Foto: Bjørn-Kåre Iversen
John Bjarne Hansen
Stillingsbeskrivelse
Forskningsgruppeleder Tromboseforskning (TREC)
Enhetsleder Senter for Tromboseforskning (TREC), Medisinsk klinikk, Universitetssykehuset Nord Norge
Eduarda Mazagao Guerreiro,
Sergei G. Kruglik,
Samantha Swamy,
Nadezhda Latysheva,
Bjarne Østerud,
Jean-Michel Guigner
m.fl.:
Extracellular vesicles from activated platelets possess a phospholipid-rich biomolecular profile and enhance prothrombinase activity
Paul S. de Vries,
Paula Reventun,
Michael R. Brown,
Adam S. Heath,
Jennifer E. Huffman,
Ngoc-Quynh Le
m.fl.:
A genetic-association study of circulating coagulation factor VIII and von Willebrand factor levels
Blood 2024 DOI
Vania Maris Morelli,
Omri Snir,
Kristian Dalsbø Hindberg,
Kristian Hveem,
Sigrid Kufaas Brækkan,
John Bjarne Hansen
:
High microRNA-145 plasma levels are associated with decreased risk of future incident venous thromboembolism: the HUNT study
Blood 2024 DOI
Carl-Arne Arnesen,
Line Holtet Evensen,
Kristian Hveem,
Maiken Elvestad Gabrielsen,
John Bjarne Hansen,
Sigrid Kufaas Brækkan
:
Proportion of venous thromboembolism attributed to recognized prothrombotic genotypes in men and women
Birgitte Gladsø Tøndel,
Joakim Knutsen Sejrup,
Vania Maris Morelli,
Maja-Lisa Løchen,
Inger Njølstad,
Ellisiv B. Mathiesen
m.fl.:
Joint effect of ischemic stroke and obesity on the risk of venous thromboembolism: the Tromsø Study
Luuk J.J. Scheres,
Sigrid Kufaas Brækkan,
Judith P.L. Verlaan,
Suzanne C. Cannegieter,
John Bjarne Hansen,
Vania Maris Morelli
:
The fatty liver index and risk of incident venous thromboembolism: the Tromsø Study
Amandine Bonifay,
Nigel Mackman,
Yohei Hisada,
Ana Teresa Azevedo Sachetto,
Chi Hau,
Elaine Gray
m.fl.:
Comparison of assays measuring extracellular vesicle tissue factor in plasma samples: communication from the ISTH SSC Subcommittee on Vascular Biology
Journal of Thrombosis and Haemostasis 2024 DOI
Daniël Duijzer,
Maria A. de Winter,
Marc Carrier,
Alexander T. Cohen,
John Bjarne Hansen,
Karin A.H. Kaasjager
m.fl.:
Impact of the VTE-PREDICT calculator on clinicians’ decision making in fictional patients with venous thromboembolism: a randomized controlled trial
Steven P. Grover,
Tomohiro Kawano,
Jun Wan,
Pansakorn Tanratana,
Zsofia Polai,
Young J. Shim
m.fl.:
C1 inhibitor deficiency enhances contact pathway–mediated activation of coagulation and venous thrombosis
Steven P. Grover,
Omri Snir,
Kristian Dalsbø Hindberg,
Tatianna M. Englebert,
Sigrid Kufaas Brækkan,
Vania Maris Morelli
m.fl.:
High plasma levels of C1-inhibitor are associated with lower risk of future venous thromboembolism
Safak Caglayan,
John Bjarne Hansen,
Omri Snir
:
Optimized workflow to modify microRNA expression in primary human intravascular cells
Sigrid Kufaas Brækkan,
John Bjarne Hansen
:
VTE epidemiology and challenges for VTE prevention at the population level: VTE epidemiology
Magnus Edvardsen,
Ellen-Sofie Hansen,
Thor Ueland,
Pål Aukrust,
Sigrid Kufaas Brækkan,
Vania Maris Morelli
m.fl.:
Impact of the von Willebrand factor-ADAMTS-13 axis on the risk of future venous thromboembolism
Monique J.T. Crobach,
Rayna J.S. Anijs,
Sigrid Kufaas Brækkan,
Marianne T. Severinsen,
Jens Hammerstrøm,
Hanne Skille
m.fl.:
Survival after cancer-related venous thrombosis: the Scandinavian Thrombosis and Cancer Study
Ellen-Sofie Hansen,
