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Bilde av Øie, Cristina Ionica
Bilde av Øie, Cristina Ionica
Senior Forsker Institutt for medisinsk biologi cristina.ionica.oie@uit.no +4777620764 Her finner du meg

Cristina Ionica Øie

Stillingsbeskrivelse

PI of RCN FRIPRO - Young Research Talent (2018-2024) Sugar Crush: Metabolism-induced sinusoidal endothelial cell defenestration as critical deteminant of fatty liver disease progression

https://en.uit.no/prosjekter/prosjekt?p_document_id=632072

Co-PI for InterNASH - An intercellular-pathway therapeutic for non-alcoholic steatohepatitis, which received funding from 

- RCN FORNI 2020 - Commercialisation Project Proof of Concept (2024-2026)

- Novo Nordisk Foundation, Pioneer Innovator Grant (2024-2025)

- UiT Innovation fond (2023-2024)

  • Cihang Kong, Stefanie Bobe, Christian Pilger, Mario Lachetta, Cristina Ionica Øie, Nils Kirschnick m.fl.:
    Multiscale and Multimodal Optical Imaging of the Ultrastructure of Human Liver Biopsies
    Frontiers in Physiology 2021 ARKIV / DOI
  • Yakubu Princely Abudu, Birendra Kumar Shrestha, Wenxin Zhang, Anthimi Palara, Hanne Britt Brenne, Kenneth Bowitz Larsen m.fl.:
    SAMM50 acts with p62 in piecemeal basal- and OXPHOS-induced mitophagy of SAM and MICOS components
    Journal of Cell Biology 2021 ARKIV / DOI
  • Karolina Szafranska, Christopher Florian Holte, Larissa Dorothea Kruse, Hong Mao, Cristina Ionica Øie, Marek Symonski m.fl.:
    Quantitative analysis methods for studying fenestrations in liver sinusoidal endothelial cells. A comparative study
    Micron 2021 ARKIV / DOI
  • Willeke De Haan, Cristina Ionica Øie, Mohammed Benkheil, Wouter Dheedene, Stefan Vinckier, Giulia Coppiello m.fl.:
    Unraveling the transcriptional determinants of liver sinusoidal endothelial cell specialization
    American Journal of Physiology - Gastrointestinal and Liver Physiology 2020 DOI
  • Cristina Ionica Øie, Deanna Wolfson, Tanji Yasunori, Gianina Dumitriu, Karen Kristine Sørensen, Peter Anthony McCourt m.fl.:
    Liver sinusoidal endothelial cells contribute to the uptake and degradation of entero bacterial viruses.
    Scientific Reports 2020 ARKIV / DOI
  • Jean-Claude Tinguely, Steyer Anna Maria, Cristina Ionica Øie, Øystein Ivar Helle, Firehun Tsige Dullo, Randi Olsen m.fl.:
    Photonic-chip assisted correlative light and electron microscopy
    Communications Biology 2020 ARKIV / DOI
  • David Andre Coucheron, Øystein Ivar Helle, Cristina Ionica Øie, Jean-Claude Tinguely, Balpreet Singh Ahluwalia :
    High-Throughput Total Internal Reflection Fluorescence and Direct Stochastic Optical Reconstruction Microscopy Using a Photonic Chip
    Journal of Visualized Experiments 2019 ARKIV / DOI
  • Jean-Claude Tinguely, Steyer Anna Maria, Cristina Ionica Øie, Øystein Ivar Helle, Firehun Tsige Dullo, Randi Olsen m.fl.:
    Photonic-chip assisted corelative light and electron microscopy
    arXiv.org 2019
  • Luis Villegas, Cristina Ionica Øie, Mona Nystad, Balpreet Singh Ahluwalia :
    Optical nanoscopy in histopathology
    Semantic Web Journal 2019
