Ingebrigt Sylte
Professor, forskningsgruppeleder,
Ingebrigt Sylte,
Mari Gabrielsen,
kurt Kristiansen
:
Homology Modeling of Transporter Proteins
Methods in molecular biology 2023 DOI
Kyohei Imai,
Rysouke Saito,
Takyua Ezawa,
Satoshi Sugiyama,
Ingebrigt Sylte,
Noriyuki Kurita
:
Proposal of selective inhibitor for bacterial zinc metalloprotease: Molecular mechanics and ab initio molecular orbital calculations
Fatema Rahman,
Tra-Mi Nguyen,
Olayiwola Adekoya,
Cristina Campestre,
Paolo Tortorella,
Ingebrigt Sylte
m.fl.:
Inhibition of bacterial and human zincmetalloproteases
by bisphosphonate- and catechol-containing compounds
Fatema Rahman,
Imin Wushur,
Nabin Malla,
Ove Alexander Høgmoen Åstrand,
Pål Rongved,
Jan-Olof Winberg
m.fl.:
Zinc-Chelating Compounds as Inhibitors of Human and Bacterial Zinc Metalloproteases
Ryosuke Saito,
Kyohei Imai,
Shohei Yamamoto,
Takuya Ezawa,
Satohsi Sugiyama,
Linn Evenseth
m.fl.:
Specific interactions between the alkaline protease of P. aeruginosa and its natural peptide inhibitor: ab initio molecular simulations
Takuya Ezawa,
Ryosuke Saito,
Shusuke Suzuki,
Satoshi Sugiyama,
Ingebrigt Sylte,
Noriyuki Kurita
:
Protonation states of central amino acids in a zinc metalloprotease complexed with inhibitor: Molecular mechanics optimizations and ab initio molecular orbital calculations
Rangita Dawadi,
Nabin Malla,
Beate Hegge,
Imin Wushur,
Eli Berg,
Gunbjørg Svineng
m.fl.:
Molecular Interactions Stabilizing the Promatrix Metalloprotease-9·Serglycin Heteromer
Linn Evenseth,
Riccardo Ocello,
Mari Gabrielsen,
Matteo Masetti,
Maurizio Recanatini,
Ingebrigt Sylte
m.fl.:
Exploring Conformational Dynamics of the Extracellular Venus flytrap Domain of the GABA B Receptor: A Path-Metadynamics Study
Linn Evenseth,
Mari Gabrielsen,
Ingebrigt Sylte
:
The GABAB Receptor—Structure, Ligand Binding and Drug Development
Åse-Karen Mortensen,
Silje Mæhre,
kurt Kristiansen,
Eldbjørg Sofie Heimstad,
Geir W. Gabrielsen,
Bjørn Munro Jenssen
m.fl.:
Homology modeling to screen for potential binding of contaminants to thyroid hormone receptor and transthyretin in glaucous gull (Larus hyperboreus) and herring gull (Larus argentatus)
Linn Evenseth,
Dawid Warszycki,
Andrzej J Bojarski,
Mari Gabrielsen,
Ingebrigt Sylte
:
In Silico Methods for the Discovery of Orthosteric GABAB Receptor Compounds
Marthe Fredheim Fjelldal,
Thibaud Freyd,
Linn Evenseth,
Ingebrigt Sylte,
Avi Ring,
Ragnhild Elisabeth Paulsen
:
Exploring the overlapping binding sites of ifenprodil and EVT‐101 in GluN2B‐containing NMDA receptors using novel chicken embryo forebrain cultures and molecular modeling
Linn M Evenseth,
Kurt Kristiansen,
You Song,
Knut Erik Tollefsen,
Ingebrigt Sylte
:
In silico site-directed mutagenesis of the Daphnia magna ecdysone receptor identifies critical amino acids for species-specific and inter-species differences in agonist binding
Liv Henriette Arnesen,
Nadia Haj Yasein,
Jørn Eivind Tungen,
Helen Södling,
Jason Matthews,
Steinar M Paulsen
m.fl.:
Molecular modelling, synthesis, and biological evaluations of a 3,5-disubstituted isoxazole fatty acid analogue as a PPARα-selective agonist
Takuya Ezawa,
Satoshi Sugiyama,
Ayami Ara,
Ingebrigt Sylte,
Noriyuki Kurita
:
Design of galardine analogs as putative psudolysin inhibitors based on ab initio fragment molecular orbital calculations
Katie L. Hill,
Åse-Karen Mortensen,
Daniel Teclechiel,
William G. Willmore,
Ingebrigt Sylte,
Bjørn Munro Jenssen
m.fl.:
In Vitro and in Silico Competitive Binding of Brominated Polyphenyl Ether Contaminants with Human and Gull Thyroid Hormone Transport Proteins
Ingebrigt Sylte,
Rangita Dawadi,
Nabin Malla,
Susannah von Hofsten,
Tra-Mi Nguyen,
Ann Iren Solli
m.fl.:
The selectivity of galardin and an azasugar-based hydroxamate compound for human Matrix metalloproteases and bacterial metalloproteases
