Jorunn Jørgensen
Shiferaw Jenberie,
Henriette R. Nordli,
Guro Strandskog,
Linn Greiner-Tollersrud,
Ma Michelle Demogina Penaranda,
Jorunn B Jørgensen
m.fl.:
Virus-specific antibody secreting cells reside in the peritoneal cavity and systemic immune sites of Atlantic salmon (Salmo salar) challenged intraperitoneally with salmonid alphavirus
Shiferaw Jenberie,
Yorick Andreas van der Wal,
Ingvill Jensen,
Jorunn B Jørgensen
:
There and back again? A B cell's tale on responses and spatial distribution in teleosts
Thomais Tsoulia,
Arvind Sundaram,
Stine Braaen,
Jorunn B Jørgensen,
Espen Rimstad,
Øystein Wessel
m.fl.:
Transcriptomics of early responses to purified Piscine orthoreovirus-1 in Atlantic salmon (Salmo salar L.) red blood cells compared to non-susceptible cell lines
Yorick Andreas van der Wal,
Henriette R. Nordli,
Allan Akandwanaho,
Linn Greiner-Tollersrud,
Jaap Kool,
Jorunn B Jørgensen
:
CRISPR-Cas– induced IRF3 and MAVS knockouts in a salmonid cell line disrupt PRR signaling and affect viral replication
Yorick Andreas van der Wal,
Shiferaw Jenberie,
Henriette Nordli,
Linn Greiner-Tollersrud,
Jaap Kool,
Ingvill Jensen
m.fl.:
The importance of the Atlantic salmon peritoneal cavity B cell response: Local IgM secreting cells are predominant upon Piscirickettsia salmonis infection
Dimitar Borisov Iliev,
Guro Strandskog,
Mehrdad Sobhkhez,
Jack-Ansgar Bruun,
Jorunn B Jørgensen
:
Secretome Profiling of Atlantic Salmon Head Kidney Leukocytes Highlights the Role of Phagocytes in the Immune Response to Soluble β-Glucan
Muhammad Salman Malik,
Lena Hammerlund Teige,
Stine Braaen,
Anne Berit Olsen,
Monica Nordberg,
Marit Måsøy Amundsen
m.fl.:
Piscine Orthoreovirus (PRV)-3, but Not PRV-2, Cross-Protects against PRV-1 and Heart and Skeletal Muscle Inflammation in Atlantic Salmon
Shiferaw Jenberie,
Ma Michelle Demogina Penaranda,
Hanna Leena Thim,
Morten Bay Styrvold,
Guro Strandskog,
Jorunn B Jørgensen
m.fl.:
Salmonid Alphavirus Subtype 3 Induces Prolonged Local B Cell Responses in Atlantic Salmon (Salmo salar) After Intraperitoneal Infection
Arpita Nepal,
Deanna Wolfson,
Balpreet Singh Ahluwalia,
Ingvill Jensen,
Jorunn B Jørgensen,
Dimitar Borisov Iliev
:
Intracellular distribution and transcriptional regulation of Atlantic salmon (Salmo salar) Rab5c, 7a and 27a homologs by immune stimuli
Lena Hammerlund Teige,
Ida Aksnes,
Magnus Vikan Røsæg,
Ingvill Jensen,
Jorunn Jørgensen,
Hilde Sindre
m.fl.:
Detection of specific Atlantic salmon antibodies against salmonid alphavirus using a bead-based immunoassay
Dennis Bela-Ong,
Linn Greiner-Tollersrud,
Yorick Andreas van der Wal,
Ingvill Jensen,
Ole Morten Seternes,
Jorunn Jørgensen
:
Infection and microbial molecular motifs modulate transcription of the interferon-inducible gene ifit5 in a teleost fish
Dimitar Borisov Iliev,
Leidy Lagos,
Hanna Leena Thim,
Sven Martin Jørgensen,
Aleksei Krasnov,
Jorunn B Jørgensen
:
CpGs Induce Differentiation of Atlantic Salmon Mononuclear Phagocytes Into Cells With Dendritic Morphology and a Proinflammatory Transcriptional Profile but an Exhausted Allostimulatory Activity
Steingrim Svenning,
Agata Teresa Wyrozemska,
Yorick Andreas van der Wal,
Børre Robertsen,
Ingvill Jensen,
Jorunn B Jørgensen
m.fl.:
Microbial danger signals control transcriptional induction of distinct MHC class I L lineage genes in Atlantic salmon
Maria Dahle,
Jorunn B Jørgensen
:
Antiviral defense in salmonids – Mission made possible?
