Bilde av Helland, Ronny
Bilde av Helland, Ronny
Institutt for kjemi ronny.helland@uit.no +4777646474 +47 90940431 Tromsø REALF C 317

Ronny Helland


Kontorsjef Institutt for kjemi


  • Bjarni Ásgeirsson, Sigurbjörn Markússon, Sigríður S. Hlynsdóttir, Ronny Helland, Jens G. Hjörleifsson :
    X-ray crystal structure of Vibrio alkaline phosphatase with the non-competitive inhibitor cyclohexylamine
    Biochemistry and Biophysics Reports 2020 ARKIV / DOI
  • Jens Guðmundur Hjörleifsson, Ronny Helland, Manuela Magnusdottir, Bjarni Ásgeirsson :
    The high catalytic rate of the cold-active Vibrio alkaline phosphatase requires a hydrogen bonding network involving a large interface loop
    FEBS Open Bio 2020 ARKIV / DOI
  • Scott Mazurkewich, Ronny Helland, Alasdair Mackenzie, Vincent Eijsink, Phillip Byron Pope, Gisela Brändén m.fl.:
    Structural insights of the enzymes from the chitin utilization locus of Flavobacterium johnsoniae
    Scientific Reports 13. august 2020 ARKIV / DOI
  • Man Kumari Gurung, Bjørn Altermark, Ronny Helland, Arne O. Smalås, Inger Lin Uttakleiv Ræder :
    Features and structure of a cold active N-acetylneuraminate lyase
    PLOS ONE 2019 ARKIV / FULLTEKST / DOI
  • Ronny Helland, Eva katrin Bjørkeng, Ulli Rothweiler, Magne Olav Sydnes, Daniela Maria Pampanin :
    The crystal structure of haemoglobin from Atlantic cod
    Acta Crystallographica. Section F : Structural Biology and Crystallization Communications 2019 ARKIV / DOI
  • Concetta De Santi, Osman A. B. S. M. Gani, Ronny Helland, Adele Kim Williamson :
    Structural insight into a CE15 esterase from the marine bacterial metagenome
    Scientific Reports 2017 ARKIV / DOI
  • Marit Seppola, Kathrine Ryvold Bakkemo, Helene V. Mikkelsen, Bjørnar Myrnes, Ronny Helland, David Irwin m.fl.:
    Multiple specialised goose-type lysozymes potentially compensate for an exceptional lack of chickentype lysozymes in Atlantic cod
    Scientific Reports 2016 ARKIV / FULLTEKST / DOI
  • Hilde Lysvand, Ronny Helland, Lars Hagen, Geir Slupphaug, Ole-Jan Iversen :
    Psoriasis pathogenesis – Pso p27 constitutes a compact structure forming large aggregates
    Biochemistry and Biophysics Reports 2015 ARKIV / DOI
  • Tony Christopeit, Trine Josefine Olsen Carlsen, Ronny Helland, Hanna-Kirsti S. Leiros :
    Discovery of novel inhibitor scaffolds against the metallo-β-lactamase VIM-2 by surface plasmon resonance (SPR) based fragment screening
    Journal of Medicinal Chemistry 2015 ARKIV / DOI
  • Kenneth Johnson, Thomas Ve, Øivind Larsen, Rolf B. Pedersen, Johan R. Lillehaug, Harald B Jensen m.fl.:
    CorA is a copper repressible surface-associated copper(I)-binding protein produced in Methylomicrobium album BG8
    PLOS ONE 2014 ARKIV / DOI
  • Zarah Forsberg, Alasdair Mackenzie, Morten Sørlie, Åsmund Kjendseth Røhr, Ronny Helland, Andrew S. Arvai m.fl.:
    Structural and functional characterization of a conserved pair of bacterial cellulose-oxidizing lytic polysaccharide monooxygenases
    Proceedings of the National Academy of Sciences of the United States of America 28. april 2014 DOI
  • D. Cazamea-Catalan, E. Magnanou, Ronny Helland, L. Besseau, Gilles Boeuf, Jack Falcòn m.fl.:
    Unique arylalkylamine N-acetyltransferase-2 polymorphism in salmonids and profound variations in thermal stability and catalytic efficiency conferred by two residues
    Journal of Experimental Biology 2013 DOI
  • Damien D. Cazamèa-Catalan, Elodie Magnanou, Ronny Helland, Gilmer Vanegas, Laurence Besseau, Gilles Boeuf m.fl.:
    Functional diversity of Teleost arylalkylamine N-acetyltransferase-2: is the timezyme evolution driven by habitat temperature?
    Molecular Ecology 2012 DOI
  • Thomas Ve, Karina Mathisen, Ronny Helland, Odd Andre Karlsen, Anne Fjellbirkeland, Åsmund Kjendseth Røhr m.fl.:
    The Methylococcus capsulatus (Bath) Secreted Protein, MopE*, Binds Both Reduced and Oxidized Copper
    PLOS ONE 2012 ARKIV / DOI
  • Leidy Lagos, Dimitar Borisov Iliev, Ronny Helland, Mario Rosemblatt, Jorunn B Jørgensen :
    CD40L-A costimulatory molecule involved in the maturation of antigen presenting cells in Atlantic salmon (Salmo salar)
    Developmental and Comparative Immunology 2012 DOI
