Bilde av McCourt, Peter
Bilde av McCourt, Peter
Institutt for medisinsk biologi peter.mccourt@uit.no +4777646391 40281968 Tromsø MH L8.240 E

Peter McCourt


Professor


  • Karolina Szafranska, Tanja Neuman, Zbigniew Baster, Zenon Rajfur, Oskar Szelest, Christopher Florian Holte m.fl.:
    From fixed-dried to wet-fixed to live-comparative super-resolution microscopy of liver sinusoidal endothelial cell fenestrations
    Nanophotonics 2022 ARKIV / DOI
  • Nicholas J Hunt, Peter Anthony McCourt, Zdenka Kuncic, David G Le Couteur, Victoria C Cogger :
    Opportunities and Challenges for Nanotherapeutics for the Aging Population
    Frontiers in Nanotechnology 25. januar 2022 ARKIV / DOI
  • Elise Anne van Os, Laura Cools, Nathalie Eysackers, Karolina Szafranska, Ayla Smout, Stefaan Verhulst m.fl.:
    Modelling fatty liver disease with mouse liver-derived multicellular spheroids
    Biomaterials 2022 DOI
  • Barlomiej Zapotoczny, Karolina Szafranska, Malgorzata Lekka, Balpreet Singh Ahluwalia, Peter Anthony McCourt :
    Tuning of Liver Sieve: The Interplay between Actin and Myosin Regulatory Light Chain Regulates Fenestration Size and Number in Murine Liver Sinusoidal Endothelial Cells
    International Journal of Molecular Sciences 2022 DOI
  • Sabin Bhandari, Anett Kristin Larsen, Peter Anthony McCourt, Bård Smedsrød, Karen Kristine Sørensen :
    The scavenger function of liver sinusoidal endothelial cells in health and disease
    Frontiers in Physiology 11. oktober 2021 ARKIV / DOI
  • Anett Kristin Larsen, Jaione Simon-Santamaria, kjetil helge Elvevold, Bo Gøran Ericzon, Kim Erlend Mortensen, Peter Anthony McCourt m.fl.:
    Autofluorescence in freshly isolated adult human liver sinusoidal cells
    European journal of histochemistry 2021 ARKIV / DOI
  • Karolina Szafranska, Larissa Dorothea Kruse, Christopher Florian Holte, Peter Anthony McCourt, Bartlomiej Zapotoczny :
    The wHole Story About Fenestrations in LSEC
    Frontiers in Physiology 2021 ARKIV / DOI
  • Karolina Szafranska, Christopher Florian Holte, Larissa Dorothea Kruse, Hong Mao, Cristina Ionica Øie, Marek Symonski m.fl.:
    Quantitative analysis methods for studying fenestrations in liver sinusoidal endothelial cells. A comparative study
    Micron 2021 ARKIV / DOI
  • Ankit Butola, David Andre Coucheron, Karolina Szafranska, Azeem Ahmad, Hong Mao, Jean-Claude Tinguely m.fl.:
    Multimodal on-chip nanoscopy and quantitative phase imaging reveals the nanoscale morphology of liver sinusoidal endothelial cells
    Proceedings of the National Academy of Sciences of the United States of America 2021 ARKIV / FULLTEKST / DOI
  • Nicholas J. Hunt, Glen P Lockwood, Sun W. S. Kang, Lara Westwood, Christina Limantoro, Wojciech Chrzanowski m.fl.:
    Quantum Dot Nanomedicine Formulations Dramatically Improve Pharmacological Properties and Alter Uptake Pathways of Metformin and Nicotinamide Mononucleotide in Aging Mice
    ACS Nano 2021 ARKIV / DOI
  • Jean-Claude Tinguely, Steyer Anna Maria, Cristina Ionica Øie, Øystein Ivar Helle, Firehun Tsige Dullo, Randi Olsen m.fl.:
    Photonic-chip assisted correlative light and electron microscopy
