Bilde av McCourt, Peter
Bilde av McCourt, Peter
Professor Institutt for medisinsk biologi peter.mccourt@uit.no +4777646391 40281968 Her finner du meg

Peter McCourt



  • Nicholas J Hunt, Glen P Lockwood, Scott Heffernan, Jarryd Daymond, Meng Ngu, Ramesh Narayanan m.fl.:
    Oral nanotherapeutic formulation of insulin with reduced episodes of hypoglycaemia
    Nature Nanotechnology 2024 ARKIV / DOI
  • Javier Sánchez Romano, Jaione Simon-Santamaria, Peter Anthony McCourt, Bård Helge Smedsrød, Kim Erlend Mortensen, Antonia Sagona m.fl.:
    Liver sinusoidal cells eliminate blood-borne phage K1F
    mSphere 2024 ARKIV / DOI
  • Hong Mao, Karolina Szafranska, Larissa Dorothea Kruse, Christopher Florian Holte, Deanna Wolfson, Balpreet Singh Ahluwalia m.fl.:
    Effect of caffeine and other xanthines on liver sinusoidal endothelial cell ultrastructure
    Scientific Reports 2023 ARKIV / DOI
  • Henning Ortkrass, Jasmin Schürstedt, Gerd Wiebusch, Karolina Joanna Szafranska, Peter Anthony McCourt, Thomas Rolf Huser :
    High-speed TIRF and 2D super-resolution structured illumination microscopy with a large field of view based on fiber optic components
    Optics Express 2023 ARKIV / DOI
  • Henning Ortkrass, Gerd Wiebusch, Jochen Linnenbrügger, Jasmin Schürstedt, Karolina Joanna Szafranska, Peter Anthony McCourt m.fl.:
    Grazing incidence to total internal reflection fluorescence structured illumination microscopy enabled by a prism telescope
    Optics Express 2023 ARKIV / DOI
  • Christopher Florian Holte, Karolina Joanna Szafranska, Larissa Dorothea Kruse, Jaione Simon-Santamaria, Ruomei Li, Dmitri Svistounov m.fl.:
    Highly oxidized albumin is cleared by liver sinusoidal endothelial cells via the receptors stabilin-1 and -2
    Scientific Reports 2023 ARKIV / DOI
  • Matteo Boninsegna, Peter Anthony McCourt, Christopher Florian Holte :
    The Computed Sinusoid
    Livers 2023 ARKIV / DOI
  • Nicholas J Hunt, Peter Anthony McCourt, Zdenka Kuncic, David G Le Couteur, Victoria C Cogger :
    Opportunities and Challenges for Nanotherapeutics for the Aging Population
    Frontiers in Nanotechnology 25. januar 2022 ARKIV / DOI
  • Karolina Szafranska, Tanja Neuman, Zbigniew Baster, Zenon Rajfur, Oskar Szelest, Christopher Florian Holte m.fl.:
    From fixed-dried to wet-fixed to live-comparative super-resolution microscopy of liver sinusoidal endothelial cell fenestrations
    Nanophotonics 2022 ARKIV / DOI
  • Elise Anne van Os, Laura Cools, Nathalie Eysackers, Karolina Szafranska, Ayla Smout, Stefaan Verhulst m.fl.:
    Modelling fatty liver disease with mouse liver-derived multicellular spheroids
    Biomaterials 2022 ARKIV / DOI
  • Barlomiej Zapotoczny, Karolina Szafranska, Malgorzata Lekka, Balpreet Singh Ahluwalia, Peter Anthony McCourt :
    Tuning of Liver Sieve: The Interplay between Actin and Myosin Regulatory Light Chain Regulates Fenestration Size and Number in Murine Liver Sinusoidal Endothelial Cells
    International Journal of Molecular Sciences 2022 ARKIV / DOI
  • Karolina Szafranska, Christopher Florian Holte, Larissa Dorothea Kruse, Hong Mao, Cristina Ionica Øie, Marek Symonski m.fl.:
    Quantitative analysis methods for studying fenestrations in liver sinusoidal endothelial cells. A comparative study
    Micron 2021 ARKIV / DOI
  • Ankit Butola, David Andre Coucheron, Karolina Szafranska, Azeem Ahmad, Hong Mao, Jean-Claude Tinguely m.fl.:
    Multimodal on-chip nanoscopy and quantitative phase imaging reveals the nanoscale morphology of liver sinusoidal endothelial cells
    Proceedings of the National Academy of Sciences of the United States of America (PNAS) 2021 ARKIV / FULLTEKST / DOI
  • Anett Kristin Larsen, Jaione Simon-Santamaria, kjetil helge Elvevold, Bo Gøran Ericzon, Kim Erlend Mortensen, Peter Anthony McCourt m.fl.:
    Autofluorescence in freshly isolated adult human liver sinusoidal cells
