Tom Dønnem


Professor

Stillingsbeskrivelse

Leder Translasjonell Kreftforskningsgruppe, IKM. Bistilling som overlege ved kreftavdelingen (UNN) og Enhet for Lindrende Behandling (UNN).


  • Per Niklas Benzler Waaler, Hasse Melbye, Henrik Schirmer, Markus Kreutzer Johnsen, Tom Dønnem, Johan Fredrik Ravn m.fl.:
    Algorithm for predicting valvular heart disease from heart sounds in an unselected cohort
    Frontiers in Cardiovascular Medicine 2024 ARKIV / DOI
  • Mehrdad Rakaee, Sigve Andersen, K. Giannikou, Erna-Elise Paulsen, Thomas Karsten Kilvær, Lill-Tove Rasmussen Busund m.fl.:
    Machine learning-based immune phenotypes correlate with STK11/KEAP1 co-mutations and prognosis in resectable NSCLC: a sub-study of the TNM-I trial
    Annals of Oncology 2023 ARKIV / DOI
  • Erna-Elise Paulsen, Sigve Andersen, Mehrdad Rakaee, Mona Irene Pedersen, Ana Paola Lombardi, Mette Pøhl m.fl.:
    Impact of microvessel patterns and immune status in NSCLC: a non-angiogenic vasculature is an independent negative prognostic factor in lung adenocarcinoma
    Frontiers in Oncology 2023 ARKIV / DOI
  • Bente Ervik, Tom Dønnem, May Lill Johansen :
    Dying at “home” - a qualitative study of end-of-life care in rural Northern Norway from the perspective of health care professionals
    BMC Health Services Research 2023 ARKIV / DOI
  • Mehrdad Rakaee, Elio Adib, Biagio Ricciuti, Lynette M. Sholl Sholl, Weiwei Shi, Joao V. Alessi m.fl.:
    Association of machine learning-based assessment of tumor-infiltrating lymphocytes on standard histologic images with outcomes of immunotherapy in patients with NSCLC
    JAMA Oncology 17. november 2022 DOI
  • Therese Haugdahl Nøst, Anne Heidi Skogholt, Ilona Halva Urbarova, Robin Mjelle, Erna-Elise Paulsen, Tom Dønnem m.fl.:
    Increased levels of microRNA-320 in blood serum and plasma is associated with imminent and advanced lung cancer
    Molecular Oncology 2022 ARKIV / DOI
  • Maria Jenvin Støen, Sigve Andersen, Mehrdad Rakaee, Mona I. Pedersen, Lise Martine Ingebriktsen, Tom Dønnem m.fl.:
    Overexpression of mir-20a-5p in tumor epithelium is an independent negative prognostic indicator in prostate cancer—a multi-institutional study
    Cancers 2021 ARKIV / DOI
  • Maria Jenvin Støen, Sigve Andersen, Mehrdad Rakaee, Mona Irene Pedersen, Lise Martine Ingebriktsen, Roy M. Bremnes m.fl.:
    High expression of miR-17-5p in tumor epithelium is a predictor for poor prognosis for prostate cancer patients
    Scientific Reports 2021 ARKIV / DOI
  • Sissel Gyrid Freim Wahl, Yan Dai Hong, Elisabeth Fritzke Emdal, Thomas Berg, Tarje Onsøien Halvorsen, Anine Larsen Ottestad m.fl.:
    The prognostic effect of KRAS mutations in non-small cell lung carcinoma revisited: A norwegian multicentre study
    Cancers 2021 ARKIV / DOI
  • Mehrdad Rakaee, Thomas Karsten Kilvær, Simin Jamaly, Thomas Berg, Erna-Elise Paulsen, Marte Berglund m.fl.:
    Tertiary lymphoid structure score: a promising approach to refine the TNM staging in resected non-small cell lung cancer
    British Journal of Cancer 2021 DOI
  • Therese H. Nøst, Marit Holden, Tom Dønnem, Hege Bøvelstad, Charlotta Rylander, Eiliv Lund m.fl.:
    Transcriptomic signals in blood prior to lung cancer focusing on time to diagnosis and metastasis
    Scientific Reports 2021 ARKIV / DOI
  • Thomas Karsten Kilvær, Erna-Elise Paulsen, Sigve Andersen, Mehrdad Rakaee, Roy M. Bremnes, Lill-Tove Rasmussen Busund m.fl.:
    Digitally quantified CD8+ cells: the best candidate marker for an immune cell score in non-small cell lung cancer?
    Carcinogenesis 2020 ARKIV / DOI
  • Mehrdad Rakaee, Lill-Tove Busund, Simin Jamaly, Erna-Elise Paulsen, Elin Richardsen, Sigve Andersen m.fl.:
    Prognostic Value of Macrophage Phenotypes in Resectable Non–Small Cell Lung Cancer Assessed by Multiplex Immunohistochemistry
    Neoplasia 12. februar 2019 ARKIV / DOI
  • Elin Richardsen, Sigve Andersen, Samer Al-Saad, Mehrdad Rakaee, Yngve Nordby, Mona Irene Pedersen m.fl.:
    Low expression of miR-424-3p is highly correlated with clinical failure in prostate cancer
    Scientific Reports 2019 ARKIV / DOI
  • Elin Richardsen, Sigve Andersen, Christian Melbø-Jørgensen, Mehrdad Rakaee, Nora Ness, Samer Al-Saad m.fl.:
    MicroRNA 141 is associated to outcome and aggressive tumor characteristics in prostate cancer
    Scientific Reports 2019 ARKIV / DOI
  • Thomas Karsten Kilvær, Mehrdad Rakaee, Turid Hellevik, Jørg Vik, Luigi de Petris, Tom Dønnem m.fl.:
    Differential prognostic impact of platelet-derived growth factor receptor Expression in NSCLC
    Scientific Reports 2019 ARKIV / DOI
  • Kaja Konstanse Skjefstad, Charles Johannessen, Thea K.W. Grindstad, Thomas Karsten Kilvær, Erna Elise Paulsen, Mona Irene Pedersen m.fl.:
    A gender specific improved survival related to stromal miR-143 and miR-145 expression in non-small cell lung cancer
    Scientific Reports 2018 ARKIV / DOI
  • Mehrdad Rakaee, Thomas Karsten Kilvær, Stig Manfred Dalen, Elin Richardsen, Erna Elise Paulsen, Sigurd Hald m.fl.:
    Evaluation of tumor-infiltrating lymphocytes using routine H&E slides predicts patient survival in resected non-small cell lung cancer
    Human Pathology 2018 DOI
  • Thomas Karsten Kilvær, Mehrdad Rakaee, Turid Hellevik, Arne Östman, Carina Strell, Roy M. Bremnes m.fl.:
    Tissue analyses reveal a potential immune-adjuvant function of FAP-1 positive fibroblasts in non-small cell lung cancer
    PLOS ONE 2018 ARKIV / DOI
  • Tom Dønnem, Andrew Reynolds, Elizabeth A. Kuczynski, Kevin C. Gatter, Peter B. Vermeulen, Robert S. Kerbel m.fl.:
    Non-angiogenic tumours and their influence on cancer biology
    Nature Reviews Cancer 2018 DOI
  • Thea K.W. Grindstad, Elin Richardsen, Sigve Andersen, Kaja Konstanse Skjefstad, Mehrdad Rakaee, Tom Dønnem m.fl.:
    Progesterone receptors in prostate cancer: Progesterone receptor B is the isoform associated with disease progression
    Scientific Reports 2018 ARKIV / DOI
  • Sigurd Hald, Mehrdad Rakaee, Inigo Zubiavrre Martinez, Elin Richardsen, Samer Al-Saad, Erna Elise Paulsen m.fl.:
    LAG-3 in Non-Small-cell Lung Cancer: Expression in Primary Tumors and Metastatic Lymph Nodes Is Associated With Improved Survival
    Clinical Lung Cancer 2018 DOI
  • Yury Kiselev, Sigve Andersen, Charles Johannessen, Bjørn Fjukstad, Karina Standahl Olsen, Helge Stenvold m.fl.:
    Transcription factor PAX6 as a novel prognostic factor and putative tumour suppressor in non-small cell lung cancer
    Scientific Reports 2018 ARKIV / DOI
  • Nora Ness, Sigve Andersen, Mehrdad Rakaee, Cecilie Nordbakken, Andrey Yurjevich Valkov, Erna-Elise Paulsen m.fl.:
    The prognostic role of immune checkpoint markers programmed cell death protein 1 (PD-1) and programmed death ligand 1 (PD-L1) in a large, multicenter prostate cancer cohort
    OncoTarget 2017 ARKIV / DOI
  • Erna-Elise Paulsen, Thomas Karsten Kilvær, Mehrdad Rakaee, Elin Richardsen, Sigurd Hald, Sigve Andersen m.fl.:
    CTLA-4 expression in the non-small cell lung cancer patient tumor microenvironment: diverging prognostic impact in primary tumors and lymph node metastases
    Cancer Immunology and Immunotherapy 2017 ARKIV / DOI
  • Elin Richardsen, Sigve Andersen, Samer Al-Saad, Mehrdad Rakaee, Yngve Nordby, Mona Irene Pedersen m.fl.:
    Evaluation of the proliferation marker Ki-67 in a large prostatectomy cohort
    PLOS ONE 2017 ARKIV / DOI
  • Yngve Nordby, Elin Richardsen, Nora Ness, Tom Dønnem, Hitendra R.H. Patel, Lill-Tove Busund m.fl.:
    High miR-205 expression in normal epithelium is associated with biochemical failure - An argument for epithelial crosstalk in prostate cancer?
    Scientific Reports 2017 ARKIV / DOI
  • Tom Dønnem, Micklem Kingsley, Pezzella Francesco :
    Evolution and cancer (Chapter 3), Oxford Textbook of Cancer Biology
    Oxford University Press 2019
  • Mehrdad Rakaee, Masoud Tafavvoghi, Elio Adib, Biagio Ricciuti, Joao Alessi, Alessio Cortellini m.fl.:
    Artificial intelligence algorithm developed to predict immune checkpoint inhibitors efficacy in non–small-cell lung cancer
    2023
  • Bente Ervik, Tom Dønnem, May Lill Johansen :
    Home-death in Rural North Norway - Health Care Professionals Perspectives
    2023
  • Mehrdad Rakaee, Elio Adib, Biagio Ricciuti, Lynette M. Sholl, Weiwei Shi, Joao V Alessi m.fl.:
    Computational pathology by Artificial Intelligence (AI) on quantifying the lymphocytic infiltration predicts the immunotherapy response in NSCLC
    2022
  • Åslaug Helland, Hege Elisabeth Giercksky Russnes, Gro Live Fagereng, Khalid Ibrahim Al-Shibli, Yvonne Andersson, Thomas Berg m.fl.:
    Correction to: Improving public cancer care by implementing precision medicine in Norway: IMPRESS-Norway (Journal of Translational Medicine, (2022), 20, 1, (225), 10.1186/s12967-022-03432-5)
    Journal of Translational Medicine 2022 DOI
  • Therese Haugdahl Nøst, Ilona Halva Urbarova, Anne Heidi Skogholt, Robin Mjelle, Erna Elise Paulsen, Tom Dønnem m.fl.:
    Increased levels of mRNAs and miRNAs associated with imminent and advanced lung cancer
    2022
  • Mehrdad Rakaee, Elio Adib, Biagio Ricciuti, Lynette M. Sholl, Weiwei Shi, Joao V.Alessi m.fl.:
    Artificial intelligence in digital pathology approach identifies the predictive impact of tertiary lymphoid structures with immune-checkpoints therapy in NSCLC
    2022
  • Mehrdad Rakaee, Elio Adib, Biagio Ricciuti, Lynette M. Sholl, Joao V.Alessi, Alessio Cortellini m.fl.:
    Digital quantification of lymphocytic infiltration on routine H&E images and immunotherapy response in non-small cell lung cancer
    2022
  • Åslaug Helland, Hege Elisabeth Giercksky Russnes, Gro Live Fagereng, Khalid Ibrahim Al-Shibli, Yvonne Andersson, Thomas Berg m.fl.:
    Improving public cancer care by implementing precision medicine in Norway: IMPRESS-Norway
    Journal of Translational Medicine 14. mai 2022 ARKIV / FULLTEKST / DOI
  • Bente Ervik, Sigve Andersen, Helge Skirbekk, Tom Dønnem :
    Evaluating a centralised cancer support centre in the remote region of Northern Norway
    Rural and remote health 02. september 2020 ARKIV / DOI
  • Sigve Andersen, Tom Dønnem :
    Krafttak mot kreft
    14. mars 2019
  • Tom Dønnem :
    Lungekreftforskning i et samfunnspersepktiv
    2019
  • Tom Dønnem, Sigve Andersen :
    Jakter på kroppens krigerceller
    05. september 2019
  • Tom Dønnem, Sigve Andersen :
    Jakter på kroppens krigerceller
    18. september 2019
  • Tom Dønnem :
    Er angiogenese en "hallmark of cancer"? - paradigmeskifte og betydning for behandling
    BestPractice Nordic 2019
  • Tom Dønnem :
    Kræftsvulster er mere komplicerede, end forskerne tidligere antaget
    19. juli 2018
  • Tom Dønnem :
    Kreftsvulsten er mer komplisert enn forskerer tidligere har trodd
    25. juni 2018
  • Tom Dønnem :
    Knuser sentral sannhet innen kreftforskning
    16. mai 2018
  • Tom Dønnem :
    Tumours are more complicated than previously believed
    04. juli 2018
  • Kaja Konstanse Skjefstad, Thea K.W. Grindstad, Mehrdad Rakaee, Elin Richardsen, Tom Dønnem, Thomas Karsten Kilvær m.fl.:
    Corrigendum to "Prognostic relevance of estrogen receptor α, β and aromatase expression in non-small cell lung cancer" [Steroids 113 (2016) 5-13]
    Steroids 2018 DOI
  • Tom Dønnem :
    "Immunologi innen lungekreft"
    2017
  • Tom Dønnem :
    "Foredrag om forskning og brukermedvirkning"
    2017
  • Tom Dønnem :
    "IT og medisinsk forskning"
    01. september 2017

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    Forskningsinteresser

    Hovedfokus på translasjonell kreftforskning relatert til tumor immunologi og angiogense ved lungekreft. I tillegg forskning relatert persontilpasset medisin på tvers av flere krefttyper samt forskning knyttet til palliativ kreftbehandling.

    Undervisning

    Fagenhetsleder kreft. Medlem av nasjonal eksamenskomite 6. års medisinstudenter.