Bilde av Stuge, Tor Brynjar
Foto: Ukjent
Bilde av Stuge, Tor Brynjar
Institutt for medisinsk biologi tor.stuge@uit.no +4777645888 97713935 Tromsø UNN A1.802

Tor Brynjar Stuge


Scientist and lecturer, Immunology


  • Trude Victoria Mørtberg, Huiying Zhi, Gestur Vidarsson, Stian Foss, Suzanne Lissenberg-Thunnissen, Manfred Wuhrer m.fl.:
    Prevention of Fetal/Neonatal Alloimmune Thrombocytopenia in Mice: Biochemical and Cell Biological Characterization of Isoforms of a Human Monoclonal Antibody
    ImmunoHorizons 2022 ARKIV / DOI
  • Maria Therese Ahlen, Gøril Heide, Anne Husebekk, Bjørn Skogen, Jens Kjeldsen-Kragh, Tor Brynjar Stuge :
    The prevalence of HPA-1a alloimmunization and the potential risk of FNAIT depend on both the DRB3*01:01 allele and associated DR-DQ haplotypes
    Scandinavian Journal of Immunology 16. april 2020 ARKIV / DOI
  • Anno Saris, Ivan Peyron, Pieter F. Van Der Meer, Tor Brynjar Stuge, Jaap Jan Zwaginga, S Marieke van Ham m.fl.:
    Storage-induced platelet apoptosis is a potential risk factor for alloimmunization upon platelet transfusion
    Frontiers in Immunology 2018 ARKIV / DOI
  • Heidi Tiller, Anne Husebekk, Maria Therese Ahlen, Tor Brynjar Stuge, Bjørn Ragnar Skogen :
    Current perspectives on fetal and neonatal alloimmune thrombocytopenia - Increasing clinical concerns and new treatment opportunities
    International Journal of Women's Health 2017 ARKIV / DOI
  • Mariana Eksteen, Gøril Heide, Heidi Tiller, Yan Zhou, Nora Hersoug Nedberg, Inigo Zubiavrre Martinez m.fl.:
    Anti-human platelet antigen (HPA)-1a antibodies may affect trophoblast functions crucial for placental development: A laboratory study using an in vitro model
    Reproductive Biology and Endocrinology 2017 ARKIV / DOI
  • Jesper Dahl, Erle Refsum, Maria Therese Ahlen, Torstein Egeland, Tore Jensen, Marte K Viken m.fl.:
    Unraveling the role of maternal anti-HLA class I antibodies in fetal and neonatal thrombocytopenia?Antibody specificity analysis using epitope data
    Journal of Reproductive Immunology 2017 DOI
  • J Dahl, Anne Husebekk, Ganesh Acharya, Kari Flo, Tor Brynjar Stuge, Bjørn Ragnar Skogen m.fl.:
    Maternal anti-HLA class I antibodies are associated with reduced birthweight in thrombocytopenic neonates
    Journal of Reproductive Immunology 2016 DOI
  • Erin B Taylor, Mohadetheh Moulana, Tor Brynjar Stuge, Sylvie M A Quiniou, Eva Bengten, Melanie Wilson :
    A Leukocyte Immune-Type Receptor Subset Is a Marker of Antiviral Cytotoxic Cells in Channel Catfish, Ictalurus punctatus
    Journal of Immunology 2016 DOI
  • Maria Therese Ahlen, Anne Husebekk, Ida Løken Killie, Bjørn Ragnar Skogen, Tor Brynjar Stuge :
    T cell responses to human platelet antigen-1a involve a unique form of indirect allorecognition
    JCI Insight 2016 DOI
  • Laia Gorchs, Turid Hellevik, Jack-Ansgar Bruun, Ketil Andre Camilio, Samer Al-Saad, Tor Brynjar Stuge m.fl.:
    Cancer-associated fibroblasts from lung tumors maintain their immunosuppressive abilities after high-dose irradiation
    Frontiers in Oncology 2015 ARKIV / DOI
  • Mariana Eksteen, Heidi Tiller, Maria Averina, Gøril Heide, Mette Kjær Killie, Cedric Ghevaert m.fl.:
