Roy M. Bremnes
Stillingsbeskrivelse
Professor Roy M. Bremnes leder Translasjonell kreftforskningsgruppe, Institutt for klinisk medisin, Universitetet i Tromsø og er overlege i bistilling ved Kreftavdelingen, Universitetssykehuset i Nord-Norge.
Hallgeir Selven,
Lill-Tove Rasmussen Busund,
Sigve Andersen,
Roy M. Bremnes,
Thomas Karsten Kilvær
:
High expression of microRNA‑126 relates to favorable prognosis for colon cancer patients
Ragnhild Hellesnes,
Tor Åge Myklebust,
Roy M. Bremnes,
Åsa Karlsdottir,
Øivind Kvammen,
Helene Francisca Stigter Negaard
m.fl.:
Metachronous Contralateral Testicular Cancer in the Cisplatin Era: A Population-Based Cohort Study
Maria Jenvin Støen,
Sigve Andersen,
Mehrdad Rakaee,
Mona Irene Pedersen,
Lise Martine Ingebriktsen,
Roy M. Bremnes
m.fl.:
High expression of miR-17-5p in tumor epithelium is a predictor for poor prognosis for prostate cancer patients
Ragnhild Hellesnes,
Tor Åge Myklebust,
Sophie Dorothea Fosså,
Roy M. Bremnes,
Åsa Karlsdottir,
Øivind Kvammen
m.fl.:
Testicular cancer in the cisplatin era: Causes of death and mortality rates in a population-based cohort
Mehrdad Rakaee,
Thomas Karsten Kilvær,
Simin Jamaly,
Thomas Berg,
Erna-Elise Paulsen,
Marte Berglund
m.fl.:
Tertiary lymphoid structure score: a promising approach to refine the TNM staging in resected non-small cell lung cancer
Thomas Karsten Kilvær,
Erna-Elise Paulsen,
Sigve Andersen,
Mehrdad Rakaee,
Roy M. Bremnes,
Lill-Tove Rasmussen Busund
m.fl.:
Digitally quantified CD8+ cells: the best candidate marker for an immune cell score in non-small cell lung cancer?
Elin Richardsen,
Sigve Andersen,
Christian Melbø-Jørgensen,
Mehrdad Rakaee,
Nora Ness,
Samer Al-Saad
m.fl.:
MicroRNA 141 is associated to outcome and aggressive tumor characteristics in prostate cancer
Mehrdad Rakaee,
Lill-Tove Busund,
Simin Jamaly,
Erna-Elise Paulsen,
Elin Richardsen,
Sigve Andersen
m.fl.:
Prognostic Value of Macrophage Phenotypes in Resectable Non–Small Cell Lung Cancer Assessed by Multiplex Immunohistochemistry
Elin Richardsen,
Sigve Andersen,
Samer Al-Saad,
Mehrdad Rakaee,
Yngve Nordby,
Mona Irene Pedersen
m.fl.:
Low expression of miR-424-3p is highly correlated with clinical failure in prostate cancer
Ragnhild Hellesnes,
Øivind Kvammen,
Tor Åge Myklebust,
Roy M. Bremnes,
Åsa Karlsdottir,
Helene Francisca Stigter Negaard
m.fl.:
Continuing increased risk of second cancer in long-term testicular cancer survivors after treatment in the cisplatin era
Line Veronika Hjelle,
Per Ole Mobråten Gundersen,
Ragnhild Hellesnes,
Mette Sprauten,
Marianne Brydøy,
Torgrim Tanstad
m.fl.:
Long-term serum platinum changes and their association with cisplatin-related late effects in testicular cancer survivors
Kaja Konstanse Skjefstad,
Charles Johannessen,
Thea K.W. Grindstad,
Thomas Karsten Kilvær,
Erna Elise Paulsen,
Mona Irene Pedersen
m.fl.:
A gender specific improved survival related to stromal miR-143 and miR-145 expression in non-small cell lung cancer
Thea K.W. Grindstad,
Elin Richardsen,
Sigve Andersen,
Kaja Konstanse Skjefstad,
Mehrdad Rakaee,
Tom Dønnem
m.fl.:
Progesterone receptors in prostate cancer: Progesterone receptor B is the isoform associated with disease progression
