Bilde av Odeberg, Jacob
Bilde av Odeberg, Jacob
Translational Vascular Research Group jacob.o.odeberg@uit.no +4777645483 Tromsø FARM F4.111

Jacob Odeberg


Professor/Overlege

Stillingsbeskrivelse

Professor ved Institutt for Klinisk Medisin.

Overlege, enhetsleder för Akutt og Mottaksmedisin vid Medisinsk Klinikk, Universitetssykehuset Nord-Norge (UNN)


  • Fredrik Edfors, Maria Jesus Iglesias, Lynn Butler, Jacob Odeberg :
    Proteomics in thrombosis research
    Research and Practice in Thrombosis and Haemostasis 2022 ARKIV / DOI
  • Philip Smith, Axel Rosell, Maria Farm, Maria Bruzelius, Katherina Aguilera Gatica, Nigel Mackman m.fl.:
    Markers of neutrophil activation and neutrophil extracellular traps in diagnosing patients with acute venous thromboembolism: A feasibility study based on two VTE cohorts
    PLOS ONE 28. juli 2022 ARKIV / DOI
  • Marthe Norreen-Thorsen, Eike Christopher Struck, Sofia Maria Öling, Martin Zwahlen, Kalle Von Feilitzen, Jacob Odeberg m.fl.:
    A human adipose tissue cell-type transcriptome atlas
    Cell reports 2022 ARKIV / DOI
  • Ozvan Bocher, Thomas E. Ludwig, Marie-Sophie Oglobinsky, Gaëlle Marenne, Jean-François Deleuze, Suryakant Suryakant m.fl.:
    Testing for association with rare variants in the coding and non-coding genome: RAVA-FIRST, a new approach based on CADD deleteriousness score
    PLoS Genetics 2022 DOI
  • Misbah Razzaq, Maria Jesus Iglesias, Manal Ibrahim-Kosta, Louisa Goumidi, Omar Soukarieh, Carole Proust m.fl.:
    An artificial neural network approach integrating plasma proteomics and genetic data identifies PLXNA4 as a new susceptibility locus for pulmonary embolism
    Scientific Reports 2021 ARKIV / DOI
  • Max Karlsson, Zhang Cheng, Lorén Mear, Wen Zhong, Andreas Digre, Barbola Katona m.fl.:
    A single-cell type transcriptomics map of human tissues
    Science Advances 2021 ARKIV / DOI
  • Maria Jesus Iglesias, Larissa D. Kruse, Laura Sanchez-Rivera, Linnea Enge, Philip James Dusart, Mun-Gwan Hong m.fl.:
    Identification of Endothelial Proteins in Plasma Associated With Cardiovascular Risk Factors
    Arteriosclerosis, Thrombosis and Vascular Biology 2021 ARKIV / DOI
  • Reiner K. Mailer, Mikel Allende, Marco Heestermans, Michaela Schweizer, Carsten Deppermann, Maike Frye m.fl.:
    Xenotropic and polytropic retrovirus receptor 1 regulates procoagulant platelet polyphosphate
    Blood 2021 ARKIV / DOI
  • Tea Dodig-Crnković, Mun-Gwan Hong, Cecilia Engel Thomas, Ragna S. Häussler, Annika Bendes, Matilda Dale m.fl.:
    Facets of individual-specific health signatures determined from longitudinal plasma proteome profiling
    EBioMedicine 2020 ARKIV / DOI
  • Philip James Dusart, Björn M. Hallström, Thomas Renne, Jacob Olof Odeberg, Mathias Uhlén, Lynn Butler :
    A Systems-Based Map of Human Brain Cell-Type Enriched Genes and Malignancy-Associated Endothelial Changes
    Cell reports 2019 ARKIV / DOI

  • De 50 siste resultatene fra Cristin vises på siden. Se alle arbeider i Cristin her →

    Publikasjoner utenom Cristin

    Selected

    1.      Holmberg K, Persson ML, Uhlen M, Odeberg J*. Pyrosequencing analysis of thrombosis-associated risk markers. Clin Chem. 2005; 51: 1549

    2.      Mercke Odeberg J, Andrade J, Holmberg K, Hoglund P, Malmqvist U, Odeberg J*. UGT1A polymorphisms in a Swedish cohort and a human diversity panel, and the relation to bilirubin plasma levels in males and females. Eur J Clin Pharmacol. 2006; 62: 829-37. PMID:16909274

    3.      Andrade J, Andersen M, Sillen A, Graff C, Odeberg J.* The use of grid computing to drive data-intensive genetic research. Eur J Hum Genet. 2007; 15: 694-702.  PMID:17377522

    4.      Andersen MC, Engstrom PG, Lithwick S, Arenillas D, Eriksson P, Lenhard B, Wasserman WW, Odeberg J.* In silico detection of sequence variations modifying transcriptional regulation. PLoS Comput Biol. 2008; 4: e5. PMID:18208319

