Bilde av Seternes, Ole Morten
Foto: Bjørn-Kåre Iversen
Bilde av Seternes, Ole Morten
Cellesignalering og målrettet terapi ole-morten.seternes@uit.no +4777646506 Her finner du meg

Ole Morten Seternes


Gruppeleder for forskningsgruppen Cellesignalering og målrettet terapi

Stillingsbeskrivelse

Professor i Farmakologi og gruppeleder for forskningsgruppen i Celle signallering og målrettet terapi. Emneleder for Farmakologi


  • Fadia Boudghene-Stambouli, Mathilde Soulez, Natalia Ronkina, Anneke Dörrie, Alexey Kotlyarov, Ole Morten Seternes m.fl.:
    On the Therapeutic Potential of ERK4 in Triple-Negative Breast Cancer
    Cancers 2023 ARKIV / DOI
  • Benedicte Sjo Tislevoll, Monica Hellesøy, Oda Helen Eck Fagerholt, Stein-Erik Gullaksen, Aashish Srivastava, Even Birkeland m.fl.:
    Early response evaluation by single cell signaling profiling in acute myeloid leukemia
    Nature Communications 2023 ARKIV / DOI
  • Erik Knutsen, Saikat Das Sajib, Tonje Fiskaa, James Bradley Lorens, Thorarinn Gudjonsson, Gunhild Mari Mælandsmo m.fl.:
    Identification of a core EMT signature that separates basal-like breast cancers into partial- and post-EMT subtypes
    Frontiers in Oncology 2023 ARKIV / DOI
  • Joaquim Javary, Eugénie Goupil, Mathilde Soulez, Evgeny Kanshin, Antoine Bouchard, Ole Morten Seternes m.fl.:
    Phosphoproteomic analysis identifies supervillin as an ERK3 substrate regulating cytokinesis and cell ploidy
    Journal of Cellular Physiology 2022 ARKIV / DOI
  • Lisa Zeyen Øyås, Ole Morten Seternes, Ingvild Mikkola :
    Crosstalk between p38 MAPK and GR Signaling
    International Journal of Molecular Sciences 2022 ARKIV / DOI
  • Anup Shrestha, Henrike Bruckmüller, Hanne Kildalsen, Gurjit Kaur, Matthias Gaestel, Hilde Ljones Wetting m.fl.:
    Phosphorylation of steroid receptor coactivator-3 (SRC-3) at serine 857 is regulated by the p38 MAPK-MK2 axis and affects NF-κB-mediated transcription
    Scientific Reports 2020 ARKIV / DOI
  • Dennis Bela-Ong, Linn Greiner-Tollersrud, Yorick Andreas van der Wal, Ingvill Jensen, Ole Morten Seternes, Jorunn Jørgensen :
    Infection and microbial molecular motifs modulate transcription of the interferon-inducible gene ifit5 in a teleost fish
    Developmental and Comparative Immunology 2020 ARKIV / DOI
  • Anna Lucja Czarna, Wang Jinhua, Diana Zelencova, Yao Liu, Xianming Deng, Hwan Geun Choi m.fl.:
    Novel Scaffolds for Dual Specificity Tyrosine-Phosphorylation-Regulated Kinase (DYRK1A) Inhibitors
    Journal of Medicinal Chemistry 2018 ARKIV / DOI
  • Ole Morten Seternes, Andrew M Kidger, Stephen M Keyse :
    Dual-specificity MAP kinase phosphatases in health and disease
    BBA - Molecular Cell Research 2018 ARKIV / DOI
  • Maria Perander, Rania Al-Mahdi, Thomas Clemens Jensen, Jennifer Ann Lillebo Nunn, Hanne Kildalsen, Bjarne Herold Johansen m.fl.:
    Regulation of atypical MAP kinases ERK3 and ERK4 by the phosphatase DUSP2
    Scientific Reports 2017 ARKIV / DOI
  • Maria Perander, Stephen M Keyse, Ole Morten Seternes :
    New insights into the activation, interaction partners and possible functions of MK5/PRAK
    Frontiers in Bioscience 2016
  • Sampada Satchidanand Bhagwat, Anett Kristin Larsen, Ole Morten Seternes, Berit Bang :
    Mixed exposure to bacterial lipopolysaccharide and seafood proteases augments inflammatory signalling in an airway epithelial cell model (A549)
    Toxicology and industrial health 2016 ARKIV / DOI