    Communications Biology 2020 ARKIV / DOI
  • Matteo Boninsegna, Nikhil Jayakumar, Firehun Tsige Dullo, Peter Anthony McCourt, Thomas Rolf Huser, Balpreet Singh Ahluwalia m.fl.:
    Waveguide chip coupled with microfluidics enables super-resolution live-cell imaging
    Proceedings of SPIE, the International Society for Optical Engineering 2020 DOI
  • Sabin Bhandari, Ruomei Li, Jaione Simon-Santamaria, Peter Anthony McCourt, Steinar Daae Johansen, Bård Smedsrød m.fl.:
    Transcriptome and proteome profiling reveal complementary scavenger and immune features of rat liver sinusoidal endothelial cells and liver macrophages
    BMC Molecular and Cell Biology 2020 ARKIV / DOI
  • Nicholas J Hunt, Glen P Lockwood, Frank H. Le Couteur, Peter Anthony McCourt, Nidhi Singla, Sun Kang m.fl.:
    Rapid Intestinal Uptake and Targeted Delivery to the Liver Endothelium Using Orally Administered Silver Sulfide Quantum Dots.
    ACS Nano 2020 ARKIV / DOI
  • Cristina Ionica Øie, Deanna Wolfson, Tanji Yasunori, Gianina Dumitriu, Karen Kristine Sørensen, Peter Anthony McCourt m.fl.:
    Liver sinusoidal endothelial cells contribute to the uptake and degradation of entero bacterial viruses.
    Scientific Reports 2020 ARKIV / DOI
  • Jean-Claude Tinguely, Steyer Anna Maria, Cristina Ionica Øie, Øystein Ivar Helle, Firehun Tsige Dullo, Randi Olsen m.fl.:
    Photonic-chip assisted corelative light and electron microscopy
    arXiv.org 2019
  • Nicholas J Hunt, Glen P Lockwood, Alessandra Warren, Hong Mao, Peter Anthony McCourt, David George Le Couteur m.fl.:
    Manipulating fenestrations in young and old liver sinusoidal endothelial cells
    American Journal of Physiology - Gastrointestinal and Liver Physiology 2019 ARKIV / DOI
  • Hong Mao, Robin Diekmann, Hai Po H Liang, Victoria Carroll Cogger, David George Le Couteur, Glen P Lockwood m.fl.:
    Cost-efficient nanoscopy reveals nanoscale architecture of liver cells and platelets
    Nanophotonics 09. juli 2019 ARKIV / DOI
  • Nick Hunt, Glen P Lockwood, Sun Kang, Tamara Pupitel, Ximonie Clark, Hong Mao m.fl.:
    The effects of metformin on age-related changes in the liver sinusoidal endothelial cell
    The journals of gerontology. Series A, Biological sciences and medical sciences 2019 ARKIV / DOI
  • Cristina Ionica Øie, Viola Mönkemöller, Wolfgang Hubner, Mark Schuttpelz, Hong Mao, Balpreet Singh Ahluwalia m.fl.:
    New ways of looking at very small holes – using optical nanoscopy to visualize liver sinusoidal endothelial cell fenestrations
    Nanophotonics 2018 ARKIV / FULLTEKST / DOI
  • Nicholas J Hunt, Peter Anthony McCourt, David George Le Couteur, Victoria C Cogger :
    Novel targets for delaying aging: The importance of the liver and advances in drug delivery
    Advanced Drug Delivery Reviews 2018 ARKIV / DOI
  • Robin Diekmann, Øystein Ivar Helle, Cristina Ionica Øie, Peter Anthony McCourt, Thomas Rolf Huser, Mark Schuttpelz m.fl.:
    Chip-based wide field-of-view nanoscopy
    Nature Photonics 2017 ARKIV / DOI
  • Javier Sanchez Romano, Anett Kristin Larsen, Jaione Simon-Santamaria, Cristina Ionica Øie, Bård Smedsrød, Peter Anthony McCourt m.fl.:
