Bilde av Sundsfjord, Arnfinn
Bilde av Sundsfjord, Arnfinn
Institutt for medisinsk biologi arnfinn.sundsfjord@uit.no +4777644764 90616118 Tromsø MH L9.207

Arnfinn Sundsfjord


Professor i Medisinsk Mikrobiologi


  • Caillan Crowe-McAuliffe, Victoriia Murina, Kathryn Jane Turnbull, Susanne Huch, Marje Kasari, Hiraku Takada m.fl.:
    Structural basis for PoxtA-mediated resistance to phenicol and oxazolidinone antibiotics
    Nature Communications 2022 ARKIV / DOI
  • Faheema Ebrahim Choonara, Bjørg Haldorsen, Jessin Janice, Joshua Mbanga, Isaac Ndhlovu, Osborne Saulosi m.fl.:
    Molecular Epidemiological Characterisation of ESBL- and Plasmid-Mediated AmpC-Producing Escherichia coli and Klebsiella pneumoniae at Kamuzu Central Hospital, Lilongwe, Malawi
    Tropical Medicine and Infectious Disease 2022 ARKIV / DOI
  • Faheema E. Choonara, Bjørg Haldorsen, Isaac Ndhlovu, Osborne Saulosi, Tarsizio Maida, Fanuel Lampiao m.fl.:
    Antimicrobial susceptibility profiles of clinically important bacterial pathogens at the Kamuzu Central Hospital in Lilongwe, Malawi
    Malawi Medical Journal 2022 ARKIV / DOI
  • Kenneth Lindstedt, Dorota Julia Buczek, Torunn Annie Pedersen, Erik Hjerde, Niclas Peter Raffelsberger, Yutaka Suzuki m.fl.:
    Detection of Klebsiella pneumoniae human gut carriage: a comparison of culture, qPCR, and whole metagenomic sequencing methods
    Gut microbes 31. august 2022 ARKIV / DOI
  • Jessin Janice, Nicholas Agyepong, Alex Owusu-Ofori, Usha Govinden, Sabiha Essack, Ørjan Samuelsen m.fl.:
    Carbapenem resistance determinants acquired through novel chromosomal integrations in extensively drug-resistant pseudomonas aeruginosa
    Antimicrobial Agents and Chemotherapy 2021 ARKIV / DOI
  • Niclas Peter Raffelsberger, Marit Andrea Klokkhammer Hetland, Kristian Svendsen, Lars Småbrekke, Iren Høyland Löhr, Lotte Andreassen m.fl.:
    Gastrointestinal carriage of Klebsiella pneumoniae in a general adult population: a cross-sectional study of risk factors and bacterial genomic diversity
    Gut microbes 2021 ARKIV / DOI
  • Marit Østlyngen Riibe, Sveinung Wergeland Sørbye, Gunnar Skov Simonsen, Arnfinn Sundsfjord, Josef Ekgren, Jan Martin Maltau :
    Risk of cervical intraepithelial neoplasia grade 3 or higher (CIN3+) among women with HPV-test in 1990–1992, a 30-year follow-up study
    Infectious Agents and Cancer 2021 ARKIV / DOI
  • Abel F.N.D. Phiri, Akebe Luther King Abia, Daniel Gyamfi Amoako, Rajab Mkakosya, Arnfinn Sundsfjord, Sabiha Essack m.fl.:
    Burden, antibiotic resistance, and clonality of shigella spp. Implicated in community-acquired acute diarrhoea in Lilongwe, Malawi
    Tropical Medicine and Infectious Disease 2021 ARKIV / DOI
  • Calvina Estalva, Tomas Zimba, Sekyere John, Usha Govinden, Hafizah Y. Chenia, Gunnar Skov Simonsen m.fl.:
    High prevalence of multidrug resistant ESBL- and plasmid mediated AmpC-producing clinical isolates of Escherichia coli at Maputo Central Hospital, Mozambique
    BMC Infectious Diseases 2021 ARKIV / DOI
  • Aasmund Fostervold, Marit Andrea Klokkhammer Hetland, Ragna-Johanne Bakksjø, Eva Bernhoff, Kathryn E. Holt, Ørjan Samuelsen m.fl.:
    A nationwide genomic study of clinical Klebsiella pneumoniae in Norway 2001–15: introduction and spread of ESBLs facilitated by clonal groups CG15 and CG307
    Journal of Antimicrobial Chemotherapy 2021 ARKIV / DOI
  • Mushtaq T.S. Al-Rubaye, Jessin Janice, Jørgen Vildershøj Bjørnholt, Aleksandra Jakovljev, Maria Elisabeth Hultström, Arnfinn Sundsfjord m.fl.:
    Novel genomic islands and a new vanD-subtype in the first sporadic VanD-type vancomycin resistant enterococci in Norway