    Characterization of a human platelet antigen-1a-specific monoclonal antibody derived from a B cell from a woman alloimmunized in pregnancy
    Journal of Immunology 2015 ARKIV / DOI
  • Brile Chung, Tor Brynjar Stuge, John P. Murad, Georg Beilhack, Emily Andersen, Brian D. Armstrong m.fl.:
    Antigen-specific inhibition of high-avidity T cell target lysis by low-avidity T cells via trogocytosis
    Cell reports 2014 DOI
  • Gwendolen Y Chang, Holbrook E Kohrt, Tor Brynjar Stuge, Erich J Schwartz, Jeffrey S Weber, Peter P Lee :
    Cytotoxic T lymphocyte responses against melanocytes and melanoma
    Journal of Translational Medicine 2011 DOI
  • Tor Brynjar Stuge, Bjørn Ragnar Skogen, Maria Therese Ahlen, Anne Husebekk, SJ Urbaniak, H Bessos :
    The Cellular immunobiology associated with fetal and neonatal alloimmune thrombocytopenia
    Transfusion and Apheresis Science 2011 DOI
  • Anne Husebekk, Maria Therese Ahlen, Mette Kjær Killie, Heidi Tiller, Mariana Eksteen, Ida Løken Killie m.fl.:
    Blood group antigens and immune responses-detailed knowledge is necessary to prevent immunization and to follow up immunized individuals
    ISBT Science Series 2010
  • Bjørn Ragnar Skogen, Mette Kjær Killie, Jens Kjeldsen-Kragh, Maria Therese Ahlen, Heidi Tiller, Tor Brynjar Stuge m.fl.:
    Reconsidering fetal and neonatal alloimmune thrombocytopenia with a focus on screening and prevention
    Expert Review of Hematology 2010 DOI
  • Maria Therese Ahlen, Anne Husebekk, Mette Kjær Killie, Bjørn Ragnar Skogen, Tor Brynjar Stuge :
    T-cell responses associated with neonatal alloimmune thrombocytopenia: isolation of HPA-1a-specific, HLA-DRB3*0101-restricted CD4+ T cells
    Blood 2009 DOI
  • Mohadetheh Moulana, Jason Evenhuis, Mark Albertino, Ulla Godwin, Evgueni I. Kountikov, Tor Brynjar Stuge m.fl.:
    Characterization of anti-channel catfish MHC class IIβ monoclonal antibodies
    Veterinary Immunology and Immunopathology 2008 DOI
  • Matthew Siegel, Micheal T Bethune, Jonathan Gass, Jennifer Ehren, Jiang Xia, Alexandre Johannsen m.fl.:
    Rational design of combination enzyme therapy for celiac sprue.
    Chemistry and Biology 2006 DOI
  • Daniel S Chen, Yoav Soen, Tor Brynjar Stuge, Peter P. Lee, Jeffrey S Weber, Patrick O Brown m.fl.:
    Marked differences in human melanoma antigen-specific T cell responsiveness after vaccination using a functional microarray.
    PLoS Medicine 2005 DOI
  • Holbrook E Kohrt, Chen-Tsen Shu, Tor Brynjar Stuge, Susan P Holmes, Jeffrey S Weber, Peter P. Lee :
    Rapid assessment of recognition efficiency and functional capacity of antigen-specific T-cell responses.
    Journal of immunotherapy 2005 DOI
  • Tor Brynjar Stuge, Susan P Holmes, Sahdev Saharan, Andrea Tuettenberg, Mario Roederer, Jeffrey S Weber m.fl.:
    Diversity and recognition efficiency of T cell responses to cancer.
    PLoS Medicine 2004 DOI
  • Linling Shen, Tor Brynjar Stuge, Eva Bengten, Melanie Wilson, V. Gregory Chinchar, John P Naftel m.fl.:
    Identification and characterization of clonal NK-like cells from channel catfish (Ictalurus punctatus).
    Developmental and Comparative Immunology 2004 DOI
  • Valerie Rubio, Tor Brynjar Stuge, Naileshni Singh, Michael R Betts, Jeffrey S Weber, Mario Roederer m.fl.:
    Ex vivo identification, isolation and analysis of tumor-cytolytic T cells.
