Ansatt-Kenneth-Bowitz-Larsen
Foto: Kenneth Bowitz Larsen
Ansatt-Kenneth-Bowitz-Larsen
Institutt for medisinsk biologi kenneth.larsen@uit.no +4777645320 Tromsø MH

Kenneth Bowitz Larsen


Konfokalmikroskopi

Stillingsbeskrivelse

Jeg er involvert i en rekke prosjekter der konfokalmikroskopi er sentralt for forskningen. I noen tilfeller er jeg direkte involvert i planlegging og gjennomføring av forsøk, i andre tilfeller sørger jeg for teknisk opplæring og veiledning av andre, samt databehandling.

I tillegg driver jeg metodeutvikling og utprøving av ny teknologi som kan være av interesse for brukere av kjernefasiliteten, eller som de ulike forskningsgruppene etterspør.


  • Nthiga, Thaddaeus Mutugi; Shrestha, Birendra Kumar; Bruun, Jack-Ansgar; Larsen, Kenneth Bowitz; Lamark, Trond; Johansen, Terje. Regulation of Golgi turnover by CALCOCO1-mediated selective autophagy. Journal of Cell Biology 2021; Volum 220 (6). ISSN 0021-9525.s e202006128 - .s doi: 10.1083/jcb.202006128.
  • Abudu, Yakubu Princely; Shrestha, Birendra Kumar; Zhang, Wenxin; Palara, Anthimi; Brenne, Hanne Britt; Larsen, Kenneth Bowitz; Wolfson, Deanna; Dumitriu, Gianina; Øie, Cristina Ionica; Ahluwalia, Balpreet Singh; Levy, Gahl; Behrends, Christian; Tooze, Sharon A; Mouilleron, Stephane; Lamark, Trond; Johansen, Terje. SAMM50 acts with p62 in piecemeal basal- and OXPHOS-induced mitophagy of SAM and MICOS components. Journal of Cell Biology 2021; Volum 220 (8). ISSN 0021-9525.s doi: 10.1083/jcb.202009092.
  • Knutsen, Erik; Lellahi, Seyed Mohammad; Aure, Miriam Ragle; Nord, Silje; Fismen, Silje; Larsen, Kenneth Bowitz; Tellez Gabriel, Marta; Hedberg, Annica; Bjørklund, Sunniva; Bofin, Anna M.; Mælandsmo, Gunhild Mari; Sørlie, Therese; Mortensen, Elin Synnøve; Perander, Maria. The expression of the long NEAT1_2 isoform is associated with human epidermal growth factor receptor 2-positive breast cancers. Scientific Reports 2020; Volum 10:1277. ISSN 2045-2322.s 1 - 14.s doi: 10.1038/s41598-020-57759-4.
  • Overå, Katrine Stange; Garcia Garcia, Juncal; Bhujabal, Zambarlal; Jain, Ashish; Øvervatn, Aud Karin; Larsen, Kenneth Bowitz; Deretic, Vojo; Johansen, Terje; Lamark, Trond; Sjøttem, Eva. TRIM32, but not its muscular dystrophy-associated mutant, positively regulates and is targeted to autophagic degradation by p62/SQSTM1. Journal of Cell Science 2019; Volum 132:jcs236596 (23). ISSN 0021-9533.s 1 - 16.s doi: 10.1242/jcs.236596.
  • Shrestha, Birendra Kumar; Rasmussen, Mads Skytte; Abudu, Yakubu Princely; Bruun, Jack-Ansgar; Larsen, Kenneth Bowitz; Alemu, Endalkachew Ashenafi; Sjøttem, Eva; Lamark, Trond; Johansen, Terje. NIMA-related kinase 9–mediated phosphorylation of the microtubule-associated LC3B protein at Thr-50 suppresses selective autophagy of p62/sequestosome 1. Journal of Biological Chemistry 2019; Volum 295 (5). ISSN 0021-9258.s 1240 - 1260.s doi: 10.1074/jbc.RA119.010068.
  • Hoem, Gry; Larsen, Kenneth Bowitz; Øvervatn, Aud Karin; Brech, Andreas; Lamark, Trond; Sjøttem, Eva; Johansen, Terje. The FMRpolyGlycine protein mediates aggregate formation and toxicity independent of the CGG mRNA hairpin in a cellular model for FXTAS. Frontiers in Genetics 2019; Volum 10. ISSN 1664-8021.s doi: 10.3389/fgene.2019.00249.
  • Mejlvang, Jakob; Olsvik, Hallvard Lauritz; Svenning, Steingrim; Bruun, Jack-Ansgar; Abudu, Yakubu Princely; Larsen, Kenneth Bowitz; Brech, Andreas; Hansen, Tom Egil; Brenne, Hanne Britt; Hansen, Terkel; Stenmark, Harald Alfred; Johansen, Terje. Starvation induces rapid degradation of selective autophagy receptors by endosomal microautophagy. Journal of Cell Biology 2018; Volum 217 (10). ISSN 0021-9525.s 3640 - 3655.s doi: 10.1083/jcb.201711002.
  • Rasmussen, Mads Skytte; Mouilleron, Stephane; Shrestha, Birendra Kumar; Wirth, Martina; Lee, Rebecca; Larsen, Kenneth Bowitz; Abudu, Yakubu Princely; O'Reilly, Nicola; Sjøttem, Eva; Tooze, Sharon A; Lamark, Trond; Johansen, Terje. ATG4B contains a C-terminal LIR motif important for binding and efficient cleavage of mammalian orthologs of yeast Atg8. Autophagy 2017; Volum 13 (5). ISSN 1554-8627.s 834 - 853.s doi: 10.1080/15548627.2017.1287651.