  • Peter Kyomuhendo, Bjørnar Myrnes, Bjørn Olav Brandsdal, Arne Smalås, Inge Waller Nilsen, Ronny Helland :
    Thermodynamics and structure of a salmon cold active goose-type lysozyme
    Comparative Biochemistry and Physiology - Part B: Biochemistry & Molecular Biology 2010 DOI
  • Anna Szlachcic, M Zakrzewska, D Krowarsch, vibeke Os, Ronny Helland, Arne Oskar Smalås m.fl.:
    Structure of a highly stable mutant of human fibroblast growth factor 1
    Acta Crystallographica Section D: Biological Crystallography 2009 DOI
  • Ronny Helland, Renate Lie Larsen, Bjarni Åsgeirsson :
    The 1.4 angstrom crystal structure of the large and cold-active Vibrio sp. alkaline phosphatase
    Biochimica et Biophysica Acta - Proteins and Proteomics 2009 DOI
  • Ronny Helland, Renate Lie Larsen, Solrun Finstad, Peter Kyomuhendo, Atle Noralf Larsen :
    Crystal structures of g-type lysozyme from Atlantic cod shed new light on substrate binding and the catalytic mechanism
    Cellular and Molecular Life Sciences (CMLS) 2009 DOI
  • Bjørn Altermark, Ronny Helland, Elin Moe, Nils Peder Willassen, Arne Oskar Smalås :
    Structural adaptation of endonuclease I from the cold-adapted and halophilic bacterium Vibrio salmonicida
    Acta Crystallographica Section D: Biological Crystallography 2008 DOI
  • Ronny Helland, Anne Fjellbirkeland, Odd-Arne Karlsen, Johan Richard Lillehaug, Harald Jensen, Thomas Ve :
    An oxidized tryptophan facilitates copper binding in Methylococcus capsulatus-secreted protein MopE
    Journal of Biological Chemistry 2008 DOI
  • Bjørn Altermark, Ronny Helland, Elin Moe, Nils Peder Willassen, Arne Oskar Smalås :
    Environmental adaptation of endonuclease I from Vibrio salmonicida
    Acta Crystallographica Section D: Biological Crystallography 2008
  • Laila Mirja Niiranen, Bjørn Altermark, Bjørn Olav Brandsdal, Hanna-Kirsti S. Leiros, Ronny Helland, Arne Oskar Smalås m.fl.:
    Effects of salt on the kinetics and thermodynamic stability of endonuclease I from Vibrio salmonicida and Vibrio cholerae
    The FEBS Journal 2008 DOI
  • G Saelensminde, Gisle Sælensminde, O Halskau, Øyvind Halskau, Ronny Helland, Nils Peder Willassen m.fl.:
    Structure-dependent relationships between growth temperature of prokaryotes and the amino acid frequency in their proteins
    Extremophiles 2007 DOI
  • Ellen Kristin Riise, marit sjo Lorentzen, Ronny Helland, Arne Oskar Smalås, Hanna-Kirsti S. Leiros, Nils Peder Willassen :
    The first structure of a cold-active catalase from Vibrio salmonicida at 1.96 angstrom reveals structural aspects of cold adaptation
    Acta Crystallographica Section D: Biological Crystallography 2007 DOI
  • Olayiwola Adekoya, Ronny Helland, Nils P Willassen, Ingebrigt Sylte :
    Comparative sequence and structure analysis reveal features of cold adaptation of an enzyme in the thermolysin family
    Proteins: Structure, Function, and Bioinformatics 2006
  • Ronny Helland, Atle Noralf Larsen, Arne Oskar Smalås, Nils Peder Willassen :
    The 1.8 angstrom crystal structure of a proteinase K-like enzyme from a psychrotroph Serratia species
    The FEBS Journal 2006
  • Atle Noralf Larsen, Elin Moe, Ronny Helland, Dag Rune Gjellesvik, Nils Peder Willassen :
    Characterization of a recombinantly expressed proteinase K-like enzyme from a psychrotrophic Serratia sp
    The FEBS Journal 2006
  • Bjørn Altermark, Arne Oskar Smalås, Nils Peder Willassen, Ronny Helland :
    The structure of Vibrio cholerae extracellular endonuclease I reveals the presence of a buried chloride ion
    Acta Crystallographica Section D: Biological Crystallography 2006
  • Ellen Kristin Riise, Marit Sjo Lorentzen, Ronny Helland, Nils P Willassen :
    Crystallization and preliminary X-ray diffraction analysis of a cold-adapted catalase from Vibrio salmonicida
    Acta Crystallographica. Section F : Structural Biology and Crystallization Communications 2006
  • Hanna-Kirsti S. Leiros, Hanna Kirsti Schrøder Leiros, Bjørn Olav Brandsdal, Ole Andreas Andersen, vibeke Os, Ingar Leiros m.fl.:
    Trypsin specificity as elucidated by LIE calculations, X-ray structures, and association constant measurements
    Protein Science 2004
