Personkort bilde

Hilde Hansen

Forsker, Biomolekylær og strukturkjemi Institutt for kjemi
Engelsk flaggikon Samisk flaggikon

Microbiology, Virology, Host-pathogen interactions, Molecular biology and biotechnology

 

Main research activities

My recent research has mainly focused on studying quorum sensing (QS) in the marine, pathogenic bacteria Aliivibiro salmonicida. QS is a cell-to-cell signaling system that enables bacterial populations to collectively regulate gene expression in response to cell density and thus coordinate group behaviors. Our study shows that A. salmonicida produces eight different QS signal molecules (N-acyl-homoserine lactones) to regulate activities such as biofilm formation, colony morphology, motility, and virulence amongst others. A. salmonicida causes disease in the Atlantic salmon only during winter seasons when the sea temperature is low, and our studies show that temperature is an important environmental factor for QS in this bacteria.

The most recent project I have focused on explores the potential of using Arctic, marine bacteria as bioplastics producers. When grow in an environment with nutrient imbalance, many bacteria can store carbon as polyhydroxyalkonates (PHA), a fully biodegradable biopolyester. These carbon storages are visible as large granules in the cytoplasm. Based on the presence of pha synthase genes we have selected and screened different marine proteobacteria for their ability to produce PHA. Several promising candidates have been identified and shown to produce intracellular PHA granules.

My MSc and PhD work was within the field of virology where I studied orthopoxviruses. The aims were to study distribution of orthopoxviruses within the Norwegian fauna, to characterize cowpox viruses isolated from Fennoscandinavia and to study risks associated with using genetically modified orthopoxviruses as vaccine vectors.

 

Research projects

MarPlast (2017-2020) Marine microorganisms for bioplastics production (WP-leader)

MarVal From unexploited marine biomass to high value products (Researcher)

  • Khider, Miriam; Hjerde, Erik; Hansen, Hilde; Willassen, Nils Peder. Differential expression profiling of ΔlitR and ΔrpoQ mutants reveals insight into QS regulation of motility, adhesion and biofilm formation in Aliivibrio salmonicida. BMC Genomics 2019; Volum 20. ISSN 1471-2164.s 1 - 18.s doi: 10.1186/s12864-019-5594-4.

  • Khider, Miriam; Hansen, Hilde; Hjerde, Erik; Johansen, Jostein a; Willassen, Nils Peder. Exploring the transcriptome of luxI- and ΔainS mutants and the impact of N-3-oxo-hexanoyl-L- and N-3-hydroxy- decanoyl-L-homoserine lactones on biofilm formation in Aliivibrio salmonicida. PeerJ 2019; Volum 2019. ISSN 2167-8359.s doi: 10.7717/peerj.6845.

  • Khider, Miriam; Willassen, Nils Peder; Hansen, Hilde. The alternative sigma factor RpoQ regulates colony morphology, biofilm formation and motility in the fish pathogen Aliivibrio salmonicida. (fulltekst) BMC Microbiology 2018; Volum 18. ISSN 1471-2180.s doi: 10.1186/s12866-018-1258-9.

  • Thode, Sunniva Katharina; Bækkedal, Cecilie; Johansson Söderberg, Jenny; Hjerde, Erik; Hansen, Hilde; Haugen, Peik. Construction of a fur null mutant and RNA-sequencing provide deeper global understanding of the Aliivibrio salmonicida Fur regulon. PeerJ 2017. ISSN 2167-8359.s 1 - 24.s doi: 10.7717/peerj.3461.

  • Hansen, Hilde; Purohit, Amit Anand; Leiros, Hanna-Kirsti S.; Johansen, Jostein; Kellermann, Stefanie J.; Bjelland, Ane Mohn; Willassen, Nils Peder. The autoinducer synthases LuxI and AinS are responsible for temperature-dependent AHL production in the fish pathogen Aliivibrio salmonicida. BMC Microbiology 2015; Volum 15 (69). ISSN 1471-2180.s doi: 10.1186/s12866-015-0402-z.

