1. Enheten
  2. Ansatte
  3. Ingvild Mikkola
Ingvild-Mikkola.jpg
Ingvild-Mikkola.jpg
Institutt for farmasi ingvild.mikkola@uit.no 77646643 480 30498 Tromsø FARM F2. 102

Mikkola, Ingvild

Professor

Stillingsbeskrivelse

Forskning og undervisning.

Undervisning av farmasi-, medisin- og biologistudenter i biokjemi på laveregrads-nivå. Veiledning av masterstudenter i farmasi og molekylærbiologi. Veiledning av PhD studenter.

Fagansvarlig for

  • Shrestha, Anup; Bruckmüller, Henrike; Kildalsen, Hanne; Kaur, Gurjit; Gaestel, Matthias; Ljones Wetting, Hilde; Mikkola, Ingvild; Seternes, Ole Morten. Phosphorylation of steroid receptor coactivator-3 (SRC-3) at serine 857 is regulated by the p38 MAPK-MK2 axis and affects NF-κB-mediated transcription. Scientific Reports 2020; Volum 10. ISSN 2045-2322.s doi: 10.1038/s41598-020-68219-4.
  • Sarah Andrea, Roth; Hald, Øyvind Holsbø; Fuchs, Steffen; Løkke, Cecilie; Mikkola, Ingvild; Flægstad, Trond; Schulte, Johannes; Einvik, Christer. MicroRNA-193b-3p represses neuroblastoma cell growth via downregulation of Cyclin D1, MCL-1 and MYCN. OncoTarget 2018; Volum 9 (26). ISSN 1949-2553.s 18160 - 18179.s doi: 10.18632/oncotarget.24793.
  • Lellahi, Seyed Mohammad; Rosenlund, Ingrid Arctander; Hedberg, Annica; Kiær, Liv Torill; Mikkola, Ingvild; Knutsen, Erik; Perander, Maria. The long noncoding RNA NEAT1 and nuclear paraspeckles are up-regulated by the transcription factor HSF1 in the heat shock response. Journal of Biological Chemistry 2018; Volum 293 (49). ISSN 0021-9258.s 18965 - 18976.s doi: 10.1074/jbc.RA118.004473.
  • Hegge, Beate; Sjøttem, Eva; Mikkola, Ingvild. Generation of a PAX6 knockout glioblastoma cell line with changes in cell cycle distribution and sensitivity to oxidative stress. BMC Cancer 2018; Volum 18 (1). ISSN 1471-2407.s doi: 10.1186/s12885-018-4394-6.
  • Austdal, Lars Peter Engeset; Bjørnstad, Sigrid; Mathisen, Gro Haarklou; Aden, Petra; Mikkola, Ingvild; Paulsen, Ragnhild Elisabeth; Rakkestad, Kirsten Eline. Glucocorticoid effects on cerebellar development in a chicken embryo model: exploring changes in PAX6 and Metalloproteinase-9 after exposure to dexamethasone. Journal of neuroendocrinology 2016; Volum 28 (12). ISSN 0953-8194.s doi: 10.1111/jne.12438.
  • Forsdahl, Siri; Kiselev, Yury; Hogseth, Rune; Mjelle, Janne erikke; Mikkola, Ingvild. Pax6 regulates the expression of Dkk3 in murine and human cell lines, and altered responses to Wnt signaling are shown in Flpln-3T3 cells stably expressing either the Pax6 or the Pax6(5a) Isoform. PLOS ONE 2014; Volum 9 (7). ISSN 1932-6203.s doi: 10.1371/journal.pone.0102559.
  • Gruber, Franz; Lundan, Tuija; Goll, Rasmus; Silye, Aleksandra; Mikkola, Ingvild; Rekvig, Ole Petter; Knuutila, S.; Remes, Kari; Gedde-Dahl, Thobias; Porkka, Kimmo; Hjorth-Hansen, Henrik. BCR-ABL isoforms associated with intrinsic or acquired resistance to imatinib: more heterogeneous than just ABL kinase domain point mutations?. Medical Oncology (MO) 2012; Volum 29 (1). ISSN 1357-0560.s 219 - 226.s doi: 10.1007/s12032-010-9781-z.
  • Kiselev, Yury; Eriksen, Tonje Engevik; Forsdahl, Siri; Nguyen, Lan; Mikkola, ingvild. 3T3 cell lines stably expressing Pax6 or Pax6(5a)--a new tool used for identification of common and isoform specific target genes. PLOS ONE 2012; Volum 7 (2). ISSN 1932-6203.s doi: 10.1371/journal.pone.0031915.
  • Gruber, Franz; Ernst, Thomas; Kiselev, Yury; Hochhaus, A; Mikkola, ingvild. Detection of Drug-Resistant Clones in Chronic Myelogenous Leukemia Patients during Dasatinib and Nilotinib Treatment. Clinical Chemistry 2010; Volum 56 (3). ISSN 0009-9147.s 469 - 473.s doi: 10.1373/clinchem.2009.133843.
  • Ernst, Thomas; Gruber, Franz; Pelz-Ackermann, Oliver; Maier, J; Pfirrmann, M; Muller, MC; Mikkola, ingvild; Porkka, Kimmo; Niederwieser, D; Hochhaus, A; Lange, T. A co-operative evaluation of different methods of detecting BCR-ABL kinase domain mutations in patients with chronic myeloid leukemia on second-line dasatinib or nilotinib therapy after failure of imatinib. Haematologica 2009; Volum 94 (9). ISSN 0390-6078.s 1227 - 1235.s doi: 10.3324/haematol.2009.006981.
