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  3. Atle Noralf Larsen
Bilde av Larsen, Atle Noralf
Bilde av Larsen, Atle Noralf
Forsker, Biologisk kjemi og bioinformatikk Institutt for kjemi atle.larsen@uit.no +4777644478 Her finner du meg

Atle Noralf Larsen

  • Yvonne Piotrowski, Man Kumari Gurung, Atle Noralf Larsen :
    Characterization and engineering of a DNA polymerase reveals a single amino-acid substitution in the fingers subdomain to increase strand-displacement activity of A-family prokaryotic DNA polymerases
    BMC Molecular and Cell Biology 2019 ARKIV / DOI
  • Yvonne Piotrowski, Kristel Berg, David P. Klebl, Ingar Leiros, Atle Noralf Larsen :
    Characterization of an intertidal zone metagenome oligoribonuclease and the role of the intermolecular disulfide bond for homodimer formation and nuclease activity
    FEBS Open Bio 2019 ARKIV / DOI
  • Natasha Hynes, Clemens Furnes, Børge Nilsen Fredriksen, Tori Winther, Jarl Bøgwald, Atle Noralf Larsen m.fl.:
    Immune response of Atlantic salmon to recombinant flagellin
    Vaccine 2011 DOI
  • Makoto Inami, Stein Tore Solem, Trond Ø. Jørgensen, Atle Noralf Larsen :
    Characterization of an antiserum against Atlantic cod (Gadus morhua L.) g-type lysozyme
    Fish and Shellfish Immunology 2010 DOI
  • Atle Noralf Larsen, Terese Solstad, Gunbjørg Svineng, Marit Seppola, Trond Ø. Jørgensen :
    Molecular characterisation of a goose-type lysozyme gene in Atlantic cod (Gadus morhua L.)
    Fish and Shellfish Immunology 2009 DOI
  • Ronny Helland, Renate Lie Larsen, Solrun Finstad, Peter Kyomuhendo, Atle Noralf Larsen :
    Crystal structures of g-type lysozyme from Atlantic cod shed new light on substrate binding and the catalytic mechanism
    Cellular and Molecular Life Sciences (CMLS) 2009 DOI
  • Jaya Kumari, Atle Noralf Larsen, Jarl Bøgwald, Roy Ambli Dalmo :
    Interleukin-17D in Atlantic salmon (Salmo salar): Molecular characterization, 3D modelling and promoter analysis
    Fish and Shellfish Immunology 2009 DOI
  • Terese Solstad, Atle Noralf Larsen, Marit Seppola, Trond Ø. Jørgensen :
    Identification, cloning and expression analysis of a hepcidin cDNA of the Atlantic cod (Gadus morhua L.)
    Fish and Shellfish Immunology 2008 DOI
  • Marit Seppola, Atle Noralf Larsen, Kari Steiro, Børre Robertsen, Ingvill Jensen :
    Characterisation and expression analysis of the interleukin genes, IL-1 beta, IL-8 and IL-10, in Atlantic cod (Gadus morhua L.)
    Molecular Immunology 2008 DOI
  • Ronny Helland, Atle Noralf Larsen, Arne Oskar Smalås, Nils Peder Willassen :
    The 1.8 angstrom crystal structure of a proteinase K-like enzyme from a psychrotroph Serratia species
    The FEBS Journal 2006
  • Atle Noralf Larsen, Elin Moe, Ronny Helland, Dag Rune Gjellesvik, Nils Peder Willassen :
    Characterization of a recombinantly expressed proteinase K-like enzyme from a psychrotrophic Serratia sp
    The FEBS Journal 2006
  • Yvonne Piotrowski, Netsanet Gizaw Assefa, Ronny Helland, Kirsti Merete Johannessen, Nils Peder Willassen, Atle Noralf Larsen :
    Enzymes from the Arctic - The cold gold
    2015
  • Yvonne Piotrowski, Netsanet Gizaw Assefa, Ronny Helland, Kirsti Merete Johannessen, Bjarne Landfald, Arne O. Smalås m.fl.:
    Enzymes from the Arctic - The cold gold
    2014
  • Yvonne Piotrowski, Kirsti Merete Johannessen, Netsanet Gizaw Assefa, Bjarne Landfald, Arne O. Smalås, Trond Ø. Jørgensen m.fl.:
    MabCent - Discovery of arctic marine enzymes
    2012
  • Atle Noralf Larsen, Laila Niiranen, Kirsti Merete Johannessen, Solrun Finstad, Trond Ø. Jørgensen, Nils Peder Willassen :
    MabCent - Hunting for Enzymes in the cold North
    2009
  • Roy Ambli Dalmo, jan-eirik Killie, Merete Bjørgan Schrøder, Atle Noralf Larsen :
    Vil løse fiskesykdomsgåten
    26. mars 2008
  • Atle Noralf Larsen :
    CodImm- Defence genes and immune mechanisms against viral and bacterial diseases of Atlantic cod
    2007
  • Atle Noralf Larsen, Ronny Helland, Gunbjørg Svineng, Trond Ø. Jørgensen :
    Identification, cloning and recombinant expression of a goose-type lysozyme from Atlantic cod (Gadus Morhua)
    2007
  • Makoto Inami, Atle Noralf Larsen, jan rombout, Merete Bjørgan Schrøder, Kiron Viswanath :
    A preliminary study on the intestinal immune system of Atlantic cod (Gadus morhua L.)
    2007
  • Ronny Helland, Atle Noralf Larsen, Nils Peder Willassen :
    Structural basis for substrate specificity in two enzymes in the Proteinase K family
    2005
  • Atle Noralf Larsen, Ronny Helland, Dag Rune Gjellesvik, Nils Peder Willassen :
    Structural basis for S1-S4 specificity in two enzymes of the proteinase K family
    2004

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    Publikasjoner utenom Cristin

    Commercially available enzyme products from our research:

    Heat-labile exonuclease I: https://arcticzymes.com/technology/hl-exol/

    DNA polymerase – Isopol™ : https://arcticzymes.com/technology/isopol-dna-polymerase/

    DNA polymerase - Isopol™ SD+: https://arcticzymes.com/technology/isopol-sd/

    DNA polymerase - IsoPol™ BST+: https://arcticzymes.com/technology/isopol-bst/

     

    Patents:

    Larsen A.N., Piotrowski Y., “Position based increase in application relevant properties”. Patent application filed in UK December 2017

    Larsen A.N., Piotrowski Y., Assefa N.G., Lanes O. ”Marine DNA polymerase”. Patent application filed in UK March 2016, Patent Application No. 1604876.1

    Larsen A.N., Piotrowski Y., Willassen N.P., Lanes O., Lorentzen M.S., Solstad T., Andreassen E., Elde M. ”Heat Labile Exonucleases” International Patent Application, PCT/EP2015/001703

    Forskningsinteresser

    My research interest is to characterise and develop enzymes originating from the arctic marine environment for use in molecular biology and diagnostic applications as well as RNA therapeutics. I have a particular research focus on nucleases and polymerases.


    Medlem i forskningsgruppe

    Biological Chemistry and Bioinformatics   English content