Jan-Olof Winberg
Fatema Amatur Rahman,
Imin Wushur,
Ida Kristine Østnes Hansen,
Tor Haug,
Klara Stensvåg,
Bibek Chaulagain
m.fl.:
Interactions of substrates and phosphinyl
containing inhibitors with bacterial and human
zinc proteases
Fatema Rahman,
Tra-Mi Nguyen,
Olayiwola Adekoya,
Cristina Campestre,
Paolo Tortorella,
Ingebrigt Sylte
m.fl.:
Inhibition of bacterial and human zincmetalloproteases
by bisphosphonate- and catechol-containing compounds
Fatema Rahman,
Imin Wushur,
Nabin Malla,
Ove Alexander Høgmoen Åstrand,
Pål Rongved,
Jan-Olof Winberg
m.fl.:
Zinc-Chelating Compounds as Inhibitors of Human and Bacterial Zinc Metalloproteases
Rangita Dawadi,
Nabin Malla,
Beate Hegge,
Imin Wushur,
Eli Berg,
Gunbjørg Svineng
m.fl.:
Molecular Interactions Stabilizing the Promatrix Metalloprotease-9·Serglycin Heteromer
Elin Synnøve Hadler-Olsen,
Jan-Olof Winberg
:
Method for Determining Gelatinolytic Activity in Tissue Extracts: Real-Time Gelatin Zymography.
Elin Synnøve Hadler-Olsen,
Jan-Olof Winberg
:
Method for Determining Gelatinolytic Activity in Tissue: In Situ Gelatin Zymography
Berit Bang,
Nabin Malla,
Sampada Bhagwat,
lisbeth Aasmoe,
Jan-Olof Winberg
:
A Sensitive Assay for Proteases in Bioaerosol Samples: Characterization and Quantification of Airborne Proteases in Salmon Industry Work Environments
Ingebrigt Sylte,
Rangita Dawadi,
Nabin Malla,
Susannah von Hofsten,
Tra-Mi Nguyen,
Ann Iren Solli
m.fl.:
The selectivity of galardin and an azasugar-based hydroxamate compound for human Matrix metalloproteases and bacterial metalloproteases
Elisabeth Øya,
Komlavi Anani Afanou,
Nabin Malla,
Silvio Uhlig,
Elin Rolen,
Ida Skaar
m.fl.:
Characterization and pro-inflammatory responses of spore and hyphae samples from various mold species
Conny Tümmler,
Igor Snapkov,
Malin Wickström,
Ugo Moens,
Linda Ljungblad,
Maria Elfman
m.fl.:
Inhibition of chemerin/CMKLR1 axis in neuroblastoma cells reduces clonogenicity and cell viability in vitro and impairs tumor growth in vivo
Synnøve Magnussen,
Elin Synnøve Hadler-Olsen,
Daniela Elena Costea,
Eli Berg,
Cristiane de Albuquerque Cavalcanti Jacobsen,
Bente Mortensen
m.fl.:
Cleavage of the urokinase receptor (uPAR) on oral cancer cells: Regulation by transforming growth factor - beta1 (TGF-beta1) and potential effects on migration and invasion
Stian Sjøli,
Elisa Nuti,
Caterina Camodeca,
Irina Bilto,
Armando Rossello,
Jan-Olof Winberg
m.fl.:
Synthesis, experimental evaluation and molecular modelling of hydroxamate derivatives as zinc metalloproteinase inhibitors
Imin Wushur,
Ingebrigt Sylte,
Jan-Olof Winberg
:
The catalytic reaction mechanism of drosophilid alcohol dehydrogenases
