Ann Mari Holsæter
Stillingsbeskrivelse
Ann Mari Holsæter er førsteamanuensis ved Insitutt for farmasi (IFA), og forskningsgruppen Drug Transport and Delivery (DTD).
Ann Mari Holsæter er Cand Pharm fra UiT i 1999 med doktorgrad (Dr.Scient) fra samme institusjon i 2004.
I tillegg til lang akademisk karrierer ved UiT Norges Arktiske Universitet, har Holsæter også erfaring fra jobb i industrien, og som tidligere ansatt ved både ProBio Neutraceuticals AS (2006-2008) og Biotec Pharmacon ASA (2008-2011). Her hadde hun ulike roller inne kvalitetsorganisasjonene, inkludert Kvalitetssjef og QP
Hennes nåværende jobb som førsteamanuensis innebærer en 50/50 fordeling mellom forskning og undervisning. I tillegg til emneansvar og undervisning på alle nivå av farmasiutdanningen, veileder hun fortløpende både Master- og PhD studenter.
Laura Victoria Schulte-Werning,
Bhupender Singh,
Mona Susan Johannessen,
Rolf Einar Engstad,
Ann-Mari Holsæter
:
Antimicrobial liposomes-in-nanofiber wound dressings prepared by a green and sustainable wire-electrospinning set-up
Jakob Tobias Lynnerup,
Jonas Borregaard Eriksen,
Annette Bauer-Brandl,
Ann Mari Holsæter,
Martin Brandl
:
Insight into the mechanism behind oral bioavailability-enhancement by nanosuspensions through combined dissolution/permeation studies
Ann Mari Holsæter,
Kristina Wizgird,
Iselin Karlsen,
Jeanette Frimand Hemmingsen,
Martin Brandl,
Natasa Skalko-Basnet
:
How docetaxel entrapment, vesicle size, zeta potential and stability change with liposome composition–A formulation screening study
Jostein Grip,
Erik Steene,
Rolf Einar Engstad,
Jeff Hart,
Andrea Bell,
Ingrid Skjæveland
m.fl.:
Development of a novel beta-glucan supplemented hydrogel spray formulation and wound healing efficacy in a db/db diabetic mouse model
May Wenche Jøraholmen,
Selenia Ternullo,
Ann Mari Holsæter,
Gøril Eide Flaten,
Natasa Skalko-Basnet
:
Advanced Drug Delivery Systems for Biologics
John Wiley & Sons 2021
Laura Schulte Werning,
Anjanah Murugaiah,
Bhupender Singh,
Mona Johannessen,
Rolf Einar Engstad,
Natasa Skalko-Basnet
m.fl.:
Multifunctional Nanofibrous Dressing with Antimicrobial and Anti-Inflammatory Properties Prepared by Needle-Free Electrospinning
Selenia Ternullo,
Laura Schulte Werning,
Ann Mari Holsæter,
Natasa Skalko-Basnet
:
Curcumin-In-Deformable Liposomes-In-ChitosanHydrogel as a Novel Wound Dressing
Jennifer Cauzzo,
Mona Nystad,
Ann Mari Holsæter,
Purusotam Basnet,
Natasa Skalko-Basnet
:
Following the fate of dye-containing liposomes in vitro
Selenia Ternullo,
Purusotam Basnet,
Ann Mari Holsæter,
Gøril Eide Flaten,
Louis de Weerd,
Natasa Skalko-Basnet
:
Deformable liposomes for skin therapy with human epidermal growth factor: The effect of liposomal surface charge
Jostein Grip,
Rolf Einar Engstad,
Ingrid Skjæveland,
Natasa Skalko-Basnet,
Johan Isaksson,
Purusotam Basnet
m.fl.:
Beta-glucan-loaded nanofiber dressing improves wound healing in diabetic mice
Ulrich Massing,
Sveinung Gaarden Ingebrigtsen,
Natasa Skalko-Basnet,
Ann Mari Holsæter
:
Dual Centrifugation - A Novel “in-vial” Liposome Processing Technique
Sveinung Gaarden Ingebrigtsen,
Natasa Skalko-Basnet,
Cristiane de Albuquerque Cavalcanti Jacobsen,
Ann Mari Holsæter
:
Successful co-encapsulation of benzoyl peroxide and chloramphenicol in liposomes by a novel manufacturing method - dual asymmetric centrifugation
Selenia Ternullo,
Louis de Weerd,
Gøril Eide Flaten,
Ann Mari Holsæter,
Natasa Skalko-Basnet
:
The isolated perfused human skin flap model: A missing link in skin penetration
studies?
