Angel Moldes.jpg
Angel Moldes.jpg
Institutt for medisinsk biologi amo000@post.uit.no +4777649165 +47 41310997 Tromsø FARM F1.216

Angel Moldes-Anaya


Førsteamanuensis II

Stillingsbeskrivelse

Laboratory Manager Cyclotron and Radiochemistry

Tracer Development and Cyclotron

PET Imaging Center, University Hospital of North Norway (UNN)

Vitenskapelige arbeidsområder


  • Ahmet Oguzhan Bicakci, Mousumi Sarkar, Yu-Hsin Chang, Evelyn Kahl, Lorenzo Ragazzi, Angel Moldes-Anaya m.fl.:
    Anxiolytic-like Effects of the Positive GABA-B Receptor Modulator GS39783 Correlate with Mice's Individual Basal Anxiety and Stress Reactivity
    Pharmaceuticals 16. februar 2022 ARKIV / FULLTEKST / DOI
  • Ahmet Oguzhan Bicakci, Mousumi Sarkar, Yu-Hsin Chang, Evelyn Kahl, Lorenzo Ragazzi, Angel Moldes-Anaya m.fl.:
    Anxiolytic‐like Effects of the Positive GABAB Receptor Modulator GS39783 Correlate with Mice’s Individual Basal Anxiety and Stress Reactivity
    Pharmaceuticals 2022 ARKIV / DOI
  • Hanne Friis Berntsen, Angel Moldes-Anaya, Cesilie Granum Bjørklund, Lorenzo Ragazzi, Trude M Haug, Rønnaug Strandabø m.fl.:
    Perfluoroalkyl acids potentiate glutamate excitotoxicity in rat cerebellar granule neurons
    Toxicology 2020 ARKIV / DOI
  • Richard Fjellaksel, Angel Moldes-Anaya, Terje Vasskog, Ana Oteiza, Maria Montserrat Martin-Armas, Ole Kristian Hjelstuen m.fl.:
    Evaluation by metabolic profiling and in vitro autoradiography of two promising GnRH‐receptor ligands for brain SPECT imaging
    Journal of labelled compounds & radiopharmaceuticals 08. desember 2019 ARKIV / DOI
  • Hanne Friis Berntsen, Cesilie Granum Bjørklund, Rønnaug Strandabø, Trude Haug, Angel Moldes-Anaya, Judit Fuentes-Lazaro m.fl.:
    PFOS-induced excitotoxicity is dependent on Ca2+ influx via NMDA receptors in rat cerebellar granule neurons
    Toxicology and Applied Pharmacology 2018 ARKIV / DOI
  • Angel Moldes-Anaya, Thomas Sæther, Silvio Uhlig, Hilde Irene Nebb, Terje Larsen, Hans Christian Eilertsen m.fl.:
    Two Isomeric C16 Oxo-Fatty Acids from the Diatom Chaetoceros karianus Show Dual Agonist Activity towards Human Peroxisome Proliferator-Activated Receptors (PPARs) α/γ
    Marine Drugs 2017 ARKIV / FULLTEKST / DOI
  • Hanne Friis Berntsen, Inger Lise Bogen, Mattis B Wigestrand, Frode Fonnum, S. Ivar Walaas, Angel Moldes-Anaya :
    The fungal neurotoxin penitrem A induces the production of reactive oxygen species in human neutrophils at submicromolar concentrations
    Toxicology 2017 DOI
  • Christiane Kruse Fæste, Angel Moldes-Anaya :
    Biotransformation of the fungal neurotoxin Thomitrem A by primary rat hepatocytes
    Toxicon 2016 DOI
  • H F Berntsen, Mattis Brænne Wigestrand, Inger Lise Bogen, Frode Fonnum, S. Ivar Walaas, Angel Moldes-Anaya :
    Mechanisms of penitrem-induced cerebellar granule neuron death in vitro: Possible involvement of GABA(A) receptors and oxidative processes
    Neurotoxicology 2013 DOI
  • Gunnar Sundstøl Eriksen, Angel Moldes-Anaya, Christiane Kruse Fæste :
    Penitrem A and analogues: toxicokinetics, toxicodynamics including mechanism of action and clinical significance
    World Mycotoxin Journal 09. august 2013 DOI
  • Angel Moldes-Anaya, Thomas Rundberget, Christiane Kruse Fæste, Gunnar Sundstøl Eriksen, Aksel Bernhoft :
    Neurotoxicity of Penicillium crustosum secondary metabolites: Tremorgenic activity of orally administered penitrem A and thomitrem A and E in mice
    Toxicon 2012 DOI
  • Angel Moldes-Anaya, Thomas Rundberget, Silvio Uhlig, Frode Rise, Alistair Lawrence Wilkins :
    Isolation and structure elucidation of secopenitrem D, an indole alkaloid from Penicillium crustosum Thom
    Toxicon 2011 DOI
  • Angel S. Moldes-Anaya, Frode Fonnum, Gunnar Sundstøl Eriksen, Thomas Rundberget, S. Ivar Walaas, Mattis Brænne Wigestrand :