Bjørn Henning Grønberg,
Bjørg Sjøblom,
Tore Wentzel-Larsen,
Vickie Elaine Baracos,
Marianne Jensen Hjermstad,
Nina Kathrine Aass
m.fl.:
A comparison of CT based measures of skeletal muscle mass and density from the Th4 and L3 levels in patients with advanced non-small-cell lung cancer
Christine Damgaard Valan,
Jens Erik Slagsvold,
Tarje Onsøien Halvorsen,
Martin Herje,
Roy M. Bremnes,
Paal Fr. Brunsvig
m.fl.:
Survival in Limited Disease Small Cell Lung Cancer According to N3 Lymph Node Involvement
Yury Kiselev,
Sigve Andersen,
Charles Johannessen,
Bjørn Fjukstad,
Karina Standahl Olsen,
Helge Stenvold
m.fl.:
Transcription factor PAX6 as a novel prognostic factor and putative tumour suppressor in non-small cell lung cancer
Mehrdad Rakaee,
Thomas Karsten Kilvær,
Stig Manfred Dalen,
Elin Richardsen,
Erna Elise Paulsen,
Sigurd Hald
m.fl.:
Evaluation of tumor-infiltrating lymphocytes using routine H&E slides predicts patient survival in resected non-small cell lung cancer
Sigurd Hald,
Mehrdad Rakaee,
Inigo Zubiavrre Martinez,
Elin Richardsen,
Samer Al-Saad,
Erna Elise Paulsen
m.fl.:
LAG-3 in Non-Small-cell Lung Cancer: Expression in Primary Tumors and Metastatic Lymph Nodes Is Associated With Improved Survival
Thomas Karsten Kilvær,
Mehrdad Rakaee,
Turid Hellevik,
Arne Östman,
Carina Strell,
Roy M. Bremnes
m.fl.:
Tissue analyses reveal a potential immune-adjuvant function of FAP-1 positive fibroblasts in non-small cell lung cancer
Nora Ness,
Sigve Andersen,
Mehrdad Rakaee,
Cecilie Nordbakken,
Andrey Yurjevich Valkov,
Erna-Elise Paulsen
m.fl.:
The prognostic role of immune checkpoint markers programmed cell death protein 1 (PD-1) and programmed death ligand 1 (PD-L1) in a large, multicenter prostate cancer cohort
Yngve Nordby,
Elin Richardsen,
Nora Ness,
Tom Dønnem,
Hitendra R.H. Patel,
Lill-Tove Busund
m.fl.:
High miR-205 expression in normal epithelium is associated with biochemical failure - An argument for epithelial crosstalk in prostate cancer?
Åslaug Helland,
Odd Terje Brustugun,
Sigve Nakken,
Ann Rita Halvorsen,
Tom Dønnem,
Roy M. Bremnes
m.fl.:
High number of kinome-mutations in non-small cell lung cancer is associated with reduced immune response and poor relapse-free survival
Asta Bye,
Bjørg Sjøblom,
Tore Wentzel-Larsen,
Bjørn Henning Grønberg,
Vickie E. Baracos,
Marianne Jensen Hjermstad
m.fl.:
Muscle mass and association to quality of life in non-small cell lung cancer patients
Elin Richardsen,
Sigve Andersen,
Samer Al-Saad,
Mehrdad Rakaee,
Yngve Nordby,
Mona Irene Pedersen
m.fl.:
Evaluation of the proliferation marker Ki-67 in a large prostatectomy cohort
Yngve Nordby,
Elin Richardsen,
Mehrdad Rakaee,
Nora Ness,
Tom Dønnem,
Hitendra R.H. Patel
m.fl.:
High expression of PDGFR-β in prostate cancer stroma is independently associated with clinical and biochemical prostate cancer recurrence
Sigve Andersen,
Elin Richardsen,
Mehrdad Rakaee,
Helena Bertilsson,
Roy M. Bremnes,
Magne Børset
m.fl.:
Expression of phosphatase of regenerating liver (PRL)-3, is independently associated with biochemical failure, clinical failure and death in prostate cancer
Erna-Elise Paulsen,
Thomas Karsten Kilvær,
Mehrdad Rakaee,
Elin Richardsen,
