Lars Småbrekke
Stillingsbeskrivelse
Stillingen har undervisningsansvar for emnene Far-2101 og Far-3101, og jeg deltar i undervisning i flere andre emner på master og PhD-nivå.
Forskningen er rettet mot ulike aspekter relatert til legemiddelbruk, først og fremst antibiotika, og er i hovedsak basert på data fra befolkningsstudier, Legemiddelregisteret og data samlet fra klinisk praksis i sykehus.
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Forskningsinteresser
Legemiddelbruk på individ- og populasjonsnivå, med hovedfokus på antibiotikabruk.
Medlem i forskningsgruppe
CV
Academic Curriculum Vitae for Lars Småbrekke
Personal data and contact information
Date of birth: 18.01.59
Position: Professor
Work address: Department of Pharmacy, UiT The Arctic University of Norway
Phone: +4799249663 (cell) / +4777645792 (office)
E-mail: lars.smabrekke@uit.no
Research unique identifier: https://orcid.org/0000-0001-6474-3368
UiT web-site: https://uit.no/ansatte/lars.smabrekke
CRISTIN-ID: 55832
Education
2013 – 2014 Basic competency in Pedagogy in higher education, RESULT, UiT
2009 PhD. Faculty of Health Sciences, UiT https://munin.uit.no/handle/10037/2135
1999 Master in Public Health. Faculty of Health Sciences, UiT
1985 Candidatus Pharmaciae, UiO
Current and previous positions
2022 – now Prof. UiT The Arctic University of Norway, Department of Pharmacy
2009 – 2021 A/Prof. UiT The Arctic University of Norway, Department of Pharmacy
2008 – 2009 University scholarship (UiT The Arctic University of Norway)
2004 – 2008 University Hospital North-Norway, Head of the regional drug information centre
2003 – 2004 UiT The Arctic University of Norway (lecturer)
1999 – 2003 University Hospital North-Norway, Head of the regional drug information centre
1991-1999 Hospital Pharmacy, University Hospital North-Norway
1986-1991 Hospital Pharmacy, Kirkenes Hospital, Norway
Development of curricula
2010 – 2012 Working group for the new BSc and MSc program in Pharmacy at UiT
2012 – 2013 Revision of pharmacy education in Norway. (Head of the working group)
2016 Profesjonsrådet. Head of national group establishing for learning outcomes in statistics in a 3+2 curriculum in pharmacy
Boards and committees
1994 – 1997 Interim board for establishing the pharmacy program at UiT
1999 – 2004 External member. Board for the Department of Pharmacy
Regional and national boards and committees
1999 – 2000 Bivirkningsnemda (National board of adverse reactions to medicines)
2008 – 2012 Blåreseptnemda (National board on reimbursement)
2016 – now Board member. The Regional Health Authority
2010 – now Board member. Norwegian Society of Pharmacoepidemiology
Panels, workshops and conference organization
2018 Critical thinking. Member of working group for the workshop (approx. 225 participants)
2019 Conference on antibiotic stewardship and conservation in Africa. Durban (South-Africa). Organizing of the conference and chaired one afternoon session.
2019 Critical thinking. Leader of the working group for the workshop. (approx. 275 participants)
2020 Critical thinking. Member of working group for the workshop (approx. 225 participants)
2023 NSPC. International Conference in Social Pharmacy. Member of working group
Scientific evaluation committees
2012 UiO. Position as A/Prof in community pharmacy
2012 UiT The arctic university of Norway. Position as A/Prof in pharmacy practice
2013 UiO. Position as A/Prof in community pharmacy
2016 UiO. Position as Professor in community pharmacy
2016 UiO. Position as A/Prof in community pharmacy
2019 UiT The arctic university of Norway. Position as university lecturer
2019 UKZN. Evaluation of PhD-thesis
2022 NTNU. Exam for research line student
Chronological list of publications
1. Rygnestad T, Småbrekke L, Nesje L, Talsethagen H, Rogne P, Myhr K, Bentzen I. Impact of improved treatment of sexually transmitted disease on HIV infection. Lancet. 1995 Oct 28;346(8983):1157
2. Simonsen T, Braathen P, Småbrekke L. Folsyre eller folinsyre som tilskudd ved samtidig behandling med metotrexat? Utposten. 1999;28:42-44
3. Endresen PC, Braathen P, Småbrekke L. Legemiddelbruk under graviditet. Utposten. 2000:29:45-46
4. Braathen P, Endresen PC, Småbrekke L, Ulvestad L. Ginko biloba, naturlegemiddel med mulig interaksjon med antitrombotiske midler. Utposten. 2000;29:32-33
5. Roland DDH, Schjøtt J, Småbrekke L, Westergren T. RELIS spørsmål og svar-database på internett. Utposten. 2001;30:38-39
6. Småbrekke L, Braathen P. Legemidler med laktose til pasienter med laktoseintoleranse? Tidsskr Nor Laegeforen. 2000 Aug 20;120(19):2303-4. Norwegian. PMID: 10997093
7. Småbrekke L. Stor skilnad i forbruksprofil mellom to universitetssykehus i Norge. Norsk Epidemiologi 2001;11: 61-5