    The role of scavenger endothelial cells in bacteriophage pharmacokinetics
    2022
  • Javier Sanchez Romano, Anett Kristin Larsen, Jaione Simon-Santamaria, Cristina Ionica Øie, Bård Smedsrød, Peter Anthony McCourt m.fl.:
    THE ROLE OF SCAVENGER ENDOTHELIAL CELLS IN BACTERIOPHAGE PHARMACOKINETICS
    2022
  • Anett Kristin Larsen, Javier Sanchez Romano, Jaione Simon-Santamaria, Kim Erlend Mortensen, Bo Gøran Ericzon, Peter Anthony McCourt m.fl.:
    Role of liver sinusoidal endothelial cells in elimination of virus
    2022
  • Anett Kristin Larsen, Javier Sanchez Romano, Eirik Abrahamsen Lænsman, Anne Lotte Vada Hatlegjerde, Jaione Simon-Santamaria, Kim Erlend Mortensen m.fl.:
    Liver sinusoidal scavenger cells eliminate betaherpesvirus from the blood stream
    2022
  • Peter Anthony McCourt :
    Reinvigorating old holes in the ageing liver, and how to watch this happen.
    2019
  • Christopher Florian Holte, Larissa Dorothea Kruse, Hong Mao, Karolina Szafranska, Peter Anthony McCourt :
    How do fenestrations work?
    2019
  • Andres Maldonado, Ida Sundvor Opstad, Luis Hernández, Mona Nystad, Milton Aguilera, Merete Storflor m.fl.:
    Fluorescence Nanoscopy Using Multiple Signal Classification Algorithm (MUSICAL): From Electromagnetics Inverse Scattering Problem to Optics Inverse Source Problem.
    2019
  • Sebastian Andres Acuña Maldonado, Ida Sundvor Opstad, Luis Enrique Villegas Hernandez, Mona Nystad, Milton O Aguilera, Merete Storflor m.fl.:
    Fluorescence Nanoscopy Using Multiple Signal Classiflcation Algorithm (MUSICAL): From Electromagnetics Inverse Scattering Problem to Optics Inverse Source Problem
    2019
  • Javier Sanchez Romano, Anett Kristin Larsen, kjetil helge Elvevold, Christopher Florian Holte, Jaione Simon-Santamaria, Hans H. Hirsch m.fl.:
    SECVIR - The role of scavenger endothelial cells in elimination of virus
    2019
  • Deanna Wolfson, Cristina Ionica Øie, Tanji Yasunori, Gianina Dumitriu, Peter Anthony McCourt, Karen Kristine Sørensen m.fl.:
    Uptake and Degradation of Bacteriophages by Liver Sinusoidal Endothelial Cells
    2018
  • Viola Mönkemöller, Cristina Ionica Øie, Peter Heimann, Christian Kaltschmidt, Barbara Kaltschmidt, Peter Dedecker m.fl.:
    Revealing Structural Dynamics Of Liver Sinusoidal Endothelial Cells By Super-Resolution Optical Microscopy
    2018
  • Viola Mönkemöller, Cristina Ionica Øie, Peter Heimann, Christian Kaltschmidt, Barbara Kaltschmidt, Peter Anthony McCourt m.fl.:
    Revealing Structural Dynamics of Liver Sinusoidal Endothelial Cells
    2017
  • Deanna Wolfson, Cristina Ionica Øie, Yasunori Tanji, Karen Kristine Sørensen, Peter Anthony McCourt, Bård Smedsrød m.fl.:
    Multimodal Microscopy to Study the Fate of Bacteriophages in Liver Sinusoidal Endothelial Cells
    2017
  • Robin Diekmann, Øystein Ivar Helle, Cristina Ionica Øie, Peter Anthony McCourt, Thomas Huser, Balpreet Singh Ahluwalia m.fl.:
    Waveguide Chip-Based Super-Resolution Microscopy Enables Multi-Modal Imaging over Large Fields-of-View
    2017
