Foto: Bjørn-Kåre Iversen
John Bjarne Hansen
Professor
Stillingsbeskrivelse
Leder av K. G. Jebsen TREC - senter for tromboseforskning
Overlege i hematologi, medisinsk klinikk, Universitetssykehuset Nord Norge
Espen Waage Skjeflo,
Line Holtet Evensen,
Søren Beck Jensen,
Nadezhda Latysheva,
Annika Elisabet Michelsen,
Thor Ueland
m.fl.:
Complement factors B, D, C3bBbP and risk of future venous thromboembolism
Clinical Immunology 2023 DOI
Magnus Edvardsen,
Ellen-Sofie Hansen,
Thor Ueland,
Pål Aukrust,
Sigrid Kufaas Brækkan,
Vania Maris Morelli
m.fl.:
Impact of the von Willebrand factor-ADAMTS-13 axis on the risk of future venous thromboembolism
Journal of Thrombosis and Haemostasis 2023 DOI
Steven P. Grover,
Tomohiro Kawano,
Jun Wan,
Pansakorn Tanratana,
Zsofia Polai,
Young J. Shim
m.fl.:
C1 inhibitor deficiency enhances contact pathway–mediated activation of coagulation and venous thrombosis
Blood 2023 DOI
Samantha Swamy,
Thor Ueland,
John Bjarne Hansen,
Omri Snir,
Sigrid Kufaas Brækkan
:
Plasma levels of P-selectin and future risk of incident venous thromboembolism
Sigrid Kufaas Brækkan,
John Bjarne Hansen
:
VTE epidemiology and challenges for VTE prevention at the population level: VTE epidemiology
Maria A. de Winter,
Alicia Uijl,
Harry R. Büller,
Marc Carrier,
Alexander T. Cohen,
John Bjarne Hansen
m.fl.:
Redefining clinical venous thromboembolism phenotypes: a novel approach using latent class analysis
Journal of Thrombosis and Haemostasis 2023 DOI
Safak Caglayan,
John Bjarne Hansen,
Omri Snir
:
Optimized workflow to modify microRNA expression in primary human intravascular cells
Steven P. Grover,
Omri Snir,
Kristian Dalsbø Hindberg,
Tatianna M. Englebert,
Sigrid Kufaas Brækkan,
Vania Maris Morelli
m.fl.:
High plasma levels of C1-inhibitor are associated with lower risk of future venous thromboembolism
Fridtjof Balteskard Rinde,
Camilla Tøvik Jørgensen,
Heidi Hassel Pettersen,
John Bjarne Hansen,
Waleed Ghanima,
Sigrid Kufaas Brækkan
:
Low D-dimer levels at diagnosis of venous thromboembolism are associated with reduced risk of recurrence: data from the TROLL registry
Ellen-Sofie Hansen,
Magnus Edvardsen,
Pål Aukrust,
Thor Ueland,
John Bjarne Hansen,
Sigrid Kufaas Brækkan
m.fl.:
Combined effect of high factor VIII levels and high mean platelet volume on the risk of future incident venous thromboembolism
Journal of Thrombosis and Haemostasis 2023 DOI
Oda Leknessund,
Vania Maris Morelli,
John Bjarne Hansen,
Sigrid Kufaas Brækkan
:
Hand grip strength in venous thromboembolism: risk of recurrence and mortality
Dana Meknas,
Sigrid Kufaas Brækkan,
John Bjarne Hansen,
Vania Maris Morelli
:
Surgery As a Trigger for Incident Venous Thromboembolism: Results from a Population-Based Case-Crossover Study
Vårin Eiriksdatter Wikan,
Birgitte Gladsø Tøndel,
Vania Maris Morelli,
Ellen Elisabeth Brodin,
Sigrid Kufaas Brækkan,
John Bjarne Hansen
:
Diagnostic Blood Biomarkers for Acute Pulmonary Embolism: A Systematic Review
Maria A. De Winter,
Harry R. Büller,
Marc Carrier,
Alexander T. Cohen,
John Bjarne Hansen,
Karin A. H. Kaasjager
m.fl.:
Recurrent venous thromboembolism and bleeding with extended anticoagulation: the VTE-PREDICT risk score
European Heart Journal 2023 DOI
Monique J.T. Crobach,
Rayna J.S. Anijs,