    PLOS ONE 2021 ARKIV / DOI
  • Fredrik Håkonsholm, Marit Andrea Klokkhammer Hetland, Cecilie Smith Svanevik, Arnfinn Sundsfjord, Bjørn Tore Lunestad, Nachiket Marathe :
    Antibiotic sensitivity screening of Klebsiella spp. and Raoultella spp. isolated from marine bivalve molluscs reveal presence of CTX-M-producing K. pneumoniae
    Microorganisms 30. november 2020 ARKIV / DOI
  • Theresa Wagner, Jessin Janice, Audun Sivertsen, Ingegerd Sjögren, Arnfinn Sundsfjord, Kristin Hegstad :
    Alternative vanHAX promoters and increased vanA-plasmid copy number resurrect silenced glycopeptide resistance in Enterococcus faecium
    Journal of Antimicrobial Chemotherapy 2020 ARKIV / DOI
  • Veronika Vorobieva, Anne-Sofie Furberg, Hans-Christian Slotved, Tatiana Bazhukova, Bjørg Haldorsen, Dominique A Caugant m.fl.:
    Epidemiological and molecular characterization of Streptococcus pneumoniae carriage strains in pre-school children in Arkhangelsk, northern European Russia, prior to the introduction of conjugate pneumococcal vaccines
    BMC Infectious Diseases 2020 FULLTEKST / ARKIV / DOI
  • Sara Lino Faife, Tomas Zimba, John Osei Sekyere, Usha Govinden, Hafizah Y. Chenia, Gunnar Skov Simonsen m.fl.:
    β-lactam and fluoroquinolone resistance in Enterobacteriaceae from imported and locally-produced chicken in Mozambique
    Journal of Infection in Developing Countries 2020 ARKIV / DOI
  • Alison Holmes, Mark Holmes, Thomas Gottlieb, Lance B Price, Arnfinn Sundsfjord :
    End non-essential use of antimicrobials in livestock
    The BMJ 2019 DOI
  • Nicholas Agyepong, Usha Govinden, Alex Owusu-Ofori, Daniel Gyamfi Amoako, Mushal Allam, Jessin Janice James Peter m.fl.:
    Genomic characterization of multidrug-resistant ESBL-producing Klebsiella pneumoniae isolated from a Ghanaian teaching hospital
    International Journal of Infectious Diseases 2019 ARKIV / DOI
  • Ilya Nikolaevich Zykov, Niels Frimodt-Møller, Lars Småbrekke, Arnfinn Sundsfjord, Ørjan Samuelsen :
    Efficacy of mecillinam against clinical multidrug-resistant Escherichia coli in a murine urinary tract infection model
    International Journal of Antimicrobial Agents 02. november 2019 ARKIV / DOI
  • Torunn Annie Pedersen, John Osei Sekyere, Usha Govinden, Krishnee Moodley, Audun Sivertsen, Ørjan Samuelsen m.fl.:
    Spread of plasmid-encoded NDM-1 and GES-5 carbapenemases among extensively drug-resistant and pandrug-resistant clinical enterobacteriaceae in durban, South Africa
    Antimicrobial Agents and Chemotherapy 2018 DOI
  • Bjørg Haldorsen, Christian G Giske, Dennis S Hansen, Kristjan Orri Helgason, Gunnar Kahlmeter, Iren Høyland Löhr m.fl.:
    Performance of the EUCAST disc diffusion method and two MIC methods in detection of Enterobacteriaceae with reduced susceptibility to meropenem: the NordicAST CPE study.
    Journal of Antimicrobial Chemotherapy 2018 ARKIV / DOI
  • Lourenco Marcos Chirindze, Tomas F. Zimba, John Osei Sekyere, Usha Govinden, Hafizah Y. Chenia, Arnfinn Sundsfjord m.fl.:
    Faecal colonization of E. coli and Klebsiella spp. producing extended-spectrum beta-lactamases and plasmid-mediated AmpC in Mozambican university students
    BMC Infectious Diseases 2018 ARKIV / DOI
  • Ilya Nikolaevich Zykov, Ørjan Samuelsen, Lotte Jakobsen, Lars Småbrekke, Dan I. Andersson, Arnfinn Sundsfjord m.fl.:
    Pharmacokinetics and pharmacodynamics of fosfomycin and its activity against extended-spectrum-lactamase-, plasmid-mediated AmpC-, and carbapenemase-producing escherichia coli in a murine urinary tract infection model
    Antimicrobial Agents and Chemotherapy 2018 ARKIV / DOI
