Ingvild Mikkola
Professor
Stillingsbeskrivelse
Forskning og undervisning.
Undervisning av farmasi-, medisin- og biologistudenter i biokjemi på laveregrads-nivå. Veiledning av masterstudenter i farmasi og molekylærbiologi. Veiledning av PhD studenter.
Vitenskapelige arbeidsområder
Lisa Zeyen Øyås,
Ole Morten Seternes,
Ingvild Mikkola
:
Crosstalk between p38 MAPK and GR Signaling
Anup Shrestha,
Henrike Bruckmüller,
Hanne Kildalsen,
Gurjit Kaur,
Matthias Gaestel,
Hilde Ljones Wetting
m.fl.:
Phosphorylation of steroid receptor coactivator-3 (SRC-3) at serine 857 is regulated by the p38 MAPK-MK2 axis and affects NF-κB-mediated transcription
Roth Sarah Andrea,
Øyvind Holsbø Hald,
Steffen Fuchs,
Cecilie Løkke,
Ingvild Mikkola,
Trond Flægstad
m.fl.:
MicroRNA-193b-3p represses neuroblastoma cell growth via downregulation of Cyclin D1, MCL-1 and MYCN
Beate Hegge,
Eva Sjøttem,
Ingvild Mikkola
:
Generation of a PAX6 knockout glioblastoma cell line with changes in cell cycle distribution and sensitivity to oxidative stress
Seyed Mohammad Lellahi,
Ingrid Arctander Rosenlund,
Annica Hedberg,
Liv Torill Kiær,
Ingvild Mikkola,
Erik Knutsen
m.fl.:
The long noncoding RNA NEAT1 and nuclear paraspeckles are up-regulated by the transcription factor HSF1 in the heat shock response
Lars Peter Engeset Austdal,
Sigrid Bjørnstad,
Gro Haarklou Mathisen,
Petra Aden,
Ingvild Mikkola,
Ragnhild Elisabeth Paulsen
m.fl.:
Glucocorticoid effects on cerebellar development in a chicken embryo model: exploring changes in PAX6 and Metalloproteinase-9 after exposure to dexamethasone
Journal of neuroendocrinology 2016 DOI
Siri Forsdahl,
Yury Kiselev,
Rune Hogseth,
Janne erikke Mjelle,
Ingvild Mikkola
:
Pax6 regulates the expression of Dkk3 in murine and human cell lines, and altered responses to Wnt signaling are shown in Flpln-3T3 cells stably expressing either the Pax6 or the Pax6(5a) Isoform
Yury Kiselev,
Tonje Engevik Eriksen,
Siri Forsdahl,
Lan Nguyen,
ingvild Mikkola
:
3T3 cell lines stably expressing Pax6 or Pax6(5a)--a new tool used for identification of common and isoform specific target genes
Franz Gruber,
Tuija Lundan,
Rasmus Goll,
Aleksandra Silye,
Ingvild Mikkola,
Ole Petter Rekvig
m.fl.:
BCR-ABL isoforms associated with intrinsic or acquired resistance to imatinib: more heterogeneous than just ABL kinase domain point mutations?
Medical Oncology (MO) 2012 DOI
Franz Gruber,
Thomas Ernst,
Yury Kiselev,
A Hochhaus,
ingvild Mikkola
:
Detection of Drug-Resistant Clones in Chronic Myelogenous Leukemia Patients during Dasatinib and Nilotinib Treatment
Clinical Chemistry 2010 DOI
Thomas Ernst,
Franz Gruber,
Oliver Pelz-Ackermann,
J Maier,
M Pfirrmann,
MC Muller
m.fl.:
A co-operative evaluation of different methods of detecting BCR-ABL kinase domain mutations in patients with chronic myeloid leukemia on second-line dasatinib or nilotinib therapy after failure of imatinib
Jack-Ansgar Bruun,
Ernst I.s. Thomassen,
Kurt Kristiansen,
Garth Daryl Tylden,
Turid Holm,
Ingvild Mikkola
m.fl.:
The third helix of the homeodomain of paired class homeodomain proteins acts as a recognition helix both for DNA and protein interactions
Nucleic Acids Research (NAR) 2005 ARKIV
Ingvild Mikkola,
Barry Heavey,
Markus Horcher,
Meinrad Busslinger
:
Reversion of B Cell Commitment upon Loss of Pax5 Expression
Science 2002 DOI
Svanhild Nornes,
Michael Clarkson,
Ingvild Mikkola,
Marit Pedersen Delghandi,
Anne Bardsley,
Juan Pedro Martinez
m.fl.:
Zebrafish contains two Pax6 genes involved in eye development
Mechanisms of Development 1998
Svanhild Nornes,
Ingvild Mikkola,
Stefan Krauss,
Madjid Delghandi,
maria Perander,
Terje Johansen
:
Zebrafish Pax9 Encodes Two Proteins with Distinct C-terminal Transactivating Domains of Different Potency Negatively Regulated by Adjacent N-terminal Sequences
Journal of Biological Chemistry 1996
Rachel Macdonald,
K. Anukampa Barth,
Nigel Holder,
Ingvild Mikkola,
Stephen W. Wilson
:
Midline signalling is required for Pax gene regulation and patterning of the eyes
Development 1995
R. Macdonald,
Q. Xu,
A. Barth,
Ingvild Mikkola,
N. Holder,
Anders Fjose
m.fl.:
Regulatory gene expression boundaries demarcate sites of neuronal differentiation in the embryonic zebrafish forebrain
Neuron 1994
Ingvild Mikkola,
Anders Fjose,
John Y. Kuwada,
Stephen Wilson,
Per Henrik Guddal,
Stefan Krauss
:
The Paired Domain-Containing Nuclear Factor pax[b] Is Expressed in Specific Commissural lnterneurons in Zebrafish Embryos
Journal of Neurobiology 1992
Yury Kiselev,
Andrey Yurjevich Valkov,
Lill-Tove Busund,
Roy M. Bremnes,
Igor Snapkov,
Ingvild Mikkola
m.fl.:
Transcription factor PAX6 is expressed in human soft tissue sarcomas and confers negative impact on patients' survival
2014
Franz Gruber,
Thomas Ernst,
Kimmo Porkka,
Richard Alan Engh,
ingvild Mikkola,
Jacqueline Maier
m.fl.:
Dynamics of the emergence of dasatinib and nilotinib resistance in imatinib-resistant CML patients
Leukemia 2012 DOI
Franz Gruber,
H Hjorth-Hansen,
ingvild Mikkola,
L Stenke,
Terje Johansen
:
A novel Bcr-Abl splice isoform is associated with the L248V mutation in CML patients with acquired resistance to imatinib
Leukemia 2006
ingvild Mikkola
:
The quest for new target genes for the transcription factor Pax6
2005
ingvild Mikkola,
Rune Hogseth,
Terje Johansen
:
Chromatin Immunoprecipitation (ChIP) as a method for identification of new target genes for Pax6
2004
Ingvild Mikkola
:
Regulation of two members of of the Pax family of transcription factors; Involvement of alternative splicing, phosphorylation and protein-protein interactions
UiT Norges arktiske universitet 1999
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Forskningsinteresser
Transkripsjonsfaktoren Pax6 og de genene den regulerer, både normalt og ved sykdom (kreft).
CML, Bcr-Abl og resistens.
Zebrafisk som modellsystem.