  • Hansen, Hilde; Johansen, Jostein a; Leiros, Hanna-Kirsti S.; Purohit, Amit Anand; Willassen, Nils Peder; Bjelland, Ane Mohn; Kellermann, Stefanie J.. The autoinducer synthases LuxI and AinS are responsible for temperature-dependent AHL production in the fish pathogen Aliivibrio salmonicida. BMC Microbiology 2015. ISSN 1471-2180.s doi: 10.1186/s12866-015-0402-z.

  • Thode, Sunniva Katharina; Kahlke, Tim; Robertsen, Espen Mikal; Hansen, Hilde; Haugen, Peik. The immediate global responses of Aliivibrio salmonicida to iron limitations. BMC Microbiology 2015; Volum 15 (9). ISSN 1471-2180.s doi: 10.1186/s12866-015-0342-7.

  • Hansen, Hilde; Bjelland, Ane Mohn; Pain, Maria; Robertsen, Espen Mikal; Willassen, Nils Peder. LitR Is a Repressor of syp Genes and Has a Temperature-Sensitive Regulatory Effect on Biofilm Formation and Colony Morphology in Vibrio (Aliivibrio) salmonicida. Applied and Environmental Microbiology 2014; Volum 80 (17). ISSN 0099-2240.s 5530 - 5541.s doi: 10.1128/AEM.01239-14.

  • Purohit, Amit Anand; Johansen, Jostein a; Hansen, Hilde; Leiros, Hanna-Kirsti S.; Kashulin, Alexander; Karlsen, Christian; Smalås, Arne O.; Haugen, Peik; Willassen, Nils Peder. Presence of acyl-homoserine lactones in 57 members of the Vibrionaceae family. Journal of Applied Microbiology 2013; Volum 115 (3). ISSN 1364-5072.s 835 - 847.s doi: 10.1111/jam.12264.

  • Okeke, malachy ifeanyi; Hansen, Hilde; Traavik, Terje. A naturally occurring cowpox virus with an ectromelia virus A-type inclusion protein gene displays atypical A-type inclusions. Infection, Genetics and Evolution 2012; Volum 12 (1). ISSN 1567-1348.s 160 - 168.s doi: 10.1016/j.meegid.2011.09.017.

  • Ahmad, Rafi; Hansen, Geir Åsmund; Hansen, Hilde; Hjerde, Erik; Pedersen, hege lynum; Paulsen, steinar; Nyrud, May Liss Julianne; Strauss, Anja; Willassen, Nils Peder; Haugen, Peik. Prediction, microarray and northern blot analyses identify new intergenic small RNAs in aliivibrio salmonicida. Journal of Molecular Microbiology and Biotechnology 2012; Volum 22 (6). ISSN 1464-1801.s 352 - 360.s doi: 10.1159/000345769.

  • Bjelland, Ane Mohn; Sørum, Henning; Tegegne, Daget Ayana; Winther-Larsen, Hanne Cecilie; Willassen, Nils Peder; Hansen, Hilde. LitR of Vibrio salmonicida Is a Salinity-Sensitive Quorum-Sensing Regulator of Phenotypes Involved in Host Interactions and Virulence. Infection and Immunity 2012; Volum 80 (5). ISSN 0019-9567.s 1681 - 1689.s doi: 10.1128/IAI.06038-11.

  • Bjelland, Ane Mohn; Johansen, Renate; Brudal, Espen; Hansen, Hilde; Winther-Larsen, Hanne Cecilie; Sørum, Henning. Vibrio salmonicida pathogenesis analyzed by experimental challenge of Atlantic salmon (Salmo salar). Microbial Pathogenesis 2012; Volum 52 (1). ISSN 0882-4010.s 77 - 84.s doi: 10.1016/j.micpath.2011.10.007.

  • Johansen, Steinar D.; Emblem, Åse; Karlsen, Bård Ove; Okkenhaug, Siri; Hansen, Hilde; Moum, Truls; Coucheron, Dag-Hugo; Seternes, ole morten. Approaching marine bioprospecting in hexacorals by RNA deep sequencing. New Biotechnology 2010; Volum 27 (3). ISSN 1871-6784.s 267 - 275.s doi: 10.1016/j.nbt.2010.02.019.