    5.      Iglesisas MJ, Reilly S, Emanuelsson O, Sennblad B, Najafabadi MP, Folkersen L, Malarstig A, Eriksson P, Hamsten A, Odeberg J*. Combined chromatin and expression analysis reveals specific regulatory mechanisms within cytokine genes in the macrophage early immune response. PLoS One. 2012;7(2):e32306. Epub 2012 Feb 27. PMID:22384210

    6.      Odeberg J*, Freitag M, Forssell H, Vaara I, Persson ML, Odeberg H, Halling A, Råstam L, Lindblad U. The influence of smoking and impaired glucose homoeostasis on the outcome in patients presenting with an acute coronary syndrome: a cross-sectional study. British Medical Journal Open 2014;4(7):e005077. PMID:24993762

    7.      Habuka M, Fagerberg L, Hallström BM, Kampf C, Edlund K, Sivertsson Å, Yamamoto T, Pontén F, Uhlén M, Odeberg J*. The kidney transcriptome and proteome defined by transcriptomics and antibody-based profiling. PloS One 2014;9(12):e116125. PMID:25551756

    8.      Uhlén M, Fagerberg L, Hallström BM, Lindskog C, Oksvold P, Mardinoglu A, Sivertsson Å, Kampf C, Sjöstedt E, Asplund A, Olsson I, Edlund K, Lundberg E, Navani S, Szigyarto CA, Odeberg J, Djureinovic D, Takanen JO, Hober S, Alm T, Edqvist PH, Berling H, Tegel H, Mulder J, Rockberg J, Nilsson P, Schwenk JM, Hamsten M, von Feilitzen K, Forsberg M, Persson L, Johansson F, Zwahlen M, von Heijne G, Nielsen J, Pontén F. Proteomics. Tissue-based map of the human proteome. Science 2015;347(6220):1260419. PMID:25613900

    9.      Bruzelius M, Bottai M, Sabater-Lleal M, Strawbridge RJ, Bergendal A, Silveira A, Sundström A, Kieler H, Hamsten A, Odeberg J*. Predicting venous thrombosis in women using a combination of genetic markers and clinical risk factors. Journal of Thrombosis and Haemostasis 2015;13(2):219-27. PMID:25472531

    10.   Bruzelius M, Ljungqvist M ,Bottai M, BergendalA, Strawbridge RJ, Holmström M, Silveira A, Kieler H, Hamsten A, Lärfars G, Odeberg J*. F11 is associated with recurrent VTE in women: A prospective cohort study. Thrombosis and Haemostasis 2015;115(2):406-14. PMID:26423325

    11.   Odeberg J*, Freitag M, Forssell H, Vaara, I, Persson ML, Odeberg H, Halling A, Råstam L, Lindblad U. The influence of pre-existing inflammation on the outcome of acute coronary syndrome: a cross sectional study. British Medical Journal Open, 2016;6(1):e009968 doi:10.1136/bmjopen-2015-009968. PMID:26758266

    12.   Edsgard D, Jesus Iglesias M, Reilly SJ, Hamsten A, Tornvall P, Odeberg J*, Emanuelsson O*. GeneiASE: Detection of condition-dependent and static allele-specific expression from RNA-seq data without haplotype information. Scientific Reports 2016;6:21134. PMID:26887787

    13.   Butler LM, Hallström BM, Fagerberg L, Pontén F, Uhlén M, Renné T, Odeberg J. Analysis of Body-wide Unfractionated Tissue Data to Identify a Core Human Endothelial Transcriptome. Cell Systems. 2016;3(3):287-301.e3. PMID:27641958

    14.   Bruzelius M, Iglesias MJ, Hong MG, Sanchez-Rivera L, Gyorgy B, Souto JC, Frånberg M, Fredolini C, Strawbridge RJ, Holmström M, Hamsten A, Uhlén M, Silveira A, Soria JM, Smadja DM, Butler LM, Schwenk JM, Morange PE, Trégouët DA, Odeberg J*. PDGFB, a new candidate plasma biomarker for venous thromboembolism: results from the VEREMA affinity proteomics study. Blood. 2016;128(23):e59-e66. PMID:27742707

    15.   Majeed A, Ågren A, Holmström M, Bruzelius M, Chaireti R, Odeberg J, Hempel EL, Magnusson M, Frisk T, Schulman S. Management of rivaroxaban- or apixaban-associated major bleeding with prothrombin complex concentrates: a cohort study. Blood. 2017 Oct 12;130(15):1706-1712. doi: 10.1182/blood-2017-05-782060. Epub 2017 Aug 23. PMID: 28835439

    16.   Matic LP, Jesus Iglesias M, Vesterlund M, Lengquist M, Hong MG, Saieed S, Sanchez-Rivera L, Berg M, Razuvaev A, Kronqvist M, Lund K, Caidahl K, Gillgren P, Pontén F, Uhlén M, Schwenk JM, Hansson GK, Paulsson-Berne G, Fagman E, Roy J, Hultgren R, Bergström G, Lehtiö J, Odeberg J*, Hedin U*. Novel Multiomics Profiling of Human Carotid Atherosclerotic Plaques and Plasma Reveals Biliverdin Reductase B as a Marker of Intraplaque Hemorrhage. JACC: Basic to Translational Science Aug 2018, 222. PMID: 30175270