Elin Synnøve Hadler-Olsen,
Ann Iren Solli,
Anne Dragøy Hafstad,
Jan-Olof Winberg,
Lars Uhlin-Hansen
:
Intracellular MMP-2 Activity in Skeletal Muscle is Associated with Type II Fibers
Sampada Satchidanand Bhagwat,
Anett Kristin Larsen,
Jan-Olof Winberg,
Ole Morten Seternes,
Berit Bang
:
Salmon and king crab trypsin stimulate interleukin-8 and matrix metalloproteinases via protease-activated receptor-2 in the skin keratinocytic HaCaT cell line
Synnøve Magnussen,
Elin Synnøve Hadler-Olsen,
Nadezhda Latysheva,
Emma Pirila,
Sonja Eriksson Steigen,
Robert Hanes
m.fl.:
Tumour Microenvironments Induce Expression of Urokinase Plasminogen Activator Receptor (uPAR) and Concomitant Activation of Gelatinolytic Enzymes
Imin Wushur,
Jan-Olof Winberg,
Ingebrigt Sylte
:
Comparative molecular dynamic simulations of wild type and Thr114Val mutated Scaptodrosophila lebanonensis alcohol dehydrogenase
Olayiwola Adekoya,
Stian Sjøli,
Imin Wushur,
Irina Bilto,
Sergio M Marques,
M Amelia Santos
m.fl.:
Inhibition of pseudolysin and thermolysin by hydroxamate-based MMP inhibitors
Stian Sjøli,
Ann Iren Solli,
Øyvind Wilhelm Akselsen,
Yang Jiang,
Eli Berg,
Trond Vidar Hansen
m.fl.:
PAC-1 and isatin derivatives are weak matrix metalloproteinase inhibitors
Yimingjiang Wuxiuer,
Jan-Olof Winberg,
Ingebrigt Sylte
:
Comparative molecular dynamics simulations of wild type and Thr114Val mutated Scaptodrosophila lebanonensis alcohol dehydrogenase
ingvild Pettersen,
Ninib Baryawno,
Frida Abel,
wenche helen Bakkelund,
Svetlana Zykova,
Jan-Olof Winberg
m.fl.:
Expression of TWEAK/Fn14 in neuroblastoma: Implications in tumorigenesis
Elin Synnøve Hadler-Olsen,
Jan-Olof Winberg,
Lars Uhlin-Hansen
:
Matrix metalloproteinases in cancer: their value as diagnostic and prognostic markers and therapeutic targets
Nabin Malla,
Eli Berg,
Achilleas D. Theocharis,
Gunbjørg Svineng,
Lars Uhlin-Hansen,
Jan-Olof Winberg
:
Invitro reconstitution of complexes between pro-matrix metalloproteinase-9 and the proteoglycans serglycin and versican
Ann Iren Solli,
Bodil Irene Fadnes,
Jan-Olof Winberg,
Lars Uhlin-Hansen,
Elin Synnøve Hadler-Olsen
:
Tissue- and Cell-Specific Co-localization of Intracellular Gelatinolytic Activity and Matrix Metalloproteinase 2
Turid Hellevik,
ingvild Pettersen,
Vivian Berg,
Jan-Olof Winberg,
Bjørn Torvald Greve Moe,
Kristian Bartnes
m.fl.:
Cancer-associated fibroblasts from human NSCLC survive ablative doses of radiation but their invasive capacity is reduced
Bodil Irene Fadnes,
Elin Synnøve Hadler-Olsen,
Ingebrigt Sylte,
Lars Uhlin-Hansen,
Jan-Olof Winberg
:
Matrix metalloproteinase complexes and their biological significance
Yimingjiang Wuxiuer,
Ekaterina Morgunova,
Neus Cols,
Alexander Popov,
Andrey Karshikoff,
Ingebrigt Sylte
m.fl.:
An intact eight-membered water chain in drosophilid alcohol dehydrogenases is essential for optimal enzyme activity
Nabin Malla,
Eli Berg,
Ugo Moens,
Lars Uhlin-Hansen,
Jan-Olof Winberg
:
Biosynthesis of Promatrix Metalloproteinase-9/Chondroitin Sulphate Proteoglycan Heteromer Involves a Rottlerin-Sensitive Pathway
Hilde Ljones,
Elin Synnøve Hadler-Olsen,
Synnøve Magnussen,
Oddveig G Rikardsen,
sonja eriksson Steigen,
elisabeth Sundkvist
m.fl.:
S100A4 Expression in Xenograft Tumors of human carcinoma cell lines is induced by the tumor microenvironment
Elin Synnøve Hadler-Olsen,
Hilde Ljones,
Chandra Sekhar Ravuri,
Ahmad Omair,
Oddveig G Rikardsen,
Gunbjørg Svineng
m.fl.:
Organ specific regulation of tumour invasiveness and gelatinolytic activity at the invasive front
Elin Synnøve Hadler-Olsen,
Jan-Olof Winberg,
Finn P. Reinholt,
Terje Larsen,
Lars Uhlin-Hansen,
Trond Geir Jenssen
m.fl.:
Proteases in plasma and kidney of db /db mice as markers of diabetes-induced nephropathy
Elin Synnøve Hadler-Olsen,
Bodil Irene Fadnes,
Ingebrigt Sylte,
Lars Uhlin-Hansen,
Jan-Olof Winberg
:
Regulation of matrix metalloproteinase activity in health and disease
Elin Synnøve Hadler-Olsen,
Premasany Kanapathippillai,
Eli Berg,
Gunbjørg Svineng,
Jan-Olof Winberg,
Lars Uhlin-Hansen
:
Gelatin In Situ Zymography on Fixed, Paraffin-embedded Tissue: Zinc and Ethanol Fixation Preserve Enzyme Activity
Elin Synnøve Hadler-Olsen,
Hilde Ljones,
Oddveig G Rikardsen,
Sonja Eriksson Steigen,
Premasany Kanapathippillai,
Reidar Grenman
m.fl.:
Stromal impact on tumor growth and lymphangiogenesis in human carcinoma xenografts
Fatema Rahman,
Imin Wushur,
Ingebrigt Sylte,
Jan-Olof Winberg
:
Extracellular human and bacterial zinc metalloproteases – challenges in design of specific inhibitors
NBS-nytt 2021 ARKIV
Berit Bang,
Anett Kristin Larsen,
Sampada Satchidanand Bhagwat,
Nabin Malla,
Ole Morten Seternes,
Jan-Olof Winberg
:
Seafood proteases present in workplace bioaerosols – effects on inflammatory pathways in skin and airway cell models.
2016 ARKIV
Berit Bang,
Anett Kristin Larsen,
Sampada Satchidanand Bhagwat,
Nabin Malla,
Ole Morten Seternes,
Jan-Olof Winberg
:
Seafood proteases present in workplace bioaerosols – effects on inflammatory pathways in skin and airway cell models.
2016 ARKIV
Berit Bang,
Nabin Malla,
Sampada Satchidanand Bhagwat,
Merethe Larsen,
Jan-Olof Winberg
:
A sensitive assay for proteases in work environmental samples based on zymography.
