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  3. Maria Therese Ahlen
Bilde av Ahlen, Maria Therese
Bilde av Ahlen, Maria Therese
Førsteamanuensis Institutt for medisinsk biologi maria.t.ahlen@uit.no

Maria Therese Ahlen

Stillingsbeskrivelse

Forskning, undervisning og veiledning av studenter, Immunolgi.

Forsker ved Laboratoriemedisin og Nasjonal behandlingstjeneste for avanasert trombocyttimmunologi ved UNN www.unn.no/nnupi

 

  • Tina Coucheron, Malgorzata Uhrynowska, Katarzyna Guz, Agnieszka Orzińska, Marzena Debska, Agnieszka Gierszon m.fl.:
    What's with the boys? Lower birth weight in boys from HPA-1a alloimmunized pregnancies – New insights from a large prospective screening study in Poland
    Journal of Reproductive Immunology 2023 ARKIV / DOI
  • Ingvild Jenssen Lægreid, Mats Irgen Olsen, Jon Inge Harr, Renathe Henriksen Grønli, Trude Victoria Mørtberg, Siw Leiknes Ernstsen m.fl.:
    Acute drug-induced immune thrombocytopenia - A work of articaine
    Transfusion 2022 DOI
  • Siw Leiknes Ernstsen, Maria Therese Ahlen, Tiril Johansen, Eirin Listau Bertelsen, Jens Kjeldsen-Kragh, Heidi Tiller :
    Antenatal intravenous immunoglobulins in pregnancies at risk of fetal and neonatal alloimmune thrombocytopenia: comparison of neonatal outcome in treated and nontreated pregnancies
    American Journal of Obstetrics and Gynecology 2022 ARKIV / DOI
  • Trude Victoria Mørtberg, Huiying Zhi, Gestur Vidarsson, Stian Foss, Suzanne Lissenberg-Thunnissen, Manfred Wuhrer m.fl.:
    Prevention of Fetal/Neonatal Alloimmune Thrombocytopenia in Mice: Biochemical and Cell Biological Characterization of Isoforms of a Human Monoclonal Antibody
    ImmunoHorizons 2022 ARKIV / DOI
  • Lamya Samir Noori Garabet, Anna Maria Eriksson, Eirik Tjønnfjord, Xueyan Cui, Magnus Kringstad Olsen, Hege Jacobsen m.fl.:
    SARS-CoV-2 vaccines are not associated with hypercoagulability in apparently healthy people
    Research and Practice in Thrombosis and Haemostasis (RPTH) 2022 ARKIV / DOI
  • Nina Haagenrud Schultz, Arne Vasli Søraas, Ingvild Hausberg Sørvoll, Cigdem Ahaein Akkøk, Annette Vetlesen, Bhamra Singh Jagjit m.fl.:
    Vaccine associated benign headache and cutaneous hemorrhage after ChAdOx1 nCoV-19 vaccine: A cohort study
    Journal of Stroke & Cerebrovascular Diseases 2022 ARKIV / DOI
  • Thor Ueland, Ingvild Hausberg Sørvoll, Trude Victoria Mørtberg, Tuva Børresdatter Dahl, Tøri Vigeland Lerum, Annika Elisabet Michelsen m.fl.:
    Anti-PF4/polyanion antibodies in COVID-19 patients are associated with disease severity and pulmonary pathology
    Platelets 2022 ARKIV / DOI
  • Silje Johansen, Ingvild Jenssen Lægreid, Siw Leiknes Ernstsen, Nessar Ahmad Azrakhsh, Astrid Marta Olsnes Kittang, Roald Lindås m.fl.:
    Thrombosis and thrombocytopenia after HPV vaccination
    Journal of Thrombosis and Haemostasis 2021 ARKIV / DOI
  • Huiying Zhi, Maria Therese Ahlen, Bjørn Skogen, Debra K. Newman, Peter J. Newman :
    Preclinical evaluation of immunotherapeutic regimens for fetal/neonatal alloimmune thrombocytopenia
    Blood Advances 2021 DOI
  • Ishac Nazy, Ulrich J. Sachs, Donald M. Arnold, Steven E. McKenzie, Phil Choi, Karina Althaus m.fl.:
    Recommendations for the clinical and laboratory diagnosis of VITT against COVID-19: Communication from the ISTH SSC Subcommittee on Platelet Immunology
    Journal of Thrombosis and Haemostasis 2021 DOI
  • Ingvild Hausberg Sørvoll, Kjersti Daae Horvei, Siw Leiknes Ernstsen, Ingvild Jenssen Lægreid, Svetlana Lund, Renathe Henriksen Grønli m.fl.:
    An observational study to identify the prevalence of thrombocytopenia and anti-PF4/polyanion antibodies in Norwegian health care workers after COVID-19 vaccination