  • Øystein Ivar Helle, David Andre Coucheron, Jean-Claude Tinguely, Cristina Ionica Øie, Balpreet Singh Ahluwalia :
    Nanoscopy on-a-chip: super-resolution imaging on the millimeter scale
    Optics Express 2019 ARKIV / DOI
  • Ida Sundvor Opstad, Deanna Wolfson, Cristina Ionica Øie, Balpreet Singh Ahluwalia :
    Multi-color imaging of sub-mitochondrial structures in living cells using structured illumination microscopy
    Nanophotonics 2018 ARKIV / DOI
  • Viola Monkemoller, Hong Mao, Wolfgang Hubner, Gianina Dumitriu, Peter Heimann, Gahl Levy m.fl.:
    Primary rat LSECs preserve their characteristic phenotype after cryopreservation
    Scientific Reports 2018 ARKIV / DOI
  • Azeem Ahmad, Vishesh Dubey, Vijay Singh, Jean-Claude Tinguely, Cristina Ionica Øie, Deanna Wolfson m.fl.:
    Quantitative phase microscopy of red blood cells during planar trapping and propulsion
    Lab on a Chip 2018 ARKIV / DOI
  • Cristina Ionica Øie, Viola Mönkemöller, Wolfgang Hubner, Mark Schuttpelz, Hong Mao, Balpreet Singh Ahluwalia m.fl.:
    New ways of looking at very small holes – using optical nanoscopy to visualize liver sinusoidal endothelial cell fenestrations
    Nanophotonics 2018 ARKIV / FULLTEKST / DOI
  • David Andre Coucheron, Øystein Ivar Helle, Cristina Ionica Øie, Firehun Tsige Dullo, Balpreet Singh Ahluwalia :
    Chip Based Nanoscopy: Towards Integration and High-throughput Imaging
    Proceedings of SPIE, the International Society for Optical Engineering 2017 ARKIV / DOI
  • Robin Diekmann, Øystein Ivar Helle, Cristina Ionica Øie, Peter Anthony McCourt, Thomas Rolf Huser, Mark Schuttpelz m.fl.:
    Chip-based wide field-of-view nanoscopy
    Nature Photonics 2017 ARKIV / DOI
  • L Stradiot, Stefaan Verhulst, Tiffany Roosens, Cristina Ionica Øie, Ivan M Moya, G Halder m.fl.:
    Functionality based method for simultaneous isolation of rodent hepatic sinusoidal cells
    Biomaterials 2017 DOI
  • Cristina Ionica Øie, Kirstine Roepstorff, Carsten Behrens, Jesper Bøggild Kristensen, Ditte Maria Karpf, Gert Bolt m.fl.:
    High-affinity von Willebrand factor binding does not affect the anatomical or hepatocellular distribution of factor VIII in rats
    Journal of Thrombosis and Haemostasis 2016 ARKIV / DOI
  • Cristina Ionica Øie, Igor Snapkov, Kjetil Elvevold, Baldur Sveinbjørnsson, Bård Smedsrød :
    FITC conjugation markedly enhances hepatic clearance of N-formyl peptides
    PLOS ONE 2016 ARKIV / DOI
  • Javier Sanchez Romano, Anett Kristin Larsen, Jaione Simon-Santamaria, Cristina Ionica Øie, Bård Smedsrød, Peter Anthony McCourt m.fl.:
    The role of scavenger endothelial cells in bacteriophage pharmacokinetics
    2022
  • Javier Sanchez Romano, Anett Kristin Larsen, Jaione Simon-Santamaria, Cristina Ionica Øie, Bård Smedsrød, Peter Anthony McCourt m.fl.:
    The role of scavenger endothelial cells in bacteriophage pharmacokinetics
    2022
  • Andres Maldonado, Ida Sundvor Opstad, Luis Hernández, Mona Nystad, Milton Aguilera, Merete Storflor m.fl.:
    Fluorescence Nanoscopy Using Multiple Signal Classification Algorithm (MUSICAL): From Electromagnetics Inverse Scattering Problem to Optics Inverse Source Problem.
    2019
  • Sebastian Andres Acuña Maldonado, Ida Sundvor Opstad, Luis Enrique Villegas Hernandez, Mona Nystad, Milton O Aguilera, Merete Storflor m.fl.:
    Fluorescence Nanoscopy Using Multiple Signal Classiflcation Algorithm (MUSICAL): From Electromagnetics Inverse Scattering Problem to Optics Inverse Source Problem
    2019
  • Luis Enrique Villegas Hernandez, Cristina Ionica Øie, Mona Nystad, Balpreet Singh Ahluwalia :
    OPTICAL NANOSCOPY IN HISTOPATHOLOGY
    2019
  • David Andre Coucheron, Øystein Ivar Helle, Cristina Ionica Øie, Jean-Claude Tinguely, Dushan Nawoda Wadduwage, Peter T. C. So m.fl.:
    Optical Nanoscopy and Raman Spectroscopy Using an Integrated Photonic Chip Platform
    2018
  • David Andre Coucheron, Øystein Ivar Helle, Cristina Ionica Øie, Firehun Tsige Dullo, Balpreet Singh Ahluwalia :
    High-throughput Nanoscopy Using Different Photonics Integrated Circuits
    2018
  • Viola Mönkemöller, Cristina Ionica Øie, Peter Heimann, Christian Kaltschmidt, Barbara Kaltschmidt, Peter Dedecker m.fl.:
    Revealing Structural Dynamics Of Liver Sinusoidal Endothelial Cells By Super-Resolution Optical Microscopy
    2018
  • Jean-Claude Tinguely, Øystein Ivar Helle, David Andre Coucheron, Firehun Tsige Dullo, Cristina Ionica Øie, Balpreet Singh Ahluwalia :
    Photonic integrated circuits for nanoscopy
    2018
  • Øystein Ivar Helle, David Andre Coucheron, Jean-Claude Tinguely, Firehun Tsige Dullo, Cristina Ionica Øie, Balpreet Singh Ahluwalia :
    Nanoscopy-on-a-chip: high throughput super-resolution imaging
    2018
  • Øystein Ivar Helle, David Andre Coucheron, Jean-Claude Tinguely, Cristina Ionica Øie, Balpreet Singh Ahluwalia :
    Chip-based single molecule localization microscopy using planar optical waveguides
    2018
  • Øystein Ivar Helle, David Andre Coucheron, Cristina Ionica Øie, Jean-Claude Tinguely, Balpreet Singh Ahluwalia :
    On-Chip Nanoscopy
    2018
  • Øystein Ivar Helle, Jean-Claude Tinguely, David Andre Coucheron, Firehun Tsige Dullo, Cristina Ionica Øie, Krishna Agarwal m.fl.:
    Photonic chip-based multi-modality TIRF nanoscopy platform
    2018
  • Deanna Wolfson, Luis Villegas, Ida Sundvor Opstad, Åsa birna Birgisdottir, Cristina Ionica Øie, Balpreet Singh Ahluwalia :
    Structured Illumination Microscopy of Biological Structures
    2018 ARKIV
  • Deanna Wolfson, Cristina Ionica Øie, Tanji Yasunori, Gianina Dumitriu, Peter Anthony McCourt, Karen Kristine Sørensen m.fl.:
    Uptake and Degradation of Bacteriophages by Liver Sinusoidal Endothelial Cells
    2018 ARKIV
  • Krishna Agarwal, Biswajoy Ghosh, Deanna Wolfson, Cristina Ionica Øie, Jyotirmoy Chatterjee, Balpreet Singh Ahluwalia :
    Computational nanoscopy using Multiple Signal Classification Algorithm (MUSICAL) for fluorescence imaging
    2017
  • Balpreet Singh Ahluwalia, Øystein Ivar Helle, Jean-Claude Tinguely, David Andre Coucheron, Marcel Lahrberg, Firehun Tsige Dullo m.fl.:
    Development of integrated optical nanoscopy using photonic chips