  • Tusco, Radu; Jacomin, Anne-Claire; Jain, Ashish; Penman, Bridget S; Larsen, Kenneth Bowitz; Johansen, Terje; Nezis, Ioannis. Kenny mediates selective autophagic degradation of the IKK complex to control innate immune responses. Nature Communications 2017; Volum 8. ISSN 2041-1723.s doi: 10.1038/s41467-017-01287-9.
  • Olsvik, Hallvard Lauritz; Lamark, Trond; Takagi, Kenji; Larsen, Kenneth Bowitz; Evjen, gry; Øvervatn, Aud Karin; Mizushima, Tsunehiro; Johansen, Terje. FYCO1 contains a C-terminally extended, LC3A/B-preferring LC3-interacting region (LIR) motif required for efficient maturation of autophagosomes during basal autophagy. Journal of Biological Chemistry 2015; Volum 290 (49). ISSN 0021-9258.s 29361 - 29374.s doi: 10.1074/jbc.M115.686915.
  • Deosaran, Elizabeth; Larsen, Kenneth Bowitz; Hua, Rong; Sargent, Graeme; Wang, Yuqing; Kim, Sarah; Lamark, Trond; Jauregui, Miluska; Law, Kelsey; Lippincott-Schwartz, Jennifer; Brech, Andreas; Johansen, Terje; Kim, Peter K.. NBR1 acts as an autophagy receptor for peroxisomes. Journal of Cell Science 2013; Volum 126 (4). ISSN 0021-9533.s 939 - 952.s doi: 10.1242/jcs.114819.
  • Alemu, Endalkachew Ashenafi; Lamark, Trond; Torgersen, Knut Martin; Birgisdottir, Åsa birna; Larsen, Kenneth Bowitz; Jain, Ashish; Olsvik, Hallvard Lauritz; Øvervatn, Aud Karin; Kirkin, Vladimir; Johansen, Terje. ATG8 Family Proteins Act as Scaffolds for Assembly of the ULK Complex SEQUENCE REQUIREMENTS FOR LC3-INTERACTING REGION (LIR) MOTIFS. Journal of Biological Chemistry 2012; Volum 287 (47). ISSN 0021-9258.s doi: 10.1074/jbc.M112.378109.
  • Alemu, Endalkachew; Sjøttem, Eva; Outzen, heidi; Larsen, Kenneth Bowitz; Holm, turid; Bjørkøy, Geir; Johansen, Terje. Transforming growth factor-beta-inducible early response gene 1 is a novel substrate for atypical protein kinase Cs. Cellular and Molecular Life Sciences (CMLS) 2011; Volum 68 (11). ISSN 1420-682X.s 1953 - 1968.s doi: 10.1007/s00018-010-0541-1.
  • Jain, Ashish; Lamark, Trond; Sjøttem, Eva; Larsen, Kenneth Bowitz; Awuh, Jane Atesoh; Øvervatn, Aud Karin; McMahon, Michael; Hayes, John D; Johansen, Terje. p62/SQSTM1 Is a Target Gene for Transcription Factor NRF2 and Creates a Positive Feedback Loop by Inducing Antioxidant Response Element-driven Gene Transcription. Journal of Biological Chemistry 2010; Volum 285 (29). ISSN 0021-9258.s 22576 - 22591.s doi: 10.1074/jbc.M110.118976.
  • Larsen, Kenneth Bowitz; Lamark, Trond; Øvervatn, Aud Karin; Harneshaug, Ingvill; Johansen, Terje; Bjørkøy, Geir. A reporter cell system to monitor autophagy based on p62/SQSTM1. Autophagy 2010; Volum 6 (6). ISSN 1554-8627.s 784 - 793.
  • Clausen, Terje; Lamark, Trond; Isakson, Pauline; Finley, Kim; Larsen, Kenneth Bowitz; Brech, Andreas; Øvervatn, Aud Karin; Stenmark, Harald; Bjørkøy, Geir; Simonsen, Anne; Johansen, Terje. p62/SQSTM1 and ALFY interact to facilitate the formation of p62 bodies/ALIS and their degradation by autophagy. Autophagy 2010; Volum 6 (3). ISSN 1554-8627.s 330 - 344.s doi: 10.4161/auto.6.3.11226.
  • Seem, Martin; Sporsheim, Bjørnar; Winge, Per; Larsen, Kenneth Bowitz; Bones, Atle M.. Selective photobleaching: The missing manual. The 5th NorMIC Symposium on Light Microscopy 2012-10-25 - 2012-10-26 2012.
  • Seem, Martin; Sporsheim, Bjørnar; Winge, Per; Larsen, Kenneth Bowitz; Bones, Atle M.. Molecular imaging as a tool for studying intracellular transport. Årsmøte for The Norwegian Molecular Imaging Consortium (NorMIC) 2008-11-11 - 2009-11-12 2008.
  • Bones, Atle M.; Larsen, Kenneth Bowitz; Sparstad, Torfinn; Christensen, Tone; Winge, Per; Rohloff, Jens. Microarray Services available at the Norwegian Arabidopsis Research Centre (NARC). 4th International Conference on Plant Metabolomics (data) 2006-04-07 - 2006-04-10 2006.
  • Larsen, Kenneth Bowitz; Bones, Atle M.. Molekylær analyse av COPII-komponenter i Arabidopsis thaliana. 2005.
  • Se alle arbeider i CRIStin →


    Forskningsinteresser

    Kvantitativ mikroskopi, levende celle-mikroskopi, fluorescerende proteiner



    MH