    Journal of Thrombosis and Haemostasis 2021 ARKIV / DOI
  • Nina Haagenrud Schultz, Ingvild Hausberg Sørvoll, Annika Michelsen, Ludvig Andre Munthe, Fridtjof Lund-Johansen, Maria Therese Ahlen m.fl.:
    Thrombosis and thrombocytopenia after CHADOX1 NCoV-19 vaccination
    New England Journal of Medicine 2021 ARKIV / DOI
  • Trude Victoria Rasmussen, Maria Therese Ahlen :
    Murine models for studying treatment, prevention and pathogenesis of FNAIT
    Transfusion and Apheresis Science 2020 ARKIV / DOI
  • Jens Kjeldsen-Kragh, Maria Therese Ahlen :
    Foetal and neonatal alloimmune thrombocytopenia - The role of the HLA-DRB3*01:01 allele for HPA-1a-immunisation and foetal/neonatal outcome
    Transfusion and Apheresis Science 2020 DOI
  • Maria Therese Ahlen, Gøril Heide, Anne Husebekk, Bjørn Skogen, Jens Kjeldsen-Kragh, Tor Brynjar Stuge :
    The prevalence of HPA-1a alloimmunization and the potential risk of FNAIT depend on both the DRB3*01:01 allele and associated DR-DQ haplotypes
    Scandinavian Journal of Immunology 16. april 2020 ARKIV / DOI
  • Heidi Tiller, Maria Therese Ahlen, Cigdem Ahaein Akkøk, Anne Husebekk :
    Fetal and neonatal alloimmune thrombocytopenia - The Norwegian management model
    Transfusion and Apheresis Science 2019 ARKIV / DOI
  • Huiying Zhi, Maria Therese Ahlen, Aye Myat Myat Thinn, Hartmut Weiler, Brian R. Curtis, Bjørn Skogen m.fl.:
    High-resolutionmappingofthepolyclonalimmuneresponsetothehuman platelet alloantigen HPA-1a (PlA1)
    Blood Advances 2018 DOI
  • Agnieszka Orzińska, Katarzyna Guz, Małgorzata Uhrynowska, Marzena Dȩbska, Michal Mikula, Jerzy Ostrowski m.fl.:
    Noninvasive prenatal HPA-1 typing in HPA-1a negative pregnancies selected in the Polish PREVFNAIT screening program
    Transfusion 2018 DOI
  • Jesper Dahl, Erle Refsum, Maria Therese Ahlen, Torstein Egeland, Tore Jensen, Marte K Viken m.fl.:
    Unraveling the role of maternal anti-HLA class I antibodies in fetal and neonatal thrombocytopenia?Antibody specificity analysis using epitope data
    Journal of Reproductive Immunology 2017 DOI
  • Heidi Tiller, Anne Husebekk, Maria Therese Ahlen, Tor Brynjar Stuge, Bjørn Ragnar Skogen :
    Current perspectives on fetal and neonatal alloimmune thrombocytopenia - Increasing clinical concerns and new treatment opportunities
    International Journal of Women's Health 2017 ARKIV / DOI
  • Maria Therese Ahlen, Anne Husebekk, Ida Løken Killie, Bjørn Ragnar Skogen, Tor Brynjar Stuge :
    T cell responses to human platelet antigen-1a involve a unique form of indirect allorecognition
    JCI Insight 2016 DOI
  • Maria Therese Ahlen, Anne Husebekk, Mette Kjær Killie, Jens Kjeldsen-Kragh, Martin L. Olsson, Bjørn Ragnar Skogen :
    The Development of Severe Neonatal Alloimmune Thrombocytopenia due to Anti-HPA-1a Antibodies Is Correlated to Maternal ABO Genotypes
    Clinical & Developmental Immunology 2012 FULLTEKST / ARKIV / DOI
  • Anne Husebekk, M El Ekiaby, G Gorgy, Mette Kjær Killie, Camilla Uhlin Hansen, Wahida Salma m.fl.:
    Foetal/neonatal alloimmune thrombocytopenia in Egypt; human platelet antigen genotype frequencies and antibody detection and follow-up in pregnancies
    Transfusion and Apheresis Science 2012 DOI
  • Tor Brynjar Stuge, Bjørn Ragnar Skogen, Maria Therese Ahlen, Anne Husebekk, SJ Urbaniak, H Bessos :
    The Cellular immunobiology associated with fetal and neonatal alloimmune thrombocytopenia
    Transfusion and Apheresis Science 2011 DOI
  • Bjørn Ragnar Skogen, Mette Kjær Killie, Jens Kjeldsen-Kragh, Maria Therese Ahlen, Heidi Tiller, Tor Brynjar Stuge m.fl.:
    Reconsidering fetal and neonatal alloimmune thrombocytopenia with a focus on screening and prevention
    Expert Review of Hematology 2010 DOI