  • Bruun, Jack-Ansgar; Thomassen, Ernst I.s.; Kristiansen, Kurt; Tylden, Garth Daryl; Holm, Turid; Mikkola, Ingvild; Bjørkøy, Geir; Johansen, Terje. The third helix of the homeodomain of paired class homeodomain proteins acts as a recognition helix both for DNA and protein interactions. Nucleic Acids Research (NAR) 2005; Volum 33. ISSN 0305-1048.
  • Mikkola, Ingvild; Heavey, Barry; Horcher, Markus; Busslinger, Meinrad. Reversion of B Cell Commitment upon Loss of Pax5 Expression. Science 2002; Volum 297 (5578). ISSN 0036-8075.s 110 - 113.s doi: 10.1126/science.1067518.
  • Nornes, Svanhild; Clarkson, Michael; Mikkola, Ingvild; Delghandi, Marit Pedersen; Bardsley, Anne; Martinez, Juan Pedro; Krauss, Stefan; Johansen, Terje. Zebrafish contains two Pax6 genes involved in eye development. Mechanisms of Development 1998; Volum 77. ISSN 0925-4773.s 185 - 196.
  • Nornes, Svanhild; Mikkola, Ingvild; Krauss, Stefan; Delghandi, Madjid; Perander, maria; Johansen, Terje. Zebrafish Pax9 Encodes Two Proteins with Distinct C-terminal Transactivating Domains of Different Potency Negatively Regulated by Adjacent N-terminal Sequences. Journal of Biological Chemistry 1996; Volum 271 (43). ISSN 0021-9258.s 26914 - 26923.
  • Macdonald, Rachel; Barth, K. Anukampa; Holder, Nigel; Mikkola, Ingvild; Wilson, Stephen W.. Midline signalling is required for Pax gene regulation and patterning of the eyes. Development 1995; Volum 121. ISSN 0950-1991.s 3267 - 3278.
  • Macdonald, R.; Xu, Q.; Barth, A.; Mikkola, Ingvild; Holder, N.; Fjose, Anders; Krauss, Stefan; Wilson, S. W.. Regulatory gene expression boundaries demarcate sites of neuronal differentiation in the embryonic zebrafish forebrain. Neuron 1994; Volum 13. ISSN 0896-6273.s 1039 - 1053.
  • Mikkola, Ingvild; Fjose, Anders; Kuwada, John Y.; Wilson, Stephen; Guddal, Per Henrik; Krauss, Stefan. The Paired Domain-Containing Nuclear Factor pax[b] Is Expressed in Specific Commissural lnterneurons in Zebrafish Embryos. Journal of Neurobiology 1992; Volum 23 (8). ISSN 0022-3034.s 933 - 946.
  • Kiselev, Yury; Valkov, Andrey Yurjevich; Busund, Lill-Tove; Bremnes, Roy M.; Snapkov, Igor; Mikkola, Ingvild; Kilvær, Thomas Karsten; Sorbye, SW; Smeland, Eivind; Dønnem, Tom. Transcription factor PAX6 is expressed in human soft tissue sarcomas and confers negative impact on patients' survival. American Association of Cancer Research Annual Conference 2014-04-06 - 2014-04-07 2014.
  • Gruber, Franz; Ernst, Thomas; Porkka, Kimmo; Engh, Richard Alan; Mikkola, ingvild; Maier, Jacqueline; Lange, Thoralf; Hochhaus, Andreas. Dynamics of the emergence of dasatinib and nilotinib resistance in imatinib-resistant CML patients. Leukemia 2012; Volum 26 (1). ISSN 0887-6924.s 172 - 177.s doi: 10.1038/leu.2011.187.
  • Gruber, Franz; Hjorth-Hansen, H; Mikkola, ingvild; Stenke, L; Johansen, Terje. A novel Bcr-Abl splice isoform is associated with the L248V mutation in CML patients with acquired resistance to imatinib. Leukemia 2006; Volum 20 (11). ISSN 0887-6924.s 2057 - 2060.
  • Mikkola, ingvild. The quest for new target genes for the transcription factor Pax6. Foredrag ved NTNU 2005-01-01 - 2005.
  • Mikkola, ingvild; Hogseth, Rune; Johansen, Terje. Chromatin Immunoprecipitation (ChIP) as a method for identification of new target genes for Pax6. The 6th EMBL Transcription meeting 2004-01-01 - 2004.
  • Mikkola, Ingvild. Regulation of two members of of the Pax family of transcription factors; Involvement of alternative splicing, phosphorylation and protein-protein interactions. 1999.
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    Forskningsinteresser

    Transkripsjonsfaktoren Pax6 og de genene den regulerer, både normalt og ved sykdom (kreft).

    CML, Bcr-Abl og resistens.

    Zebrafisk som modellsystem.


    Medlem i forskergruppe

    Cell Signalling and Targeted therapy   English content
    FARM F2. 102