Magnus Edvardsen,
Pål Aukrust,
Thor Ueland,
John Bjarne Hansen,
Sigrid Kufaas Brækkan
m.fl.:
Combined effect of high factor VIII levels and high mean platelet volume on the risk of future incident venous thromboembolism
Samantha Swamy,
Thor Ueland,
John Bjarne Hansen,
Omri Snir,
Sigrid Kufaas Brækkan
:
Plasma levels of P-selectin and future risk of incident venous thromboembolism
Maria A. de Winter,
Alicia Uijl,
Harry R. Büller,
Marc Carrier,
Alexander T. Cohen,
John Bjarne Hansen
m.fl.:
Redefining clinical venous thromboembolism phenotypes: a novel approach using latent class analysis
Fridtjof Balteskard Rinde,
Camilla Tøvik Jørgensen,
Heidi Hassel Pettersen,
John Bjarne Hansen,
Waleed Ghanima,
Sigrid Kufaas Brækkan
:
Low D-dimer levels at diagnosis of venous thromboembolism are associated with reduced risk of recurrence: data from the TROLL registry
Espen Waage Skjeflo,
Line Holtet Evensen,
Søren Beck Jensen,
Nadezhda Latysheva,
Annika Elisabet Michelsen,
Thor Ueland
m.fl.:
Complement factors B, D, C3bBbP and risk of future venous thromboembolism
Oda Leknessund,
Vania Maris Morelli,
John Bjarne Hansen,
Sigrid Kufaas Brækkan
:
Hand grip strength in venous thromboembolism: risk of recurrence and mortality
Maria A. De Winter,
Harry R. Büller,
Marc Carrier,
Alexander T. Cohen,
John Bjarne Hansen,
Karin A. H. Kaasjager
m.fl.:
Recurrent venous thromboembolism and bleeding with extended anticoagulation: the VTE-PREDICT risk score
Dana Meknas,
Sigrid Kufaas Brækkan,
John Bjarne Hansen,
Vania Maris Morelli
:
Surgery As a Trigger for Incident Venous Thromboembolism: Results from a Population-Based Case-Crossover Study
Vårin Eiriksdatter Wikan,
Birgitte Gladsø Tøndel,
Vania Maris Morelli,
Ellen Elisabeth Brodin,
Sigrid Kufaas Brækkan,
John Bjarne Hansen
:
Diagnostic Blood Biomarkers for Acute Pulmonary Embolism: A Systematic Review
Casper Jan Elis Ullsten-Wahlund,
Safak Caglayan,
Paulo Czarnewski,
John Bjarne Hansen,
Omri Snir
:
Sustained and intermittent hypoxia differentially modulate primary monocyte immunothrombotic responses to IL-1β stimulation
Tobias Frischmuth,
Birgitte Gladsø Tøndel,
Sigrid Kufaas Brækkan,
John Bjarne Hansen,
Vania Maris Morelli
:
The Risk of Incident Venous Thromboembolism Attributed to Overweight and Obesity: The Tromso Study
Helle Jørgensen,
Erzsébet Horváth-Puhó,
Kristina Laugesen,
Sigrid Kufaas Brækkan,
John Bjarne Hansen,
Henrik Toft Sørensen
:
The Interaction Between Venous Thromboembolism and Socioeconomic Status on the Risk of Disability Pension
Tobias Frischmuth,
Kristian Hindberg,
Pål Aukrust,
Thor Ueland,
Sigrid Kufaas Brækkan,
John Bjarne Hansen
m.fl.:
Elevated plasma levels of plasminogen activator inhibitor-1 are associated with risk of future incident venous thromboembolism
Lisa Jakobsen,
Tobias Frischmuth,
Sigrid Kufaas Brækkan,
John Bjarne Hansen,
Vania Maris Morelli
:
Joint Effect of Multiple Prothrombotic Genotypes and Mean Platelet Volume on the Risk of Incident Venous Thromboembolism
Paul L. den Exter,
Scott C. Woller,
Helia Robert-Ebadi,
Camila Masias,
Pierre-Emmanuel Morange,
David Castelli
m.fl.:
Management of bleeding risk in patients who receive anticoagulant therapy for venous thromboembolism: Communication from the ISTH SSC Subcommittee on Predictive and Diagnostic Variables in Thrombotic Disease
Line Holtet Evensen,
Carl-Arne Arnesen,