    European journal of histochemistry 2021 ARKIV / DOI
  • Sabin Bhandari, Anett Kristin Larsen, Peter Anthony McCourt, Bård Smedsrød, Karen Kristine Sørensen :
    The scavenger function of liver sinusoidal endothelial cells in health and disease
    Frontiers in Physiology 11. oktober 2021 ARKIV / DOI
  • Karolina Szafranska, Larissa Dorothea Kruse, Christopher Florian Holte, Peter Anthony McCourt, Bartlomiej Zapotoczny :
    The wHole Story About Fenestrations in LSEC
    Frontiers in Physiology 2021 ARKIV / DOI
  • Nicholas J. Hunt, Glen P Lockwood, Sun W. S. Kang, Lara Westwood, Christina Limantoro, Wojciech Chrzanowski m.fl.:
    Quantum Dot Nanomedicine Formulations Dramatically Improve Pharmacological Properties and Alter Uptake Pathways of Metformin and Nicotinamide Mononucleotide in Aging Mice
    ACS Nano 2021 ARKIV / DOI
  • Matteo Boninsegna, Nikhil Jayakumar, Firehun Tsige Dullo, Peter Anthony McCourt, Thomas Rolf Huser, Balpreet Singh Ahluwalia m.fl.:
    Waveguide chip coupled with microfluidics enables super-resolution live-cell imaging
    Proceedings of SPIE, the International Society for Optical Engineering 2020 DOI
  • Sabin Bhandari, Ruomei Li, Jaione Simon-Santamaria, Peter Anthony McCourt, Steinar Daae Johansen, Bård Smedsrød m.fl.:
    Transcriptome and proteome profiling reveal complementary scavenger and immune features of rat liver sinusoidal endothelial cells and liver macrophages
    BMC Molecular and Cell Biology 2020 ARKIV / DOI
  • Nicholas J Hunt, Glen P Lockwood, Frank H. Le Couteur, Peter Anthony McCourt, Nidhi Singla, Sun Kang m.fl.:
    Rapid Intestinal Uptake and Targeted Delivery to the Liver Endothelium Using Orally Administered Silver Sulfide Quantum Dots.
    ACS Nano 2020 ARKIV / DOI
  • Cristina Ionica Øie, Deanna Wolfson, Tanji Yasunori, Gianina Dumitriu, Karen Kristine Sørensen, Peter Anthony McCourt m.fl.:
    Liver sinusoidal endothelial cells contribute to the uptake and degradation of entero bacterial viruses.
    Scientific Reports 2020 ARKIV / DOI
  • Jean-Claude Tinguely, Steyer Anna Maria, Cristina Ionica Øie, Øystein Ivar Helle, Firehun Tsige Dullo, Randi Olsen m.fl.:
    Photonic-chip assisted correlative light and electron microscopy
    Communications Biology 2020 ARKIV / DOI
  • Jean-Claude Tinguely, Steyer Anna Maria, Cristina Ionica Øie, Øystein Ivar Helle, Firehun Tsige Dullo, Randi Olsen m.fl.:
    Photonic-chip assisted corelative light and electron microscopy
    arXiv.org 2019
  • Nick Hunt, Glen P Lockwood, Sun Kang, Tamara Pupitel, Ximonie Clark, Hong Mao m.fl.:
    The effects of metformin on age-related changes in the liver sinusoidal endothelial cell
    The journals of gerontology. Series A, Biological sciences and medical sciences 2019 ARKIV / DOI
  • Nicholas J Hunt, Glen P Lockwood, Alessandra Warren, Hong Mao, Peter Anthony McCourt, David George Le Couteur m.fl.:
    Manipulating fenestrations in young and old liver sinusoidal endothelial cells
    American Journal of Physiology - Gastrointestinal and Liver Physiology 2019 ARKIV / DOI
  • Hong Mao, Robin Diekmann, Hai Po H Liang, Victoria Carroll Cogger, David George Le Couteur, Glen P Lockwood m.fl.:
    Cost-efficient nanoscopy reveals nanoscale architecture of liver cells and platelets
    Nanophotonics 09. juli 2019 ARKIV / DOI
  • Nicholas J Hunt, Peter Anthony McCourt, David George Le Couteur, Victoria C Cogger :
    Novel targets for delaying aging: The importance of the liver and advances in drug delivery
    Advanced Drug Delivery Reviews 2018 ARKIV / DOI
  • Peter Anthony McCourt :
    Go with the flow: Hemodynamic changes affect liver ultrastructure
    Acta Physiologica 2024 DOI
  • Peter Anthony McCourt :
    Lovende diabetesfunn
    16. januar 2024 DATA
  • Peter Anthony McCourt, Ellen Kathrine Bludd :
    Bavianer has spist sjokolade som kan bli medisiner for mennesker
    2024 DATA
  • Peter Anthony Gerard Mccourt :