Jon A. Doering,
Sehan Lee,
kurt Kristiansen,
Linn Evenseth,
Ingebrigt Sylte,
Mace G. Barron
m.fl.:
In silico site-directed mutagenesis informs species-specific predictions of chemical susceptibility derived from the Sequence Alignment to Predict Across Species Susceptibility (SeqAPASS) tool
Toxicological Sciences 2018 DOI
Nora Al-Kazaale,
Phuong Dan Dinh Tran,
Farhad Haidari,
Eirik Johansson Solum,
Sandra Liekens,
Peter Vervaeke
m.fl.:
Synthesis, molecular modeling and biological evaluation of potent analogs of 2-methoxyestradiol
Steroids 2018 DOI
Thibaud Freyd,
Dawid Warszycki,
Stefan Mordalski,
Andrzej J Bojarski,
Ingebrigt Sylte,
Mari Gabrielsen
:
Ligand-guided homology modelling of the GABA<sub>B2</sub> subunit of the GABA<sub>B</sub> receptor
Ayami Ara,
Ryushi Kadoya,
Hiromi Ishimura,
Kanako Shimamura,
Ingebrigt Sylte,
Noriyuki Kurita
:
Specific interactions between zinc metalloproteinase and its inhibitors: Ab initio fragment molecular orbital calculations
Journal of Molecular Graphics and Modelling 2017 DOI
Dawid Warszycki,
Manuel Rueda,
Stefan Mordalski,
kurt Kristiansen,
Grzegorz Satala,
Krzysztof Rataj
m.fl.:
From Homology Models to a Set of Predictive Binding Pockets-a 5-HT<sub>1A</sub> Receptor Case Study
Journal of Chemical Information and Computer Sciences 2017 DOI
Elvar Örn Viktorsson,
Mari Gabrielsen,
Nugalya Kumarachandran,
Ingebrigt Sylte,
Pål Rongved,
Ove Alexander Høgmoen Åstrand
m.fl.:
Regulation of liver X receptor target genes by 22-functionalized oxysterols. Synthesis, in silico and in vitro evaluations
Steroids 2017 DOI
Zdzislaw Chilmonczyk,
Andrzej J. Bojarski,
Andrzej Pilc,
Ingebrigt Sylte
:
Serotonin transporter and receptor ligands with antidepressant activity as neuroprotective and proapoptotic agents
Pharmacological Reports 2017 DOI
Ove Alexander Høgmoen Åstrand,
Elvar Örn Viktorsson,
Aleksander Lim Kristensen,
Dag Ekeberg,
Hanne Røberg-Larsen,
Steven Ray Haakon Wilson
m.fl.:
Synthesis, in vitro and in vivo biological evaluation of new oxysterols as modulators of the liver X receptors
Stian Sjøli,
Elisa Nuti,
Caterina Camodeca,
Irina Bilto,
Armando Rossello,
Jan-Olof Winberg
m.fl.:
Synthesis, experimental evaluation and molecular modelling of hydroxamate derivatives as zinc metalloproteinase inhibitors
Heli Anna Irmeli Routti,
Roger Lille-Langøy,
Mari Katrine Berg,
Trine Fink,
Mikael Harju,
Kurt Kristiansen
m.fl.:
Environmental chemicals modulate polar bear (Ursus maritimus) Peroxisome Proliferator-Activated Receptor Gamma (PPARG) and adipogenesis in vitro
Environmental Science and Technology 2016 DOI
Odutayo O. Odunuga,
Olayiwola Adekoya,
Ingebrigt Sylte
:
High-level expression of pseudolysin, the extracellular elastase of Pseudomonas aeruginosa, in Escherichia coli and its purification
Protein Expression and Purification 2015 DOI
Eirik Johansson Solum,
Jing-Jy Cheng,
Ingebrigt Sylte,
Anders Vik,
Trond Vidar Hansen
:
Synthesis, biological evaluation and molecular
modeling of new analogs of the anti-cancer agent
2-methoxyestradiol: potent inhibitors of
angiogenesis
Åsmund Kaupang,
Steinar Martin Paulsen,
Calin Constantin Steindal,
Aina Westrheim Ravna,
Ingebrigt Sylte,
Trine Grønhaug Halvorsen
m.fl.:
Synthesis, biological evaluation and molecular modeling studies of the PPARβ/δ antagonist CC618
Zdzislaw Chilmonczyk,
Andrzej Jacek Bojarski,
Andrzej Pilc,
Ingebrigt Sylte
:
Functional selectivity and antidepressant activity of serotonin 1A receptor ligands
Imin Wushur,
Ingebrigt Sylte,
Jan-Olof Winberg
:
The catalytic reaction mechanism of drosophilid alcohol dehydrogenases
Ove Alexander Høgmoen Åstrand,
Marcel Sandberg,
Ingebrigt Sylte,
Carl Henrik Gorbitz,
G. Hege Thoresen,
Eili Tranheim Kase
m.fl.:
Synthesis and initial biological evaluation of new mimics of the LXR-modulator 22(S)-hydroxycholesterol