  • Øystein Ivar Helle, Robin Diekmann, Cristina Ionica Øie, Peter Anthony McCourt, Thomas R. Huser, Mark Schüttpelz m.fl.:
    Optical Nanoscopy using Waveguides
    2017
  • Peter Anthony McCourt, Hong Mao, Thomas Rolf Huser, Balpreet Singh Ahluwalia, David George Le Couteur, Victoria Carroll Cogger :
    New ways to look at very small holes: using super-resolution optical microscopy to reveal the secrets of holey liver cells
    2017
  • Hong Mao, Cristina Ionica Øie, Ruomei Li, Ana Oteiza, Karen Kristine Sørensen, Deanna Wolfson m.fl.:
    Disruption of rat liver sinusoidal endothelial cell morphology by oxidised low density lipoproteins
    2017
  • Hong Mao, Cristina Ionica Øie, Ruomei Li, Ana Oteiza, Karen Kristine Sørensen, Deanna Wolfson m.fl.:
    Using super-resolution microscopy to image disruption of liver sinusoidal endothelial cell morphology by oxidized low-density lipoproteins
    2017
  • Sabin Bhandari, Ruomei Li, Jaione Simon-Santamaria, Peter Anthony McCourt, Steinar Daae Johansen, Bård Smedsrød m.fl.:
    The liver sinusoidal endothelial cell – an endothelial cell with a macrophage-like identity
    2017
  • Viola Monkemoller, Cristina Ionica Øie, Wolfgang Hubner, Thomas Rolf Huser, Peter Anthony McCourt :
    Multimodal super-resolution optical microscopy visualizes the close connection between membrane and the cytoskeleton in liver sinusoidal endothelial cell fenestrations
    2016
  • Peter Anthony McCourt, Ana Oteiza, Melonie J. Storan, Brenda Williams, Chad K. Heazlewood, Karen Kristine Sørensen m.fl.:
    Identification of adult hemogenic sinusoidal endothelial cells in adult bone marrow.
    2016
  • Hong Mao, Cristina Ionica Øie, Ruomei Li, Ana Oteiza, Karen Kristine Sørensen, Deanna Wolfson m.fl.:
    Disruption of liver sinusoidal endothelial cell morphology by oxidized low–density lipoproteins
    2016
  • Øystein Ivar Helle, Robin Diekmann, Cristina Ionica Øie, Peter Anthony McCourt, Thomas R. Huser, Mark Schuttpelz m.fl.:
    Integrated Optical Nanoscopy
    2016
  • Viola Mönkemöller, Cristina Ionica Øie, Peter Heimann, Christian Kaltschmidt, Barbara Kaltschmidt, Peter Anthony McCourt m.fl.:
    Multimodal nanoscopy reveals unique structural dynamics of liver endothelial cells
    2016
  • Robin Diekmann, Øystein Ivar Helle, Cristina Ionica Øie, Ida Sundvor Opstad, Deanna Wolfson, Peter Anthony McCourt m.fl.:
    Live cell fluctuation-based SR imaging using high-frequency, near-field illumination patterns enabled by planar waveguides
    2016
  • Deanna Wolfson, Cristina Ionica Øie, Ida Sundvor Opstad, Peter Anthony McCourt, Balpreet Singh Ahluwalia :
    Nanoscale Dynamics of Liver Sinusoidal Endothelial Cells
    2016
  • Sabin Bhandari, Ruomei Li, Jaione Simon-Santamaria, Peter Anthony McCourt, Steinar Daae Johansen, Bård Smedsrød m.fl.:
    Next generation deep sequencing of rat liver sinusoidal endothelial cell and Kupffer cell transcriptomes suggests functional complementarity
    2016
  • Øystein Ivar Helle, Cristina Ionica Øie, Peter Anthony McCourt, Balpreet Singh Ahluwalia :
    Integrated Optical Nanoscopy for Imaging Membrane Fenestration of Liver Cell
    2015