  • Jennifer L. Whiting, Leah Ogier, Katherine A Forbush, Paula Bucko, Janani Gopalan, Ole Morten Seternes m.fl.:
    AKAP220 manages apical actin networks that coordinate aquaporin-2 location and renal water reabsorption
    Proceedings of the National Academy of Sciences of the United States of America 2016 DOI
  • Tonje Fiskaa, Erik Knutsen, Malene Nikolaisen, Tor Erik Jørgensen, Steinar Daae Johansen, maria Perander m.fl.:
    Distinct small RNA signatures in extracellular vesicles derived from breast cancer cell lines
    PLOS ONE 2016 ARKIV / DOI
  • Ka Bian, Naveen Reddy Muppani, Lobna Elkhadragy, Wei Wang, Cheng Zhang, Tenghui Chen m.fl.:
    ERK3 regulates TDP2-mediated DNA damage response and chemoresistance in lung cancer cells
    OncoTarget 2015 ARKIV / DOI
  • Rania Al-Mahdi, Nouf Babteen, Kiruthikah Thillai, Mark Holt, Bjarne Herold Johansen, Hilde Ljones Wetting m.fl.:
    A novel role for atypical MAPK kinase ERK3 in regulating breast cancer cell morphology and migration
    Cell Adhesion & Migration 2015 DOI
  • Jennifer L. Whiting, Patrick J. Nygren, Brian J. Tunquist, Lorene K. Langeberg, Ole Morten Seternes, John D. Scott :
    Protein kinase A opposes the phosphorylation-dependent recruitment of glycogen synthase kinase 3β to A-kinase Anchoring Protein 220
    Journal of Biological Chemistry 2015 ARKIV / DOI
  • Sampada Satchidanand Bhagwat, Anett Kristin Larsen, Jan-Olof Winberg, Ole Morten Seternes, Berit Bang :
    Salmon and king crab trypsin stimulate interleukin-8 and matrix metalloproteinases via protease-activated receptor-2 in the skin keratinocytic HaCaT cell line
    Food and Chemical Toxicology (FCT) 2014 DOI
  • Anett Kristin Larsen, kurt Kristiansen, Ingebrigt Sylte, Ole Morten Seternes, Berit Bang :
    Differences in PAR-2 activating potential by king crab (Paralithodes camtschaticus), salmon (Salmo salar), and bovine (Bos taurus) trypsin
    BMC Research Notes 2013 ARKIV / DOI
  • Erik Knutsen, Tonje Fiskaa, anita Ursvik, Tor Erik Jørgensen, maria Perander, Eiliv Lund m.fl.:
    Performance Comparison of Digital microRNA Profiling Technologies Applied on Human Breast Cancer Cell Lines
    PLOS ONE 2013 ARKIV / DOI
  • Ilona Urbarova, Bård Ove Karlsen, Siri Okkenhaug, Ole Morten Seternes, Steinar Johansen, Åse Emblem :
    Digital Marine Bioprospecting: Mining New Neurotoxin Drug Candidates from the Transcriptomes of Cold-Water Sea Anemones
    Marine Drugs 2012 ARKIV / DOI
  • Anett Kristin Larsen, ole morten Seternes, Merethe Larsen, Hideki Kishimura, Galina N Rudenskaya, Berit Bang :
    Purified sardine and king crab trypsin display individual differences in PAR-2-, NF-kappa B-, and IL-8 signaling
    Toxicological & Environmental Chemistry 2011 ARKIV / DOI
  • Steinar D. Johansen, Åse Emblem, Bård Ove Karlsen, Siri Okkenhaug, Hilde Hansen, Truls Moum m.fl.:
    Approaching marine bioprospecting in hexacorals by RNA deep sequencing
    New Biotechnology 2010 DOI
  • ole morten Seternes, Bjarne Herold Johansen, Beate Hegge, Mona Johannessen, Stephen M Keyse, Ugo Moens :
    Both Binding and Activation of p38 Mitogen-Activated Protein Kinase (MAPK) Play Essential Roles in Regulation of the Nucleocytoplasmic Distribution of MAPK-Activated Protein Kinase 5 by Cellular Stress
    Molecular and Cellular Biology 2010 DOI
  • espen Åberg, Knut Martin Torgersen, Bjarne Herold Johansen, Stephen M Keyse, maria Perander, ole morten Seternes :
    Docking of PRAK/MK5 to the Atypical MAPKs ERK3 and ERK4 Defines a Novel MAPK Interaction Motif
    Journal of Biological Chemistry 2009 DOI
