Structural Bioinformatics

Selcted resources in the field of structural bioinformatics.  The idea is to collect attactive tools to perfrom Structural Bioinformatics :

1. Elixir has a web page with tools and resources in the field of structural bioinformatics.
2. A version of the structure prediction program AlphaFold through "Colab notebook". 
3. AlphaFold Protein Structure Database. This database provides open access to > 200 million protein structure predictions to accelerate scientific research. 
4. The SWISS-MODEL Repository is a database of annotated 3D protein structure models generated by the SWISS-MODEL homology-modelling pipeline.
5. SWISS-MODEL Workspace

Diagnostics

Some general aspects of diagnosing of bacterial infections 

Samples can be from e.g.

• Blood
• Urine
• Sputum
• Stool
• Tissue
• Cerebrospinal fluid
• Mucus (from nose/throat/genital area)

It is important to identify type of organism, anf if the bacteria is 

• gram positive (blue because they retain the violet Gram stain) or
• gram negative (look red because they do not retain the stain)

Diagnostic tests for infectious diseases

• PCR (polymerase chain reaction (PCR)-based test)
• Lab-on-a-chip (LOC) technologies
• point-of-care testing (POCT)

Antibiograms: 

A way to observe the susceptibility rates and in addition monitor antibiotic resistance.

A summary of in vitro antimicrobial susceptibility test results of a bacteria and/or fungi taken from a patient.

References on diagnostics

• Vazquez-Pertejo (2022) Diagnosis of Infectious Disease. MSD Manuals