  • Pedersen, hege lynum; Hjerde, erik; Paulsen, steinar; Hansen, Hilde; Olsen, Lotte; Thode, Sunniva Katharina; Dos Santos, Marcos Tadeu; Paulssen, Ruth H; Willassen, Nils P; Haugen, Peik. Global responses of Aliivibrio salmonicida to hydrogen peroxide as revealed by microarray analysis. Marine Genomics 2010; Volum 3. ISSN 1874-7787.s 193 - 200.s doi: 10.1016/j.margen.2010.10.002.

  • Hansen, Hilde; Okeke, Malachy Ifeanyi; Nilssen, Øivind; Traavik, Terje. Comparison and phylogenetic analysis of cowpox viruses isolated from cats and humans in Fennoscandia. Archives of Virology 2009; Volum 154 (8). ISSN 0304-8608.s 1293 - 1302.s doi: 10.1007/s00705-009-0442-5.

  • Winnenburg, Rainer; Urban, Martin; Beacham, Andrew; Baldwin, Thomas K; Holland, Sabrina; Lindeberg, Magdalen; Hansen, Hilde; Rawlings, Christopher; Hammond-Kosack, Kim E; Kohler, Jacob Tilman. PHI-base update: additions to the pathogen-host interaction database. Nucleic Acids Research (NAR) 2008; Volum 36. ISSN 0305-1048.s D572 - D576.s doi: 10.1093/nar/gkm858.

  • Rinaldo, Christine H; Hansen, Hilde; Traavik, Terje I. Human endothelial cells allow passage of an archetypal BK virus (BKV) strain - a tool for cultivation and functional studies of natural BKV strains. Archives of Virology 2005; Volum 150. ISSN 0304-8608.s 1449 - 1458.

  • Åsbakk, Kjetil; Stuen, Snorre; Hansen, Hilde; Forbes, Lorry. A serological survey for brucellosis in reindeer in Finnmark county, northern Norway. Rangifer 1999; Volum 19 (1). ISSN 0333-256X.s 19 - 24.

  • Chiciudean, Iulia; Mereuta, Ioana; Mihalachi, Elena Luiza; Lascu, Irina; Avramescu, Sorin Marius; Jablonski, Piotr; Christensen, Mikkel; Hansen, Hilde; Stoica, Ileana; Tanase, Ana Maria. Halotolerant Black Sea bacteria for bioplastics production. "Halophiles 2019" - 12th International Conference on Halophilic Microorganisms 2019-06-24 - 2019-06-28 2019.

  • Hansen, Hilde; Altermark, Bjørn; Christensen, Mikkel. Confronting Plastic Pollution With Bacteria. (fulltekst) Journal of the North Atlantic & Arctic 2019.

  • Hansen, Hilde; Altermark, Bjørn; Christensen, Mikkel. Confronting one of our greatest challenges – plastic waste in nature. (fulltekst) Fram Forum 2019. ISSN 1893-5532.s 42 - 45.

  • Hansen, Hilde. Naturens små plastfabrikker. Kjemikonferansen 2019-03-14 - 2019-03-15 2019.

  • Christensen, Mikkel; Jablonski, Piotr; Pandur, Seila; Assefa, Netsanet Gizaw; Altermark, Bjørn; Hansen, Hilde. Investigation of promising bioplastic producing Arctic marine bacteria from the Halomonadacea family. The 3rd annual BioCat conference 2019-06-05 - 2019-06-07 2019.

  • Assefa, Netsanet Gizaw; Christensen, Mikkel; Pandur, Seila; Altermark, Bjørn; Hansen, Hilde. Conversion of renewable feedstocks into bioplastics by Arctic marine bacteria. BIOPROSP_19 2019-02-25 - 2019-02-27 2019.

