Alex West
Daniel Appenroth,
Chandra Sekhar Ravuri,
Sara K. Torppa,
Shona Hiedi Wood,
David Grey Hazlerigg,
Alexander Christopher West
:
The Reindeer Circadian Clock Is Rhythmic and Temperature-compensated But Shows Evidence of Weak Coupling Between the Secondary and Core Molecular Clock Loops
Journal of Biological Rhythms 2024 DOI
Chiara Ciccone,
Fayiri Kante,
Lars Folkow,
David Grey Hazlerigg,
Alexander Christopher West,
Shona Hiedi Wood
:
Circadian coupling of mitochondria in a deep-diving mammal
Daniel Appenroth,
Alexander Christopher West,
Shona Hiedi Wood,
David Grey Hazlerigg
:
Tanycytes from a bird’s eye view: gene expression profiling of the tanycytic region under different seasonal states in the Svalbard ptarmigan
David Grey Hazlerigg,
Barbara Mizumo Tomotani,
Alexander Christopher West,
Daniel Appenroth,
Shona Hiedi Wood
:
Biological timekeeping in polar environments: lessons from terrestrial vertebrates
Chiara Ciccone,
Fayiri Kante,
Lars Folkow,
David Grey Hazlerigg,
Alexander Christopher West,
Shona Hiedi Wood
:
Circadian coupling of mitochondria in a deep-diving mammal
bioRxiv 2023 DOI
Daniel Appenroth,
Gabriela Wagner,
David Hazlerigg,
Alexander Christopher West
:
Evidence for circadian-based photoperiodic timekeeping in Svalbard ptarmigan, the northernmost resident bird
Alexander Christopher West,
Yasutaka Mizoro,
Shona Wood,
Louise M. Ince,
Marianne Iversen,
Even Hjalmar Jørgensen
m.fl.:
Immunologic Profiling of the Atlantic Salmon Gill by Single Nuclei Transcriptomics
Marianne Iversen,
Teshome Dagne Mulugeta,
Alexander Christopher West,
Even Hjalmar Jørgensen,
Samuel A. M. Martin,
Simen Rød Sandve
m.fl.:
Photoperiod-dependent developmental reprogramming of the transcriptional response to seawater entry in Atlantic salmon (Salmo salar)
Marianne Iversen,
Teshome Dagne Mulugeta,
Børge Gellein Blikeng,
Alexander Christopher West,
Even Hjalmar Jørgensen,
Simen Rød Sandve
m.fl.:
RNA profiling identifies novel, photoperiodhistory dependent markers associated with enhanced saltwater performance in juvenile Atlantic salmon
Daniel Appenroth,
Vebjørn Jacobsen Melum,
Alexander Christopher West,
Hugues Dardente,
David Hazlerigg,
Gabriela Wagner
:
Photoperiodic induction without light-mediated circadian entrainment in a High Arctic resident bird
Alexander Christopher West,
Yasutaka Mizoro,
Shona Hiedi Wood,
Marianne Iversen,
Louise Ince,
Even Jørgensen
m.fl.:
A single nuclei transcriptomic analysis of the Atlantic salmon gill through smoltification and seawater transfer
bioRxiv 2020 DOI
Alexander Christopher West,
Marianne Iversen,
Even Hjalmar Jørgensen,
Simen Rød Sandve,
David Hazlerigg,
Shona Hiedi Wood
:
Diversified regulation of circadian clock gene expression following whole genome duplication
Shona Hiedi Wood,
Alexander Christopher West
:
Seasonal physiology: making the future a thing of the past
Current Opinion in Physiology 2018 DOI
Alexander Christopher West,
Laura Smith,
David Ray,
Andrew S.I. Loudon,
Tim Brown,
David A. Bechtold
:
Misalignment with the external light environment drives metabolic and cardiac dysfunction
Nature Communications 2017 DOI
Alexander Christopher West,
David A. Bechtold
:
The cost of circadian desynchrony: Evidence, insights and open questions
Bioessays 2015 DOI
Lauren Walmsley,
Lydia Hanna,
Josh Mouland,
Franck Marshall,
Alexander Christopher West,
Andrew R.D. Smedley
m.fl.:
Colour as a signal for entraining the mammalian circadian clock
PLoS Biology 2015 DOI
Violetta Pilorz,
Peter Cunningham,
Anthony Jackson,
Alexander Christopher West,
Travis Wager,
Andrew S.I. Loudon
m.fl.:
A Novel Mechanism Controlling Resetting Speed of the Circadian Clock to Environmental Stimuli
Current Biology 2014 DOI
Alexander Christopher West,
Sandrine M Dupre,
Le Yu,
Robert Patton,
K Miedzinska,
Alan McNeilly
m.fl.:
Npas4 Is Activated by Melatonin, and Drives the Clock Gene Cry1 in the Ovine Pars Tuberalis
Molecular Endocrinology 2013 DOI
Chiara Ciccone,
Fayiri Kante,
David Grey Hazlerigg,
Lars Folkow,
Alexander Christopher West,
Shona Hiedi Wood
:
Circadian clockwork and mitochondrial metabolism in a diving mammal: a link between hypoxia tolerance and time of the day
2022
Alexander Christopher West,
David Hazlerigg,
Gabrielle Grenier
:
Calendar Timing in Teleost Fish
Springer Nature 2021 DOI
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Publikasjoner utenom Cristin
Publications from the last five years:
- Appenroth D, Wagner G, Hazlerigg DG, West AC (2021). Evidence for circadian-based photoperiodic timekeeping in Svalbard ptarmigan, the northernmost resident bird. Current Biology, 31, 2720–2727.