Sigrid Kufaas Brækkan,
Marianne T. Severinsen,
Jens Hammerstrøm,
Hanne Skille
m.fl.:
Survival after cancer-related venous thrombosis: the Scandinavian Thrombosis and Cancer Study
Tobias Frischmuth,
Birgitte G. Tondel,
Sigrid Kufaas Brækkan,
John Bjarne Hansen,
Vania Maris Morelli
:
The Risk of Incident Venous Thromboembolism Attributed to Overweight and Obesity: The Tromso Study
Thrombosis and Haemostasis 2023 DOI
Casper Jan Elis Ullsten-Wahlund,
Safak Caglayan,
Paulo Czarnewski,
John Bjarne Hansen,
Omri Snir
:
Sustained and intermittent hypoxia differentially modulate primary monocyte immunothrombotic responses to IL-1β stimulation
Helle Jørgensen,
Erzsébet Horváth-Puhó,
Kristina Laugesen,
Sigrid Kufaas Brækkan,
John Bjarne Hansen,
Henrik Toft Sørensen
:
The Interaction Between Venous Thromboembolism and Socioeconomic Status on the Risk of Disability Pension
Tobias Frischmuth,
Kristian Hindberg,
Pål Aukrust,
Thor Ueland,
Sigrid Kufaas Brækkan,
John Bjarne Hansen
m.fl.:
Elevated plasma levels of plasminogen activator inhibitor-1 are associated with risk of future incident venous thromboembolism
Birgitte Gladsø Tøndel,
Vania Maris Morelli,
John Bjarne Hansen,
Sigrid Kufaas Brækkan
:
Risk factors and predictors for venous thromboembolism in people with ischemic stroke: A systematic review
Omri Snir,
line Wilsgård,
Nadezhda Latysheva,
Casper Ullsten-Wahlund,
Sigrid Kufaas Brækkan,
Kristian Dalsbø Hindberg
m.fl.:
Plasma levels of platelet-derived microvesicles are associated with risk of future venous thromboembolism
Lisa Jakobsen,
Tobias Frischmuth,
Sigrid Kufaas Brækkan,
John Bjarne Hansen,
Vania Maris Morelli
:
Joint Effect of Multiple Prothrombotic Genotypes and Mean Platelet Volume on the Risk of Incident Venous Thromboembolism
Paul L. den Exter,
Scott C. Woller,
Helia Robert-Ebadi,
Camila Masias,
Pierre-Emmanuel Morange,
David Castelli
m.fl.:
Management of bleeding risk in patients who receive anticoagulant therapy for venous thromboembolism: Communication from the ISTH SSC Subcommittee on Predictive and Diagnostic Variables in Thrombotic Disease
Carolina E. Touw,
Banne Nemeth,
Willem M. Lijfering,
Raymond A. van Adrichem,
line Wilsgård,
Nadezhda Latysheva
m.fl.:
Effect of lower-leg trauma and knee arthroscopy on procoagulant phospholipid-dependent activity
Aniket Mishra,
Rainer Malik,
Tsuyoshi Hachiya,
Tuuli Jürgenson,
Shinichi Namba,
Daniel C. Posner
m.fl.:
Stroke genetics informs drug discovery and risk prediction across ancestries
Christabel Esi Damoah,
Omri Snir,
Kristian Dalsbø Hindberg,
Peter Garred,
Judith K Ludviksen,
Sigrid Kufaas Brækkan
m.fl.:
High Levels of Complement Activating Enzyme MASP-2 Are Associated With the Risk of Future Incident Venous Thromboembolism
Elias Allarai,
Wei-Hsuan Lee,
Stephen Burgess,
Susanna C. Larsson,
Sara Lindstrom,
Lu Wang
m.fl.:
Genetically predicted cortisol levels and risk of venous thromboembolism
Scott C. Woller,
Kerstin de Wit,
Helia Robert-Ebadi,
Camila Masias,
Frederikus A. Klok,
Paul L. den Exter
m.fl.:
A systematic review of biomarkers among hospitalized patients with COVID-19 predictive of venous thromboembolism: A communication from the Predictive and Diagnostic Variables Scientific and Standardization Committee of the ISTH
Oda Leknessund,