8. Småbrekke L, Berild D, Giæver A, Myrbakk T, Fuskevåg A, Ericson JU, Flaegstad T, Olsvik O, Ringertz SH. Educational intervention for parents and healthcare providers leads to reduced antibiotic use in acute otitis media. Scand J Infect Dis. 2002;34(9):657-9. doi: 10.1080/00365540210147651. PMID: 12374355
9. Simonsen GS, Småbrekke L, Monnet DL, Sørensen TL, Møller JK, Kristinsson KG, Lagerqvist-Widh A, Torell E, Digranes A, Harthug S, Sundsfjord A. Prevalence of resistance to ampicillin, gentamicin and vancomycin in Enterococcus faecalis and Enterococcus faecium isolates from clinical specimens and use of antimicrobials in five Nordic hospitals. J Antimicrob Chemother 2003 Feb;51(2):323-31. doi: 10.1093/jac/dkg052. PMID: 12562698.6):X3. PMID: 33428587; PMCID: PMC7849480
10. Berild D, Småbrekke L, Halvorsen DS, Lelek M, Stahlsberg EM, Ringertz SH. Clostridium difficile infections related to antibiotic use and infection control facilities in two university hospitals. J Hosp Infect. 2003 Jul;54(3):202-6. doi: 10.1016/s0195-6701(03)00149-x. PMID: 12855235
11. Klingenberg C, Småbrekke L, Lier T, Flaegstad T. Validation of a simplified netilmicin dosage regimen in infants. Scand J Infect Dis. 2004;36(6-7):474-9. doi: 10.1080/00365540410020613. PMID: 15307571
12. Nordmo E, Småbrekke L. Kalseormedrue (Black cohosh) mot menopausale plager. Utposten 2005;34:42-43
13. Raknes G, Småbrekke L. Echinacea spp. (solhatt) og øvre luftveisinfeksjon. Tidsskr Nor Laegeforen. 2006 Oct 5;126(19):2526-7. Norwegian. PMID: 17028634
14. Vorren S, Småbrekke L. Reductil (sibutramin) og graviditet. Utposten 2008;37:44-45
15. Nordmo E, Småbrekke L. Melasma ved bruk av p-piller. NFT 2007: (5):12
16. Nordmo E, Småbrekke L. Interaksjon mellom metadon og valerianapreparater. NFT 2007; (10):10
17. Nordmo E, Småbrekke L. Nattlysolje mot atopisk eksem. NFT 2008; (3):11-12
18. Småbrekke L, Melbye H. Medikamentell behandling av akutt hoste. Tidsskr Nor Laegeforen. 2009 May 14;129(10):998-9. Norwegian. doi: 10.4045/tidsskr.08.0438. PMID: 19448753.
19. Klingenberg C, Småbrekke L, Døllner H, Simonsen GS. Peroral antibiotikabehandling av urinveisinfeksjon hos barn. Tidsskr Nor Laegeforen. 2009 Jun 25;129(13):1342-4. Norwegian. doi: 10.4045/tidsskr.09.0092. PMID: 19561661
20. Nordmo E, Aronsen L, Wasland K, Småbrekke L, Vorren S. Severe apnea in an infant exposed to lamotrigine in breast milk. Ann Pharmacother. 2009 Nov;43(11):1893-7. doi: 10.1345/aph.1M254. Epub 2009 Oct 13. PMID: 19826099
21. Garcia BH, Småbrekke L, Trovik T, Giverhaug T. Application of the MAT-CHDSP to assess guideline adherence and therapy goal achievement in secondary prevention of coronary heart disease after percutaneous coronary intervention. Eur J Clin Pharmacol. 2013 Mar;69(3):703-9. doi: 10.1007/s00228-012-1402-7. Epub 2012 Sep 19. PMID: 22990329
22. Høgli JU, Småbrekke L, Garcia BH. MAT-CAP: a novel medication assessment tool to explore adherence to clinical practice guidelines in community-acquired pneumonia. Pharmacoepidemiol Drug Saf. 2014 Sep;23(9):933-41. doi: 10.1002/pds.3640. Epub 2014 May 2. PMID: 24797586
23. Garcia BH, Storli SL, Småbrekke L. A pharmacist-led follow-up program for patients with coronary heart disease in North Norway--a qualitative study exploring patient experiences. BMC Res Notes. 2014 Mar 29;7:197. doi: 10.1186/1756-0500-7-197. PMID: 24679131; PMCID: PMC3974183
24. Garcia BH, Giverhaug T, Høgli JU, Skjold F, Småbrekke L. A pharmacist-led follow-up program for patients with established coronary heart disease in North Norway - a randomized controlled trial. Pharm Pract (Granada). 2015 Apr-Jun;13(2):575. doi: 10.18549/pharmpract.2015.02.575. Epub 2015 Jun 15. PMID: 26131047; PMCID: PMC4482847
25. Melis M, Biagi C, Småbrekke L, Nonino F, Buccellato E, Donati M, Vaccheri A, Motola D. Drug-Induced Progressive Multifocal Leukoencephalopathy: A Comprehensive Analysis of the WHO Adverse Drug Reaction Database. CNS Drugs. 2015;29(10):879-91. doi: 10.1007/s40263-015-0286-3. PMID: 26507833
26. Høgli JU, Garcia BH, Skjold F, Skogen V, Småbrekke L. An audit and feedback intervention study increased adherence to antibiotic prescribing guidelines at a Norwegian hospital. BMC Infect Dis. 2016 Feb 27;16:96. doi: 10.1186/s12879-016-1426-1. PMID: 26920549; PMCID: PMC4769530
27. Zykov IN, Sundsfjord A, Småbrekke L, Samuelsen Ø. The antimicrobial activity of mecillinam, nitrofurantoin, temocillin and fosfomycin and comparative analysis of resistance patterns in a nationwide collection of ESBL-producing Escherichia coli in Norway 2010-2011. Infect Dis (Lond). 2016 Feb;48(2):99-107. doi: 10.3109/23744235.2015.1087648. Epub 2015 Sep 28. PMID: 26414659
28. Raknes G, Småbrekke L. A sudden and unprecedented increase in low dose naltrexone (LDN) prescribing in Norway. Patient and prescriber characteristics, and dispense patterns. A drug utilization cohort study. Pharmacoepidemiol Drug Saf. 2017 Feb;26(2):136-142. doi: 10.1002/pds.4110. Epub 2016 Sep 26. PMID: 27670755; PMCID: PMC5298009