    A novel nanoformulation for oral administration of insulin
    2024
  • Peter Anthony Gerard Mccourt :
    Drugs that impair liver sinusoidal endothelial cell function, and their metabolic consequences
    2024
  • Peter Anthony McCourt :
    Can Chocolate-Coated Insulin Pills Replace Needles?
    2024 DATA
  • Ellen Kathrine Bludd, Peter Anthony McCourt :
    Bavianer har spist sjokolade som kan bli medisin for mennesker (ung/forskning.no)
    2024 DATA
  • Julie Haugen Egge, Peter Anthony McCourt :
    Lovende diabetesforsøk: Insulin via sukkerfri sjokolade ga god effekt
    2024 DATA
  • Javier Sanchez Romano, Jaione Santamaria Simon, Peter Anthony Gerard Mccourt, Christopher Florian Holte, Bård Smedsrød, Antonia Sagona m.fl.:
    Rapid blood clearance of phage K1F-GFP is mediated by the liver and executed by Kupffer cells and liver sinusoidal endothelial cells in collaboration
    2023
  • Anett Kristin Larsen, Javier Sanchez Romano, Jaione Santamaria Simon, Kim Erlend Mortensen, Ingelin Kyrrestad Karlstrøm, Eirik Abrahamsen Lænsman m.fl.:
    Liver sinusoidal scavenger cells eliminate betaherpesvirus from the blood stream.
    Journal of Hepatology 2023 DOI
  • Javier Sanchez Romano, Anett Kristin Larsen, Jaione Simon-Santamaria, Cristina Ionica Øie, Bård Smedsrød, Peter Anthony McCourt m.fl.:
    The role of scavenger endothelial cells in bacteriophage pharmacokinetics
    2022
  • Javier Sanchez Romano, Anett Kristin Larsen, Jaione Simon-Santamaria, Cristina Ionica Øie, Bård Smedsrød, Peter Anthony McCourt m.fl.:
    The role of scavenger endothelial cells in bacteriophage pharmacokinetics
    2022
  • Anett Kristin Larsen, Javier Sanchez Romano, Jaione Simon-Santamaria, Kim Erlend Mortensen, Bo Gøran Ericzon, Peter Anthony McCourt m.fl.:
    Role of liver sinusoidal endothelial cells in elimination of virus
    2022
  • Anett Kristin Larsen, Javier Sanchez Romano, Eirik Abrahamsen Lænsman, Anne Lotte Vada Hatlegjerde, Jaione Simon-Santamaria, Kim Erlend Mortensen m.fl.:
    Liver sinusoidal scavenger cells eliminate betaherpesvirus from the blood stream
    2022
  • Peter Anthony McCourt :
    Rejuvenating old holes in ageing livers, and watching this happen.
    2022
  • Ankit Butola, David Andre Coucheron, Karolina Szafranska, Azeem Ahmad, Hong Mao, Jean-Claude Tinguely m.fl.:
    Quantitative phase imaging and on-chip nanoscopy for 3D imaging of liver sinusoidal endothelial cells
    2022
  • Peter Anthony Gerard Mccourt :
    Rejuvenating old holes in ageing livers, and watching this happen
    2022
  • Christopher Florian Holte, Larissa Dorothea Kruse, Hong Mao, Karolina Szafranska, Peter Anthony McCourt :
    How do fenestrations work?
    2019
  • Andres Maldonado, Ida Sundvor Opstad, Luis Hernández, Mona Nystad, Milton Aguilera, Merete Storflor m.fl.:
    Fluorescence Nanoscopy Using Multiple Signal Classification Algorithm (MUSICAL): From Electromagnetics Inverse Scattering Problem to Optics Inverse Source Problem.
    2019
  • Sebastian Andres Acuña Maldonado, Ida Sundvor Opstad, Luis Enrique Villegas Hernandez, Mona Nystad, Milton O Aguilera, Merete Storflor m.fl.:
    Fluorescence Nanoscopy Using Multiple Signal Classiflcation Algorithm (MUSICAL): From Electromagnetics Inverse Scattering Problem to Optics Inverse Source Problem
    2019
  • Javier Sanchez Romano, Anett Kristin Larsen, kjetil helge Elvevold, Christopher Florian Holte, Jaione Simon-Santamaria, Hans H. Hirsch m.fl.:
    SECVIR - The role of scavenger endothelial cells in elimination of virus
    2019
  • Peter Anthony McCourt :
    Reinvigorating old holes in the ageing liver, and how to watch this happen.
    2019
  • Viola Mönkemöller, Cristina Ionica Øie, Peter Heimann, Christian Kaltschmidt, Barbara Kaltschmidt, Peter Dedecker m.fl.:
    Revealing Structural Dynamics Of Liver Sinusoidal Endothelial Cells By Super-Resolution Optical Microscopy
    2018

