MBI-8008 Molecular and Clinical Aspects of Cancer - Block II - 10 ECTS
PhD course. It is available as a singular course.
PhD students and students at the Medical Student Research Program at UiT - The Arctic University of Norway apply for admission by registering for class in Studentweb by September 1st.
Application deadline for other applicants is 1 June. Application code is 9301.
PhD students and students at the Student Research Programme, or holders of a Norwegian master´s degree of five years or 3+2 years (or equivalent) may be admitted.
External applicants apply for the right to study by June 1st for courses that are taught in the autumn semester. Application is sent through SøknadsWeb. Please use the appliction code "9301 - Singular courses at the PhD level". If granted admission to the course students must register for class and exam in Studentweb by September 1st for autumn semester.
The course is divided into three modules:
Module I cover the topics DNA repair, Transcriptional regulation, Chromatin and Epigenetics and the impact of these processes for maintenance and proper proliferation and differentiation of the cell. How dysregulation of any these processes may contribute to cancer development is discussed.
The topics of Module II are infectious agents and their involvement in different cancer types, inflammation and cancer, and cancer stem cells. The infectious agents discussed are viruses, and how some of their encoded proteins have the ability to disturb the normal regulation of a eukaryotic cell. The inflammation section discusses the role of inflammatory factors for survival and proliferation of cancer cells. The cancer stem cell hypothesis in vascular and solid cancers will be discussed.
Module III covers targeted cancer therapy, cancer omics and cancer epidemiology. Factors that may have a preventive effect on cancer development, immunotherapy and molecular medicines and how such
medicines specifically hit the oncoproteins and thereby inhibit growth of cancer cells are discussed. The epidemiology part highlights the impact of genetic and environmental factors in cancer development.
After completing the course the students will have the
- Explain the main mechanisms of DNA repair, Transcriptional regulation, Chromatin and Epigenetics and the impact of these processes for maintenance and proper proliferation and differentiation of the cell.
- Discuss how proteins encoded by infectious agents have the ability to disturb the normal regulation of a eukaryotic cell and contribute to cancer development.
- Explain the roles of inflammatory factors in cancer development, and how the immune system can be modulated to recognise and destroy cancer cells.
- Discuss the impact of genetic and environmental factors in cancer development.
- Describe the roles of cancer stem cells as important targets of cancer treatment.
- Discuss the cancer stem cell hypothesis.
- Describe central methods in cancer biology research.
- Justify factors that may have a preventive effect on cancer development, the basics of immunotherapy and molecular medicines and how such medicines specifically hit the oncoproteins and thereby inhibit growth of cancer cells.
- Justify how dysregulation of epigenetics, DNA repair and inflammation processes may contribute to cancer development.
- Present and critically review high impact research papers within the field of basic and translational cancer research.
- Interpret results from own research and link it scientifically into the context of international basic and translational cancer research.
- Evaluate and Implement relevant methods of advanced cancer research in own project.
|Oral exam||Passed / Not Passed|
To take an examination, the student must have passed the following coursework requirements:
|Presentation of their PhD project||Approved – not approved|
- About the course
- Campus: Tromsø |
- ECTS: 10
- Course code: MBI-8008
- Ekstra informasjon
Ph.d. candidates from UiT apply for the course in StudentWeb. Deadline 1. september 2023. External candidates have to apply for admission for singular courses before 1. juni 2023. More information can be found here: https://en.uit.no/admission#innhold_768667
- Responsible unit
- Institutt for medisinsk biologi
- Tidligere år og semester for dette emnet