29. Raknes G, Småbrekke L. Low-dose naltrexone and opioid consumption: a drug utilization cohort study based on data from the Norwegian prescription database. Pharmacoepidemiol Drug Saf. 2017 Jun;26(6):685-693. doi: 10.1002/pds.4201. Epub 2017 Mar 29. PMID: 28370746; PMCID: PMC5485080
30. Sørensen M, Kuehn A, Mills ENC, Costello CA, Ollert M, Småbrekke L, Primicerio R, Wickman M, Klingenberg C. Cross-reactivity in fish allergy: A double-blind, placebo-controlled food-challenge trial. J Allergy Clin Immunol 2017 Oct;140(4):1170-1172. doi: 10.1016/j.jaci.2017.03.043. Epub 2017 May 4. PMID: 28479332
31. Raknes G, Småbrekke L. Low dose naltrexone in multiple sclerosis: Effects on medication use. A quasi-experimental study. PLoS One 2017 Nov 3;12(11):e0187423. doi: 10.1371/journal.pone.0187423. PMID: 29099849; PMCID: PMC5669439
32. Haugen P, Simonsen GS, Primicerio R, Furberg AS, Småbrekke L. Antibiotics to outpatients in Norway-Assessing effect of latitude and municipality population size using quantile regression in a cross-sectional study. Pharm Stat. 2018 Feb;17(1):4-11. doi: 10.1002/pst.1831. Epub 2017 Sep 29. PMID: 28961357
33. Svendsen K, Karlstad Ø, Småbrekke L. Lower Cancer Incidence-Warfarin Effect or Immortal Time Bias? JAMA Intern Med. 2018 Apr 1;178(4):585. doi: 10.1001/jamainternmed.2018.0370. PMID: 29610882
34. Zykov IN, Samuelsen Ø, Jakobsen L, Småbrekke L, Andersson DI, Sundsfjord A, Frimodt-Møller N. Pharmacokinetics and Pharmacodynamics of Fosfomycin and Its Activity against Extended-Spectrum-β-Lactamase-, Plasmid-Mediated AmpC-, and Carbapenemase-Producing Escherichia coli in a Murine Urinary Tract Infection Model. Antimicrob Agents Chemother. 2018 May 25;62(6):e02560-17. doi: 10.1128/AAC.02560-17. PMID: 29581117; PMCID: PMC5971609.
35. Raknes G, Simonsen P, Småbrekke L. The Effect of Low-Dose Naltrexone on Medication in Inflammatory Bowel Disease: A Quasi Experimental Before-and-After Prescription Database Study. J Crohns Colitis. 2018 May 25;12(6):677-686. doi: 10.1093/ecco-jcc/jjy008
36. Haldorsen B, Giske CG, Hansen DS, Helgason KO, Kahlmeter G, Löhr IH, Matuschek E, Österblad M, Rantakokko-Jalava K, Wang M, Småbrekke L, Samuelsen Ø, Sundsfjord A; NordicAST CPE Study Group. Performance of the EUCAST disc diffusion method and two MIC methods in detection of Enterobacteriaceae with reduced susceptibility to meropenem: the NordicAST CPE study. J Antimicrob Chemother. 2018 Oct 1;73(10):2738-2747. doi: 10.1093/jac/dky276
37. Stensen DB, Småbrekke L, Olsen K, Grimnes G, Nielsen CS, Simonsen GS, Sollid JUE, Furberg AS. Hormonal contraceptive use and Staphylococcus aureus nasal and throat carriage in a Norwegian youth population. PLoS One. 2019 Jul 5;14(7):e0218511. doi: 10.1371/journal.pone.0218511. PMID: 31276521; PMCID: PMC6611591
38. D'Annibali O, Bonaldo G, Donati M, Småbrekke L, Motola D, Vaccheri A. Antibacterial prescription in Italian preschool children: analysis of 7 years of data from the Emilia-Romagna region reimbursement database. J Antimicrob Chemother. 2019 Aug 1;74(8):2434-2439. doi: 10.1093/jac/dkz153. PMID: 30993338
39. Raknes G, Småbrekke L. Changes in the consumption of antiepileptics and psychotropic medicines after starting low dose naltrexone: A nation-wide register-based controlled before-after study. Sci Rep. 2019 Oct 21;9(1):15085.doi: 10.1038/s41598-019-51569-z. PMID: 31636347; PMCID: PMC6803623
40. Sambakunsi CS, Småbrekke L, Varga CA, Solomon V, Mponda JS. Knowledge, attitudes and practices related to self-medication with antimicrobials in Lilongwe, Malawi. Malawi Med J. 2019 Dec;31(4):225-232. doi: 10.4314/mmj.v31i4.2. PMID: 32128032; PMCID: PMC7036431
41. Zykov IN, Frimodt-Møller N, Småbrekke L, Sundsfjord A, Samuelsen Ø. Efficacy of mecillinam against clinical multidrug-resistant Escherichia coli in a murine urinary tract infection model. Int J Antimicrob Agents. 2020 Feb;55(2):105851. doi: 10.1016/j.ijantimicag.2019.11.008. Epub 2019 Nov 23. PMID: 31770624
42. Middleton L, Lampiao, F, Zimba T, Muzime SN, Simonsen GS, Småbrekke L, Musaya J, Solomon V, Suleman F, Sundsfjord A, Essack S. (2019) Antimicrobial stewardship and concervancy in Africa. In Halvorsen T, Orgeret KS 6 Krøvel R (eds). Sharing knowledge, Transforming Societies: The Norhed Programme 2013-2020. pp. 68-82. ISBN 978-1-928502-00-5
43. Høgli JU, Garcia BH, Svendsen K, Skogen V, Småbrekke L. Empirical prescribing of penicillin G/V reduces risk of readmission of hospitalized patients with community-acquired pneumonia in Norway: a retrospective observational study. BMC Pulm Med. 2020 Jun 15;20(1):169. doi: 10.1186/s12890-020-01188-6. PMID: 32539706; PMCID: PMC7294665.