Frits Richard Rosendaal,
Maiken Elvestad Gabrielsen,
Ben Michael Brumpton,
Kristian Hveem
m.fl.:
The Risk of Venous Thromboembolism Attributed to Established Prothrombotic Genotypes
Christabel Esi Damoah,
Omri Snir,
Kristian Dalsbø Hindberg,
Peter Garred,
Judith K Ludviksen,
Sigrid Kufaas Brækkan
m.fl.:
High Levels of Complement Activating Enzyme MASP-2 Are Associated With the Risk of Future Incident Venous Thromboembolism
Oda Leknessund,
Vania Maris Morelli,
Bjørn Heine Strand,
John Bjarne Hansen,
Sigrid Kufaas Brækkan
:
Hand grip strength and risk of incident venous thromboembolism: The Tromsø study
Aniket Mishra,
Rainer Malik,
Tsuyoshi Hachiya,
Tuuli Jürgenson,
Shinichi Namba,
Daniel C. Posner
m.fl.:
Stroke genetics informs drug discovery and risk prediction across ancestries
Florian Thibord,
Derek Klarin,
Jennifer A. Brody,
Ming-Huei Chen,
Michael G. Levin,
Daniel I. Chasman
m.fl.:
Cross-Ancestry Investigation of Venous Thromboembolism Genomic Predictors
Scott C. Woller,
Kerstin de Wit,
Helia Robert-Ebadi,
Camila Masias,
Frederikus A. Klok,
Paul L. den Exter
m.fl.:
A systematic review of biomarkers among hospitalized patients with COVID-19 predictive of venous thromboembolism: A communication from the Predictive and Diagnostic Variables Scientific and Standardization Committee of the ISTH
Birgitte Gladsø Tøndel,
Vania Maris Morelli,
John Bjarne Hansen,
Sigrid Kufaas Brækkan
:
Risk factors and predictors for venous thromboembolism in people with ischemic stroke: A systematic review
Joakim Knutsen Sejrup,
Birgitte Gladsø Tøndel,
Vania Maris Morelli,
Maja-Lisa Løchen,
Inger Njølstad,
Ellisiv B. Mathiesen
m.fl.:
Joint effect of myocardial infarction and obesity on the risk of venous thromboembolism: The Tromsø Study
Elias Allarai,
Wei-Hsuan Lee,
Stephen Burgess,
Susanna C. Larsson,
Sara Lindstrom,
Lu Wang
m.fl.:
Genetically predicted cortisol levels and risk of venous thromboembolism
Helle Jørgensen,
Erzsebet Horvath-Puho,
Kristina Laugesen,
Sigrid Kufaas Brækkan,
John Bjarne Hansen,
Henrik Toft Sørensen
:
Venous thromboembolism and risk of depression: a population-based cohort study
Carolina E. Touw,
Banne Nemeth,
Willem M. Lijfering,
Raymond A. van Adrichem,
line Wilsgård,
Nadezhda Latysheva
m.fl.:
Effect of lower-leg trauma and knee arthroscopy on procoagulant phospholipid-dependent activity
Omri Snir,
line Wilsgård,
Nadezhda Latysheva,
Casper Ullsten-Wahlund,
Sigrid Kufaas Brækkan,
Kristian Dalsbø Hindberg
m.fl.:
Plasma levels of platelet-derived microvesicles are associated with risk of future venous thromboembolism
Espen Waage Skjeflo,
Sigrid Kufaas Brækkan,
Judith K Ludviksen,
Omri Snir,
Kristian Hindberg,
Tom Eirik Mollnes
m.fl.:
Elevated plasma concentration of complement factor C5 is associated with risk of future venous thromboembolism
Carl Arne Løchen Arnesen,
Katalin Veres,
Erzsébet Horváth-Puhó,
John-Bjarne Hansen,
Henrik Toft Sørensen,
Sigrid K. Brækkan
:
Estimated lifetime risk of venous thromboembolism in men and women in a Danish nationwide cohort: impact of competing risk of death
Tobias Frischmuth,
Kristian Hindberg,
Maiken Elvestad Gabrielsen,
Ben Michael Brumpton,
Kristian Hveem,
Sigrid Kufaas Brækkan
m.fl.:
Joint Effect of Multiple Prothrombotic Genotypes and Obesity on the Risk of Incident Venous Thromboembolism
Hanne Skille,
Benedikte Paulsen,
Kristian Hveem,