  • Ørjan Samuelsen, Søren Overballe-Petersen, Jørgen Bjørnholt, Sylvain Brisse, Michel Doumith, Neil Woodford m.fl.:
    Molecular and epidemiological characterization of carbapenemase-producing Enterobacteriaceae in Norway, 2007 to 2014
    PLOS ONE 2017 ARKIV / FULLTEKST / DOI
  • Silje Jørgensen, Arne Vasli Søraas, Lotte Pia Stenfors Arnesen, Truls Michael Leegaard, Arnfinn Sundsfjord, Pål Jenum :
    A comparison of extended spectrum beta-lactamase producing Escherichia coli from clinical, recreational water and wastewater samples associated in time and location
    PLOS ONE 2017 ARKIV / DOI
  • Silje Jørgensen, Arne Vasli Søraas, Lotte Pia Stenfors Arnesen, Truls Michael Leegaard, Arnfinn Sundsfjord, Pål Jenum :
    First environmental sample containing plasmid-mediated colistin-resistant ESBL-producing Escherichia coli detected in Norway
    APMIS - Journal of Pathologiy, Microbiology and Immunology 2017 ARKIV / DOI
  • Silje Jørgensen, Arne Vasli Søraas, Arnfinn Sundsfjord, Knut Liestøl, Truls Michael Leegaard, Pål Jenum :
    Fecal carriage of extended spectrum β-lactamase producing Escherichia coli and Klebsiella pneumoniae after urinary tract infection - A three year prospective cohort study
    PLOS ONE 2017 ARKIV / DOI
  • A Freitas, A Tedim, Maria V. Francia, Lars B Jensen, C Novais, L Peixe m.fl.:
    Multilevel population genetic analysis of vanA and vanB Enterococcus faecium causing nosocomial outbreaks in 27 countries (1986-2012)
    Journal of Antimicrobial Chemotherapy 2016 DOI
  • Alison H Holmes, Luke S P Moore, Arnfinn Sundsfjord, Martin Steinbakk, Sadie Regmi, Abhilasha Karkey m.fl.:
    Understanding the mechanisms and drivers of antimicrobial resistance
    The Lancet 2016 DOI
  • Theresa Mikalsen, Torunn Annie Pedersen, Rob Willems, Teresa M. Coque, Guido Werner, Ewa Sadowy m.fl.:
    Investigating the mobilome in clinically important lineages of enterococcus faecium and enterococcus faecalis
    BMC Genomics 2015 ARKIV / DOI
  • Ilya Nikolaevich Zykov, Arnfinn Sundsfjord, Lars Småbrekke, Ørjan Samuelsen :
    The antimicrobial activity of mecillinam, nitrofurantoin, temocillin and fosfomycin and comparative analysis of resistance patterns in a nationwide collection of ESBL-producing Escherichia coli in Norway 2010–2011
    Infectious Diseases 2015 DOI
  • Siren Rettedal, Iren Høyland Löhr, Eva Bernhoff, Olav Bjarte Natås, Arnfinn Sundsfjord, Knut Øymar :
    Extended-spectrum β-lactamase-producing Enterobacteriaceae among pregnant women in Norway: Prevalence and maternal-neonatal transmission
    Journal of Perinatology 2015 DOI
  • Iren Høyland Löhr, Nils Fredrik Hülter, Eva Bernhoff, Pål Jarle Johnsen, Arnfinn Sundsfjord, Mohammed Umaer Naseer :
    Persistence of a pKPN3-like CTX-M-15-encoding IncFIIK plasmid in a Klebsiella pneumonia ST17 host during two years of intestinal colonization
    PLOS ONE 2015 ARKIV / FULLTEKST / DOI
  • Dagfinn Skaare, Inger Lill Anthonisen, Gunnar Kahlmeter, Erika Matuschek, Olav Bjarte Natås, Martin Steinbakk m.fl.:
    Emergence of clonally related multidrug resistant haemophilus influenzae with penicillin-binding protein 3-mediated resistance to extended-spectrum cephalosporins, Norway, 2006 to 2013
    Eurosurveillance 2014 ARKIV / FULLTEKST
  • Theresa Wagner, Jessin Janice James Peter, Marc Schulz, Susan A. Ballard, Anders Goncalves da Silva, Geoffrey W Coombs m.fl.:
    Australian vancomycin variable E. faecium ST1421 revert to resistance by the use of an alternative vanHAX promoter and increased vanA-plasmid copy number
    2021
  • Yngvild Wasteson, Henning Sørum, Bjørn-Arne Lindstedt, Adriana Dorota Osinska, Arnfinn Sundsfjord, Hans Geir Eiken m.fl.:
    CORNELIA – Antimicrobial Resistance (AMR) in One Health Interfaces
    2021
  • Yngvild Wasteson, Henning Sørum, Bjørn-Arne Lindstedt, Arnfinn Sundsfjord, Hans Geir Eiken, Erik Joner m.fl.:
    CORNELIA – Antimicrobial Resistance (AMR) in One Health Interfaces
    2021 PROSJEKT
  • Paul Christoffer Lindemann, Karianne Wiger Gammelsrud, Iren Høyland Löhr, Per Espen Akselsen, Morten Lindbæk, Arnfinn Sundsfjord :
    Valg av antibiotika - viktig endring i prøvesvar fra mikrobiologen
    Tidsskrift for Den norske legeforening 2019 DOI
  • Nicholas Agyepong, Usha Govinden, Alex Owusu-Ofori, Mushal Allam, Arshad Ismail, Torunn Annie Pedersen m.fl.:
    Whole-genome sequences of two multidrug-resistant acinetobacter baumannii strains isolated from patients with urinary tract infection in Ghana
    Microbiology Resource Announcements (MRA) 2019 DOI
  • Theresa Wagner, Jessin Janice, Audun Sivertsen, Ingegerd Sjögren, Arnfinn Sundsfjord, Kristin Hegstad :
    The bag of tricks of vancomycin variable enterococci: an alternative constitutive vanHAX-promoter, varying copy numbers and transferable resistance
    2019
  • Mushtaq Talib Shawi Al-Rubaye, Jessin Janice, Iren Høyland Löhr, Arnfinn Sundsfjord, Kristin Hegstad :
    THE FIRST VANE VANCOMYCIN RESISTANT ENTEROCOCCUS FAECALIS IN NORWAY
    2019
  • Mushtaq Talib Shawi Al-Rubaye, Jessin Janice, Jørgen Vildershøj Bjørnholt, Oliver Kacelink, Biørg C. Haldorsen, Randi M. Nygaard m.fl.:
    POPULATION STRUCTURE OF THE NORWEGIAN VANCOMYCIN RESISTANT AND SENSITIVE ENTEROCOCCI 2010-2015
    2019
  • A Basic, Erika Matuschek, O Karatuna, Bjørg C Haldorsen, Kristin Hegstad, Jenny Åhman m.fl.:
    Evaluation of gradient tests for vancomycin MIC determination in Enterococcus faecalis and Enterococcus faecium. Effect of incubation for 16-20 hours vs. 24 hours
    2019
  • Lyn Middleton, F Lampiao, Tomas F. Zimba, SM Muzime, Gunnar Skov Simonsen, Lars Småbrekke m.fl.:
    Sharing Knowledge Transforming Societies. The Norhed Programme 2013-2020
    African Minds 2019
  • Jessin Janice James Peter, Joachim Hegstad, Ellen H. Josefsen, Arnfinn Sundsfjord, Kristin Hegstad :
    Increased prevalence of linezolid resistance mong clinical enterococci in Norway mainly due to spread of optrA E. faecalis
    2019
  • Theresa Wagner, Audun Sivertsen, Jessin Janice, Ingegerd Sjögren, Arnfinn Sundsfjord, Kristin Hegstad :
    Vancomycin variable resistance may occur through creation of a novel constitutive vanHAX-promoter by illegitimate recombination
    2018
  • Jessin Janice James Peter, Ellen H. Josefsen, Arnfinn Sundsfjord, Kristin Hegstad :
    Increased prevalence of linezolid resistance among clinical enterococci in Norway.
    2018
  • Maria Chiara Di Luca, Dagfinn Skaare, Bettina Aasnæs, Arnfinn Sundsfjord, Ørjan Samuelsen :
    Identification of a novel IMI carbapenemase variant (IMI-9) in Enterobacter cloacae complex
    International Journal of Antimicrobial Agents 2016 DOI
  • Henning Onarheim, RAGNVALD LJONES BREKKE, Rafael Alexander Mo Leiva, Dorthea Hagen Oma, Helge Kolstad, Ørjan Samuelsen m.fl.:
    H. Onarheim og medarbeidere svarer
    Tidsskrift for Den norske legeforening 2016 DOI
  • Henning Onarheim, Ragnvald Ljones Brekke, Rafael Alexander Mo Leiva, Dorthea Hagen Oma, Helge Kolstad, Ørjan Samuelsen m.fl.:
    En kvinne med sepsis etter brannskade i Pakistan
    Tidsskrift for Den norske legeforening 2016
  • Kristin Hegstad, Ørjan Samuelsen, Joachim Hegstad, Arnfinn Sundsfjord :
    Molecular methods for detection of antibacterial resistance genes: rationale and applications
    Wolters Kluwer 2015