Jostein Grip,
Rolf Einar Engstad,
Ingrid Skjærveland,
Natasa Skalko-Basnet,
Ann Mari Holsæter
:
Sprayable Carbopol hydrogel with soluble beta-1,3/1,6-glucan as an active ingredient for wound healing – Development and in-vivo evaluation
Selenia Ternullo,
Louis de Weerd,
Ann Mari Holsæter,
Gøril Eide Flaten,
Natasa Skalko-Basnet
:
Going skin deep: a direct comparison of penetration potential of lipid-based nanovesicles on the isolated perfused human skin flap model
Anders Øverbye,
Ann Mari Holsæter,
Markus Fusser,
Natasa Skalko-Basnet,
Tore Geir Iversen,
Maria Lyngaas Torgersen
m.fl.:
Ceramide-containing liposomes with doxorubicin: time and
cell-dependent effect of C6 and C12 ceramide
Sveinung Gaarden Ingebrigtsen,
Alena Didriksen,
Mona Johannessen,
Natasa Skalko-Basnet,
Ann Mari Holsæter
:
Old drug, new wrapping – A possible comeback for chloramphenicol?
Sveinung Gaarden Ingebrigtsen,
Natasa Skalko-Basnet,
Ann Mari Holsæter
:
Development and optimization of a new processing approach for manufacturing topical liposomes-in-hydrogel drug formulations by dual asymmetric centrifugation
Laura Victoria Schulte-Werning,
Ivo Laimäe,
Lisa Myrseth Hemmingsen,
Jyrki Heinämäki,
Liis Preem,
Karin Kogermann
m.fl.:
Core-Shell Nanofibers Prepared by Coaxial Electrospinning Challanged by Polyelectrolyte Complexation Between Chitosan and Pectin
2024
Ann-Mari Holsæter
:
Nanofibers to combat antimicrobial resistance – How and Why?
2024
Laura Victoria Schulte-Werning,
Ann-Mari Holsæter
:
Enhanced Stability and Topical Promise of Chloramphenicol in a Dry Dressing Format
2024
Ann Mari Holsæter
:
Cancer and drug delivery
2023
Agnhild Johansen,
Kjersti Sellæg,
Synnøve Norvoll Magnussen,
May Wenche Jøraholmen,
Ann Mari Holsæter
:
Docetaxel liposomes – Can curcumin be co-entrapped and improve the in vitro cytotoxicity?
2023
Ann Mari Holsæter
:
Nærings-Ph.d. prosjekt for utvikling av nye sårprodukter ga etablering av forskning på nanofibre som legemiddelform i Norge
2022
Paul Gottschalk,
Ann Mari Holsæter
:
Optimierung der Herstellung von Liposomen mittels dualer
asymmetrischer Zentrifugation
2022
Jakob T. Lynnerup,
Jonas B. Eriksen,
Ann Mari Holsæter,
Martin Brandl
:
The effect of nano-milling on dissolution/permeation of poorly soluble drug compounds
2022
Laura Schulte Werning,
Natasa Skalko-Basnet,
Ann Mari Holsæter
:
Needle-free electrospinning of nanofibers with chloramphenicol-liposomes using the NanospiderTM
2022
Ann Mari Holsæter
:
Ann Mari Holsæter: - Etikk må læres gjennom hele livet
01. mars 2021
Laura Schulte Werning,
Anjanah Murugaiah,
Natasa Skalko-Basnet,
Ann Mari Holsæter
:
In vitro testing of biocompatibility and anti-inflammatory activity of chloramphenicol loaded multifunctional nanofibers
2021
Laura Schulte Werning,
Anjanah Murugaiah,
Natasa Skalko-Basnet,
Ann Mari Holsæter
:
Electrospinning of chloramphenicol-containing nanofibrous dressings for treatment of chronic wounds
2021 ARKIV
Laura Schulte Werning,
Anjanah Murugaiah,
Natasa Skalko-Basnet,
Ann Mari Holsæter
:
Successful entrapment of chloramphenicol in electrospun nanofiber dressings
2021
Jeanette Frimand Hemmingsen,
Martin Brandl,
Natasa Skalko-Basnet,
Ann Mari Holsæter
:
Design, preparation, characterization and stability of
docetaxel-containing liposomes
2020
Laura Schulte Werning,
Julie Wik Olaussen,
Natasa Skalko-Basnet,
Ann Mari Holsæter
:
Electrospinning chitosan-nanofibers using the needle-free Nanospider™ technology; Optimization of the polymer solution
2020
Jennifer Cauzzo,
Mona Nystad,
Ann Mari Holsæter,
Purusotam Basnet,
Natasa Skalko-Basnet
:
Dyes in Disguise: characterization of fluorescently labeled liposomes
2020 ARKIV
Ann Mari Holsæter
:
Fokus på utnyttelse av digitale læringsressurser for økt fleksibilitet og kvalitet i undervisningen av de farmasøytiske laboratoriefagene
2019
Jennifer Cauzzo,
Mona Nystad,
Ann Mari Holsæter,