2016 ARKIV
Anna Maria Wirsing,
Ann Iren Solli,
Gunbjørg Svineng,
Jan-Olof Winberg,
Elin Synnøve Hadler-Olsen
:
Intracellular Matrix Metalloproteinase-2 in skeletal muscle: effect of glucose and oxidative stress
2015 ARKIV
Anna Maria Wirsing,
Ann Iren Solli,
Gunbjørg Svineng,
Jan-Olof Winberg,
Elin Synnøve Hadler-Olsen
:
Intracellular Matrix Metalloproteinase-2 in skeletal muscle - a 3D skeletal muscle tissue engineering approach -
2015 ARKIV
Ann Iren Solli,
Bodil Irene Fadnes,
Jan-Olof Winberg,
Lars Uhlin-Hansen,
Elin Synnøve Hadler-Olsen
:
Intracellular MMP-2 localization and activity
2013 ARKIV
Elin Synnøve Hadler-Olsen,
Ann Iren Solli,
Anne Dragøy Hafstad,
Jan-Olof Winberg,
Lars Uhlin-Hansen
:
Intracellular MMP-2 Activity in Skeletal Muscle is Associated with Type II Fibers
2013 ARKIV
Gunbjørg Svineng,
Synnøve Magnussen,
Elin Synnøve Hadler-Olsen,
Nadezhda Latysheva,
Emma Pirila,
Sonja Eriksson Steigen
m.fl.:
Stromal induced expression of uPAR
2013 ARKIV
Jan-Olof Winberg
:
Matrix proteinases: biological significance in health and disease - Introduction
2012 ARKIV
Turid Hellevik,
ingvild Pettersen,
Jan-Olof Winberg,
Vivian Berg,
Jack-Ansgar Bruun,
Bjørn Thorvald Greve Moe
m.fl.:
Consequential effects of ablative ionizing radiation on tumor stromal fibroblasts from lung tumors
2012 ARKIV
Turid Hellevik,
ingvild Pettersen,
Jan-Olof Winberg,
Vivian Berg,
Kristian Bartnes,
Lill-Tove Busund
m.fl.:
Secretory profile of Cancer-Associated Fibroblasts after exposure to ablative radiation doses: Impact on angiogenesis and tumor growth
2012 ARKIV
Elin Synnøve Hadler-Olsen,
Ann Iren Solli,
Bodil Irene Fadnes,
Lars Uhlin-Hansen,
Jan-Olof Winberg
:
Tissue localization of intracellular gelatinolytic activity
The FEBS Journal 2012 ARKIV
Turid Hellevik,
Inger Pettersen,
Jan-Olof Winberg,
Vivian Berg,
Ruth H Paulssen,
Kristian Bartnes
m.fl.:
The Impact of Ionizing Radiation on the Motility and Matrix Remodelling Properties of Carcinoma-associated Fibroblasts
European Journal of Cancer 2011 ARKIV
Elin Synnøve Hadler-Olsen,
Chandra Sekhar Ravuri,
Hilde Ljones Wetting,
Oddveig G Rikardsen,
sonja eriksson Steigen,
Gunbjørg Svineng
m.fl.:
Stromal Impact on Tumor Invasiveness and Gelatinolytic Activity at the Invasive Front
2011 ARKIV
Elin Synnøve Hadler-Olsen,
Hilde Ljones,
O Rikardsen,
sonja eriksson Steigen,
Jan-Olof Winberg,
Gunbjørg Svineng
m.fl.:
Stromal impact on tumor growth and lymphangiogenesis in human carcinoma xenografts
APMIS - Journal of Pathologiy, Microbiology and Immunology 2010 ARKIV
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Forskningsinteresser
Min forskning er fokusert på enzymer, enzymhemmere og strukturproteiner. Disse enzymene og proteinene er normalt involvert i metabolisme, regulering av blodtrykk, utvikling, cellesignalering og den strukturelle integriteten av vev (ekstracellulær matriks). Disse enzymene og proteinene er også involvert i ulike typer av sykdommer slik som kreft, multiple sklerose, artritt og hudsykdommer. Arbeidet er for tilfellet fokusert rundt to hovedgrupper av enzymer, dehydrogenaser og proteinaser. Rensede enzymer studeres for å forstå disse enzymenes virkningsmekanisme, hvordan de kan aktiveres og hemmes, deres substratpreferanser, deres interaksjoner med andre proteiner, rollen til individuelle aminosyrer i katalysen og i interaksjoner med andre molekyler. Vi ser også på uttrykket av disse enzymene i celler og vev for å få en oppfatning om hvordan de reguleres, samt om det er et endret uttrykk av disse enzymene i ulike sykdommer. Målet for våre studier er å generere ny kunnskap som skal kunne brukes til å fremskaffe nye legemidler.