Sigurd Hald,
Sigve Andersen
m.fl.:
CTLA-4 expression in the non-small cell lung cancer patient tumor microenvironment: diverging prognostic impact in primary tumors and lymph node metastases
Samer Al-Saad,
Elin Richardsen,
Thomas Karsten Kilvær,
Tom Dønnem,
Sigve Andersen,
Mehrdad Rakaee
m.fl.:
The impact of MET, IGF-1, IGF1R expression and EGFR mutations on survival of patients with non-small-cell lung cancer
Kaja Skjefstad,
Thea Grindstad,
Mehrdad Rakaee,
Elin Richardsen,
Tom Dønnem,
Thomas Karsten Kilvær
m.fl.:
Prognostic relevance of estrogen receptor α, β and aromatase expression in non-small cell lung cancer
Roy M. Bremnes,
Lill-Tove Busund,
Thomas Karsten Kilvær,
Sigve Andersen,
Elin Richardsen,
Erna-Elise Paulsen
m.fl.:
The role of tumor-infiltrating lymphocytes in development, progression, and prognosis of non-small cell lung cancer
Mette Pøhl,
Karen Ege Olsen,
Rene Holst,
Tom Dønnem,
Lill-Tove Busund,
Roy M. Bremnes
m.fl.:
Keratin 34betaE12/keratin7 expression is a prognostic factor of cancer-specific and overall survival in patients with early stage non-small cell lung cancer
Tom Dønnem,
Thomas Karsten Kilvær,
Sigve Andersen,
Elin Richardsen,
Erna-Elise Paulsen,
Sigurd Hald
m.fl.:
Strategies for clinical implementation of TNM-Immunoscore in resected nonsmall-cell lung cancer
Marta Usó,
Eloísa Jantus-Lewintre,
Roy M. Bremnes,
Silvia Calabuig,
Ana Blasco,
Enrique Pastor
m.fl.:
Analysis of the immune microenvironment in resected non-small cell lung cancer: The prognostic value of different T lymphocyte markers
Tarje Onsøien Halvorsen,
Stein Harald Sundstrøm,
Øystein Fløtten,
Odd Terje Brustugun,
Paal Fr. Brunsvig,
Ulf Aasebø
m.fl.:
Comorbidity and outcomes of concurrent chemo- and radiotherapy in limited disease small cell lung cancer
Sigve Andersen,
Elin Richardsen,
Line Moi,
Tom Dønnem,
Yngve Nordby,
Nora Ness
m.fl.:
Fibroblast miR-210 overexpression is independently associated with clinical failure in Prostate Cancer – a
multicenter (in situ hybridization)study
Line Veronika Hjelle,
Roy M. Bremnes,
Per Ole Mobråten Gundersen,
Mette Sprauten,
Marianne Brydøy,
Torgrim Tandstad
m.fl.:
Associations between long-term serum platinum and neurotoxicity and ototoxicity, endocrine gonadal function, and cardiovascular disease in testicular cancer survivors
Mehrdad Rakaee,
Lill-Tove Busund,
Erna-Elise Paulsen,
Elin Richardsen,
Samer Al-Saad,
Sigve Andersen
m.fl.:
Prognostic effect of intratumoral neutrophils across histological subtypes of non-small cell lung cancer
Alv A Dahl,
Marie Østby-Deglum,
Jan Oldenburg,
Roy M. Bremnes,
Olav Dahl,
Olbjørn Klepp
m.fl.:
Aspects of posttraumatic stress disorder in long-term testicular cancer survivors: cross-sectional and longitudinal findings
Bjørg Sjøblom,
Bjørn Henning Grønberg,
Tore Wentzel-Larsen,
Vickie E. Baracos,
Marianne Jensen Hjermstad,
Nina Kathrine Aass
m.fl.:
Skeletal muscle radiodensity is prognostic for survival in patients with advanced non-small cell lung cancer
Erna-Elise Paulsen,
Thomas Karsten Kilvær,
Mehrdad Rakaee,
Samer Al-Saad,
Sigurd Hald,
Sigve Andersen
m.fl.:
Assessing PDL-1 and PD-1 in non-small cell lung cancer: a novel immunoscore approach
Tarje Onsøien Halvorsen,