44. Gravningen K, Field N, Blix HS, Asfeldt AM, Småbrekke L. Non-prescription purchase of antibiotics during travel abroad among a general adult population in Norway: Findings from the seventh Tromsø Study. PLoS One. 2020 Feb 13;15(2):e0228792. doi: 10.1371/journal.pone.0228792. PMID: 32053671
45. Raknes G, Småbrekke L. Low dose naltrexone: Effects on medication in rheumatoid and seropositive arthritis. A nationwide register-based controlled quasi-experimental before-after study. PLoS One. 2019 Oct 1;14(10):e0223545. 10.1371/journal.pone.0212460 PMID: 31574126
46. Raknes G, Småbrekke L. No change in the consumption of thyroid hormones after starting low dose naltrexone (LDN): a quasi-experimental before-after study. BMC Endocr Disord. 2020 Oct 1;20(1):151. doi: 10.1186/s12902-020-00630-4. PMID: 33004044
47. Stensen DB, Småbrekke L, Olsen K, Grimnes G, Nielsen CS, Sollid JUE, Simonsen GS, Almås B, Furberg AS. Circulating sex-steroids and Staphylococcus aureus nasal carriage in a general female population. Eur J Endocrinol. 2021 Feb;184(2):337-346. doi: 10.1530/EJE-20-0877.
48. Raffelsberger N, Hetland MAK, Svendsen K, Småbrekke L, Löhr IH, Andreassen LLE, Brisse S, Holt KE, Sundsfjord A, Samuelsen Ø, Gravningen K. Gastrointestinal carriage of Klebsiella pneumoniae in a general adult population: a cross-sectional study of risk factors and bacterial genomic diversity. Gut Microbes. 2021 Jan-Dec;13(1):1939599. doi: 10.1080/19490976.2021.1939599. PMID: 34182896; PMCID: PMC8244762.
49. Beckstrøm S, Svendsen K, Småbrekke L. Antibacterial use by birth year and birth season in children 0-2 years in Norway. Norsk Epidemiologi 2021; 29: 35-43. DOI:10.5324/nje.v29il-2.4044
50. Lupattelli A, Karlstad Ø, Engeland A, Småbrekke L, Olsen K, Øvrebust A, Waaseth, M. The Norwegian Society for Pharmacoepidemiology. Norsk Epidemiologi 2021; 29(1-2). https://doi.org/10.5324/nje.v29i1-2.4039
51. Stensen DB, Småbrekke L, Olsen K, Grimnes G, Nielsen CS, Ericson JU, Simonsen GS, Almås B, Furberg AS. Circulating sex-steroids and Staphylococcus aureus nasal carriage in a general male population. Epidemiology&Infection 2022; 150: e93. https://doi.org/10.1017/S0950268822000735
52. von Hanno T, Hareide LL, Småbrekke L, Morseth B, Sneve M, Erke MG, Mathiesen EB, Bertelsen G. Macular layer thickness and effect of BMI, body fat and traditional cardiovascular risk factors: The Tromsø study. IOVS 2022; 63(9):16 https://doi.org/10.1167/iovs.63.9.16
53. Stensen DB, Cañadas RAN, Småbrekke L, Olsen K, Nielsen CS, Svendsen K, Hanssen AM, Ericson JU, Simonsen GS, Bongo LA, Furberg AS. Social network analysis of Staphylococcus aureus carriage in a general youth population. Int J Infect Dis 2022;123: 200-209. doi: 10.1016/j.ijid.2022.08.018.
54. Johansen JS, Halvorsen KH, Svendsen K, Havnes K, Robinson EG, Wetting HL, Haustreis S, Småbrekke L, Kamycheva E, Garcia BH.BMC Health Serv Res 2022;22(1):1290. doi: 10.1186/s12913-022-08648-1.
55. Hoff Roland PD, Småbrekke L. Hostemidler – hva bør du vite? NFT 2022; 132:22
56. Walquist MJ, Svendsen K, Garcia BH, Bergmo TS, Eggen AE, Halvorsen KH, Småbrekke L, Ringberg U, Lehnbom EC, Waaseth M. Self-reported information needs among medication users in a general populatioon aged 40 years and above – The Tromsø Study. BMC Public Health 2022;22(1):2182. doi: 10.1186/s12889-022-14573-z.
57. Svalestuen S, Svendsen K, Eggen AE, Småbrekke L. Association of area-level education with the regional growth trajectories of rates of antibacterial dispensing to patients under 3 years in Norway: a longitudinal retrospective study. BMJ Open 2022 Sep 8;12(9):e058491. doi: 10.1136/bmjopen-2021-058491.
58. Bergmo TS, Sandsdalen V, Manskow US, Småbrekke L, Waaseth M. Internet Use for Obtaining Medicine Information: Cross-sectional Survey. JMIR Form Res. 2023 Feb 2;7:e40466. doi: 10.2196/40466.
59. Jakobsen AH, Småbrekke L, Chen TF, Halvorsen KH. Exploring stakeholders' perspectives on the quality of services provided through community pharmacies. Res Social Adm Pharm. 2023 Sep;19(9):1307-1313. doi: 10.1016/j.sapharm.2023.05.015. Epub 2023 Jun 2.