Marianne T. Severinsen,
Maiken Elvestad Gabrielsen,
Søren R. Kristensen
m.fl.:
Prothrombotic genotypes and risk of venous thromboembolism in occult cancer
Tobias Frischmuth,
Kristian Hindberg,
Pål Aukrust,
Thor Ueland,
Sigrid K. Brækkan,
John-Bjarne Hansen
m.fl.:
Plasma levels of leptin and risk of future incident venous thromboembolism
Ellen-Sofie Hansen,
Magnus Edvardsen,
Pål Aukrust,
Thor Ueland,
John Bjarne Hansen,
Sigrid Kufaas Brækkan
m.fl.:
Galectin-3-binding protein and future venous thromboembolism
Research and Practice in Thrombosis and Haemostasis (RPTH) 2024 DOI
Bjarne Østerud,
Nadezhda Latysheva,
John Bjarne Hansen,
Omri Snir
:
“A rapid, sensitive, and specific assay to measure tissue factor activity based on chromogenic determination of thrombin generation”: reply
Journal of Thrombosis and Haemostasis 2023 DOI
Steven P. Grover,
Sigrid Kufaas Brækkan,
Nigel Mackman,
John Bjarne Hansen
:
“High plasma levels of C1-inhibitor are associated with lower risk of future venous thromboembolism”: reply
Journal of Thrombosis and Haemostasis 2023 DOI
Steven P. Grover,
Linda Sundler Björkman,
Sigrid Kufaas Brækkan,
Bengt Zöller,
John Bjarne Hansen,
Nigel Mackman
:
“C1-inhibitor levels and Venous Thromboembolism: Results from a Mendelian Randomization Study”: comment from Grover et al
Journal of Thrombosis and Haemostasis 2023 DOI
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Forskningsinteresser
Kliniske epidemiologi og risikofaktorer for venøs tromboembolisme
Diagnostiske og prediktive biomarkører for venøs tromboembolisme
Patofysiologi ved venøs tromboembolisme
Undervisning
2010-2023: Delemneleder i delemne om hematology, immunologi, og infeksjonssykdommer for medisinstudenter ved UiT
2010-2023: Medlem i eksamenskommisjonen for tredje års eksamen for medisinstudenter ved UiT
Medlem i forskningsgruppe
Medlem i prosjekt
PREVENT
Mission-VTE
Milestone VTE
Genetics and VTE
PEPSI-VTE
Obesity-related VTE
Biomarkers of VTE risk
Diagnostic biomarkers of VTE
Cancer-associated VTE (CAT)
Sex-differences in VTE
Arterial and venous thrombosis
Life-style factors and VTE
VTE recurrence
Extracellular vesicles in thrombogenesis and VTE
Hypoxia-dependent proteins and VTE
Comorbidities and VTE
Risk of bleeding after VTE
Socioeconomic position and VTE
CV
Utdanning
1989: Cand.med (MD), Universitetet i Tromsø
1997: Dr. med (PhD i kardiovaskulær medisin) Universitetet i Tromsø
Tidligere akademiske stillinger
1991-1994: Doktorgradsstudent ved Universitetet i Tromsø
1994-1995: Postdoktor ved Universitetet i Tromsø
1996-2005: Førsteamanuensis i medisin, Universitetet i Tromsø (20-50% stilling)
2005-2008: Professor I i Indremedisin/Hematologi, Universitetet i Tromsø (100% stilling)
2007-2008: Prodekan forskning, Det helsevitenskapelige fakultet, Universitetet i Tromsø
2008-2009: Visiting professor, The Scripps Research Institute, La Jolla, CA, USA
,
Publikasjoner
>300 originale artikler i fagfellevurderte tidsskrift registret i Pubmed, 28 oversiktsartikler, og 12 bokkapitler. Bidratt til >370 abstract presentert ved og pulibsert i forbindelse med internasjonale vitenskapelige konferanser.
Veiledning av PhD-studenter og postdoktorer
Fullførte doktorgrader : Hovedveileder: 35; Biveileder: 5
Pågående doktorgrader: Hovedveileder for 7 og biveileder for 6
Mentor for 13 tidligere postdoktorer og 3 nåværende postdoktorer