Ann-Mari Holsæter


Førsteamanuensis

Stillingsbeskrivelse

Ann Mari Holsæter er førsteamanuensis ved Insitutt for farmasi (IFA), og forskningsgruppen Drug Transport and Delivery (DTD).

Ann Mari Holsæter er Cand Pharm fra UiT i 1999 med doktorgrad (Dr.Scient) fra samme institusjon i 2004.

I tillegg til lang akademisk karrierer ved UiT Norges Arktiske Universitet, har Holsæter også erfaring fra jobb i industrien, og som tidligere ansatt ved både ProBio Neutraceuticals AS (2006-2008) og Biotec Pharmacon ASA (2008-2011). Her hadde hun ulike roller inne kvalitetsorganisasjonene, inkludert Kvalitetssjef og QP

Hennes nåværende jobb som førsteamanuensis innebærer en 50/50 fordeling mellom forskning og undervisning. I tillegg til emneansvar og undervisning på alle nivå av farmasiutdanningen, veileder hun fortløpende både Master- og PhD studenter.

 

 


  • Jakob Tobias Lynnerup, Jonas Borregaard Eriksen, Annette Bauer-Brandl, Ann Mari Holsæter, Martin Brandl :
    Insight into the mechanism behind oral bioavailability-enhancement by nanosuspensions through combined dissolution/permeation studies
    European Journal of Pharmaceutical Sciences 2023 ARKIV / DOI
  • Ann Mari Holsæter, Kristina Wizgird, Iselin Karlsen, Jeanette Frimand Hemmingsen, Martin Brandl, Natasa Skalko-Basnet :
    How docetaxel entrapment, vesicle size, zeta potential and stability change with liposome composition–A formulation screening study
    European Journal of Pharmaceutical Sciences 2022 ARKIV / DOI
  • Jostein Grip, Erik Steene, Rolf Einar Engstad, Jeff Hart, Andrea Bell, Ingrid Skjæveland m.fl.:
    Development of a novel beta-glucan supplemented hydrogel spray formulation and wound healing efficacy in a db/db diabetic mouse model
    European journal of pharmaceutics and biopharmaceutics 2021 ARKIV / DOI
  • May Wenche Jøraholmen, Selenia Ternullo, Ann Mari Holsæter, Gøril Eide Flaten, Natasa Skalko-Basnet :
    Advanced Drug Delivery Systems for Biologics
    John Wiley & Sons 2021
  • Laura Schulte Werning, Anjanah Murugaiah, Bhupender Singh, Mona Johannessen, Rolf Einar Engstad, Natasa Skalko-Basnet m.fl.:
    Multifunctional Nanofibrous Dressing with Antimicrobial and Anti-Inflammatory Properties Prepared by Needle-Free Electrospinning
    Pharmaceutics 2021 ARKIV / DOI
  • Jennifer Cauzzo, Mona Nystad, Ann Mari Holsæter, Purusotam Basnet, Natasa Skalko-Basnet :
    Following the fate of dye-containing liposomes in vitro
    International Journal of Molecular Sciences 09. juli 2020 ARKIV / DOI
  • Selenia Ternullo, Laura Schulte Werning, Ann Mari Holsæter, Natasa Skalko-Basnet :
    Curcumin-In-Deformable Liposomes-In-ChitosanHydrogel as a Novel Wound Dressing
    Pharmaceutics 2020 ARKIV / DOI
  • Selenia Ternullo, Purusotam Basnet, Ann Mari Holsæter, Gøril Eide Flaten, Louis de Weerd, Natasa Skalko-Basnet :
    Deformable liposomes for skin therapy with human epidermal growth factor: The effect of liposomal surface charge
    European Journal of Pharmaceutical Sciences 2018 ARKIV / DOI
  • Jostein Grip, Rolf Einar Engstad, Ingrid Skjæveland, Natasa Skalko-Basnet, Johan Isaksson, Purusotam Basnet m.fl.:
    Beta-glucan-loaded nanofiber dressing improves wound healing in diabetic mice
    European Journal of Pharmaceutical Sciences 2018 ARKIV / DOI
  • Ulrich Massing, Sveinung Gaarden Ingebrigtsen, Natasa Skalko-Basnet, Ann Mari Holsæter :
    Dual Centrifugation - A Novel “in-vial” Liposome Processing Technique
    IntechOpen 2017 FULLTEKST / DOI
  • Jostein Grip, Rolf Einar Engstad, Ingrid Skjærveland, Natasa Skalko-Basnet, Ann Mari Holsæter :
    Sprayable Carbopol hydrogel with soluble beta-1,3/1,6-glucan as an active ingredient for wound healing – Development and in-vivo evaluation
    European Journal of Pharmaceutical Sciences 2017 ARKIV / DOI