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    Forskningsinteresser

    Studerer reseptorer som er ansvarlige for fjerning av hyaluronan, denaturert kollagen og andre molekyler fra sirkulasjonen via lever sinusoidale endotelceller (LSEC) og beinmarg sinusoidale endotelceller (BMSEC).




    CV

    Name: Peter Anthony Gerard McCourt

    Date of Birth: 09.08.1965

    Nationality: Australian

    Academic background:                       

    1986 – B.Sc. (Honours 1a) Flinders University, Australia

    1999 – Ph.D. (Biochemistry), University of Uppsala, Sweden 

    Areas of research expertise:

    1. Protein purification and analysis;

    2. Antibody production;

    3. Biochemical assays of cytochrome P450 enzymes in hepatocytes

    4. Tissue culture;

    5. Recombinant protein expression in mammalian and bacterial systems;

    6. Bioinformatic, PCR and cloning strategies;

    7. Development of clinical ELISAs and other immunoassays.

    8. Immunohistochemistry and immuno electron microscopy

    9. Isolation of liver sinusoidal endothelial cells (LSEC);

    10. Isolation of bone marrow sinusoidal endothelial cells (BMSEC), bone marrow stem cells, homing and engraftment assays.

    11. Super resolution optical microscopy methods (e.g. SIM, dSTORM) for use in the study of LSEC fenestrations.

    Teaching:

    Approved teaching portfolio (a compulsory requirement for teachers at the University of Tromsø) 19.06.12.

    Currently teach Biochemistry to Medical Laboratory Scientists and Dental Nurses.

    Research background:

    2020-present: Professor of Biochemistry, IMB, studying the effects of ageing on LSEC morphology and biochemistry.

    2016-2017: Sabbatical at the ANZAC Research Institute (Sydney, Australia), Biogerontology Research Group (hosts: Professors David Le Couteur and Victoria Cogger).

    2016-present: Honorary Affiliate of the University of Sydney Medical School (Faculty of Medicine).

    2012-2020: Associate Professor, IMB, studying the effects of ageing on LSEC morphology and biochemistry. 

    2010-11: Guest Researcher, Niche Group, CSIRO Materials Science and Engineering, Clayton, Australia, with Associate Professor Susie Nilsson, studying bone-marrow sinusoidal endothelial cells and stem cells and their utility in bone-marrow transplants.         

    1999-2012: Post-Doctoral Research Fellow/Research Scientist at the Department of Cell Biology and Histology, Institute for Medical Biology, University of Tromsø with Professor Bård Smedsrød, studying receptors responsible for the clearance of hyaluronan, denatured collagen and other waste connective tissue molecules from the circulation by LSEC.  

    1993-1999: Ph.D. Student, Department of Medical Biochemistry and Microbiology, University of Uppsala, Sweden under the supervision of Professors Torvard Laurent and Staffan Johansson, working on the purification, characterisation and cloning of hyaluronan/scavenger receptors on liver scavenger endothelial cells.

    1990-1993: Guest Researcher, Department of Medical and Physiological Chemistry, University of Uppsala, Sweden under the supervision of Professor Torvard  Laurent, studying hyaluronan-binding properties of the monocytic cell lines U937 and J774.

    1987-1990: Research Assistant, Lysosomal Diseases Research Unit, Adelaide Children's Hospital, Adelaide, Australia with Professor John Hopwood, working on the purification of lysosomal enzymes, production of hybridoma cell lines/monoclonal antibodies, and development of ELISAs for clinical assessment of lysosomal enzyme deficiencies. 

    Financial Support:

    University of Tromsø Researcher Fellowship, HelseNord, various small foundations, Norwegian Research Council Post-doctoral Fellowship, Tromsø Research Foundation, EU:Horizon 2020 MSCA.