  • maria Perander, espen Åberg, Bjarne Herold Johansen, Bo Dreyer, Ingrid Jenny Guldvik, heidi Outzen m.fl.:
    The Ser(186) phospho-acceptor site within ERK4 is essential for its ability to interact with and activate PRAK/MK5
    Biochemical Journal 2008 DOI
  • maria Perander, Stephen M Keyse, ole morten Seternes :
    Does MK5 reconcile classical and atypical MAP kinases?
    Frontiers in Bioscience 2008
  • Tom Egil Hansen, Pål Puntervoll, A.W. Borgland, ole morten Seternes, Gerald Eigen, Jorunn B Jørgensen m.fl.:
    Atlantic salmon possess three mitogen activated protein kinase kinase 6 paralogs responding differently to stress
    The FEBS Journal 2008 DOI
  • Anett Kristin Larsen, ole morten Seternes, Merethe Larsen, lisbeth Aasmoe, Berit Bang :
    Salmon trypsin stimulates the expression of interleukin-8 via protease-activated receptor-2
    Toxicology and Applied Pharmacology 2008 DOI
  • espen Michaelsen, maria Perander, Bjarne Herold Johansen, Catherine Julien, Sylvain Meloche, Stephen M Keyse m.fl.:
    Regulation of MAPK-activated protein kinase 5 activity and subcellular localization by the atypical MAPK ERK4/MAPK4
    Journal of Biological Chemistry 2006
  • Nico Hendrickx, Cédric Volanti, Ugo Moens, ole morten Seternes, Peter De Witte, Jackie R Vandenheede :
    Up-regulation of cyclooxygenase-2 and apoptosis resistance by p38 MAPK in hypericin-mediated photodynamic therapy of human cancer cells
    Journal of Biological Chemistry 2004
  • Ole Morten Seternes, Theresa Mikalsen, Bjarne Johansen, Espen Michaelsen, CG Armstrong, NA Morrice m.fl.:
    Activation of MK5/PRAK by the atypical MAP kinase ERK3 defines a novel signal transduction pathway
    EMBO Journal 2004 DOI
  • Mona Johannessen, Marit Pedersen Delghandi, Ole Morten Seternes, Bjarne Johansen, Ugo Lionel Moens :
    Synergistic activation of CREB-mediated transcription by forskolin and phorbol ester requires PKC and depends on the glutamine-rich Q2 transactivation domain
    Cellular Signalling 2004
  • Mona Johannessen, Petter Angell Olsen, Rita Irene Sørensen, Bjarne Johansen, Ole Morten Seternes, Ugo Lionel Moens :
    A role of the TATA box and the general co-activator hTAFII130/135 in promoter-specific trans-activation by simian virus 40 small t antigen
    Journal of General Virology 2003 DOI
  • Nico Hendrickx, Cédric Volanti, Ugo Lionel Moens, Ole Morten Seternes, Peter De Witte, Jackie R Vandenheede m.fl.:
    Up-regulation of cyclooxygenase-2 and apoptosis resistance by p38 MAPK in hypericin-mediated photodynamic therapy of human cancer cells
    Journal of Biological Chemistry 2003 DOI
  • Mona Johannessen, Petter Angell Olsen, Bjarne Johansen, Ole Morten Seternes, Ugo Lionel Moens :
    Activation of the coactivator foru-and-a-half-LIM-only protein FHL2 and the c-fos promoter through inhibition of protein phosphatase 2A
    Biochemical Pharmacology 2003
  • Benedicte Sjo Tislevoll, Monica Hellesøy, Oda Helen Eck Fagerholt, Stein-Erik Gullaksen, Aashish Srivastava, Even Birkeland m.fl.:
    Author Correction: Early response evaluation by single cell signaling profiling in acute myeloid leukemia (Nature Communications, (2023), 14, 1, (115), 10.1038/s41467-022-35624-4)
    Nature Communications 2023 DOI
  • Berit Bang, Anett Kristin Larsen, Sampada Satchidanand Bhagwat, Nabin Malla, Ole Morten Seternes, Jan-Olof Winberg :
    Seafood proteases present in workplace bioaerosols – effects on inflammatory pathways in skin and airway cell models.