  • Selenia Ternullo, Louis de Weerd, Ann Mari Holsæter, Gøril Eide Flaten, Natasa Skalko-Basnet :
    Going skin deep: a direct comparison of penetration potential of lipid-based nanovesicles on the isolated perfused human skin flap model
    European journal of pharmaceutics and biopharmaceutics 2017 ARKIV / DOI
  • Anders Øverbye, Ann Mari Holsæter, Markus Fusser, Natasa Skalko-Basnet, Tore Geir Iversen, Maria Lyngaas Torgersen m.fl.:
    Ceramide-containing liposomes with doxorubicin: time and cell-dependent effect of C6 and C12 ceramide
    OncoTarget 2017 ARKIV / DOI
  • Sveinung Gaarden Ingebrigtsen, Alena Didriksen, Mona Johannessen, Natasa Skalko-Basnet, Ann Mari Holsæter :
    Old drug, new wrapping – A possible comeback for chloramphenicol?
    International Journal of Pharmaceutics 2017 ARKIV / DOI
  • Selenia Ternullo, Louis de Weerd, Gøril Eide Flaten, Ann Mari Holsæter, Natasa Skalko-Basnet :
    The isolated perfused human skin flap model: A missing link in skin penetration studies?
    European Journal of Pharmaceutical Sciences 2017 ARKIV / DOI
  • Sveinung Gaarden Ingebrigtsen, Natasa Skalko-Basnet, Cristiane de Albuquerque Cavalcanti Jacobsen, Ann Mari Holsæter :
    Successful co-encapsulation of benzoyl peroxide and chloramphenicol in liposomes by a novel manufacturing method - dual asymmetric centrifugation
    European Journal of Pharmaceutical Sciences 2017 ARKIV / FULLTEKST / DOI
  • Sveinung Gaarden Ingebrigtsen, Natasa Skalko-Basnet, Ann Mari Holsæter :
    Development and optimization of a new processing approach for manufacturing topical liposomes-in-hydrogel drug formulations by dual asymmetric centrifugation
    Drug Development and Industrial Pharmacy 2016 ARKIV / DOI
  • Željka Vanić, Ann Mari Holsæter, Natasa Skalko-Basnet :
    (Phospho)lipid-based nanosystems for skin administration
    Current pharmaceutical design 2015 ARKIV / DOI
  • Ann Mari Holsæter :
    Cancer and drug delivery
    2023
  • Agnhild Johansen, Kjersti Sellæg, Synnøve Norvoll Magnussen, May Wenche Jøraholmen, Ann Mari Holsæter :
    Docetaxel liposomes – Can curcumin be co-entrapped and improve the in vitro cytotoxicity?
    2023
  • Jakob T. Lynnerup, Jonas B. Eriksen, Ann Mari Holsæter, Martin Brandl :
    The effect of nano-milling on dissolution/permeation of poorly soluble drug compounds
    2022
  • Ann Mari Holsæter :
    Nærings-Ph.d. prosjekt for utvikling av nye sårprodukter ga etablering av forskning på nanofibre som legemiddelform i Norge
    2022
  • Paul Gottschalk, Ann Mari Holsæter :
    Optimierung der Herstellung von Liposomen mittels dualer asymmetrischer Zentrifugation
    2022
  • Laura Schulte Werning, Natasa Skalko-Basnet, Ann Mari Holsæter :
    Needle-free electrospinning of nanofibers with chloramphenicol-liposomes using the NanospiderTM
    2022
  • Laura Schulte Werning, Anjanah Murugaiah, Natasa Skalko-Basnet, Ann Mari Holsæter :
    In vitro testing of biocompatibility and anti-inflammatory activity of chloramphenicol loaded multifunctional nanofibers
    2021
  • Ann Mari Holsæter :
    Ann Mari Holsæter: - Etikk må læres gjennom hele livet
    01. mars 2021
  • Laura Schulte Werning, Anjanah Murugaiah, Natasa Skalko-Basnet, Ann Mari Holsæter :
    Successful entrapment of chloramphenicol in electrospun nanofiber dressings
    2021
  • Laura Schulte Werning, Anjanah Murugaiah, Natasa Skalko-Basnet, Ann Mari Holsæter :
    Electrospinning of chloramphenicol-containing nanofibrous dressings for treatment of chronic wounds
    2021 ARKIV
  • Jennifer Cauzzo, Mona Nystad, Ann Mari Holsæter, Purusotam Basnet, Natasa Skalko-Basnet :
    Dyes in Disguise: characterization of fluorescently labeled liposomes
    2020 ARKIV
  • Jeanette Frimand Hemmingsen, Martin Brandl, Natasa Skalko-Basnet, Ann Mari Holsæter :