Ma Michelle Demogina Penaranda,
Ingvill Jensen,
Linn Greiner-Tollersrud,
Jack-Ansgar Bruun,
Jorunn B Jørgensen
:
Profiling the Atlantic Salmon IgM+ B Cell Surface Proteome: Novel Information on Teleost Fish B Cell Protein Repertoire and Identification of Potential B Cell Markers
Dimitar Borisov Iliev,
Guro Strandskog,
Arpita Nepal,
Augusta Hlin Aspar Sundbø,
Randi Olsen,
Jorunn B Jørgensen
m.fl.:
Stimulation of exosome release by extracellular DNA is conserved across multiple cell types
Shiferaw Jenberie,
Hanna Leena Thim,
J Oriol Sunyer,
Karsten Skjødt,
Ingvill Jensen,
Jorunn B Jørgensen
:
Profiling Atlantic salmon B cell populations: CpG-mediated TLR-ligation enhances IgM secretion and modulates immune gene expression
Mehrdad Sobhkhez,
Lisbeth Lindenskov Joensen,
Linn Greiner-Tollersrud,
Guro Strandskog,
Hanna Leena Thim,
Jorunn B Jørgensen
:
A conserved inhibitory role of suppressor of cytokine signaling 1 (SOCS1) in salmon antiviral immunity
Developmental and Comparative Immunology 2016 DOI
Kjersti Julin,
Lill-Heidi Johansen,
Ann-Inger Sommer,
Jorunn B Jørgensen
:
Persistent infections with infectious pancreatic necrosis virus (IPNV) of different virulence in Atlantic salmon, Salmo salar L
Journal of Fish Diseases 2015 DOI
Lill-Heidi Johansen,
Hanna Leena Thim,
Sven Martin Jørgensen,
Sergey Afanasyev,
Guro Strandskog,
Torunn Taksdal
m.fl.:
Comparison of transcriptomic responses to pancreas disease (PD) and heart and skeletal muscle inflammation (HSMI) in heart of Atlantic salmon (Salmo salar L)
Fish and Shellfish Immunology 2015 DOI
Jorunn B Jørgensen
:
The innate immune response in fish
Wiley-Blackwell 2014 DOI
Stephen Mutoloki,
Jorunn B Jørgensen,
Øystein Evensen
:
The adaptive immune response in fish
Wiley-Blackwell 2014 DOI
Mehrdad Sobhkhez,
Astrid Skjesol,
Ernst Ivan Thomassen,
Dimitar Borisov Iliev,
Baojian Sun,
Børre Robertsen
m.fl.:
Structural and functional characterization of salmon STAT1, STAT2 and IRF9 homologs sheds light on interferon signaling in teleosts
Astrid Skjesol,
Liebe Thomas de Regt,
Dimitar Borisov Iliev,
Ernst Ivan Thomassen,
Linn Greiner-Tollersrud,
Mehrdad Sobhkhez
m.fl.:
Functional conservation of suppressors of cytokine signaling proteins between teleosts and mammals: Atlantic salmon SOCS1 binds to JAK/STAT family members and suppresses type I and II IFN signaling
Developmental and Comparative Immunology 2014 DOI
Hanna Leena Thim,
Stéphane Villoing,
Marian F McLoughlin,
Karen Elina Cristie,
Søren Grove,
Petter Frost
m.fl.:
Vaccine adjuvants in fish vaccines make a difference: comparing the effects of three adjuvants (Montanide ISA763A oil, CpG/poly I:C combo and VHSV glycoprotein) used alone or in combination to formulate an inactivated salmonid alphavirus whole virus antigen
Dimitri Borisov Iliev,
Hanna Leena Thim,
Leidy Lagos,
randi Olsen,
Jorunn B Jørgensen
:
Homing of Antigen-Presenting Cells in Head Kidney and Spleen – Salmon Head Kidney Hosts Diverse APC Types
Mehrdad Sobhkhez,
Tom Egil Hansen,
Dimitri Borisov Iliev,
Astrid Skjesol,
Jorunn B Jørgensen
:
The Atlantic salmon protein tyrosine kinase Tyk2: Molecular cloning, modulation of expression and function
Developmental and Comparative Immunology 2013 DOI
Dimitri Borisov Iliev,
Tom Egil Hansen,
Sven Martin Jørgensen,
Aleksei Krasnov,
Jorunn B Jørgensen
:
CpG- and LPS-activated MAPK signaling in in vitro cultured salmon (Salmo salar) mononuclear phagocytes
Dimitar Borisov Iliev,
ingrid SkjÆveland,
Jorunn B Jørgensen
:
CpG oligonucleotides bind TLR9 and RRM-Containing proteins in Atlantic Salmon (Salmo salar)
Søren Grove,
Lars Austbø,
Kjartan Hodneland,
Petter Frost,
Marie Therese Løvoll,
Marian F McLoughlin
m.fl.:
Immune parameters correlating with reduced susceptibility to pancreas disease in experimentally challenged Atlantic salmon (Salmo salar)
Fish and Shellfish Immunology 2013 DOI
Leidy Lagos,
Dimitar Borisov Iliev,
Ronny Helland,
Mario Rosemblatt,
Jorunn B Jørgensen
:
CD40L-A costimulatory molecule involved in the maturation of antigen presenting cells in Atlantic salmon (Salmo salar)
Developmental and Comparative Immunology 2012 DOI
Monica Nordberg,
Maria Dahle,
Jorunn B Jørgensen,
Øystein Wessel
:
Specific antibody responses (IgM) against Piscine orthoreovirus (PRV) in Atlantic salmon (Salmo salar), measured in a multiplexed magnetic bead-based system
2021
Muhammad Salman Malik,
Lena Hammerlund Teige,
Stine Braaen,
Anne Berit Olsen,
Monica Nordberg,
Marit Måsøy Amundsen
m.fl.:
PRV-3, but not PRV-2, cross-protects against PRV-1 and HSMI in Atlantic salmon
2021
Sunniva Katharina Thode,
Jorunn B Jørgensen
:
Også laks produserer sin egen brems mot virussmitte
30. juli 2020 FULLTEKST
Jorunn Jørgensen,
Maria Dahle
:
Virus og vert: Hvordan forsvarer oppdrettslaksen seg mot virus?
Naturen 2020 DOI
Ma Michelle Demogina Penaranda,
Mikael Fjeld Wold,
Ingvill Jensen,
Jorunn B Jørgensen
:
The role of TNF superfamily ligands, BAFF AND APRIL, in the immune response of Atlantic salmon
2019
Ma Michelle Demogina Penaranda,
Mikael Fjeld Wold,
Shiferaw Jenberie,
Ingvill Jensen,
Jorunn B Jørgensen
:
Investigation on the role of TNF superfamily ligands, BAFF AND APRIL, in the immune response of Atlantic salmon
2018
Shiferaw Jenberie,
Ma Michelle Demogina Penaranda,
Morten Bay Styrvold,
Hanna Leena Thim,
Guro Strandskog,
Linn G. Tollersrud
m.fl.:
PERITONEAL CAVITY B CELLS IN ATLANTIC SALMON (SALMO SALAR L.) – A CONTRIBUTOR TO THE LONG TERM HUMORAL IMMUNE RESPONSE AGAINST SALMONID ALPHAVIRUS (SAV)
2018
Mahsa Jalili,
Signe Løvmo Dille,
Essa Ahsan Khan,
Egil Lien,
Jorunn B Jørgensen,
Rolf Erik Olsen
m.fl.:
Activation of sterol regulatory element binding protein-1 and suppression of toll-like receptor-9 in Atlantic salmon by probiotic feeding
2018
Ma Michelle Demogina Penaranda,
Ingvill Jensen,
Linn G. Tollersrud,
Jack-Ansgar Bruun,
Jorunn B Jørgensen
:
IDENTIFICATION AND GENE EXPRESSION ANALYSES OF POTENTIAL B CELL SURFACE MARKERS IN ATLANTIC SALMON
2018
Ma Michelle Demogina Penaranda,
Mikael Fjeld Wold,
Shiferaw Jenberie,
Ingvill Jensen,
Jorunn B Jørgensen
:
A proliferation inducing ligand (APRIL) is a survival factor that plays an important role in the immune response of Atlantic salmon
2018
Shiferaw Jenberie,
Hanna Leena Thim,
J Oriol Sunyer,
Karsten Skjødt,
Ingvill Jensen,
Jorunn B Jørgensen
:
Author Correction: Profiling Atlantic salmon B cell populations: CpG-mediated TLR-ligation enhances IgM secretion and modulates immune gene expression
Scientific Reports 2018 DOI
Jorunn B Jørgensen,
Mehrdad Sobhkhez,
Lisbeth Lindenskov Joensen,
Guro Strandskog,
Linn Greiner,
Hanna Leena Thim
:
A role of SOCS1 in antiviral immunity?