Vania Maris Morelli,
Bjørn Heine Strand,
John Bjarne Hansen,
Sigrid Kufaas Brækkan
:
Hand grip strength and risk of incident venous thromboembolism: The Tromsø study
Line Holtet Evensen,
Carl-Arne Arnesen,
Frits Richard Rosendaal,
Maiken Elvestad Gabrielsen,
Ben Michael Brumpton,
Kristian Hveem
m.fl.:
The Risk of Venous Thromboembolism Attributed to Established Prothrombotic Genotypes
Joakim Knutsen Sejrup,
Birgitte Gladsø Tøndel,
Vania Maris Morelli,
Maja-Lisa Løchen,
Inger Njølstad,
Ellisiv B. Mathiesen
m.fl.:
Joint effect of myocardial infarction and obesity on the risk of venous thromboembolism: The Tromsø Study
Helle Jørgensen,
Erzsebet Horvath-Puho,
Kristina Laugesen,
Sigrid Kufaas Brækkan,
John Bjarne Hansen,
Henrik Toft Sørensen
:
Venous thromboembolism and risk of depression: a population-based cohort study
Florian Thibord,
Derek Klarin,
Jennifer A. Brody,
Ming-Huei Chen,
Michael G. Levin,
Daniel I. Chasman
m.fl.:
Cross-Ancestry Investigation of Venous Thromboembolism Genomic Predictors
Helle Jørgensen,
Erzsebet Horvath-Puho,
Kristina Laugesen,
Sigrid Kufaas Brækkan,
John Bjarne Hansen,
Henrik Toft Sørensen
:
Socioeconomic status and risk of incident venous thromboembolism
Journal of Thrombosis and Haemostasis 2021 DOI
Espen Waage Skjeflo,
Sigrid Kufaas Brækkan,
Judith K Ludviksen,
Omri Snir,
Kristian Hindberg,
Tom Eirik Mollnes
m.fl.:
Elevated plasma concentration of complement factor C5 is associated with risk of future venous thromboembolism
Magnus Edvardsen,
Ellen-Sofie Hansen,
Kristian Hindberg,
Vania Maris Morelli,
Thor Ueland,
Pål Aukrust
m.fl.:
Combined effects of plasma von Willebrand factor and platelet measures on the risk of incident venous thromboembolism
Bjarne Østerud,
Nadezhda Latysheva,
Christian Schoergenhofer,
Bernd Jilma,
John-Bjarne Hansen,
Omri Snir
:
A rapid, sensitive, and specific assay to measure TF activity based on chromogenic determination of thrombin generation
Tobias Frischmuth,
Kristian Hindberg,
Pål Aukrust,
Thor Ueland,
Sigrid K. Brækkan,
John-Bjarne Hansen
m.fl.:
Plasma levels of leptin and risk of future incident venous thromboembolism
Magnus Edvardsen,
Kristian Hindberg,
Ellen-Sofie Hansen,
Vania Maris Morelli,
Thor Ueland,
Pål Aukrust
m.fl.:
Plasma levels of von Willebrand factor and future risk of incident venous thromboembolism
Hanne Skille,
Benedikte Paulsen,
Kristian Hveem,
Marianne T. Severinsen,
Maiken Elvestad Gabrielsen,
Søren R. Kristensen
m.fl.:
Prothrombotic genotypes and risk of venous thromboembolism in occult cancer
Gro Grimnes,
Soerajja Bhoelan,
Kristian Hindberg,
Mark Davids,
Max Nieuwdorp,
Tom E. Mollnes
m.fl.:
Impact of a Vancomycin-Induced Shift of the Gut Microbiome in a Gram-Negative Direction on Plasma Factor VIII:C Levels: Results from a Randomized Controlled Trial
Benedikte Paulsen,
Olga Vikhammer Gran,
Marianne T. Severinsen,
Jens Hammerstrøm,
Søren Risom Kristensen,
Suzanne C. Cannegieter
m.fl.:
Association of smoking and cancer with the risk of venous thromboembolism: the Scandinavian Thrombosis and Cancer cohort
Helle Jørgensen,
Erzsébet Horváth-Puhó,
Kristina Laugesen,
Sigrid Kufaas Brækkan,
John-Bjarne Hansen,
Henrik Toft Sørensen
:
Risk of a permanent work-related disability pension after incident venous thromboembolism in Denmark: A population-based cohort study