    Design, preparation, characterization and stability of docetaxel-containing liposomes
    2020
  • Laura Schulte Werning, Julie Wik Olaussen, Natasa Skalko-Basnet, Ann Mari Holsæter :
    Electrospinning chitosan-nanofibers using the needle-free Nanospider™ technology; Optimization of the polymer solution
    2020
  • Ann Mari Holsæter, Kristina Wizgird, Natasa Skalko-Basnet :
    Docetaxel-liposomes prepared by dual centrifugation: effect of propylene glycol and lipid charge
    2019
  • Jostein Grip, Erik Steene, Rolf Einar Engstad, Ingrid Skjæveland, Purusotam Basnet, Natasa Skalko-Basnet m.fl.:
    Sprayable beta-glucan hydrogel as wound dressing: in vitro and in vivo evaluation
    2019
  • Iselin Karlsen, Natasa Skalko-Basnet, Ann Mari Holsæter :
    Docetaxel Liposomes - A formulation Screening Study
    2019 ARKIV
  • Jennifer Cauzzo, Mona Nystad, Ann Mari Holsæter, Purusotam Basnet, Natasa Skalko-Basnet :
    Liposome-cell interaction: following the fate of the nanocarrier
    2019
  • Ann Mari Holsæter :
    Fokus på utnyttelse av digitale læringsressurser for økt fleksibilitet og kvalitet i undervisningen av de farmasøytiske laboratoriefagene
    2019
  • Ann Mari Holsæter, Jostein Grip, Natasa Skalko-Basnet :
    Advanced wound dressing with beta-glucans: in vivo proof of nanofibers superiority
    2018
  • Selenia Ternullo, Louis de Weerd, Ann Mari Holsæter, Gøril Eide Flaten, Natasa Skalko-Basnet :
    A Nano-Approach to Improve Local Skin Therapy: Isolated Perfused Human Skin Flap as a Tool in Optimization
    2017
  • Ann Mari Holsæter :
    New activities related to liposomes
    2017
  • Jostein Grip, Rolf Einar Engstad, Ingrid Skjæveland, Natasa Skalko-Basnet, Ann Mari Holsæter :
    Development of a novel wound healing spray: soluble beta-1,3/1,6-glucan as an active ingredient in Carbopol matrix in a db/db wound model
    2017
  • Ann Mari Holsæter, Sveinung Gaarden Ingebrigtsen, Natasa Skalko-Basnet :
    Dermal Application of Chloramphenicol - The Effect of Liposomes and Chitosan Hydrogel Formulations on ex vivo Permeation and Antimicrobial Activity
    2017 ARKIV
  • Ann Mari Holsæter :
    Vurdering av læring i laboratorieundervisning – et eksempel fra farmasiutdanningen
    2017
  • Selenia Ternullo, Louis de Weerd, Gøril Eide Flaten, Ann Mari Holsæter, Natasa Skalko-Basnet :
    Isolated perfused human skin flap model: A novel tool to evaluate drug penetration through the skin
    2016
  • Anders Øverbye, Ann Mari Holsæter, Natasa Skalko-Basnet, Iversen Tore-Geir, Maria Lyngaas Torgersen, Tonje Sønstevold m.fl.:
    Biodegradable nanoparticles in cancer diagnosis and therapy (NANOCAN):Ceramide modulation of liposomal doxorubicin
    2016
  • Ann Mari Holsæter :
    Preparation, characterization and in vitro testing of liposomes
    2016
  • Selenia Ternullo, Louis de Weerd, Gøril Eide Flaten, Ann Mari Holsæter, Natasa Skalko-Basnet :
    Isolated perfused human skin flap model: a novel tool to evaluate drug penetration through the skin
    2016
  • Selenia Ternullo, Louis de Weerd, Gøril Eide Flaten, Ann Mari Holsæter, Natasa Skalko-Basnet :
    Isolated perfused human skin flap model: a novel tool to evaluate drug penetration through the skin II
    2016
  • Ann Mari Holsæter, Natasa Skalko-Basnet :
    Liposomes as multi-functional delivery system in cancer therapy
    2015
  • Sveinung Gaarden Ingebrigtsen, Ivo Laidemäe, Jukka Saarinen, Clare J. Strachan, Ann Mari Holsæter, Natasa Skalko-Basnet m.fl.:
    Characterization of liposome-loaded nanofibers by coherent anti-Stokes Raman scattering microscopy and scanning white light interferometry
    2015
  • Ann Mari Holsæter, Natasa Skalko-Basnet :
    Multi-functional liposomes as delivery system in cancer therapy
    2015