2016
Jorunn B Jørgensen
:
The TLR9 agonist CpG: A model to explore innate and adaptive immune responses in Atlantic salmon. A potential adjuvant for fish vaccines?
2015
Dimitar Borisov Iliev,
Guro Strandskog,
Jorunn B Jørgensen
:
Exosomes released by Atlantic salmon (Salmo salar) leukocytes – composition and immunostimulatory properties
2015
Guro Strandskog,
Mehrdad Sobhkhez,
Jorunn B Jørgensen,
Dimitar Borisov Iliev
:
Composition of exosomes derived from Atlantic salmon (Salmo salar) head kidney leukocytes
2015 ARKIV
Håvard Ingulfsvann Hagen,
Ingvill Jensen,
Jorunn B Jørgensen
:
Transkripsjonsfaktorer som markør for modning av B-celler i Atlantisk laks (Salmo salar L.)
Effekt av TLR-ligander på utrykk av Pax5 in vitro og in vivo
UiT Norges arktiske universitet 2014
Einar Ringø,
Jorunn B Jørgensen,
Ragnar Ludvig Olsen,
Klara Stensvåg
:
Advances and prospects of biotechnology in aquaculture
2013
Jorge Fernandes,
Arvind Sundaram,
V. Kiron,
Jorunn B Jørgensen
:
Regulation of the innate immune response by microRNAs in zebrafish
Fish and Shellfish Immunology 2013
Lill Heidi Johansen,
Sven Martin Jørgensen,
Hanna Leena Thim,
Gerrit Timmerhaus,
Sergey Afanasyev,
Kjersti Kongsgården Fremmerlid
m.fl.:
Comparison of transcriptomic responses to pancreas disease (PD) and heart and skeletal muscle inflammation (HSMI) in Atlantic salmon (Salmo salar)
Fish and Shellfish Immunology 2013
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Forskningsinteresser
Peer-reviewed Publications (from year 2003):
- Iliev, D. B, Jørgensen, S; Rode, ; Krasnov, A; Harneshaug, I. & J. B. Jørgensen (2009). CpG-induced secretion of MHCIIb from salmon (Salmo salar) APCs. Developmental & Comparative Immunology. Epub 19. August 2009.
- Skjaeveland, I., Iliev, D. B., Strandskog, G.& J. B. Jørgensen (2009). Identification and characterization of TLR8 and MyD88 homologs in Atlantic salmon (Salmo salar). Developmental & Comparative Immunology 2009. 33: 1011-1017.
- Skjæveland,I., D. B. Iliev, & J. B. Jørgensen(2009). Identification and characterization of TLR8 and MyD88 homologs in Atlantic salmon (Salmo salar.) Developmental & Comparative Immunology. 33: 1011-1017
- Skjesol, A,. Aamo, T, M.N. Hegseth, Robertsen, B. & J.B. Jørgensen (2009). The interplay between infectious pancreatic necrosis virus (IPNV) and type I IFN. Inhibition of IFN signaling by IPNV proteins VP4 and VP5. Virus Research, 143, 53-60.
- Hansen,TE, Puntervoll,P, SeternesOM & J B. Jørgensen (2008). Atlantic salmon possess three mitogen activated protein kinase kinase 6 papralogs responding differently to stress. FEBS Journal, 275 4887-4902.
- Strandskog, G., Skjæveland, I. Ellingsen & J. B. Jørgensen (2008).Double-stranded RNA and CpG DNA induced immune responses in Atlantic salmon: Comparison and synergies. Vaccine, 26, 4704-4715.
- Skjæveland,I., D. B. Iliev,J. Zou, T. Jørgensen & J. B. Jørgensen(2008). A TLR9 homolog that is up-regulated by IFN- in Atlantic salmon (Salmon salar).Developmental and Comparative Immunology, 32, 603-607.