60. Raffelsberger N, Buczek DJ, Svendsen K, Småbrekke L, Pöntinen AK, Löhr IH, Andreassen LLE, Simonsen GS; Norwegian E. coli ESBL Study Group; Sundsfjord A, Gravningen K, Samuelsen Ø. Community carriage of ESBL-producing Escherichia coli and Klebsiella pneumoniae: a cross-sectional study of risk factors and comparative genomics of carriage and clinical isolates.
Academic Curriculum Vitae for Lars Småbrekke
Personal data and contact information
Name: Lars Småbrekke
Date of birth: 18.01.59
Position: Professor
Work address: Department of Pharmacy, UiT The Arctic University of Norway
Phone: +4799249663 (cell) / +4777645792 (office)
E-mail: lars.smabrekke@uit.no
Research unique identifier: https://orcid.org/0000-0001-6474-3368
URL for UiT web-site: https://uit.no/ansatte/lars.smabrekke
CRISTIN-ID: 55832
Education
2013 – 2014 Basic competency in Pedagogy in higher education, RESULT, UiT
2009 PhD. Faculty of Health Sciences, UiT
https://munin.uit.no/handle/10037/2135
1999 Master in Public Health. Faculty of Health Sciences, UiT
1985 Candidatus Pharmaciae, UiO
Current and previous positions
2022 – Prof. UiT The Arctic University of Norway, Faculty of Health Sciences, Department of Pharmacy
2009 – 2021 A/Prof. UiT The Arctic University of Norway, Faculty of Health Sciences, Department of Pharmacy
2008 – 2009 University scholarship (UiT The Arctic University of Norway)
2004 – 2008 University Hospital North-Norway, Head of the regional drug information centre
2003 – 2004 UiT The Arctic University of Norway (lecturer)
1999 – 2003 University Hospital North-Norway, Head of the regional drug information centre
1991-1999 Hospital Pharmacy, University Hospital North-Norway
1986-1991 Hospital Pharmacy, Kirkenes Hospital, Norway
Boards and committees
Development of curricula
2010 – 2012 Working group for the new BSc and MSc program in Pharmacy at UiT
2012 – 2013 Revision of pharmacy education in Norway. (Head of the working group)
2016 Profesjonsrådet. Head of national group establishing for learning outcomes in statistics in a 3+2 curriculum in pharmacy
Boards and committees
1994 – 1997 Interim board for establishing the pharmacy program at UiT
1999 – 2004 External member. Board for the Department of Pharmacy
1999 – 2000 Bivirkningsnemda (National board of adverse reactions to medicines)
2008 – 2012 Blåreseptnemda (National board on reimbursement)
2016 – now Board member. The Regional Health Authority
2010 – now Board member. Norwegian Society of Pharmacoepidemiology
Panels, workshops and conference organization
2018 Critical thinking. Member of working group for the workshop (approx. 225 participants)
2019 Conference on antibiotic stewardship and conservation in Africa. Durban (South-Africa). Organizing of the conference and chaired one afternoon session.
2019 Critical thinking. Leader of the working group for the workshop. (approx. 275 participants
2020 Critical thinking. Member of working group for the workshop (approx. 225 participants)
2023 NSPC. International Conference in Social Pharmacy
Member of scientific evaluation committees
2012 UiO. Position as A/Prof in community pharmacy
2012 UiT The arctic university of Norway. Position as A/Prof in pharmacy practice
2013 UiO. Position as A/Prof in community pharmacy
2016 UiO. Position as Professor in community pharmacy
2016 UiO. Position as A/Prof in community pharmacy
2019 UiT The arctic university of Norway. Position as university lecturer
2019 UKZN. Evaluation of PhD-thesis
2022 NTNU. Evaluation of research line student
2023 UiO. Evaluation of PhD thesis
Chronological list of publications
1. Rygnestad T, Småbrekke L, Nesje L, Talsethagen H, Rogne P, Myhr K, Bentzen I. Impact of improved treatment of sexually transmitted disease on HIV infection. Lancet. 1995 Oct 28;346(8983):1157
2. Simonsen T, Braathen P, Småbrekke L. Folsyre eller folinsyre som tilskudd ved samtidig behandling med metotrexat? Utposten. 1999;28:42-44
3. Endresen PC, Braathen P, Småbrekke L. Legemiddelbruk under graviditet. Utposten. 2000:29:45-46
4. Braathen P, Endresen PC, Småbrekke L, Ulvestad L. Ginko biloba, naturlegemiddel med mulig interaksjon med antitrombotiske midler. Utposten. 2000;29:32-33
5. Roland DDH, Schjøtt J, Småbrekke L, Westergren T. RELIS spørsmål og svar-database på internett. Utposten. 2001;30:38-39
6. Småbrekke L, Braathen P. Legemidler med laktose til pasienter med laktoseintoleranse? Tidsskr Nor Laegeforen. 2000 Aug 20;120(19):2303-4. Norwegian. PMID: 10997093
7. Småbrekke L. Stor skilnad i forbruksprofil mellom to universitetssykehus i Norge. Norsk Epidemiologi 2001;11: 61-5
8. Småbrekke L, Berild D, Giæver A, Myrbakk T, Fuskevåg A, Ericson JU, Flaegstad T, Olsvik O, Ringertz SH. Educational intervention for parents and healthcare providers leads to reduced antibiotic use in acute otitis media. Scand J Infect Dis. 2002;34(9):657-9. doi: 10.1080/00365540210147651. PMID: 12374355