- West AC, Mizoro Y, Wood SH, Ince L, Iversen M, Jørgensen E, Nome T, Sandve SR, Loudon ASI, Hazlerigg DG (2021). Immunologic Profiling of the Atlantic Salmon Gill by Single Nuclei Transcriptomics. Frontiers in Immunology, 4;12:669889.
- Iversen M, Mulugeta T, West AC, Jørgensen E, Martin SAM, Sandve SR, Hazlerigg DG (2021) Photoperiod-dependent developmental reprogramming of the transcriptional response to seawater entry in Atlantic salmon (Salmo salar). G3. 11(4):jkab072.
- West AC, Iversen M, Jørgensen E, Sandve SR, Hazlerigg DG, Wood SH (2020) Diversified regulation of circadian clock gene expression following whole genome duplication. PLoS Genetics, 16(10): e1009097.
- Iversen M, Mulugeta T, Blikeng BG, West AC, Hazlerigg D, and Jørgensen EH (2020) RNA profiling identifies novel, photoperiod-history dependent markers associated with enhanced saltwater performance in juvenile Atlantic salmon. PLoS One. Apr 8:15(4):e0227496.
- Appenroth D, Melum VJ, West AC, Dardente H, Hazlerigg DG and Wagner G (2020) Photoperiodic induction without light-mediated circadian entrainment in a High Arctic resident bird. Accepted in Journal of Experimental Biology.
- West AC, Wood SH (2018) Seasonal physiology: making the future a thing of the past. Current Opinions in Physiology, 5:1-8
- West AC, Smith L, Ray DW, Loudon ASI, Brown TM, Bechtold DA (2017) Misalignment with the external light environment drives metabolic and cardiac dysfunction. Nature Communications, 8(1):417.
Forskningsinteresser
The most interesting animals transform their physiology to cope/exploit seasonal changes in their environment; nowhere is this more apparent than in the Arctic. By combining classical experimental designs with cutting edge tools, my research aims to identify the pathways that control seasonal transformation and explores how biological timekeeping is influenced by the Arctic environment.
Current projects:
- Seasonal regulation of pituitary prolactin
- Seasonal control of reproduction in birds
- Arctic circadian clocks
- Seasonal control of smoltification in Atlantic salmon
Undervisning
Teaching:
- BIO-3014: Biological Timekeeping (Co-pilot 2021, Pilot 2022)
- BIO-3030: Extreme Physiology
- BIO-2002: Animal Physiology
- BIO-2310: Arctic Biology (-2022)
PhD Supervision
- Anna Hofinger (2022-2026) - Seasonal regulation of pituitary prolactin. Supervisors: Alex West, Shona Wood
- Jana Kalinova (2021-2025) - Photoperiodic control of reproduction in birds. Supervisors: David Hazlerigg, Alex West, Shona Wood
- Daniel Appenroth (2016-2020) - Circadian-based processes in the High Arctic: activity, thermoregulation and photoperiodism in the Svalbard ptarmigan (Lagopus muta hyperborea). Supervisors: David Hazlerigg, Gabriela Wagner, Alex West
Masters Supervision
- Sona Hakhverdyan (2022-2023) - In vivo CRISPR of CUZD1 in Atlantic salmon. Supervisors: Alex West, Helge Tveiten
- Therese Solberg (2021-2022) - Circadian disruption by light and its effect on the immune function of the Atlantic salmon (Salmo salar). Supervisors: Alex West, Eva-Stina Edholm, David Hazlerigg
- Anna Hofinger (2020-2021) - Characterization of the biological clock in Svalbard ptarmigan (Lagopus muta hyperborea). Supervisors: David Hazlerigg, Alex West
- Fayiri Kante (2020-2021) - Characterization of the circadian clock in Hooded Seals (Cystophora Cristata) and its interaction with mitochondrial metabolism: A multi-tissue comparison and cell culture approach. Supervisors: Shona Wood, Alex West
- Vebjørn Melum (2017-2018) - Influence of photoperiod on central appetite regulation in captive Svalbard rock ptarmigan (Lagopus muta hyperborea)
- Nora Slåttebrekk (2017-2018) - An analysis of key molecular clock components in reindeer (Rangifer t. tarandus). Supervisors: Gabriela Wagner, Alex West, David Hazlerigg
Medlem i forskningsgruppe
Medlem i prosjekt
Vedlegg:
- CV (docx)