    2017
  • Viola Mönkemöller, Cristina Ionica Øie, Peter Heimann, Christian Kaltschmidt, Barbara Kaltschmidt, Peter Anthony McCourt m.fl.:
    Revealing Structural Dynamics of Liver Sinusoidal Endothelial Cells
    2017
  • Deanna Wolfson, Cristina Ionica Øie, Yasunori Tanji, Karen Kristine Sørensen, Peter Anthony McCourt, Bård Smedsrød m.fl.:
    Multimodal Microscopy to Study the Fate of Bacteriophages in Liver Sinusoidal Endothelial Cells
    2017
  • Ida Sundvor Opstad, Deanna Wolfson, Cristina Ionica Øie, Balpreet Singh Ahluwalia :
    Three-Color Live Cell Super-Resolution Imaging of Sub-Mitochondrial Regions
    2017
  • Robin Diekmann, Øystein Ivar Helle, Cristina Ionica Øie, Peter Anthony McCourt, Thomas Huser, Balpreet Singh Ahluwalia m.fl.:
    Waveguide Chip-Based Super-Resolution Microscopy Enables Multi-Modal Imaging over Large Fields-of-View
    2017
  • Øystein Ivar Helle, Robin Diekmann, Cristina Ionica Øie, Peter Anthony McCourt, Thomas R. Huser, Mark Schüttpelz m.fl.:
    Optical Nanoscopy using Waveguides
    2017
  • Balpreet Singh Ahluwalia, Øystein Ivar Helle, Jean-Claude Tinguely, Firehun Tsige Dullo, Marcel Lahrberg, Cristina Ionica Øie :
    Optical nanoscopy using photonic integrated circuits
    2017
  • Hong Mao, Cristina Ionica Øie, Ruomei Li, Ana Oteiza, Karen Kristine Sørensen, Deanna Wolfson m.fl.:
    Disruption of rat liver sinusoidal endothelial cell morphology by oxidised low density lipoproteins
    2017
  • Hong Mao, Cristina Ionica Øie, Ruomei Li, Ana Oteiza, Karen Kristine Sørensen, Deanna Wolfson m.fl.:
    Using super-resolution microscopy to image disruption of liver sinusoidal endothelial cell morphology by oxidized low-density lipoproteins
    2017
  • Viola Monkemoller, Cristina Ionica Øie, Wolfgang Hubner, Thomas Rolf Huser, Peter Anthony McCourt :
    Multimodal super-resolution optical microscopy visualizes the close connection between membrane and the cytoskeleton in liver sinusoidal endothelial cell fenestrations
    2016
  • Deanna Wolfson, Cristina Ionica Øie, Ida Sundvor Opstad, Peter Anthony McCourt, Balpreet Singh Ahluwalia :
    Nanoscale Dynamics of Liver Sinusoidal Endothelial Cells
    2016
  • Robin Diekmann, Øystein Ivar Helle, Cristina Ionica Øie, Ida Sundvor Opstad, Deanna Wolfson, Peter Anthony McCourt m.fl.:
    Live cell fluctuation-based SR imaging using high-frequency, near-field illumination patterns enabled by planar waveguides
    2016
  • Viola Mönkemöller, Cristina Ionica Øie, Peter Heimann, Christian Kaltschmidt, Barbara Kaltschmidt, Peter Anthony McCourt m.fl.:
    Multimodal nanoscopy reveals unique structural dynamics of liver endothelial cells
    2016
  • Hong Mao, Cristina Ionica Øie, Ruomei Li, Ana Oteiza, Karen Kristine Sørensen, Deanna Wolfson m.fl.:
    Disruption of liver sinusoidal endothelial cell morphology by oxidized low–density lipoproteins
    2016
  • Øystein Ivar Helle, Robin Diekmann, Cristina Ionica Øie, Peter Anthony McCourt, Thomas R. Huser, Mark Schuttpelz m.fl.:
    Integrated Optical Nanoscopy
    2016

