Personkort bilde

Jacob Odeberg

Professor/Overlege Institutt for klinisk medisin
Engelsk flaggikon Samisk flaggikon

Biomarkers for prediction, diagnosis and prognosis of arterial and venous thrombosis

Biomarkers for diagnosis and prognosis in COVID-19 disease

Pathophysiology of thrombosis

 

Education and postdoctoral experience

1985-90           M.Sci. in Chemical Engineering, Royal Institute of Technology (KTH), Sweden

1993-98           Ph.D. in Biochemistry, KTH, Stockholm, Sweden

1995-2002       Medical Degree (MD), Karolinska Institute (KI), Sweden.                                          

2002-05           Post doc, Dept of Medicine, Atherosclerosis Research Unit, KI, Sweden

2005                 Licensed physician, Karolinska University Hospital, Stockholm, Sweden          

2013                  Specialist certification in Internal Medicine and Haematology, Sweden

Academic positions

2000-05           Researcher group leader, Dept. of Molecular Biotechnology, KTH, Sweden

2006-08           Associate Professor, Dept. of Gene Technology, KTH, Stockholm, Sweden

2006-12           Senior Researcher, Dept. of Medicine, Karolinska Institute (KI), Sweden.

2008-12           Associate Professor, Dept. of Proteomics, KTH, Stockholm, Sweden

2013-               Professor in Clinically Applied Proteomics, KTH, SciLifeLab Stockholm, Sweden

2018-               Professor in Medicine (Haematology), Dept. of Clinical Medicine, The Arctic University of Norway (UiT), Tromsø, Norway

2021 -             Affiliation: Associated Investigator EMBL Centre for Molecular Medicine, Norway

 

Clinical positions

2002-05           Internship, Karolinska University Hospital, Stockholm, Sweden

2005-13           Resident in Internal Medicine & Haematology, Karolinska University Hospital

2013-18           Consultant in Haematology, Coagulation unit, Karolinska University Hospital

2018-               Senior Consultant, Unit leader for Emergency Medicine, Division of Medicine, University Hospital North Norway (UNN), Tromsø, Norway

Fellowships

2002-2005       Clinical Intern Research Fellowship, Karolinska Institute, Sweden

2008-12           Clinical Senior Researcher Fellowship, Stockholm County Council, Sweden

 

Publication bibliometrics

Peer reviewed original research publications: 95

Total peer reviewed articles: 100

Total citations: 12801

 

Supervision of PhD students:

Ongoing PhDs: 1 as main supervisor.

Completed PhDs: 3 as main supervisor, 5 as co-supervisor.

 

Professor ved Institutt for Klinisk Medisin.

Overlege, enhetsleder för Akutt og Mottaksmedisin vid Medisinsk Klinikk, Universitetssykehuset Nord-Norge (UNN)

Selected

1.      Holmberg K, Persson ML, Uhlen M, Odeberg J*. Pyrosequencing analysis of thrombosis-associated risk markers. Clin Chem. 2005; 51: 1549

2.      Mercke Odeberg J, Andrade J, Holmberg K, Hoglund P, Malmqvist U, Odeberg J*. UGT1A polymorphisms in a Swedish cohort and a human diversity panel, and the relation to bilirubin plasma levels in males and females. Eur J Clin Pharmacol. 2006; 62: 829-37. PMID:16909274

3.      Andrade J, Andersen M, Sillen A, Graff C, Odeberg J.* The use of grid computing to drive data-intensive genetic research. Eur J Hum Genet. 2007; 15: 694-702.  PMID:17377522

4.      Andersen MC, Engstrom PG, Lithwick S, Arenillas D, Eriksson P, Lenhard B, Wasserman WW, Odeberg J.* In silico detection of sequence variations modifying transcriptional regulation. PLoS Comput Biol. 2008; 4: e5. PMID:18208319

5.      Iglesisas MJ, Reilly S, Emanuelsson O, Sennblad B, Najafabadi MP, Folkersen L, Malarstig A, Eriksson P, Hamsten A, Odeberg J*. Combined chromatin and expression analysis reveals specific regulatory mechanisms within cytokine genes in the macrophage early immune response. PLoS One. 2012;7(2):e32306. Epub 2012 Feb 27. PMID:22384210

6.      Odeberg J*, Freitag M, Forssell H, Vaara I, Persson ML, Odeberg H, Halling A, Råstam L, Lindblad U. The influence of smoking and impaired glucose homoeostasis on the outcome in patients presenting with an acute coronary syndrome: a cross-sectional study. British Medical Journal Open 2014;4(7):e005077. PMID:24993762

7.      Habuka M, Fagerberg L, Hallström BM, Kampf C, Edlund K, Sivertsson Å, Yamamoto T, Pontén F, Uhlén M, Odeberg J*. The kidney transcriptome and proteome defined by transcriptomics and antibody-based profiling. PloS One 2014;9(12):e116125. PMID:25551756

8.      Uhlén M, Fagerberg L, Hallström BM, Lindskog C, Oksvold P, Mardinoglu A, Sivertsson Å, Kampf C, Sjöstedt E, Asplund A, Olsson I, Edlund K, Lundberg E, Navani S, Szigyarto CA, Odeberg J, Djureinovic D, Takanen JO, Hober S, Alm T, Edqvist PH, Berling H, Tegel H, Mulder J, Rockberg J, Nilsson P, Schwenk JM, Hamsten M, von Feilitzen K, Forsberg M, Persson L, Johansson F, Zwahlen M, von Heijne G, Nielsen J, Pontén F. Proteomics. Tissue-based map of the human proteome. Science 2015;347(6220):1260419. PMID:25613900