  • Honorata Czapinska, Ronny Helland, Arne Oskar Smalås, Jacek Otlewski :
    Crystal Structures of Five Bovine Chymotrypsin Complexes with P1 BPTI Variants
    Journal of Molecular Biology (JMB) 2004
  • Man Kumari Gurung, Tor Olav Berg, Marie-Josée Haglund Halsør, Bjørn Altermark, Ingar Leiros, Ronny Helland m.fl.:
    Efficient production of sialic acids- Using enzymes for biomass conversion
    2017
  • Man Kumari Gurung, Tor Olav Berg, Marie-Josée Haglund Halsør, Bjørn Altermark, Ingar Leiros, Ronny Helland m.fl.:
    Efficient production of sialic acids- Using enzymes for biomass conversion
    2017
  • Tor Olav Berg, Marie-Josée Haglund Halsør, Man Kumari Gurung, Bjørn Altermark, Ingar Leiros, Ulli Rothweiler m.fl.:
    From marine rest raw materials to sialic acids: Using enzymes for biomass conversion
    2016
  • Tor Olav Berg, Bjørn Altermark, Ingar Leiros, Ronny Helland, Inger Lin Uttakleiv Ræder :
    Production of sialic acids and derivatives by enzyme catalysis
    2016
  • Yvonne Piotrowski, Netsanet Gizaw Assefa, Ronny Helland, Kirsti Merete Johannessen, Nils Peder Willassen, Atle Noralf Larsen :
    Enzymes from the Arctic - The cold gold
    2015
  • Tor Olav Berg, Bjørn Altermark, Ingar Leiros, Ronny Helland, Inger Lin Uttakleiv Ræder :
    Biocatalytical production of sialic acids and derivatives
    2015
  • Zarah Forsberg, Alasdair Mackenzie, Morten Sørlie, Åsmund Kjendseth Røhr, Ronny Helland, Gustav Vaaje-Kolstad m.fl.:
    Characterization of cellulose-active lytic polysaccharide monooxygenases with complementary activities
    2014
  • Yvonne Piotrowski, Netsanet Gizaw Assefa, Ronny Helland, Kirsti Merete Johannessen, Bjarne Landfald, Arne O. Smalås m.fl.:
    Enzymes from the Arctic - The cold gold
    2014
  • Inger Lin Uttakleiv Ræder, Bjørn Altermark, Man Kumari Gurung, Ronny Helland, Arne O. Smalås :
    Sialic acids in marine bacteria
    2014
  • Man Kumari Gurung, Bjørn Altermark, Inger Lin Uttakleiv Ræder, Ronny Helland, Arne O. Smalås :
    Features and structure of a sialic acid aldolase from Aliivibrio salmonicida
    2013
  • Inger Lin Uttakleiv Ræder, Man Kumari Gurung, Bjørn Altermark, Tor Olav Berg, Ronny Helland, Arne O. Smalås :
    Sialic acid biosynthesis in marine bacteria
    2013
  • Odd-Arne Olsen, Wenche Johansen, Sidsel Emilsen, Tatiana Belova, Zhe Liang, Arne Smalås m.fl.:
    Structural & functional significance of the DEK1 phytocalpain during land plant evolution from green algae
    2010
  • Atle Noralf Larsen, Ronny Helland, Gunbjørg Svineng, Trond Ø. Jørgensen :
    Identification, cloning and recombinant expression of a goose-type lysozyme from Atlantic cod (Gadus Morhua)
    2007
  • Bjørn Altermark, Ronny Helland, Laila Mirja Niiranen, Elin Moe, Bjørn Olav Brandsdal, Arne Oskar Smalås m.fl.:
    Optimum enzymatic activity of endonuclease I from Vibrio salmonicida and Vibrio cholerae correlateswith the bacterial growth habitat
    2006
  • Ronny Helland, Atle Noralf Larsen, Nils Peder Willassen :
    Structural basis for substrate specificity in two enzymes in the Proteinase K family
    2005
  • Olayiwola Adedotun Adekoya, Ronny Helland, Nils Peder Willassen, Ingebrigt Sylte :
    Structural determinants for a cold adapted enzyme in the thermolysin family
    2005
  • Atle Noralf Larsen, Ronny Helland, Dag Rune Gjellesvik, Nils Peder Willassen :
    Structural basis for S1-S4 specificity in two enzymes of the proteinase K family
    2004
  • Ronny Helland :
    Bioinformatics in Tromsø
    2003

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    Forskningsinteresser

    Mine forskningsinteresser inkluderer struktur-funksjonsstudier av proteiner (enzymer): Hvordan påvirker den atomære strukturen enzymers aktivitet, spesifisitet og effektivitet. Enzymer med opprinnelse i kuldetilpassede organismer har ofte helt unike biokjemiske egenskaper, og disse ønsker man kunne anvende i biokjemisk og bioteknologisk industri.

    Deltakelse i prosjekter:

    The Norwegian Structural Biology Centre
    Bacterial sialic acids
    MarSynth – Marine DNA modifying enzymes for synthetic biology
    Optimization and Application Development of Marine Cold-adapted DNA Polymerases – OptiZyme