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    Forskningsinteresser

    As a scientist with a keen interest in the field of liver biology, my research primarily focuses on understanding the role of liver sinusoidal endothelial cells (LSECs) in the development and progression of non-alcoholic fatty liver disease to steatohepatitis (NASH). NASH is a chronic liver disease that is rapidly becoming a major health concern worldwide, and its prevalence is rapidly increasing. It is characterized by a buildup of fat in the liver, leading to inflammation, liver damage, and eventually, liver failure.

    My research aims to understand the underlying mechanisms of LSEC dysfunction in NASH and identify potential therapeutic targets to prevent or treat this disease.

    I am using various cutting-edge techniques, including advanced imaging, such as super-resolution optical microscopy, transcriptomics, proteomics, and functional assays, to investigate the complex interplay between LSECs, other liver cells, and environmental factors that contribute to the development of NASH.

    Keywords for research interests:

    • LSECs in NAFLD and NASH
    • LSECs metabolic reprograming in health and disease
    • LSECs role in coagulopathy
    • Coregulation of metabolism and transcription in LSECs
    • Advanced microscopy including optical nanoscopy for metabolic studies
    Forskerprofil i Cristin
    Registreringer i Munin
    ORCID: https://orcid.org/my-orcid?orcid=0000-0001-6576-9118

    Medlem i forskningsgruppe

    Vascular Biology   English content Vaskulær biologi   Norsk innhold

    Medlem i prosjekt

    Sugar Crush

    CV

    EDUCATION
    2010 PhD: Medical Biology
    Faculty of Health Sciences, Dep. of Medical Biology, VBRG, UiT
    2006 Master’s of Philosophy
    Faculty of Health Sciences, Dep. of Medical Biology, UiT

    CURRENT AND PREVIOUS POSITIONS
    2018-present Researcher, Vascular Biology Research Group (VBRG), Dep. of Medical Biology, UiT- The Arctic University of Norway, Tromsø, Norway
    Project Manager of RCN FRIPRO-Young Research Talents grant (2018-2024), investigating the mechanisms involved in the initiation and progression of the non-alcoholic fatty liver disease
    2017-2018 Researcher and Project Manager for Centre of Nanoscopy, The Centre was established using UiT Strategic Funding
    2016-2018 Researcher, Optical Nanoscopy Research Group, Department of Physics and Technology
    Faculty of Science and Technology, UiT. Position funded by FPR-IDEAS-ERC-2014, “High-speed chip-based nanoscopy to discover real-time sub-cellular dynamics” (PI: B. Ahluwalia)
    2011-2015 Researcher, VBRG, Dep. of Medical Biology, UiT. Lead Research Coordinator for FPR-HEALTH-2010, HeMiBio: “Hepatic Microfluidic Bioreactor", Project ID: 266777 (Co-PI: B. Smedsrød)
    2008-2010 Project Director, Externally funded by Novo Nordisk A/S working on a FVIII replacement therapy drug discovery, product currently known as NovoEight®
    2010 Visiting researcher, Center for Biophotonics – Science & Technology, UCDavis, California, USA
    2006-2008 PhD student, Miljøstøtte joint-project between Dep. of Clinical Medicine and Dep. of Medical Biology, UiT
    2005-2006 Research engineer, Center for Atherothrombotic Research in Tromsø, Dep. of Clinical Medicine, UiT

    AWARDS
    2018 Prize for Young Researcher - Faculty of Health Sciences, UiT

    PROJECT MANAGEMENT EXPERIENCE

    2023-present: InterNASH: An intercellular-pathway therapeutic for non-alcoholic steatohepatitis Co-Inventor KOMMERFORSK (RCN), 0.5 MNOK
    2018-2024: Sugar Crush: Metabolism-Induced Sinusoidal Endothelial Cell Defenestration as Critical Determinant of Fatty Liver Disease Progression” PI FRIMEDBIO (RCN), 8 MNOK
    2020-present: GenSEC: A Pooled In Vivo CRISPR Genetic Screening method for Liver Sinusoidal Endothelial Cells Co-PI AKM fund (UiT), 0.65 MNOK
    2020-2022: Sugar Crush: Metabolism-Induced Sinusoidal Endothelial Cell Defenestration as Critical Determinant of Fatty Liver Disease Progression” PI AKM fund (UiT), 1.5 MNOK
    2018: Equipment: Agilent Seahorse XFp metabolic analyzer Super User UiT strategic fund, 0.5 MNOK