    Nature Medicine 2003 DOI
  • Linling Shen, Tor Brynjar Stuge, Jason P Evenhuis, Eva Bengten, Melanie Wilson, V. Gregory Chinchar m.fl.:
    Channel catfish NK-like cells are armed with IgM via a putative FcmicroR.
    Developmental and Comparative Immunology 2003 DOI
  • Jeffrey S Weber, Vernon K Sondak, Ronaldo Scotland, Ramila Phillip, Flora Wang, Valerie Rubio m.fl.:
    Granulocyte-macrophage-colony-stimulating factor added to a multipeptide vaccine for resected Stage II melanoma.
    Cancer 2003 DOI
  • Eva Bengten, Sylvie M A Quiniou, Tor Brynjar Stuge, Takayuki Katagiri, Norman W. Miller, L. William Clem m.fl.:
    The IgH locus of the channel catfish, Ictalurus punctatus, contains multiple constant region gene sequences: different genes encode heavy chains of membrane and secreted IgD.
    Journal of Immunology 2002 DOI
  • Linling Shen, Tor Brynjar Stuge, He Zhou, Morad Khayat, Katherine S Barker, Sylvie M A Quiniou m.fl.:
    Channel catfish cytotoxic cells: a mini-review.
    Developmental and Comparative Immunology 2002 DOI
  • He Zhou, Tor Brynjar Stuge, Norman W. Miller, Eva Bengten, John P Naftel, Jayne M. Bernanke m.fl.:
    Heterogeneity of channel catfish CTL with respect to target recognition and cytotoxic mechanisms employed.
    Journal of Immunology 2001 DOI
  • Peter P. Lee, F Wang, J Kuniyoshi, Valerie Rubio, Tor Brynjar Stuge, Susan G Groshen m.fl.:
    Effects of interleukin-12 on the immune response to a multipeptide vaccine for resected metastatic melanoma.
    Journal of Clinical Oncology 2001 DOI
  • Helmut Jonuleit, Andrea Giesecke-Tuettenberg, Thomas Tüting, Beatrice Thurner-Schuler, Tor Brynjar Stuge, Lydia Paragnik m.fl.:
    A comparison of two types of dendritic cell as adjuvants for the induction of melanoma-specific T-cell responses in humans following intranodal injection.
    International Journal of Cancer 2001 DOI
  • Morad Khayat, Tor Brynjar Stuge, Melanie Wilson, Eva Bengten, Norman W. Miller, L. William Clem :
    Thioredoxin acts as a B cell growth factor in channel catfish.
    Journal of Immunology 2001 DOI
  • Noel A Hawke, Jeffrey A Yoder, Robert N. Haire, Gail Mueller, Ronda T Litman, Ann L Miracle m.fl.:
    Extraordinary variation in a diversified family of immune-type receptor genes.
    Proceedings of the National Academy of Sciences of the United States of America 2001 DOI
  • Tor Brynjar Stuge, Melanie Wilson, He Zhou, Katherine S Barker, Eva Bengten, V. Gregory Chinchar m.fl.:
    Development and analysis of various clonal alloantigen-dependent cytotoxic cell lines from channel catfish.
    Journal of Immunology 2000 DOI
  • Laia Gorchs, Turid Hellevik, Jack-Ansgar Bruun, Ketil Andre Camilio, Samer Al-Saad, Tor Brynjar Stuge m.fl.:
    Cancer-associated fibroblasts from lung tumors maintain their immunosuppressive abilities after high-dose irradiation
    2015
  • Laia Gorchs, Turid Hellevik, Jack-Ansgar Bruun, Ketil Andre Camilio, Samer Al-Saad, Tor Brynjar Stuge m.fl.:
    Immunoregulatory functions of Cancer-associated Fibroblasts from lung cancers
    2015
  • Laia Gorch, Turid Hellevik, Tor Brynjar Stuge, Inigo Zubiavrre Martinez :
    Immunomodulatory properties of Cancer-Associated Fibroblasts
    Anticancer Research 2014