Purusotam Basnet,
Natasa Skalko-Basnet
:
Liposome-cell interaction: following the fate of the nanocarrier
2019
Ann Mari Holsæter,
Kristina Wizgird,
Natasa Skalko-Basnet
:
Docetaxel-liposomes prepared by dual centrifugation: effect of propylene glycol and lipid charge
2019
Iselin Karlsen,
Natasa Skalko-Basnet,
Ann Mari Holsæter
:
Docetaxel Liposomes - A formulation Screening Study
2019 ARKIV
Jostein Grip,
Erik Steene,
Rolf Einar Engstad,
Ingrid Skjæveland,
Purusotam Basnet,
Natasa Skalko-Basnet
m.fl.:
Sprayable beta-glucan hydrogel as wound dressing: in vitro and in vivo evaluation
2019
Ann Mari Holsæter,
Jostein Grip,
Natasa Skalko-Basnet
:
Advanced wound dressing with beta-glucans: in vivo proof of nanofibers superiority
2018
Ann Mari Holsæter
:
Vurdering av læring i laboratorieundervisning – et eksempel fra farmasiutdanningen
2017
Ann Mari Holsæter,
Sveinung Gaarden Ingebrigtsen,
Natasa Skalko-Basnet
:
Dermal Application of Chloramphenicol - The Effect of Liposomes and Chitosan Hydrogel Formulations on ex vivo Permeation and Antimicrobial Activity
2017 ARKIV
Selenia Ternullo,
Louis de Weerd,
Ann Mari Holsæter,
Gøril Eide Flaten,
Natasa Skalko-Basnet
:
A Nano-Approach to Improve Local Skin Therapy: Isolated Perfused Human Skin Flap as a Tool in Optimization
2017
Ann Mari Holsæter
:
New activities related to liposomes
2017
Jostein Grip,
Rolf Einar Engstad,
Ingrid Skjæveland,
Natasa Skalko-Basnet,
Ann Mari Holsæter
:
Development of a novel wound healing spray: soluble beta-1,3/1,6-glucan as an active ingredient in Carbopol matrix in a db/db wound model
2017
Selenia Ternullo,
Louis de Weerd,
Gøril Eide Flaten,
Ann Mari Holsæter,
Natasa Skalko-Basnet
:
Isolated perfused human skin flap model: a novel tool to evaluate drug penetration through the skin II
2016
Selenia Ternullo,
Louis de Weerd,
Gøril Eide Flaten,
Ann Mari Holsæter,
Natasa Skalko-Basnet
:
Isolated perfused human skin flap model: a novel tool to evaluate drug penetration through the skin
2016
Anders Øverbye,
Ann Mari Holsæter,
Natasa Skalko-Basnet,
Iversen Tore-Geir,
Maria Lyngaas Torgersen,
Tonje Sønstevold
m.fl.:
Biodegradable nanoparticles in cancer diagnosis and therapy (NANOCAN):Ceramide modulation of liposomal doxorubicin
2016
Selenia Ternullo,
Louis de Weerd,
Gøril Eide Flaten,
Ann Mari Holsæter,
Natasa Skalko-Basnet
:
Isolated perfused human skin flap model: A novel tool to evaluate drug penetration through the skin
2016
Ann Mari Holsæter
:
Preparation, characterization and in vitro testing of liposomes
2016
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Forskningsinteresser
Forskningen hennes har fokus på avanserte legemiddelformuleringer, og forbedring av legemiddelterapi gjennom forbedring av legemidlenes opptak, stabilitet og/eller spesifisitet, med reduserte bivirkninger og økt effekt av behandling som mål. Hun har særlig ekspertise og interesse for liposomer, nanofibre og hydrogeler, anvendt alene eller i kombinasjon. Disse formuleringen er i hennes tilfelle i hovedsak fremstilt for topikal (huden, og sårbehandling) og systemisk administrasjon (injeksjonsmedisin), og da gjerne med antimikrobiell, anti-cancer eller immunstimmulerende effekt som mål.
I forskningsgruppen har Ann Mari særlig ekspertise på teknologier som elektrospinning av nanofibre og bruk av "dual centrifugering" i fremstilling av nanopartikler, inkluderte liposomer.
Undervisning
Emner Ann Mari underviser i:
- FAR-2401; Legemiddelfremstilling og kvalitetskontroll (10 STP), underviser (emneansvarlig 2012-2019)
- FAR-2402; Legemiddelformulering og biofarmasi (10 STP)- emneansvarlig siden 2019, underviser siden 2012
- FAR-3401; Advansert legemiddelteknologi og biofarmasi (10 STP), foreleser
- FAR-3911; Masteroppgave i farmasi (50 STP), veileder
- FAR-3043: Nanomedisin (15 STP), foreleser
- FAR-8043; Nanomedicine and nanotechnology (15 STP), foreleser