    In vitro neuropharmacological evaluation of penitrem-induced tremorgenic syndromes: importance of the GABAergic system
    Neurochemistry International 2011 DOI
  • Aksel Bernhoft, Angel Moldes, T Rudberget, Ida Skaar :
    Mykotoksinet penitrem A gir hjerneskader hos hunder
    Norsk Veterinærtidsskrift 2010
  • Gunnar Sundstøl Eriksen, Karin Hultin Jæderlund, Angel Moldes, Jurgen Schonheit, Aksel Bernhoft, Gry Jæger m.fl.:
    Poisoning of dogs with tremorgenic Penicillium toxins
    Medical Mycology 2010 DOI
  • Angel S. Moldes-Anaya, Alistair L. Wilkins, Thomas Rundberget, Christiane Kruse Fæste :
    In vitro and in vivo hepatic metabolism of the fungal neurotoxin penitrem A
    Drug and chemical toxicology (New York, N.Y. 1978) 2009 DOI
  • Angel S Moldes-Anaya, Tone Normann Asp, Gunnar Sundstøl Eriksen, Ida Skaar, Thomas Rundberget :
    Determination of cyclopiazonic acid in food and feeds by liquid chromatography-tandem mass spectrometry
    Journal of Chromatography A 2009 DOI
  • Michel Herranz Carnero, Angel Moldes-Anaya, Bengt Erik Haug, Turid Hellevik, Inigo Zubiavrre Martinez :
    Innovative molecular imaging technique for Granzyme-B characterization as an emerging biomarker for radio-immunotherapy combinations
    2022
  • Yngve Guttormsen, Angel Moldes-Anaya, Richard Fjellaksel, Ana Oteiza, Montserrat Martin-Armas, Marcel Lindemann m.fl.:
    Development of a carbon-11 labeled thienopyrimidine based radioligand for EGFR-tyrosine-kinase-inhibitor (TKI) specific PET imaging of glioblastoma
    Journal of Nuclear Medicine 2021
  • Yngve Guttormsen, Mathias Kranz, Richard Fjellaksel, Montserrat Martin-Armas, Ana Oteiza, Julia Bihler m.fl.:
    SP-015 - Preliminary evaluation of a novel carbon-11 labeled brain-penetrant EGFR-TKI radiotracer for brain cancer imaging
    Nuclear Medicine and Biology 2021 DOI
  • Richard Fjellaksel, Ana Oteiza, armas maria montserrat Martin, Jørn H Hansen, Angel Moldes-Anaya, Terje Vasskog m.fl.:
    Development and evaluation of gonadotropin releasing hormone SPECT radioligands
    2018 DATA
  • Richard Fjellaksel, Jørn H Hansen, Angel Moldes-Anaya, armas maria montserrat Martin, Ana Oteiza, Patrick Riss m.fl.:
    Development and evaluation of gonadotropin releasing hormone (GnRH) SPECT radioligands
    2017 FULLTEKST / DATA
  • Angel Moldes-Anaya, Lorenzo Ragazzi, Samuel Kuttner, Daniel Vincenz, Jürgen Goldschmidt, Vegard Brun m.fl.:
    Targetting mnemonic pathways of stress by cerebral perfusion using 99mTc-HMPAO SPECT/CT
    2017
  • Kamilla Gjerland Haugland, Angel Moldes-Anaya, Anniken Olberg, Andreas Lande, Kirsten Brun Kjelstrup, Vegard Brun :
    Intrahippocampal growth hormone modulates spatial memory
    2017
  • Lorenzo Ragazzi, Angel Moldes-Anaya, Vegard Brun, Kirsten Brun Kjelstrup :
    Contextual fear encoded by hippocampal single units
    2016
  • Thomas Sæther, Angel Moldes-Anaya, Jørn Eivind Tungen, Anders Vik, Steinar M Paulsen, Ingebrigt Sylte m.fl.:
    Anti-diabetic activity from marine lipids: new anti-diabetic drugs
    2016
  • Kamilla Gjerland Haugland, Angel Moldes-Anaya, Kirsten Brun Kjelstrup, Vegard Brun :
    Intrahippocampal growth hormone modulates spatial memory
    2016
  • KG Haugland, Angel Moldes-Anaya, Kirsten Brun Kjelstrup, Vegard Brun :
    The role of intrahippocampal Growth hormone in spatial memmory
    2015
  • Thomas Sæther, Angel Moldes-Anaya, Jørn Eivind Tungen, Anders Vik, Steinar Martin Paulsen, Ingebrigt Sylte m.fl.:
    Anti-diabetic activity from marine lipids: new anti-diabetic drugs
    2015
  • Angel Moldes-Anaya, Samuel Kuttner, Daniel Vincenz, Jürgen Goldschmidt, Vegard Brun, Kirsten Brun Kjelstrup :
    Targeting mnemonic pathways of stress by cerebral perfusion using 99mTc-HMPAO SPECT/CT
    2015