9. Simonsen GS, Småbrekke L, Monnet DL, Sørensen TL, Møller JK, Kristinsson KG, Lagerqvist-Widh A, Torell E, Digranes A, Harthug S, Sundsfjord A. Prevalence of resistance to ampicillin, gentamicin and vancomycin in Enterococcus faecalis and Enterococcus faecium isolates from clinical specimens and use of antimicrobials in five Nordic hospitals. J Antimicrob Chemother 2003 Feb;51(2):323-31. doi: 10.1093/jac/dkg052. PMID: 12562698.6):X3. PMID: 33428587; PMCID: PMC7849480
10. Berild D, Småbrekke L, Halvorsen DS, Lelek M, Stahlsberg EM, Ringertz SH. Clostridium difficile infections related to antibiotic use and infection control facilities in two university hospitals. J Hosp Infect. 2003 Jul;54(3):202-6. doi: 10.1016/s0195-6701(03)00149-x. PMID: 12855235
11. Klingenberg C, Småbrekke L, Lier T, Flaegstad T. Validation of a simplified netilmicin dosage regimen in infants. Scand J Infect Dis. 2004;36(6-7):474-9. doi: 10.1080/00365540410020613. PMID: 15307571
12. Nordmo E, Småbrekke L. Kalseormedrue (Black cohosh) mot menopausale plager. Utposten 2005;34:42-43
13. Raknes G, Småbrekke L. Echinacea spp. (solhatt) og øvre luftveisinfeksjon. Tidsskr Nor Laegeforen. 2006 Oct 5;126(19):2526-7. Norwegian. PMID: 17028634
14. Vorren S, Småbrekke L. Reductil (sibutramin) og graviditet. Utposten 2008;37:44-45
15. Nordmo E, Småbrekke L. Melasma ved bruk av p-piller. NFT 2007: (5):12
16. Nordmo E, Småbrekke L. Interaksjon mellom metadon og valerianapreparater. NFT 2007; (10):10
17. Nordmo E, Småbrekke L. Nattlysolje mot atopisk eksem. NFT 2008; (3):11-12
18. Småbrekke L, Melbye H. Medikamentell behandling av akutt hoste. Tidsskr Nor Laegeforen. 2009 May 14;129(10):998-9. Norwegian. doi: 10.4045/tidsskr.08.0438. PMID: 19448753.
19. Klingenberg C, Småbrekke L, Døllner H, Simonsen GS. Peroral antibiotikabehandling av urinveisinfeksjon hos barn. Tidsskr Nor Laegeforen. 2009 Jun 25;129(13):1342-4. Norwegian. doi: 10.4045/tidsskr.09.0092. PMID: 19561661
20. Nordmo E, Aronsen L, Wasland K, Småbrekke L, Vorren S. Severe apnea in an infant exposed to lamotrigine in breast milk. Ann Pharmacother. 2009 Nov;43(11):1893-7. doi: 10.1345/aph.1M254. Epub 2009 Oct 13. PMID: 19826099
21. Garcia BH, Småbrekke L, Trovik T, Giverhaug T. Application of the MAT-CHDSP to assess guideline adherence and therapy goal achievement in secondary prevention of coronary heart disease after percutaneous coronary intervention. Eur J Clin Pharmacol. 2013 Mar;69(3):703-9. doi: 10.1007/s00228-012-1402-7. Epub 2012 Sep 19. PMID: 22990329
22. Høgli JU, Småbrekke L, Garcia BH. MAT-CAP: a novel medication assessment tool to explore adherence to clinical practice guidelines in community-acquired pneumonia. Pharmacoepidemiol Drug Saf. 2014 Sep;23(9):933-41. doi: 10.1002/pds.3640. Epub 2014 May 2. PMID: 24797586
23. Garcia BH, Storli SL, Småbrekke L. A pharmacist-led follow-up program for patients with coronary heart disease in North Norway--a qualitative study exploring patient experiences. BMC Res Notes. 2014 Mar 29;7:197. doi: 10.1186/1756-0500-7-197. PMID: 24679131; PMCID: PMC3974183
24. Garcia BH, Giverhaug T, Høgli JU, Skjold F, Småbrekke L. A pharmacist-led follow-up program for patients with established coronary heart disease in North Norway - a randomized controlled trial. Pharm Pract (Granada). 2015 Apr-Jun;13(2):575. doi: 10.18549/pharmpract.2015.02.575. Epub 2015 Jun 15. PMID: 26131047; PMCID: PMC4482847
25. Melis M, Biagi C, Småbrekke L, Nonino F, Buccellato E, Donati M, Vaccheri A, Motola D. Drug-Induced Progressive Multifocal Leukoencephalopathy: A Comprehensive Analysis of the WHO Adverse Drug Reaction Database. CNS Drugs. 2015;29(10):879-91. doi: 10.1007/s40263-015-0286-3. PMID: 26507833
26. Høgli JU, Garcia BH, Skjold F, Skogen V, Småbrekke L. An audit and feedback intervention study increased adherence to antibiotic prescribing guidelines at a Norwegian hospital. BMC Infect Dis. 2016 Feb 27;16:96. doi: 10.1186/s12879-016-1426-1. PMID: 26920549; PMCID: PMC4769530
27. Zykov IN, Sundsfjord A, Småbrekke L, Samuelsen Ø. The antimicrobial activity of mecillinam, nitrofurantoin, temocillin and fosfomycin and comparative analysis of resistance patterns in a nationwide collection of ESBL-producing Escherichia coli in Norway 2010-2011. Infect Dis (Lond). 2016 Feb;48(2):99-107. doi: 10.3109/23744235.2015.1087648. Epub 2015 Sep 28. PMID: 26414659
28. Raknes G, Småbrekke L. A sudden and unprecedented increase in low dose naltrexone (LDN) prescribing in Norway. Patient and prescriber characteristics, and dispense patterns. A drug utilization cohort study. Pharmacoepidemiol Drug Saf. 2017 Feb;26(2):136-142. doi: 10.1002/pds.4110. Epub 2016 Sep 26. PMID: 27670755; PMCID: PMC5298009
