmune thrombocytopenia. Zhi H, Ahlen MT, Skogen B, Newman DK, Newman PJ. Blood Adv. 2021;5(18):3552-3562. https://doi.org/10.1182/bloodadvances.2021004371.
Thrombosis and Thrombocytopenia after ChAdOx1 nCoV-19 Vaccination. Schultz NH, Sørvoll IH, Michelsen AE, Munthe LA, Lund-Johansen F, Ahlen MT, Wiedmann M, Aamodt AH, Skattør TH, Tjønnfjord GE, Holme PA. N Engl J Med. 2021;384(22):2124-2130. https://doi.org/10.1056/NEJMoa2104882
The prevalence of HPA-1a alloimmunization and the potential risk of FNAIT depend on both the DRB3*01:01 allele and associated DR-DQ haplotypes. Ahlen MT, Heide G, Husebekk A, Skogen B, Kjeldsen-Kragh J, Stuge TB. Scand J Immunol. 2020;92(1):e12890.
https://doi.org/10.1111/sji.12890
T cell responses to Human Platelet Antigen-1a involve a unique form of indirect allorecognition. Ahlen MT, Husebekk A, Killie IL, Skogen B, Stuge TB. JCI Insight. 2016;1(14):e86558 http://doi.org/10.1172/jci.insight.86558
Characterization of a Human Platelet Antigen-1a-Specific Monoclonal Antibody Derived from a B Cell from a Woman Alloimmunized in Pregnancy. Eksteen M, Tiller H, Averina M, Heide G, Kjaer M, Ghevaert C, Michaelsen TE, Ihle O, Husebekk A, Skogen B, Stuge TB. J Immunol. 2015;194: 5751-5760. https://doi.org/10.4049/jimmunol.1401599
Toward a prophylaxis against fetal and neonatal alloimmune thrombocytopenia: induction of antibody-mediated immune suppression and prevention of severe clinical complications in a murine model. Tiller H, Killie MK, Chen P, Eksteen M, Husebekk A, Skogen B, Kjeldsen-Kragh J, Ni H. Transfusion. 2012;52:1446-1457. https://doi.org/10.1111/j.1537-2995.2011.03480.x
T-cell responses associated with neonatal alloimmune thrombocytopenia: isolation of HPA-1a-specific, HLA-DRB3*0101-restricted CD4+ T cells. Ahlen MT, Husebekk A, Killie MK, Skogen B and Stuge TB. Blood. 2009;16;113(16):3838-3844. https://doi.org/10.1182/blood-2008-09-178475
A screening and intervention program aimed to reduce mortality and serious morbidity associated with severe neonatal alloimmune thrombocytopenia. Kjeldsen-Kragh J, Killie MK, Tomter G, Golebiowska E, Randen I, Hauge R, Aune B, Oian P, Dahl LB, Pirhonen J, Lindeman R, Husby H, Haugen G, Gronn M, Skogen B, Husebekk A. Blood. 2007;1;110(3):833-839. https://doi.org/10.1182/blood-2006-08-040121
Immunothrombosis
Extracellular vesicles from activated platelets possess a phospholipid-rich biomolecular profile and enhance prothrombinase activity. Guerreiro EM, Kruglik SG, Swamy S, Latysheva N, Østerud B, Guigner JM, Sureau F, Bonneau S, Kuzmin AN, Prasad PN, Hansen JB, Hellesø OG, Snir O. J Thromb Haemost. 2024;22:S1538-7836(24)00041-2. https://doi.org/10.1016/j.jtha.2024.01.004
Sustained and intermittent hypoxia differentially modulate primary monocyte immunothrombotic responses to IL-1β stimulation. Wahlund CJE, Çaglayan S, Czarnewski P, Hansen JB, Snir O. Front Immunol. 2023;11;14:1240597. https://doi.org/10.3389/fimmu.2023.1240597
Plasma levels of platelet-derived microvesicles are associated with risk of future venous thromboembolism. Snir O, Wilsgård L, Latysheva N, Wahlund CJE, Braekkan SK, Hindberg K, Hansen JB. J Thromb Haemost. 2022;20(4):899-908. https://doi.org/10.1111/jth.15638
A rapid, sensitive, and specific assay to measure TF activity based on chromogenic determination of thrombin generation. Østerud B, Latysheva N, Schoergenhofer C, Jilma B, Hansen JB, Snir O. J Thromb Haemost. 2022;20(4):866-876. https://doi.org/10.1111/jth.15606.
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