Martin Herje,
Nina Levin,
Roy M. Bremnes,
Odd Terje Brustugun,
Øystein Fløtten
m.fl.:
Tumour size reduction after the first chemotherapy-course and outcomes of chemoradiotherapy in limited disease small-cell lung cancer
Thomas Karsten Kilvær,
Erna-Elise Paulsen,
Mehrdad Rakaee,
Samer Al-Saad,
Ramona Johansen Maurseth,
Khalid Al-Shibli
m.fl.:
The presence of intraepithelial CD45RO+ cells in resected lymph nodes with metastases from NSCLC patients is an independent predictor of disease-specific survival
Øystein Fløtten,
Bjørn Henning Grønberg,
Stein Harald Sundstrøm,
Nina Helbekkmo,
Roy M. Bremnes,
Christian von Plessen
:
Oral versus intravenous vinorelbine in advanced NSCLC - a retrospective comparison
Thomas Karsten Kilvær,
Mehrdad Rakaeekhanehkenari,
Turid Hellevik,
Samer Al-Saad,
Erna-Elise Paulsen,
Roy M. Bremnes
m.fl.:
Cancer associated fibroblasts in stage I-IIIA NSCLC: Prognostic impact and their correlations with tumor molecular markers
Kaja Konstanse Skjefstad,
Thea K.W. Grindstad,
Mehrdad Rakaee,
Elin Richardsen,
Tom Dønnem,
Thomas Karsten Kilvær
m.fl.:
Corrigendum to "Prognostic relevance of estrogen receptor α, β and aromatase expression in non-small cell lung cancer" [Steroids 113 (2016) 5-13]
Roy M. Bremnes,
Tom Dønnem,
Lill-Tove Busund
:
Importance of tumor infiltrating lymphocytes in non-small cell lung cancer?
Sigurd Hald,
Yury Kiselev,
Samer Al-Saad,
Elin Helmine Richardsen,
Charles Walquist Johannessen,
Marte Eilertsen
m.fl.:
Erratum: Prognostic impact of CXCL16 and CXCR6 in non-small cell lung cancer: Combined high CXCL16 expression in tumor stroma and cancer cells yields improved survival. [BMC Cancer. 15, (2015) (441)] DOI: 10.1186/s12885-015-1446-z
Gustav Lehne,
Kirsten Sundby Hall,
Roy M. Bremnes,
Thoralf Christoffersen,
Lars Slørdal
:
Farmakologisk variabilitet og individualisering av kreftbehandling
2016 ARKIV
Stein Harald Sundstrøm,
Paal Fr. Brunsvig,
Roy M. Bremnes,
Bjørn Henning Grønberg,
Odd Terje Brustugun
:
Lungekreft
2016 ARKIV
Thea Grindstad,
Kaja Skjefstad,
Sigve Andersen,
Nora Ness,
Yngve Nordby,
Samer Al-Saad
m.fl.:
Estrogen receptors α and β and aromatase as independent predictors for prostate cancer outcome
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Forskningsinteresser
Innen klinisk forskning er hovedinteressene innen behandling og oppfølging av lungekreft og testikkelkreft. Bremnes er medlem i styringsgruppen for Norsk lungekreftgruppe (NLCG), svensk-norsk testikkelkreftgruppe (Swenoteca) og Norsk urogenitalkreftgruppe (NUCG). Disse gruppene er drivende innen fase 2-3 intervensjonsstudier og oppfølging av seneffekter hos tidligere behandlede pasienter.
Innen translasjonsforskning er hovedinteressene innen lungekreft, protastakreft og bløtvevssarkom. Her studeres molekyler og deres reseptorer, immunceller og kreftassosierte fibroblaster for å vurdere hvilken betydning de har for svulstvekst, spredning og levetid for pasienten. Molekylende undersøkes på DNA, RNA, mikroRNA og proteinnivå ved hjelp av forskjellige metoder.
Forskningsgruppen har et stort nettverk av internasjonale samarbeidspartnere.
For øvrig vises til Forskningsgruppens hjemmeside og CV.
Vedlegg:
- CV 2011 Roy Bremnes (pdf)