9.      Bruzelius M, Bottai M, Sabater-Lleal M, Strawbridge RJ, Bergendal A, Silveira A, Sundström A, Kieler H, Hamsten A, Odeberg J*. Predicting venous thrombosis in women using a combination of genetic markers and clinical risk factors. Journal of Thrombosis and Haemostasis 2015;13(2):219-27. PMID:25472531

10.   Bruzelius M, Ljungqvist M ,Bottai M, BergendalA, Strawbridge RJ, Holmström M, Silveira A, Kieler H, Hamsten A, Lärfars G, Odeberg J*. F11 is associated with recurrent VTE in women: A prospective cohort study. Thrombosis and Haemostasis 2015;115(2):406-14. PMID:26423325

11.   Odeberg J*, Freitag M, Forssell H, Vaara, I, Persson ML, Odeberg H, Halling A, Råstam L, Lindblad U. The influence of pre-existing inflammation on the outcome of acute coronary syndrome: a cross sectional study. British Medical Journal Open, 2016;6(1):e009968 doi:10.1136/bmjopen-2015-009968. PMID:26758266

12.   Edsgard D, Jesus Iglesias M, Reilly SJ, Hamsten A, Tornvall P, Odeberg J*, Emanuelsson O*. GeneiASE: Detection of condition-dependent and static allele-specific expression from RNA-seq data without haplotype information. Scientific Reports 2016;6:21134. PMID:26887787

13.   Butler LM, Hallström BM, Fagerberg L, Pontén F, Uhlén M, Renné T, Odeberg J. Analysis of Body-wide Unfractionated Tissue Data to Identify a Core Human Endothelial Transcriptome. Cell Systems. 2016;3(3):287-301.e3. PMID:27641958

14.   Bruzelius M, Iglesias MJ, Hong MG, Sanchez-Rivera L, Gyorgy B, Souto JC, Frånberg M, Fredolini C, Strawbridge RJ, Holmström M, Hamsten A, Uhlén M, Silveira A, Soria JM, Smadja DM, Butler LM, Schwenk JM, Morange PE, Trégouët DA, Odeberg J*. PDGFB, a new candidate plasma biomarker for venous thromboembolism: results from the VEREMA affinity proteomics study. Blood. 2016;128(23):e59-e66. PMID:27742707

15.   Majeed A, Ågren A, Holmström M, Bruzelius M, Chaireti R, Odeberg J, Hempel EL, Magnusson M, Frisk T, Schulman S. Management of rivaroxaban- or apixaban-associated major bleeding with prothrombin complex concentrates: a cohort study. Blood. 2017 Oct 12;130(15):1706-1712. doi: 10.1182/blood-2017-05-782060. Epub 2017 Aug 23. PMID: 28835439

16.   Matic LP, Jesus Iglesias M, Vesterlund M, Lengquist M, Hong MG, Saieed S, Sanchez-Rivera L, Berg M, Razuvaev A, Kronqvist M, Lund K, Caidahl K, Gillgren P, Pontén F, Uhlén M, Schwenk JM, Hansson GK, Paulsson-Berne G, Fagman E, Roy J, Hultgren R, Bergström G, Lehtiö J, Odeberg J*, Hedin U*. Novel Multiomics Profiling of Human Carotid Atherosclerotic Plaques and Plasma Reveals Biliverdin Reductase B as a Marker of Intraplaque Hemorrhage. JACC: Basic to Translational Science Aug 2018, 222. PMID: 30175270

17.   Dusart P, Fagerberg L, Perisic L, Civelek M, Struck E, Hedin U, Uhlén M, Trégouët DA, Renné T, Odeberg J, Butler LM. A systems-approach reveals human nestin is an endothelial-enriched, angiogenesis-independent intermediate filament protein. Sci Rep. 2018 Oct 2;8(1):14668. doi:  10.1038/s41598-018-32859-4. PMID: 30279450

18.   Uhlen M, Karlsson MJ, Zhong W, Tebani A, Pou C, Mikes J, Lakshmikanth T, Forsström B, Edfors F, Odeberg J, Mardinoglu A, Zhang C, von Feilitzen K, Mulder J, Sjöstedt E, Hober A, Oksvold P, Zwahlen M, Ponten F, Lindskog C, Sivertsson Å, Fagerberg L, Brodin P. A genome-wide transcriptomic analysis of protein-coding genes in human blood cells. Science. 2019 Dec 20;366(6472). PMID: 31857451

19.   Tebani A, Gummesson A, Zhong W, Koistinen IS, Lakshmikanth T, Olsson LM, Boulund F, Neiman M, Stenlund H, Hellström C, Karlsson MJ, Arif M, Dodig-Crnković T, Mardinoglu A, Lee S, Zhang C, Chen Y, Olin A, Mikes J, Danielsson H, von Feilitzen K, Jansson PA, Angerås O, Huss M, Kjellqvist S, Odeberg J, Edfors F, Tremaroli V, Forsström B, Schwenk JM, Nilsson P, Moritz T, Bäckhed F, Engstrand L, Brodin P, Bergström G, Uhlen M, Fagerberg L. Integration of molecular profiles in a longitudinal wellness profiling cohort. Nat Commun. 2020 Sep 8;11(1):4487. PMID: 32900998

20. Iglesias MJ, Kruse LD, Sanchez-Rivera L, Enge L, Dusart P, Hong MG, Uhlén M, Renné T, Schwenk JM, Bergstrom G, Odeberg J, Butler LM (2021) Identification of endothelial-derived proteins in plasma associated with cardiovascular risk factors. medRxiv doi.org/10.1101/2021.02.08.21251209

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