  • Kamilla Gjerland Haugland, Angel Moldes-Anaya, Kirsten Brun Kjelstrup, Vegard Brun :
    The role of intrahippocampal growth hormone in spatial memory
    2015
  • Thomas Sæther, Angel Moldes-Anaya, Laila Norrheim-Larsen, Terje Larsen, Steinar M Paulsen, Hilde Irene Nebb :
    Two near identical oxylipins from the diatom Chaetoceros karianus show isoform-specific agonist activity towards human peroxisome proliferator-activated receptors (PPARs)
    2014
  • Angel Moldes-Anaya, Thomas Sæther, Laila Norrheim Larsen, Terje Larsen, Hilde Irene Nebb, Steinar Paulsen :
    Identifying natural products with agonist activity against human nuclear receptors in extracts of cultured marine microalgae
    2013
  • Thomas Sæther, Angel Moldes-Anaya, Laila Norrheim Larsen, Terje Larsen, Steinar Paulsen, Hilde Irene Nebb :
    Identifying natural products with agonist activity against human nuclear receptors in extracts of cultured marine microalgae
    2013
  • Angel Moldes-Anaya, Thomas Sæther, Laila Norrheim-Larsen, Hilde Irene Nebb, Terje Larsen, Steinar Paulsen :
    Identifying natural products with agonist or modulatory activity against human nuclear receptors in extracts from cultured marine microalgae
    2013
  • Thomas Sæther, Angel Moldes-Anaya, Laila Norrheim-Larsen, Terje Larsen, Steinar M Paulsen, Hilde Irene Nebb :
    Identifying natural products with agonist activity against human nuclear receptors in extracts of cultured marine microalgae
    2013
  • Angel Moldes-Anaya :
    Hunden kan dø av muggsopp i matavfall
    Forskning.no 2012
  • Angel Moldes-Anaya :
    Neurological disorders caused by fungal toxins: the case of penitrem-induced neuromycotoxicosis in dogs
    2012
  • Angel Moldes-Anaya :
    Toxicokinetics and toxicodinamics of penitrem A, a fungal neuroactive compound causing neurological disease in humans and animals
    2012
  • Gunnar Sundstøl Eriksen, Thomas Rundberget, Mattis Brænne Wigestrand, Frode Fonnum, Aksel Bernhoft, Angel Moldes-Anaya :
    Poisoning by penicillium toxins-Clinical and brain receptor effects
    Toxicology Letters 2012 DOI
  • Angel S. Moldes-Anaya :
    Undervurdert muggsoppgift
    Forskning.no 2012
  • Angel S. Moldes-Anaya :
    Penitrem-induced neurological disease in Norway : clinical cases in dogs. Neuropharmacology and toxicokinetics of penitrem A. Structural elucidation of a novel penitremanalogue
    Unipub forlag 2011
  • Angel S. Moldes-Anaya, Frode Fonnum, Gunnar Sundstøl Eriksen, Thomas Rundberget, S. Ivar Walaas, Mattis Brænne Wigestrand :
    Hepatic metabolism and neuropharmacological evaluation of fungal tremorgenic syndromes: implication of the GABAergic and glutamatergic systems
    2009
  • Angel S. Moldes-Anaya, Thomas Rundberget, Christiane Kruse Fæste, Gunnar Sundstøl Eriksen :
    In vitro metabolism of tremorgenic mycotoxins in rat hepatocytes and microsomes: identification and potential toxic effects of produced metabolites
    2007

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    Forskningsinteresser

    Radio- og kjernekjemi (Bruk av spesifikke radiomerkede molekyler for medisinsl avbildning ved hjelp av PET og SPECT hybrid teknikker, hovedinteresse hjerne avbildning)

    Nevrofarmakologi og nevrotoksikologi

    Neuroimaging (SPECT and PET/CT)

     

     

     

    Undervisning

    Nevroanatomy, Nevrofysiologi, Nevropsykofarmakologi ved:

    MED-2501, Mentale Funksjoner I

    MED-2521, Mentale Funksjoner II

    FARM-2202, CNS anatopatofysiologi og psykofarmakologi



    CV

    CAS i Radiofarmasi, ETH-Zürich (2020)

    Sertifisert toksikolog (EUROTOX-registrert toksikolog) (2013)

    PhD i veterinærmedisin (nevrotoksikologi og analytisk organisk kjemi) (2011)

    MSc i nevrovitenskap og atferdsbiologi (2013)

    MSc i kjemi (2003)