- Jørgensen, J. B, A. Johansen, M. N. Hegset, J. Zou,B. Robertsen, & C. J. Secombes (2007). A recombinant CSHE-214 cell line expressing an Mx1 promoter-reporter system responds to both type I and II interferon from salmonids and represents a versatile tool to study the IFN-system in teleost fish. Fish & Shellfish Immunology, 23, 1294-1303.
- Røkenes,T. P., A. Skjesol & J.B. Jørgensen (2007). Intermolecular interactionsof infectious pancreas necrosis virus: capsid protein VP3 interacts with dsRNA and the RNA-dependent RNA polymerase VP1. Journal of Virology, 81, 6652-6663.
- Hansen, T. E. & J.B. Jørgensen (2007). Cloning and characterisation of p38 MAP kinase from Atlantic salmon. A kinase important for regulating salmon TNF-2 and IL-1β expression. Molecular Immunology, 44, 3137-3146.
- Strandskog, G. T. Ellingsen & J. B. Jørgensen (2007). Characterization of three distinct CpG oligonucleotide classes which differ in ability to induce IFNa/b activity and cell proliferation in Atlantic salmon (Salmo salar L.) leukocytes.Developmental and Comparative Immunology, 31, 39-51.
- Pedersen, G. M., Johansen, A., Olsen, R. L. & J. B. Jørgensen (2006). Stimulation of anti-viral mechanisms in Atlantic salmon (Salmo salar) leukocytes: synergetic effects of cationic proteins and CpG ODN. Fish and Shellfish Immunology, 20, 203-518.
- Johansen, A., Collett, E. B., Sandaker, B; Secombes, C. J.& Jørgensen, J. B. (2004). Quantification of Atlantic salmon type-I interferon using an Mx1 promoter reporter gene assay. Fish and Shellfish Immunology, 16,173-184.
- Jørgensen, J. B., L.-H. Johansen, K. Steiro & A. Johansen (2003). CpG DNA induces protective antiviral immune responses in Atlantic salmon (Salmo salar L.). Journal of Virology, 77, 11471-1147.
Invited speaker:
2009:
Konferansen Frisk Fisk, Bergen, januar 2009: Stimulering av medfødt immunitet - en viktig strategi for nye generasjoner av vaksiner for fisk?
Europharmas Lofoten-seminar, Lofoten juni 2009: Toll-lignende reseptorer: Ny mulighet for økt kontroll av virusinfeksjoner.
2006
10th International Congress of ISDCI, Charleston, South Carolina, USA. The use of CpG oligonucleotides as immunstimulants in fish.
2003
Funksjonell genomforskning i Norge: Til å leve av - til å leve med? NRC, Fuge conference, Oslo, april 2003: Marin funksjonell genomforskning - hvordan sette Norge på verdenskartet?
2002
Bioteknologi i primærnæringene - visjon og nytte, Biotechnology program arranged conference at Continental Hotel NRC SAS Hotell, Gardemoen, september 2002: DNA er mer enn gener, spesielle DNA-sekvenser øker motstandsevnen mot sykdom hos laks.
1999
Invited speaker at the workshop" Non-specific defence mechanisms of fish". EAFP 9th International Conference on Diseases of Fish and Shellfish, Rhodes, Greece: The potential use of DNA oligonucleotides as immunostimulants.
Publikasjoner i Frida:
https://www.cristin.no/as/WebObjects/cristin.woa/wa/fres?action=sok&etternavn=J%C3%B8rgensen&fornavn=Jorunn&ar-fra=2003&ar-til=2009&inst=186&erNorsk=1&erNordisk=1&erNasjonalt=1&erInternasjonalt=1&erUkjent=1&visParametre=1&bs=50
Medlem i forskningsgruppe
Medlem i prosjekt
FISH & CRISPR - Innovative strategies to improve salmon health
ViVaAct: Comparing the protection of attenuated and inactivated virus vaccines against PD and HSMB
Immune responses against Piscirickettsia salmonis in Atlantic salmon
Multiple routes to B cell memory in Atlantic salmon
Centre for Advanced Nanoscopy to Decode sub-cellular Biological Systems
DNA Vaccine Development for Salmon viruses - Integrating innate and adaptive immunity - ImmunDNA