  • Turid Hellevik, Laia Gorch, Tor Brynjar Stuge, Inigo Zubiavrre Martinez :
    High-dose irradiation does not modify the immunosuppressive effects elicited by cancer-associated fibroblasts
    Anticancer Research 2014
  • Inigo Zubiavrre Martinez, Laia Gorch, Tor Brynjar Stuge, Turid Hellevik :
    Immuno-modulatory properties of cancer-associated Fibroblasts and its changes during radiotherapy
    2014
  • Jesper Dahl, Anne Husebekk, Ganesh Acharya, Kari Flo, Tor Brynjar Stuge, Bjørn Ragnar Skogen m.fl.:
    Maternal anti-HLA class 1 antibodies are associated with reduced birth weight in thrombocytopenic neonates
    2014
  • Ida Løken Killie, Maria Therese Ahlen, Anne Husebekk, Bjørn Ragnar Skogen, Tor Brynjar Stuge :
    Induction and detection of in vivo immune responses to HPA-1a in a novel murine model of fetal/neonatal alloimmune thrombocytopenia (FNAIT)
    2014
  • Mariana Eksteen, Mette Kjær Killie, Anne Husebekk, Bjørn Ragnar Skogen, Tor Brynjar Stuge :
    A NOVEL HUMAN MONOCLONAL HPA-1A-SPECIFIC ANTIBODY IS A USEFUL TOOL FOR DIAGNOSTICS IN FETAL AND NEONATAL ALLOIMMUNE THROMBOCYTOPENIA
    Vox Sanguinis 2013
  • Ida Løken Killie, Anne Husebekk, Maria Therese Ahlen, M. Roalso, Bjørn Ragnar Skogen, Tor Brynjar Stuge :
    ARE CURRENT MURINE MODELS OF FETAL/NEONATAL ALLOIMMUNE THROMBOCYTOPENIA BRINGING US CLOSER TO A BETTER UNDERSTANDING OF PATHOPHYSIOLOGY AND TREATMENT OF THE DISEASE?
    Vox Sanguinis 2013
  • Gøril Heide, Tor Brynjar Stuge, Bjørn Ragnar Skogen, Anne Husebekk, Maria Therese Ahlen :
    The DR7-DQ2 Haplotype in a Native Norwegian Population
    Scandinavian Journal of Immunology 2013 DOI
  • Anne Husebekk, Heidi Tiller, Mette Kjær Killie, Mariana Eksteen, Maria Therese Ahlen, Tor Brynjar Stuge m.fl.:
    TOWARDS A PROPHYLACTIC TREATMENT OF HPA-1A-RELATED FETAL AND NEONATAL ALLOIMMUNE THROMBOCYTOPENIA (FNAIT)
    Vox Sanguinis 2012
  • Anne Husebekk, Maria Therese Ahlen, Mette Kjær Killie, Heidi Tiller, Mariana Eksteen, Ida Løken Killie m.fl.:
    MATERNAL ALLOIMMUNE RESPONSE DURING PREGNANCY: BRAKE OF MATERNAL TOLERANCE TO FETAL HUMAN PLATELET ANTIGEN 1A ANTIGEN MAY BE ASSOCIATED WITH REDUCED PLACENTAL FUNCTION
    Placenta 2011
  • C A Bauerlin, C Brede, Simone S. Riedel, Ana-Laura Jordan Garrote, C Kiesel, Miriam Ritz m.fl.:
    CD107 surface mobilization of peripheral blood T-cells to predict acute graft-versus-host disease
    Bone Marrow Transplantation 2010
  • Mariana Eksteen, Heidi Tiller, Anne Husebekk, Bjørn Ragnar Skogen, Tor Brynjar Stuge :
    GENERATION OF MONOCLONAL ANTI-HPA-1A ANTIBODIES BY IMMORTALIZATION OF MEMORY B CELLS FROM A WOMAN ALLOIMMUNIZED IN CONNECTION WITH PREGNANCY
    Vox Sanguinis 2010
  • Anne Husebekk, K Mk, Tor Brynjar Stuge, H Tiller, A Mt, J Kjeldsen-Kragh m.fl.:
    The knowledge of the pathophysiology of fetal/neonatal alloimmune thrombocytopenia is of importance to prevent immunization and to handle the immunized pregnancies in order to prevent hemorrhage
    Vox Sanguinis 2008
  • Maria Therese Ahlen, Mette Kjær Killie, Bjørn Ragnar Skogen, Anne Husebekk, Tor Brynjar Stuge :
    Isolation and Characterization of CD4+ T Cells Specific for the HPA 1a Epitope Associated with Neonatal Alloimmune Thrombocytopenia
    Blood 2007