  • Anne Husebekk, Maria Therese Ahlen, Mette Kjær Killie, Heidi Tiller, Mariana Eksteen, Ida Løken Killie m.fl.:
    Blood group antigens and immune responses-detailed knowledge is necessary to prevent immunization and to follow up immunized individuals
    ISBT Science Series 2010
  • Maria Therese Ahlen, Anne Husebekk, Mette Kjær Killie, Bjørn Ragnar Skogen, Tor Brynjar Stuge :
    T-cell responses associated with neonatal alloimmune thrombocytopenia: isolation of HPA-1a-specific, HLA-DRB3*0101-restricted CD4+ T cells
    Blood 2009 DOI
  • Ingvild Hausberg Sørvoll, Ingvild Jenssen Lægreid, Tom Sollid, Maria Therese Ahlen, Silje Johansen, Håkon Reikvam :
    Low Incidence of Anti-PF4/Heparin Antibodies in Patients with Acute Myelogenous Leukemia
    Mediterranean Journal of Hematology and Infectious Diseases (MJHID) 2024 DOI
  • Heidi Tiller, Nora Hersoug Nedberg, Mona Nystad, Maria Therese Ahlen, eirin listau Bertelsen, Anne Husebekk m.fl.:
    New insights on maternal platelet alloimmunization and placenta function
    2023
  • Adam J. Kanack, Ingvild Jenssen Lægreid, Silje Johansen, Håkon Reikvam, Maria Therese Ahlen, Anand Padmanabhan :
    Human papilloma virus vaccine and VITT antibody induction
    American Journal of Hematology 2022 DOI
  • Philip Y. Choi, Rachael F. Grace, Maria Therese Ahlen, Ishac Nazy, Ulrich J. Sachs, Donald M. Arnold m.fl.:
    The SSC platelet immunology register of VITT and VIITP: Toward standardization of laboratory and clinical parameters
    Journal of Thrombosis and Haemostasis 2021 DOI
  • Maria Therese Ahlen :
    Fighting anti-CD36–mediated FNAIT
    Blood 2021 DOI
  • Heidi Tiller, Mette Kjær, Maria Therese Ahlen, Jens Kjeldsen-Kragh :
    Føtal/neonatal alloimmun trombocytopeni (FNAIT) - hvordan redusere risiko for intrakraniell blødning hos foster/ nyfødt - erfaringer fra Norge
    Bestpractice Onkologi/Hematologi 2019
  • Ida Løken Killie, Maria Therese Ahlen, Anne Husebekk, Bjørn Ragnar Skogen, Tor Brynjar Stuge :
    Induction and detection of in vivo immune responses to HPA-1a in a novel murine model of fetal/neonatal alloimmune thrombocytopenia (FNAIT)
    2014
  • Gøril Heide, Tor Brynjar Stuge, Bjørn Ragnar Skogen, Anne Husebekk, Maria Therese Ahlen :
    The DR7-DQ2 Haplotype in a Native Norwegian Population
    Scandinavian Journal of Immunology 2013 DOI
  • Ida Løken Killie, Anne Husebekk, Maria Therese Ahlen, M. Roalso, Bjørn Ragnar Skogen, Tor Brynjar Stuge :
    ARE CURRENT MURINE MODELS OF FETAL/NEONATAL ALLOIMMUNE THROMBOCYTOPENIA BRINGING US CLOSER TO A BETTER UNDERSTANDING OF PATHOPHYSIOLOGY AND TREATMENT OF THE DISEASE?
    Vox Sanguinis 2013
  • Anne Husebekk, Heidi Tiller, Mette Kjær Killie, Mariana Eksteen, Maria Therese Ahlen, Tor Brynjar Stuge m.fl.:
    TOWARDS A PROPHYLACTIC TREATMENT OF HPA-1A-RELATED FETAL AND NEONATAL ALLOIMMUNE THROMBOCYTOPENIA (FNAIT)
    Vox Sanguinis 2012
  • Anne Husebekk, Maria Therese Ahlen, Mette Kjær Killie, Heidi Tiller, Mariana Eksteen, Ida Løken Killie m.fl.:
    MATERNAL ALLOIMMUNE RESPONSE DURING PREGNANCY: BRAKE OF MATERNAL TOLERANCE TO FETAL HUMAN PLATELET ANTIGEN 1A ANTIGEN MAY BE ASSOCIATED WITH REDUCED PLACENTAL FUNCTION
    Placenta 2011
  • Maria Therese Ahlen, Mette Kjær Killie, Anne Husebekk, Jens Kjeldsen-Kragh, ML Olsson, Bjørn Ragnar Skogen :
    The Development of Severe Anti-HPA 1a-Related Neonatal Alloimmune Thrombocytopenia Is Influenced by the Maternal ABO Type
    Blood 2007
  • Maria Therese Ahlen, Mette Kjær Killie, Bjørn Ragnar Skogen, Anne Husebekk, Tor Brynjar Stuge :
    Isolation and Characterization of CD4+ T Cells Specific for the HPA 1a Epitope Associated with Neonatal Alloimmune Thrombocytopenia
    Blood 2007