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    Forskningsinteresser

    • Antibiotika, antibiotikaresistente bakterier og evolusjon
    • Klebsiella pneumoniae (Kp) er en sentral aktør i den globale spredningen av antibiotikaresistens. Våre studier involverer komparative molekylære epidemiologiske studier (helgenomsekvensering og metagenomikk) av Kp fra ulike økologiske nisjer inkludert mennesker og dyr, feno- og genotypiske assosiasjoner  i patogenitet og antibiotikaresistens (genomassosiasjonsstudier og maskinlæring), samt prekliniske effekstudier av bakterievirus (bakteriofager) evne til å fjerne bærerskap eller infeksjoner med multiresistente Kp. Kp-studiene er finansiert av Trond Mohn Stiftelsen ( https://mohnfoundation.no/amr-prosjekter/) og partnerinstitusjoner.
    • Leder for Senter for nye antibakterielle strategier (CANS; https://uit.no/research/cans): Et tverrfaglig forskningssenter finansiert av UiT og Tromsø Forskningsstiftelse (https://tfstiftelse.no/) 2019 -.
    • Seksjonsoverlege, Nasjonal kompetansetjeneste for påvisning av antibiotikaresistens (K-res; https://unn.no/fag-og-forskning/k-res) ved Universitetssykehuset Nord-Norge (UNN) finansiert av Helse- og omsorgsdepartementet, Helse Nord RHF og UNN.


    CV

    Utdanning:
    1983: Cand.med (MD) Universitetet i Tromsø
    1991: Spesialist i Medisinsk mikrobiologi
    1994: Dr.med (PhD) Universitetet i Tromsø
    2000-01: Visiting Professor Institutt Pasteur, Paris

    Yrkespraksis:
    1983-95: Turnus-/militærlege. Assistent-/overlege Medisinsk mikrobiologi, Universitetssykehuset i Nord-Norge
    1987-90: Stipendiat, Den Norske Kreftforening, v/UiT
    1995-96: Avdelingsoverlege Mikrobiologisk avdeling, UNN
    1995 - : Førsteamanuensis/Professor Medisinsk mikrobiologi, UiT
    1996-00: Nestleder/Leder for studiestyret medisin, UiT
    2005-09: Prodekan forskning, Det Medisinske fakultet, UiT

    2009 - 17 : Dekan, Det helsevitenskapelige fakultet, UiT


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