  • Ræder, Inger Lin Uttakleiv; Altermark, Bjørn; Hansen, Hilde. Rester fra fiskeri blir bioplast, kosmetikk og kosttilskudd. Forskning.no 2019. ISSN 1891-635X.

  • Christensen, Mikkel; Jablonski, Piotr; Pandur, Seila; Assefa, Netsanet Gizaw; Altermark, Bjørn; Hansen, Hilde. Arctic marine bacteria for bioplastic production. BioCat 2018 conference 2018-06-04 - 2018-06-06 2018.

  • Altermark, Bjørn; Hansen, Hilde; Pandur, Seila. Framtidas plast kan spises. Klassekampen 2017. ISSN 0805-3839.s 10 - 11.

  • Hansen, Hilde. Bruk og kast med god samvittighet! Bakterier fra havet blir engangsbestikk.. Senioruniversitetet Tromsø (omtale) 2017-02-22 - 2017.

  • Christensen, Mikkel; Altermark, Bjørn; Assefa, Netsanet Gizaw; Pandur, Seila; Smalås, Arne O.; Hansen, Hilde. Arctic, marine bacteria and their ability to produce polyhydroxyalkonates (PHAs) using underexploited biomass as nutrient source. 1st annual BioCat Meeting 2017-06-12 - 2017-06-14 2017.

  • Assefa, Netsanet Gizaw; Hansen, Hilde; Altermark, Bjørn; Pandur, Seila; Smalås, Arne O.. Biodegradable and sustainable plastics from marine bacteria. NBS kontaktmøte 2017-01-19 - 2017-01-22 2017.

  • Altermark, Bjørn; Hansen, Hilde; Pandur, Seila. Bakterier blir engangsbestikk. Kunnskapsmagasinet Labyrint 2016; Volum 2.s 19 - 19.

  • Khider, Miriam; Haugen, Peik; Hansen, Hilde; Willassen, Nils Peder. Development of an expression host for cold-adapted enzymes. NorStruct Annual seminar 2014 2014-01-09 - 2014-01-10 2014.

  • Khider, Miriam; Haugen, Peik; Hansen, Hilde; Willassen, Nils Peder. Cloning and Characteriza0on of PUFA operon form Shewanella, with focus on EPA and DHA production in Aliivibrio wodanis. BioStruct Annual Conferance 2014 2014-08-28 - 2014-08-31 2014.

  • Klein, Jörn; Hansen, Hilde; Tryland, Morten. Characterisation of Norwegian reindeer parapoxvirus isolates. A comparative study. European Society of Clinical Virology Winter meeting; Diagnosis and Treatment of Viral Diseases 2004-01-15 - 2004-01-17 2004.

  • Chiciudean, Iulia; Mereuta, Ioana; Mihalachi, Elena Luiza; Lascu, Irina; Avramescu, Sorin Marius; Jablonski, Piotr; Christensen, Mikkel; Hansen, Hilde; Stoica, Ileana; Tanase, Ana Maria. Halotolerant Black Sea bacteria for bioplastics production. "Halophiles 2019" - 12th International Conference on Halophilic Microorganisms 2019-06-24 - 2019-06-28 2019.

  • Hansen, Hilde; Altermark, Bjørn; Christensen, Mikkel. Confronting Plastic Pollution With Bacteria. (fulltekst) Journal of the North Atlantic & Arctic 2019.

  • Hansen, Hilde; Altermark, Bjørn; Christensen, Mikkel. Confronting one of our greatest challenges – plastic waste in nature. (fulltekst) Fram Forum 2019. ISSN 1893-5532.s 42 - 45.

  • Hansen, Hilde. Naturens små plastfabrikker. Kjemikonferansen 2019-03-14 - 2019-03-15 2019.

  • Christensen, Mikkel; Jablonski, Piotr; Pandur, Seila; Assefa, Netsanet Gizaw; Altermark, Bjørn; Hansen, Hilde. Investigation of promising bioplastic producing Arctic marine bacteria from the Halomonadacea family. The 3rd annual BioCat conference 2019-06-05 - 2019-06-07 2019.