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    Forskningsinteresser

    Studerer reseptorer som er ansvarlige for fjerning av hyaluronan, denaturert kollagen og andre molekyler fra sirkulasjonen via lever sinusoidale endotelceller (LSEC) og beinmarg sinusoidale endotelceller (BMSEC).


    Medlem i forskningsgruppe


    CV

    Name: Peter Anthony Gerard McCourt

    Date of Birth: 09.08.1965

    Nationality: Australian

    Academic background:                       

    1986 – B.Sc. (Honours 1a) Flinders University, Australia

    1999 – Ph.D. (Biochemistry), University of Uppsala, Sweden 

    Areas of research expertise:

    1. Protein purification and analysis;

    2. Antibody production;

    3. Biochemical assays of cytochrome P450 enzymes in hepatocytes

    4. Tissue culture;

    5. Recombinant protein expression in mammalian and bacterial systems;

    6. Bioinformatic, PCR and cloning strategies;

    7. Development of clinical ELISAs and other immunoassays.

    8. Immunohistochemistry and immuno electron microscopy

    9. Isolation of liver sinusoidal endothelial cells (LSEC);

    10. Isolation of bone marrow sinusoidal endothelial cells (BMSEC), bone marrow stem cells, homing and engraftment assays.

    11. Super resolution optical microscopy methods (e.g. SIM, dSTORM) for use in the study of LSEC fenestrations.

    Teaching:

    Approved teaching portfolio (a compulsory requirement for teachers at the University of Tromsø) 19.06.12.

    Currently teach Biochemistry to Medical Laboratory Scientists and Dental Nurses.

    Research background:

    2020-present: Professor of Biochemistry, IMB, studying the effects of ageing on LSEC morphology and biochemistry.

    2016-2017: Sabbatical at the ANZAC Research Institute (Sydney, Australia), Biogerontology Research Group (hosts: Professors David Le Couteur and Victoria Cogger).

    2016-present: Honorary Affiliate of the University of Sydney Medical School (Faculty of Medicine).

    2012-2020: Associate Professor, IMB, studying the effects of ageing on LSEC morphology and biochemistry. 

    2010-11: Guest Researcher, Niche Group, CSIRO Materials Science and Engineering, Clayton, Australia, with Associate Professor Susie Nilsson, studying bone-marrow sinusoidal endothelial cells and stem cells and their utility in bone-marrow transplants.         

    1999-2012: Post-Doctoral Research Fellow/Research Scientist at the Department of Cell Biology and Histology, Institute for Medical Biology, University of Tromsø with Professor Bård Smedsrød, studying receptors responsible for the clearance of hyaluronan, denatured collagen and other waste connective tissue molecules from the circulation by LSEC.  

    1993-1999: Ph.D. Student, Department of Medical Biochemistry and Microbiology, University of Uppsala, Sweden under the supervision of Professors Torvard Laurent and Staffan Johansson, working on the purification, characterisation and cloning of hyaluronan/scavenger receptors on liver scavenger endothelial cells.

    1990-1993: Guest Researcher, Department of Medical and Physiological Chemistry, University of Uppsala, Sweden under the supervision of Professor Torvard  Laurent, studying hyaluronan-binding properties of the monocytic cell lines U937 and J774.

    1987-1990: Research Assistant, Lysosomal Diseases Research Unit, Adelaide Children's Hospital, Adelaide, Australia with Professor John Hopwood, working on the purification of lysosomal enzymes, production of hybridoma cell lines/monoclonal antibodies, and development of ELISAs for clinical assessment of lysosomal enzyme deficiencies. 

    Financial Support:

    University of Tromsø Researcher Fellowship, HelseNord, various small foundations, Norwegian Research Council Post-doctoral Fellowship, Tromsø Research Foundation, EU:Horizon 2020 MSCA.