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    Forskningsinteresser

    Blodplateimmunologi

    T-cellereponser ved Føtal/neonatal alloimmun trombocytopeni 
    T celler i NAIT

    Dyrking av T celler i laboratoriet

    (Foto: Elisabeth Øvreberg)

     

    Publikasjoner

    2018

     
    Zhi H, Ahlen MT, Thinn AMM, Weiler H, Curtis BR, Skogen B, Zhu J, Newman PJ. 

    High-resolution mapping of the polyclonal immune response to the human platelet alloantigen HPA-1a (PlA1). Blood Advances 2018; Nov 13;2(21):3001-3011. doi: 10.1182/bloodadvances.2018023341.

     

    Orzińska A, Guz K, Uhrynowska M, Dȩbska M, Mikula M, Ostrowski J, Ahlen MT, Husebekk A, Brojer E.Noninvasive prenatal HPA-1 typing in HPA-1a negative pregnancies selected in the Polish PREVFNAIT screening program. Transfusion 2018 s. 1-7

     

     

    2017

    Dahl, J, Refsum E, Ahlen MT, Egeland T, Jensen T, Viken MK, Stuge TB, Acharya G, Husebekk A, Skogen B, Tiller H. Unraveling the role of maternal anti-HLA class I antibodies in fetal and neonatal thrombocytopenia?Antibody specificity analysis using epitope data. Journal of Reproductive Immunology 2017 ;Volum 122. s. 1-

     

    Tiller H, Husebekk A, Ahlen, MT, Stuge, TB, Skogen, B. Current perspectives on fetal and neonatal alloimmune thrombocytopenia - Increasing clinical concerns and new treatment opportunities. International Journal of Women's Health 2017 ;Volum 9. s. 223-234

    2016

    Ahlen MT, Husebekk A, Killie IL, Skogen B, Stuge, TB. T cell responses to human platelet antigen-1a involve a unique form of indirect allorecognition. JCI Insight 2016 ;Volum Sep 8.(1) Suppl. 14 s. e86558

    2013

    Heide G, Stuge TB, Skogen B, Husebekk A, Ahlen MT. The DR7-DQ2 haplotype in a native Norwegian population. Scand J Immunol. 2013 May;77(5):429-30

    2012

    Husebekk A, El Ekiaby M, Gorgy G, Killie MK, Uhlin-Hansen C, Salma W, Navarrete C, El Afandi M, Skogen B, Ahlen MT. Foetal/neonatal alloimmune thrombocytopenia in Egypt; human platelet antigen genotype frequencies and antibody detection and follow-up in pregnancies. Transfus Apher Sci. 2012 May 26.

    Ahlen MT, Husebekk A, Killie MK, Kjeldsen-Kragh J, Olsson ML and Skogen B. The development of severe neonatal alloimmune thrombocytopenia due to anti-HPA-1a antibodies is correlated to maternal ABO genotypes. Clin Dev Immunol. 2012:156867.

    2011

    Stuge TB, Skogen B, Ahlen MT, Husebekk A, Urbaniak SJ, Bessos H. The cellular immunobiology associated with fetal and neonatal alloimmune thrombocytopenia. Transfus Apher Sci. 2011 Aug;45(1):53-9. Review.

    2010

    Husebekk A, Ahlen MT; Killie MK, Tiller H, Eksteen M, Killie IL, Heide G, Kjeldsen-Kragh J, Skogen BR, Stuge TB. Blood group antigens and immune responses-detailed knowledge is necessary to prevent immunization and to follow up immunized individuals. ISBT Science Series 2010 ;Volum 5.(1) s. 24-26

    Skogen BR, Killie MK, Kjeldsen-Kragh J, Ahlen MT, Tiller H, StugeTB, Husebekk A. Reconsidering fetal and neonatal alloimmune thrombocytopenia with a focus on screening and prevention. Expert Review of Hematology 2010 ;Volum 3.(5) s. 559-566

    2009

    Ahlen MT, Husebekk A, Killie MK, Skogen BR, Stuge TB. T-cell responses associated with neonatal alloimmune thrombocytopenia: isolation of HPA-1a-specific, HLA-DRB3*0101-restricted CD4+ T cells. Blood 2009 ;Volum 113.(16) s. 3838-3844

     

    ORCID: https://orcid.org/0000-0002-3104-3818

    Medlem i forskningsgruppe

    Immunology research group   English content

    Medlem i prosjekt

    Prophylaxis to prevent alloimmunization and FNAIT Cellular responses in FNAIT Blood Brain Barrier in FNAIT