    17.   Dusart P, Fagerberg L, Perisic L, Civelek M, Struck E, Hedin U, Uhlén M, Trégouët DA, Renné T, Odeberg J, Butler LM. A systems-approach reveals human nestin is an endothelial-enriched, angiogenesis-independent intermediate filament protein. Sci Rep. 2018 Oct 2;8(1):14668. doi:  10.1038/s41598-018-32859-4. PMID: 30279450

    18.   Uhlen M, Karlsson MJ, Zhong W, Tebani A, Pou C, Mikes J, Lakshmikanth T, Forsström B, Edfors F, Odeberg J, Mardinoglu A, Zhang C, von Feilitzen K, Mulder J, Sjöstedt E, Hober A, Oksvold P, Zwahlen M, Ponten F, Lindskog C, Sivertsson Å, Fagerberg L, Brodin P. A genome-wide transcriptomic analysis of protein-coding genes in human blood cells. Science. 2019 Dec 20;366(6472). PMID: 31857451

    19.   Tebani A, Gummesson A, Zhong W, Koistinen IS, Lakshmikanth T, Olsson LM, Boulund F, Neiman M, Stenlund H, Hellström C, Karlsson MJ, Arif M, Dodig-Crnković T, Mardinoglu A, Lee S, Zhang C, Chen Y, Olin A, Mikes J, Danielsson H, von Feilitzen K, Jansson PA, Angerås O, Huss M, Kjellqvist S, Odeberg J, Edfors F, Tremaroli V, Forsström B, Schwenk JM, Nilsson P, Moritz T, Bäckhed F, Engstrand L, Brodin P, Bergström G, Uhlen M, Fagerberg L. Integration of molecular profiles in a longitudinal wellness profiling cohort. Nat Commun. 2020 Sep 8;11(1):4487. PMID: 32900998

    20. Iglesias MJ, Kruse LD, Sanchez-Rivera L, Enge L, Dusart P, Hong MG, Uhlén M, Renné T, Schwenk JM, Bergstrom G, Odeberg J, Butler LM (2021) Identification of endothelial-derived proteins in plasma associated with cardiovascular risk factors. medRxiv doi.org/10.1101/2021.02.08.21251209


    Forskningsinteresser

    Biomarkers for prediction, diagnosis and prognosis of arterial and venous thrombosis

    Biomarkers for diagnosis and prognosis in COVID-19 disease

    Pathophysiology of thrombosis

     


    Medlem i forskningsgruppe


    CV

    Education and postdoctoral experience

    1985-90           M.Sci. in Chemical Engineering, Royal Institute of Technology (KTH), Sweden

    1993-98           Ph.D. in Biochemistry, KTH, Stockholm, Sweden

    1995-2002       Medical Degree (MD), Karolinska Institute (KI), Sweden.                                          

    2002-05           Post doc, Dept of Medicine, Atherosclerosis Research Unit, KI, Sweden

    2005                 Licensed physician, Karolinska University Hospital, Stockholm, Sweden          

    2013                  Specialist certification in Internal Medicine and Haematology, Sweden

    Academic positions

    2000-05           Researcher group leader, Dept. of Molecular Biotechnology, KTH, Sweden

    2006-08           Associate Professor, Dept. of Gene Technology, KTH, Stockholm, Sweden

    2006-12           Senior Researcher, Dept. of Medicine, Karolinska Institute (KI), Sweden.

    2008-12           Associate Professor, Dept. of Proteomics, KTH, Stockholm, Sweden

    2013-               Professor in Clinically Applied Proteomics, KTH, SciLifeLab Stockholm, Sweden

    2018-               Professor in Medicine (Haematology), Dept. of Clinical Medicine, The Arctic University of Norway (UiT), Tromsø, Norway

    2021 -             Affiliation: Associated Investigator EMBL Centre for Molecular Medicine, Norway

     

    Clinical positions

    2002-05           Internship, Karolinska University Hospital, Stockholm, Sweden

    2005-13           Resident in Internal Medicine & Haematology, Karolinska University Hospital

    2013-18           Consultant in Haematology, Coagulation unit, Karolinska University Hospital

    2018-               Senior Consultant, Unit leader for Emergency Medicine, Division of Medicine, University Hospital North Norway (UNN), Tromsø, Norway

    Fellowships

    2002-2005       Clinical Intern Research Fellowship, Karolinska Institute, Sweden

    2008-12           Clinical Senior Researcher Fellowship, Stockholm County Council, Sweden

     

    Publication bibliometrics

    Peer reviewed original research publications: 95

    Total peer reviewed articles: 100

    Total citations: 12801

     

    Supervision of PhD students:

    Ongoing PhDs: 1 as main supervisor.

    Completed PhDs: 3 as main supervisor, 5 as co-supervisor.