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    Publikasjoner utenom Cristin


    Forskningsinteresser

    Cellular Immunology

    Interplay between T cells and B cells in alloimmune responses

    Fetal and Neonatal Alloimmune Thrombocytopenia



    CV

    Born: 1963. Gjøvik, Norway.

    Citizenship: Norwegian.

    Education:

    August 1985 – February 1992:

    Norwegian College of Fishery Science, University of Tromsø, Norway.

     - Master's degree in Marine Biochemistry (February 1992)

    March 1992 – February 1998:

    Dept. of Microbiology, University of Mississippi Medical Center, Jackson, Mississippi, USA.

     - PhD degree in Immunology (May 1998)

    Professional Experience:

    February 1998 – February 2000:

    Dept. of Microbiology, University of MississippiMedical Center, Jackson, Mississippi, USA.

     - Postdoctoral Fellow.

    March 2000 – July 2006:

    Division of Hematology, Stanford University School of Medicine, Palo Alto, California, USA.

     - Postdoctoral Fellow/Research Associate.

    September 2006 – present:                                                                                                  

    Immunology Research Group, Department of Medical Biology, University of Tromsø – The Arctic University of Norway, Tromsø, Norway.

     - Professor since September 2011.

     - Leader, Immunology Research Group since August 2013.

     

    Résumé:

    I am a native of Norway and currently a professor at the University of Tromsø - The Arctic University of Norway. My current research focus is immune responses associated with Fetal and Neonatal Alloimmune Thrombocytopenia - a condition caused by maternal antibodies reactive with fetal platelets - and especially the nature of maternal T cell responses that leads to this condition. Earlier in my career, I worked with T cell responses in cancer patients and in fish

     

    Mentorship:

    I have served as principal mentor for 4 doctoral students: Maria Therese Ahlen, PhD, graduated 2011; Mariana Eksteen, PhD, graduated 2015; Gøril Heide, MD, will defend her PhD thesis in 2018; Ida Løken Killie will defend her PhD thesis 2018. In addition, I have served as co-mentor for 3 PhD students. I have also mentored 4 master's degree students and two "Forskerlinje" students ("Forskerlinje" is a medical school research graduate program). I have also mentored a number of medical students and hosted six visiting international students involved in research assignments in our laboratory. I was also a member of the PhD committee for Carina Bauerlein, a student in the research group of Dr. Andreas Beilhack at the University of Wurzburg, Germany. Graduated summer 2013.                            

     

    Teaching:

    I have been teaching continuously since fall 2006. I lecture for students in medical, dental, and graduate schools. I also teach by leading discussion groups and in laboratory classes. Mainly, I teach immunology, although I also teach a class in the philosophy of science. On average, I teach about 90 hours per year. In addition, I am responsible for arranging and coordinating several different courses and I am a permanent member of several different exam commissions. I also serve as the immunology teaching coordinator for the Institute of Medical Biology.

    Patents/Patent applications:

    1.         Methods and compositions for producing target cell reactive lymphocytes in a subject.      Inventors: Peter P. Lee and Tor B. Stuge (2006). Pub. nr: WO2006020319 A3

    2.         Treatment of neonatal alloimmune thrombocytopenia. Pub. Nr: WO 2014131856 A1

                Inventors: Tor B Stuge, Bjørn R Skogen, Anne Husebekk, Maria Therese Ahlen (2014)

    3.         Antibodies against HPA-1a. Pub. nr: WO 2015150417 A1

                 Inventors: Tor Brynjar Stuge, Mariana Eksteen, Heidi Tiller, Terje Michaelsen, Øistein Ihle, Anne   Husebekk, Bjørn Ragnar Skogen (2015)


    UNN A1.802