Carl Arne Løchen Arnesen,
Katalin Veres,
Erzsébet Horváth-Puhó,
John-Bjarne Hansen,
Henrik Toft Sørensen,
Sigrid K. Brækkan
:
Estimated lifetime risk of venous thromboembolism in men and women in a Danish nationwide cohort: impact of competing risk of death
Ellen-Sofie Hansen,
Fridtjof Balteskard Rinde,
Magnus Edvardsen,
Kristian Hindberg,
Nadezhda Latysheva,
Pål Aukrust
m.fl.:
Elevated plasma D-dimer levels are associated with risk of future incident venous thromboembolism
Grégoire Le Gal,
Marc Carrier,
Lana A. Castellucci,
Adam Cuker,
John-Bjarne Hansen,
Frederikus A. Klok
m.fl.:
Development and implementation of common data elements for venous thromboembolism research: on behalf of SSC Subcommittee on official Communication from the SSC of the ISTH
Journal of Thrombosis and Haemostasis 2021 DOI
Bjarne Østerud,
Nadezhda Latysheva,
John Bjarne Hansen,
Omri Snir
:
“A rapid, sensitive, and specific assay to measure tissue factor activity based on chromogenic determination of thrombin generation”: reply
Journal of Thrombosis and Haemostasis 2023 DOI
Steven P. Grover,
Sigrid Kufaas Brækkan,
Nigel Mackman,
John Bjarne Hansen
:
“High plasma levels of C1-inhibitor are associated with lower risk of future venous thromboembolism”: reply
Journal of Thrombosis and Haemostasis 2023 DOI
Steven P. Grover,
Linda Sundler Björkman,
Sigrid Kufaas Brækkan,
Bengt Zöller,
John Bjarne Hansen,
Nigel Mackman
:
“C1-inhibitor levels and Venous Thromboembolism: Results from a Mendelian Randomization Study”: comment from Grover et al
Journal of Thrombosis and Haemostasis 2023 DOI
Casper Ullsten-Wahlund,
Safak Caglayan,
Christabel Esi Damoah,
John Bjarne Hansen,
Omri Snir
:
Hypoxia augments proinflammatory activation of endothelial cells towards a prothrombotic phenotype
2021
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Forskningsinteresser
Risikofaktorer for venøs trombose
Patofysiologi ved venøs tromboembose
Medlem i forskningsgruppe
Medlem i prosjekt
PREVENT
Mission-VTE
Milestone VTE
Genetics and VTE subtypes
Gene variants and VTE
PEPSI-VTE
BIOBESE
NOR-CAT
MBLGEN-VTE
IMPROVE
Coffee and VTE
VWF and VTE
Biomarkers and VTE
Diagnostic biomarkers of PE
Diagnostic biomarkers of DVT
CARROT
CARTIER
Blood cell variables and VTE
Sex-differences and VTE
Stroke-related VTE
CV
Utdanning
1989 Cand.med (MD), Universitetet i Tromsø
1997 Dr. med (PhD i cardiovaskulær medisin) Universitetet i Tromsø
Tidligere stillinger
1991-94 Forsker ved Universitetet i Tromsø
1994-95 Post.doc., Universitetet i Tromsø
1996-2005 Førsteamanuensis i medisin in medicine, Universitetet i Tromsø (20-50% stilling)
2006-2008 Professor I i Hematologi Universitetet i Tromsø (100% stilling)
2007-2008 Prodekan forskning, Det helsevitenskapelige fakultet, Universitetet i Tromsø
2008-2009 Visiting professor, The Scripps Research Institute, La Jolla, CA, USA
Publikasjoner
208 originale artikler i fagfellevurderte tidsskrift registret i Pubmed. 22 oversiktsartikler og 12 bokkapitler. Bidratt til over 320 abstract presentert ved,- og pulibsert i forbindelse med internasjonale vitenskapelige konferanser.
Veiledning
Hovedveileder for 24 fullførte PhD studenter. Hovedveileder for 13 pågående PhD studenter og mentor for 5 Postdoktorer.