29. Raknes G, Småbrekke L. Low-dose naltrexone and opioid consumption: a drug utilization cohort study based on data from the Norwegian prescription database. Pharmacoepidemiol Drug Saf. 2017 Jun;26(6):685-693. doi: 10.1002/pds.4201. Epub 2017 Mar 29. PMID: 28370746; PMCID: PMC5485080
30. Sørensen M, Kuehn A, Mills ENC, Costello CA, Ollert M, Småbrekke L, Primicerio R, Wickman M, Klingenberg C. Cross-reactivity in fish allergy: A double-blind, placebo-controlled food-challenge trial. J Allergy Clin Immunol 2017 Oct;140(4):1170-1172. doi: 10.1016/j.jaci.2017.03.043. Epub 2017 May 4. PMID: 28479332
31. Raknes G, Småbrekke L. Low dose naltrexone in multiple sclerosis: Effects on medication use. A quasi-experimental study. PLoS One 2017 Nov 3;12(11):e0187423. doi: 10.1371/journal.pone.0187423. PMID: 29099849; PMCID: PMC5669439
32. Haugen P, Simonsen GS, Primicerio R, Furberg AS, Småbrekke L. Antibiotics to outpatients in Norway-Assessing effect of latitude and municipality population size using quantile regression in a cross-sectional study. Pharm Stat. 2018 Feb;17(1):4-11. doi: 10.1002/pst.1831. Epub 2017 Sep 29. PMID: 28961357
33. Svendsen K, Karlstad Ø, Småbrekke L. Lower Cancer Incidence-Warfarin Effect or Immortal Time Bias? JAMA Intern Med. 2018 Apr 1;178(4):585. doi: 10.1001/jamainternmed.2018.0370. PMID: 29610882
34. Zykov IN, Samuelsen Ø, Jakobsen L, Småbrekke L, Andersson DI, Sundsfjord A, Frimodt-Møller N. Pharmacokinetics and Pharmacodynamics of Fosfomycin and Its Activity against Extended-Spectrum-β-Lactamase-, Plasmid-Mediated AmpC-, and Carbapenemase-Producing Escherichia coli in a Murine Urinary Tract Infection Model. Antimicrob Agents Chemother. 2018 May 25;62(6):e02560-17. doi: 10.1128/AAC.02560-17. PMID: 29581117; PMCID: PMC5971609.
35. Raknes G, Simonsen P, Småbrekke L. The Effect of Low-Dose Naltrexone on Medication in Inflammatory Bowel Disease: A Quasi Experimental Before-and-After Prescription Database Study. J Crohns Colitis. 2018 May 25;12(6):677-686. doi: 10.1093/ecco-jcc/jjy008
36. Haldorsen B, Giske CG, Hansen DS, Helgason KO, Kahlmeter G, Löhr IH, Matuschek E, Österblad M, Rantakokko-Jalava K, Wang M, Småbrekke L, Samuelsen Ø, Sundsfjord A; NordicAST CPE Study Group. Performance of the EUCAST disc diffusion method and two MIC methods in detection of Enterobacteriaceae with reduced susceptibility to meropenem: the NordicAST CPE study. J Antimicrob Chemother. 2018 Oct 1;73(10):2738-2747. doi: 10.1093/jac/dky276
37. Stensen DB, Småbrekke L, Olsen K, Grimnes G, Nielsen CS, Simonsen GS, Sollid JUE, Furberg AS. Hormonal contraceptive use and Staphylococcus aureus nasal and throat carriage in a Norwegian youth population. PLoS One. 2019 Jul 5;14(7):e0218511. doi: 10.1371/journal.pone.0218511. PMID: 31276521; PMCID: PMC6611591
38. D'Annibali O, Bonaldo G, Donati M, Småbrekke L, Motola D, Vaccheri A. Antibacterial prescription in Italian preschool children: analysis of 7 years of data from the Emilia-Romagna region reimbursement database. J Antimicrob Chemother. 2019 Aug 1;74(8):2434-2439. doi: 10.1093/jac/dkz153. PMID: 30993338
39. Raknes G, Småbrekke L. Changes in the consumption of antiepileptics and psychotropic medicines after starting low dose naltrexone: A nation-wide register-based controlled before-after study. Sci Rep. 2019 Oct 21;9(1):15085.doi: 10.1038/s41598-019-51569-z. PMID: 31636347; PMCID: PMC6803623
40. Sambakunsi CS, Småbrekke L, Varga CA, Solomon V, Mponda JS. Knowledge, attitudes and practices related to self-medication with antimicrobials in Lilongwe, Malawi. Malawi Med J. 2019 Dec;31(4):225-232. doi: 10.4314/mmj.v31i4.2. PMID: 32128032; PMCID: PMC7036431
41. Zykov IN, Frimodt-Møller N, Småbrekke L, Sundsfjord A, Samuelsen Ø. Efficacy of mecillinam against clinical multidrug-resistant Escherichia coli in a murine urinary tract infection model. Int J Antimicrob Agents. 2020 Feb;55(2):105851. doi: 10.1016/j.ijantimicag.2019.11.008. Epub 2019 Nov 23. PMID: 31770624
42. Middleton L, Lampiao, F, Zimba T, Muzime SN, Simonsen GS, Småbrekke L, Musaya J, Solomon V, Suleman F, Sundsfjord A, Essack S. (2019) Antimicrobial stewardship and concervancy in Africa. In Halvorsen T, Orgeret KS 6 Krøvel R (eds). Sharing knowledge, Transforming Societies: The Norhed Programme 2013-2020. pp. 68-82. ISBN 978-1-928502-00-5
43. Høgli JU, Garcia BH, Svendsen K, Skogen V, Småbrekke L. Empirical prescribing of penicillin G/V reduces risk of readmission of hospitalized patients with community-acquired pneumonia in Norway: a retrospective observational study. BMC Pulm Med. 2020 Jun 15;20(1):169. doi: 10.1186/s12890-020-01188-6. PMID: 32539706; PMCID: PMC7294665.