  • De 50 siste resultatene fra Cristin vises på siden. Se alle arbeider i Cristin her →


    Forskningsinteresser

    Forskningen hennes har fokus på avanserte legemiddelformuleringer, og forbedring av legemiddelterapi gjennom forbedring av legemidlenes opptak, stabilitet og/eller spesifisitet, med reduserte bivirkninger og økt effekt av behandling som mål. Hun har særlig ekspertise og interesse for liposomer, nanofibre og hydrogeler, anvendt alene eller i kombinasjon. Disse formuleringen er i hennes tilfelle i hovedsak fremstilt for topikal (huden, og sårbehandling) og systemisk administrasjon (injeksjonsmedisin), og da gjerne med antimikrobiell, anti-cancer eller immunstimmulerende effekt som mål. 

    I forskningsgruppen har Ann Mari særlig ekspertise på teknologier som elektrospinning av nanofibre og bruk av "dual centrifugering" i fremstilling av nanopartikler, inkluderte liposomer. 

    Undervisning

    Emner Ann Mari underviser i:

    • FAR-2401; Legemiddelfremstilling og kvalitetskontroll (10 STP), underviser (emneansvarlig 2012-2019)
    • FAR-2402; Legemiddelformulering og biofarmasi (10 STP)- emneansvarlig siden 2019, underviser siden 2012
    • FAR-3401; Advansert legemiddelteknologi og biofarmasi (10 STP), foreleser
    • FAR-3911; Masteroppgave i farmasi (50 STP), veileder
    • FAR-3043: Nanomedisin (15 STP), foreleser
    • FAR-8043; Nanomedicine and nanotechnology (15 STP), foreleser