Bioorganic & Medicinal Chemistry 2014 DOI
Ibrahim Jantan,
Syed Nasir Abbas Bukhari,
Olayiwola Adekoya,
Ingebrigt Sylte
:
Studies of synthetic chalcone derivatives as potential inhibitors of secretory phospholipase A<sub>2</sub>, cyclooxygenases, lipoxygenase and pro-inflammatory cytokines
Imin Wushur,
Jan-Olof Winberg,
Ingebrigt Sylte
:
Comparative molecular dynamic simulations of wild type and Thr114Val mutated Scaptodrosophila lebanonensis alcohol dehydrogenase
Journal of Biomolecular Structure and Dynamics 2014 DOI
Olayiwola Adekoya,
Stian Sjøli,
Imin Wushur,
Irina Bilto,
Sergio M Marques,
M Amelia Santos
m.fl.:
Inhibition of pseudolysin and thermolysin by hydroxamate-based MMP inhibitors
European Journal of Medicinal Chemistry 2014 DOI
Zdzislaw Chilmonczyk,
Andrzej J. Bojarski,
Ingebrigt Sylte
:
Ligand-directed traffickingof receptor stimulus
Pharmacological Reports 2014 DOI
Fatema Rahman,
Imin Wushur,
Ingebrigt Sylte,
Jan-Olof Winberg
:
Extracellular human and bacterial zinc metalloproteases – challenges in design of specific inhibitors
NBS-nytt 2021
Knut-Erik Tollefsen,
Marc Timothy David Cronin,
Linn Evenseth,
James W. Firman,
Taisen Iguchi,
Carlie Lalone
m.fl.:
Endocrine Disruption in crustaceans – a “new” environmental challenge?
2019
Knut Erik Tollefsen,
Marc Timothy David Cronin,
Øystein Evensen,
Linn Evenseth,
Francesco Falciani,
Taisen Iguchi
m.fl.:
AOP-informed assessment of Endocrine Disruption in freshwater crustaceans
2018
Knut Erik Tollefsen,
Marc Timothy David Cronin,
Linn Evenseth,
James W. Firman,
Taisen Iguchi,
Carlie Lalone
m.fl.:
AOP-informed chemical screening, prioritization and risk assessment of arthropod Endocrine Disruptors
2018
You Song,
Daniel L. Villeneuve,
Taisen Iguchi,
Thomas Rundberget,
Claire Mellor,
Marc Timothy David Cronin
m.fl.:
Development of invertebrate Adverse Outcome Pathways (AOPs) for mechanistically-based risk assessment
2017
You Song,
Daniel L. Villeneuve,
Taisen Iguchi,
Thomas Rundberget,
Claire Mellor,
Marc Timothy David Cronin
m.fl.:
Development of invertebrate Adverse Outcome Pathways (AOPs) for mechanistically-based risk assessment
2017
You Song,
Daniel L. Villeneuve,
Taisen Iguchi,
Neus Rodriguez-Sanchez,
Thomas Rundberget,
Claire Mellor
m.fl.:
Development of invertebrate Adverse Outcome Pathways (AOPs) for mechanistically-based risk assessment
2017
Thomas Sæther,
Angel Moldes-Anaya,
Jørn Eivind Tungen,
Anders Vik,
Steinar M Paulsen,
Ingebrigt Sylte
m.fl.:
Anti-diabetic activity from marine lipids: new anti-diabetic drugs
2016
Åse-Karen Mortensen,
Bjørn Munro Jenssen,
Geir W. Gabrielsen,
Ingebrigt Sylte,
Eldbjørg Sofie Heimstad
:
Competitive binding of persistent organic pollutants to the thyroid hormone transport protein transthyretin in Glaucous gull (Larus hypoerboreus)
2015
Thomas Sæther,
Angel Moldes-Anaya,
Jørn Eivind Tungen,
Anders Vik,
Steinar Martin Paulsen,
Ingebrigt Sylte
m.fl.:
Anti-diabetic activity from marine lipids: new anti-diabetic drugs
2015
You Song,
Mark T. Cronin,
Øystein Evensen,
Francesco Falciani,
Tore Høgåsen,
Taisen Iguchi
m.fl.:
Development of adverse outcome pathways for endocrine disruption in Daphnia magna
2014
You Song,
Philipp Antczak,
Mark T. Cronin,
Linn Evenseth,
Øystein Evensen,
Francesco Falciani
m.fl.:
Development of adverse outcome pathways for endocrine disruption in Daphnia magna
2014
You Song,
Mark T. Cronin,
Øystein Evensen,
Francesco Falciani,
Natalia Garcia-Reyero,
Tore Høgåsen
m.fl.:
EDRISK: Development of adverse outcome pathways for endocrine disruption in Daphnia magna
2014
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Forskningsinteresser
Reseptorer og transportproteiner i CNS som mål for legemidler
Molekylære mekanismer og inhibering av bakterielle og humane zink proteaser
Undervisning
Farmakologi