  • Assefa, Netsanet Gizaw; Christensen, Mikkel; Pandur, Seila; Altermark, Bjørn; Hansen, Hilde. Conversion of renewable feedstocks into bioplastics by Arctic marine bacteria. BIOPROSP_19 2019-02-25 - 2019-02-27 2019.

  • Ræder, Inger Lin Uttakleiv; Altermark, Bjørn; Hansen, Hilde. Rester fra fiskeri blir bioplast, kosmetikk og kosttilskudd. Forskning.no 2019. ISSN 1891-635X.

  • Christensen, Mikkel; Jablonski, Piotr; Pandur, Seila; Assefa, Netsanet Gizaw; Altermark, Bjørn; Hansen, Hilde. Arctic marine bacteria for bioplastic production. BioCat 2018 conference 2018-06-04 - 2018-06-06 2018.

  • Altermark, Bjørn; Hansen, Hilde; Pandur, Seila. Framtidas plast kan spises. Klassekampen 2017. ISSN 0805-3839.s 10 - 11.

  • Hansen, Hilde. Bruk og kast med god samvittighet! Bakterier fra havet blir engangsbestikk.. Senioruniversitetet Tromsø (omtale) 2017-02-22 - 2017.

  • Christensen, Mikkel; Altermark, Bjørn; Assefa, Netsanet Gizaw; Pandur, Seila; Smalås, Arne O.; Hansen, Hilde. Arctic, marine bacteria and their ability to produce polyhydroxyalkonates (PHAs) using underexploited biomass as nutrient source. 1st annual BioCat Meeting 2017-06-12 - 2017-06-14 2017.

  • Assefa, Netsanet Gizaw; Hansen, Hilde; Altermark, Bjørn; Pandur, Seila; Smalås, Arne O.. Biodegradable and sustainable plastics from marine bacteria. NBS kontaktmøte 2017-01-19 - 2017-01-22 2017.

  • Altermark, Bjørn; Hansen, Hilde; Pandur, Seila. Bakterier blir engangsbestikk. Kunnskapsmagasinet Labyrint 2016; Volum 2.s 19 - 19.

  • Khider, Miriam; Haugen, Peik; Hansen, Hilde; Willassen, Nils Peder. Development of an expression host for cold-adapted enzymes. NorStruct Annual seminar 2014 2014-01-09 - 2014-01-10 2014.

  • Khider, Miriam; Haugen, Peik; Hansen, Hilde; Willassen, Nils Peder. Cloning and Characteriza0on of PUFA operon form Shewanella, with focus on EPA and DHA production in Aliivibrio wodanis. BioStruct Annual Conferance 2014 2014-08-28 - 2014-08-31 2014.

  • Klein, Jörn; Hansen, Hilde; Tryland, Morten. Characterisation of Norwegian reindeer parapoxvirus isolates. A comparative study. European Society of Clinical Virology Winter meeting; Diagnosis and Treatment of Viral Diseases 2004-01-15 - 2004-01-17 2004.

  • Publications not listed in CRIStin

    Hansen H, Okeke MI, Nilssen Ø, Traavik T (2004). Recombinant viruses obtained from co-infection in vitro with a live vaccinia-vectored influenza vaccine and a naturally occurring cowpox virus display different plaque phenotypes and loss of the transgene. Vaccine 23(4):499-506.

    Hansen H, Sandvik T, Tryland M, Olsvik Ø, Traavik T (1999). Comparison of thymidine kinase and A-type inclusion protein gene sequences from Norwegian and Swedish cowpox virus isolates. APMIS 107(7):667-75.

    Sandvik T, Tryland M, Hansen H, Mehl R, Moens U, Olsvik Ø, Traavik T (1998). Naturally occurring orthopoxviruses: potential for recombination with vaccine vectors. J Clin Microbiol. 36(9):2542-7.

    Tryland M, Sandvik T, Hansen H, Haukenes G, Holtet L, Bennett M, Mehl R, Moens U, Olsvik Ø, Traavik T (1998). Characteristics of four cowpox virus isolates from Norway and Sweden. APMIS 106(6):623-35.

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