    2016
  • Berit Bang, Anett Kristin Larsen, Sampada Satchidanand Bhagwat, Nabin Malla, Ole Morten Seternes, Jan-Olof Winberg :
    Seafood proteases present in workplace bioaerosols – effects on inflammatory pathways in skin and airway cell models.
    2016
  • espen Åberg, Ole Morten Seternes, Richard Alan Engh, Franz Gruber :
    Fra Mutasjon til Medisin
    2013
  • Anett Kristin Larsen, Merethe Larsen, Ole Morten Seternes, Berit Bang :
    Proteases in Seafood as activators of inflammatory reactions in airway epithelial cells
    2011
  • Erik Knutsen, morten Andreassen, Tonje Fiskaa, anita Ursvik, Eiliv Lund, Ole Morten Seternes m.fl.:
    MiRNA expression profiling based on different high-throughput platforms reveals surprising variations
    2011
  • Steinar Daae Johansen, morten Andreassen, Igor Babiak, Teshome Bizuayehu, Dag-Hugo Coucheron, M. Raafat El-Gewely m.fl.:
    Investigating miRNAs and transcriptomes at our local SOLiD sequencing facility
    2011
  • maria Perander, Trine Stiberg, Lene Elisabeth Myhren, Espen Hansen, ole morten Seternes, Lars Herfindal m.fl.:
    Characterization of cytotoxic activities in extracts from two marine invertebrates
    2011
  • Anett Kristin Larsen, Berit Bang, Ole Morten Seternes :
    Proteases from seafood as activators of protease-activated receptor-2 in airway epithelial cells
    UiT Norges arktiske universitet 2010
  • Anett Kristin Larsen, Merethe Larsen, Ole Morten Seternes, Berit Bang :
    Protease-activated signal pathways in airway cells. Purified salmon trypsin activates Nuclear factor kappa-B and induces interleukin-8 secretion in human airway epithelial cells (A549)
    2007
  • Merethe Larsen, Berit Bang, ole morten Seternes, Anett K. Larsen :
    Protease-activated signal pathways in airway cells. Purified salmon trypsin activates nuclear factor kappa-B and induces interleukin-8 secretion in human airway epithelial cells (A549)
    Allergy. European Journal of Allergy and Clinical Immunology 2007
  • ole morten Seternes :
    The atypical MAP kinases ERK3 and 4 defines novel signaling pathways
    2006
  • ole morten Seternes :
    The atypical MAP kinases ERK3 and 4 defines novel signaling pathways
    2006
  • Espen Åberg, maria Perander, Bjarne Herold Johansen, Catherine Julien, Sylvain Meloche, Stephen M Keyse m.fl.:
    Regulation of MAPK-activated protein kinase 5 activity and subcellular localization by the atypical MAP kinase ERK4/MAPK4
    2006

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