44. Gravningen K, Field N, Blix HS, Asfeldt AM, Småbrekke L. Non-prescription purchase of antibiotics during travel abroad among a general adult population in Norway: Findings from the seventh Tromsø Study. PLoS One. 2020 Feb 13;15(2):e0228792. doi: 10.1371/journal.pone.0228792. PMID: 32053671
45. Raknes G, Småbrekke L. Low dose naltrexone: Effects on medication in rheumatoid and seropositive arthritis. A nationwide register-based controlled quasi-experimental before-after study. PLoS One. 2019 Oct 1;14(10):e0223545. 10.1371/journal.pone.0212460 PMID: 31574126
46. Raknes G, Småbrekke L. No change in the consumption of thyroid hormones after starting low dose naltrexone (LDN): a quasi-experimental before-after study. BMC Endocr Disord. 2020 Oct 1;20(1):151. doi: 10.1186/s12902-020-00630-4. PMID: 33004044
47. Stensen DB, Småbrekke L, Olsen K, Grimnes G, Nielsen CS, Sollid JUE, Simonsen GS, Almås B, Furberg AS. Circulating sex-steroids and Staphylococcus aureus nasal carriage in a general female population. Eur J Endocrinol. 2021 Feb;184(2):337-346. doi: 10.1530/EJE-20-0877.
48. Raffelsberger N, Hetland MAK, Svendsen K, Småbrekke L, Löhr IH, Andreassen LLE, Brisse S, Holt KE, Sundsfjord A, Samuelsen Ø, Gravningen K. Gastrointestinal carriage of Klebsiella pneumoniae in a general adult population: a cross-sectional study of risk factors and bacterial genomic diversity. Gut Microbes. 2021 Jan-Dec;13(1):1939599. doi: 10.1080/19490976.2021.1939599. PMID: 34182896; PMCID: PMC8244762.
49. Beckstrøm S, Svendsen K, Småbrekke L. Antibacterial use by birth year and birth season in children 0-2 years in Norway. Norsk Epidemiologi 2021; 29: 35-43. DOI:10.5324/nje.v29il-2.4044
50. Lupattelli A, Karlstad Ø, Engeland A, Småbrekke L, Olsen K, Øvrebust A, Waaseth, M. The Norwegian Society for Pharmacoepidemiology. Norsk Epidemiologi 2021; 29(1-2). https://doi.org/10.5324/nje.v29i1-2.4039
51. Stensen DB, Småbrekke L, Olsen K, Grimnes G, Nielsen CS, Ericson JU, Simonsen GS, Almås B, Furberg AS. Circulating sex-steroids and Staphylococcus aureus nasal carriage in a general male population. Epidemiology&Infection 2022; 150: e93. https://doi.org/10.1017/S0950268822000735
52. von Hanno T, Hareide LL, Småbrekke L, Morseth B, Sneve M, Erke MG, Mathiesen EB, Bertelsen G. Macular layer thickness and effect of BMI, body fat and traditional cardiovascular risk factors: The Tromsø study. IOVS 2022; 63(9):16 https://doi.org/10.1167/iovs.63.9.16
53. Stensen DB, Cañadas RAN, Småbrekke L, Olsen K, Nielsen CS, Svendsen K, Hanssen AM, Ericson JU, Simonsen GS, Bongo LA, Furberg AS. Social network analysis of Staphylococcus aureus carriage in a general youth population. Int J Infect Dis 2022;123: 200-209. doi: 10.1016/j.ijid.2022.08.018.
54. Johansen JS, Halvorsen KH, Svendsen K, Havnes K, Robinson EG, Wetting HL, Haustreis S, Småbrekke L, Kamycheva E, Garcia BH.BMC Health Serv Res 2022;22(1):1290. doi: 10.1186/s12913-022-08648-1.
55. Hoff Roland PD, Småbrekke L. Hostemidler – hva bør du vite? NFT 2022; 132:22
56. Walquist MJ, Svendsen K, Garcia BH, Bergmo TS, Eggen AE, Halvorsen KH, Småbrekke L, Ringberg U, Lehnbom EC, Waaseth M. Self-reported information needs among medication users in a general populatioon aged 40 years and above – The Tromsø Study. BMC Public Health 2022;22(1):2182. doi: 10.1186/s12889-022-14573-z.
57. Svalestuen S, Svendsen K, Eggen AE, Småbrekke L. Association of area-level education with the regional growth trajectories of rates of antibacterial dispensing to patients under 3 years in Norway: a longitudinal retrospective study. BMJ Open 2022 Sep 8;12(9):e058491. doi: 10.1136/bmjopen-2021-058491.
58. Bergmo TS, Sandsdalen V, Manskow US, Småbrekke L, Waaseth M. Internet Use for Obtaining Medicine Information: Cross-sectional Survey. JMIR Form Res. 2023 Feb 2;7:e40466. doi: 10.2196/40466.
59. Jakobsen AH, Småbrekke L, Chen TF, Halvorsen KH. Exploring stakeholders' perspectives on the quality of services provided through community pharmacies. Res Social Adm Pharm. 2023 Sep;19(9):1307-1313. doi: 10.1016/j.sapharm.2023.05.015. Epub 2023 Jun 2.
60. Raffelsberger N, Buczek DJ, Svendsen K, Småbrekke L, Pöntinen AK, Löhr IH, Andreassen LLE, Simonsen GS; Norwegian E. coli ESBL Study Group; Sundsfjord A, Gravningen K, Samuelsen Ø. Community carriage of ESBL-producing Escherichia coli and Klebsiella pneumoniae: a cross-sectional study of risk factors and comparative genomics of carriage and clinical isolates.