Sigrid Kufaas Brækkan
Stillingsbeskrivelse
Professor, Tromboseforskning (TREC)
Paul S. de Vries,
Paula Reventun,
Michael R. Brown,
Adam S. Heath,
Jennifer E. Huffman,
Ngoc-Quynh Le
m.fl.:
A genetic-association study of circulating coagulation factor VIII and von Willebrand factor levels
Blood 2024 DOI
Vania Maris Morelli,
Omri Snir,
Kristian Dalsbø Hindberg,
Kristian Hveem,
Sigrid Kufaas Brækkan,
John Bjarne Hansen
:
High microRNA-145 plasma levels are associated with decreased risk of future incident venous thromboembolism: the HUNT study
Blood 2024 DOI
Carl-Arne Arnesen,
Line Holtet Evensen,
Kristian Hveem,
Maiken Elvestad Gabrielsen,
John Bjarne Hansen,
Sigrid Kufaas Brækkan
:
Proportion of venous thromboembolism attributed to recognized prothrombotic genotypes in men and women
Birgitte Gladsø Tøndel,
Joakim Knutsen Sejrup,
Vania Maris Morelli,
Maja-Lisa Løchen,
Inger Njølstad,
Ellisiv B. Mathiesen
m.fl.:
Joint effect of ischemic stroke and obesity on the risk of venous thromboembolism: the Tromsø Study
Luuk J.J. Scheres,
Sigrid Kufaas Brækkan,
Judith P.L. Verlaan,
Suzanne C. Cannegieter,
John Bjarne Hansen,
Vania Maris Morelli
:
The fatty liver index and risk of incident venous thromboembolism: the Tromsø Study
Steven P. Grover,
Tomohiro Kawano,
Jun Wan,
Pansakorn Tanratana,
Zsofia Polai,
Young J. Shim
m.fl.:
C1 inhibitor deficiency enhances contact pathway–mediated activation of coagulation and venous thrombosis
Steven P. Grover,
Omri Snir,
Kristian Dalsbø Hindberg,
Tatianna M. Englebert,
Sigrid Kufaas Brækkan,
Vania Maris Morelli
m.fl.:
High plasma levels of C1-inhibitor are associated with lower risk of future venous thromboembolism
Sigrid Kufaas Brækkan,
John Bjarne Hansen
:
VTE epidemiology and challenges for VTE prevention at the population level: VTE epidemiology
Magnus Edvardsen,
Ellen-Sofie Hansen,
Thor Ueland,
Pål Aukrust,
Sigrid Kufaas Brækkan,
Vania Maris Morelli
m.fl.:
Impact of the von Willebrand factor-ADAMTS-13 axis on the risk of future venous thromboembolism
Monique J.T. Crobach,
Rayna J.S. Anijs,
Sigrid Kufaas Brækkan,
Marianne T. Severinsen,
Jens Hammerstrøm,
Hanne Skille
m.fl.:
Survival after cancer-related venous thrombosis: the Scandinavian Thrombosis and Cancer Study
Ellen-Sofie Hansen,
Magnus Edvardsen,
Pål Aukrust,
Thor Ueland,
John Bjarne Hansen,
Sigrid Kufaas Brækkan
m.fl.:
Combined effect of high factor VIII levels and high mean platelet volume on the risk of future incident venous thromboembolism
Samantha Swamy,
Thor Ueland,
John Bjarne Hansen,
Omri Snir,
Sigrid Kufaas Brækkan
:
Plasma levels of P-selectin and future risk of incident venous thromboembolism
Fridtjof Balteskard Rinde,
Camilla Tøvik Jørgensen,
Heidi Hassel Pettersen,
John Bjarne Hansen,
Waleed Ghanima,
Sigrid Kufaas Brækkan
:
Low D-dimer levels at diagnosis of venous thromboembolism are associated with reduced risk of recurrence: data from the TROLL registry
Espen Waage Skjeflo,
Line Holtet Evensen,
Søren Beck Jensen,
Nadezhda Latysheva,
Annika Elisabet Michelsen,
Thor Ueland
m.fl.:
Complement factors B, D, C3bBbP and risk of future venous thromboembolism
loannis T. Farmakis,
Stefano Barco,
Lukas Hobohm,
Sigrid Kufaas Brækkan,
Jean M. Connors,
George Giannakoulas
m.fl.:
Maternal mortality related to pulmonary embolism in the United States, 2003–2020
Oda Leknessund,
Vania Maris Morelli,
John Bjarne Hansen,
Sigrid Kufaas Brækkan
:
Hand grip strength in venous thromboembolism: risk of recurrence and mortality
Camilla Tøvik Jørgensen,
Mazdak Tavoly,
Elise Førsund,
Heidi Hassel Pettersen,
Eirik Tjønnfjord,
Waleed Ghanima
m.fl.:
Incidence of bleeding and recurrence in isolated distal deep vein thrombosis: findings from the Venous Thrombosis Registry in Østfold Hospital
Maria A. De Winter,
Harry R. Büller,
Marc Carrier,
Alexander T. Cohen,
John Bjarne Hansen,
Karin A. H. Kaasjager
m.fl.:
Recurrent venous thromboembolism and bleeding with extended anticoagulation: the VTE-PREDICT risk score
Dana Meknas,
Sigrid Kufaas Brækkan,
John Bjarne Hansen,
Vania Maris Morelli
:
Surgery As a Trigger for Incident Venous Thromboembolism: Results from a Population-Based Case-Crossover Study
Vårin Eiriksdatter Wikan,
Birgitte Gladsø Tøndel,
Vania Maris Morelli,
Ellen Elisabeth Brodin,
Sigrid Kufaas Brækkan,
John Bjarne Hansen
:
Diagnostic Blood Biomarkers for Acute Pulmonary Embolism: A Systematic Review
Tobias Frischmuth,
Birgitte Gladsø Tøndel,
Sigrid Kufaas Brækkan,
John Bjarne Hansen,
Vania Maris Morelli
:
The Risk of Incident Venous Thromboembolism Attributed to Overweight and Obesity: The Tromso Study
Camilla Tøvik Jørgensen,
Sigrid Kufaas Brækkan,
Eli Førsund,
Heidi Hassel Pettersen,
Eirik Tjønnfjord,
Waleed Ghanima
m.fl.:
Incidence of venous thromboembolism, recurrence, and bleeding after isolated superficial vein thrombosis: findings from the Venous Thrombosis Registry in Østfold Hospital
Helle Jørgensen,
Erzsébet Horváth-Puhó,
Kristina Laugesen,
Sigrid Kufaas Brækkan,
John Bjarne Hansen,
Henrik Toft Sørensen
:
The Interaction Between Venous Thromboembolism and Socioeconomic Status on the Risk of Disability Pension
Tobias Frischmuth,
Kristian Hindberg,
Pål Aukrust,
Thor Ueland,
Sigrid Kufaas Brækkan,
John Bjarne Hansen
m.fl.:
Elevated plasma levels of plasminogen activator inhibitor-1 are associated with risk of future incident venous thromboembolism
Lisa Jakobsen,
Tobias Frischmuth,
Sigrid Kufaas Brækkan,
John Bjarne Hansen,
Vania Maris Morelli
:
Joint Effect of Multiple Prothrombotic Genotypes and Mean Platelet Volume on the Risk of Incident Venous Thromboembolism
Line Holtet Evensen,
Carl-Arne Arnesen,
Frits Richard Rosendaal,
Maiken Elvestad Gabrielsen,
Ben Michael Brumpton,
Kristian Hveem
m.fl.:
The Risk of Venous Thromboembolism Attributed to Established Prothrombotic Genotypes
Camilla Tøvik Jørgensen,
Mazdak Tavoly,
Heidi Hassel Pettersen,
Eli Førsund,
Christina Roaldsnes,
Magnus Kringstad Olsen
m.fl.:
The venous thrombosis registry in Østfold Hospital (TROLL registry) - design and cohort description
Christabel Esi Damoah,
Omri Snir,
Kristian Dalsbø Hindberg,
Peter Garred,
Judith K Ludviksen,
Sigrid Kufaas Brækkan
m.fl.:
High Levels of Complement Activating Enzyme MASP-2 Are Associated With the Risk of Future Incident Venous Thromboembolism
Oda Leknessund,
Vania Maris Morelli,
Bjørn Heine Strand,
John Bjarne Hansen,
Sigrid Kufaas Brækkan
:
Hand grip strength and risk of incident venous thromboembolism: The Tromsø study
Aniket Mishra,
Rainer Malik,
Tsuyoshi Hachiya,
Tuuli Jürgenson,
Shinichi Namba,
Daniel C. Posner
m.fl.:
Stroke genetics informs drug discovery and risk prediction across ancestries
Florian Thibord,
Derek Klarin,
Jennifer A. Brody,
Ming-Huei Chen,
Michael G. Levin,
Daniel I. Chasman
m.fl.:
Cross-Ancestry Investigation of Venous Thromboembolism Genomic Predictors
Birgitte Gladsø Tøndel,
Vania Maris Morelli,
John Bjarne Hansen,
Sigrid Kufaas Brækkan
:
Risk factors and predictors for venous thromboembolism in people with ischemic stroke: A systematic review
Joakim Knutsen Sejrup,
Birgitte Gladsø Tøndel,
Vania Maris Morelli,
Maja-Lisa Løchen,
Inger Njølstad,
Ellisiv B. Mathiesen
m.fl.:
Joint effect of myocardial infarction and obesity on the risk of venous thromboembolism: The Tromsø Study
Elias Allarai,
Wei-Hsuan Lee,
Stephen Burgess,
Susanna C. Larsson,
Sara Lindstrom,
Lu Wang
m.fl.:
Genetically predicted cortisol levels and risk of venous thromboembolism
Helle Jørgensen,
Erzsebet Horvath-Puho,
Kristina Laugesen,
Sigrid Kufaas Brækkan,
John Bjarne Hansen,
Henrik Toft Sørensen
:
Venous thromboembolism and risk of depression: a population-based cohort study
Omri Snir,
line Wilsgård,
Nadezhda Latysheva,
Casper Ullsten-Wahlund,
Sigrid Kufaas Brækkan,
Kristian Dalsbø Hindberg
m.fl.:
Plasma levels of platelet-derived microvesicles are associated with risk of future venous thromboembolism
Espen Waage Skjeflo,
Sigrid Kufaas Brækkan,
Judith K Ludviksen,
Omri Snir,
Kristian Hindberg,
Tom Eirik Mollnes
m.fl.:
Elevated plasma concentration of complement factor C5 is associated with risk of future venous thromboembolism
Carl Arne Løchen Arnesen,
Katalin Veres,
Erzsébet Horváth-Puhó,
John-Bjarne Hansen,
Henrik Toft Sørensen,
Sigrid K. Brækkan
:
Estimated lifetime risk of venous thromboembolism in men and women in a Danish nationwide cohort: impact of competing risk of death
Tobias Frischmuth,
Kristian Hindberg,
Maiken Elvestad Gabrielsen,
Ben Michael Brumpton,
Kristian Hveem,
Sigrid Kufaas Brækkan
m.fl.:
Joint Effect of Multiple Prothrombotic Genotypes and Obesity on the Risk of Incident Venous Thromboembolism
Hanne Skille,
Benedikte Paulsen,
Kristian Hveem,
Marianne T. Severinsen,
Maiken Elvestad Gabrielsen,
Søren R. Kristensen
m.fl.:
Prothrombotic genotypes and risk of venous thromboembolism in occult cancer
Tobias Frischmuth,
Kristian Hindberg,
Pål Aukrust,
Thor Ueland,
Sigrid K. Brækkan,
John-Bjarne Hansen
m.fl.:
Plasma levels of leptin and risk of future incident venous thromboembolism
Cathrine Ramberg,
Line Wilsgård,
Nadezhda Latysheva,
Sigrid Kufaas Brækkan,
Kristian Hindberg,
Timofey Sovershaev
m.fl.:
Plasma procoagulant phospholipid clotting time and venous thromboembolism risk
Ellen-Sofie Hansen,
Magnus Edvardsen,
Pål Aukrust,
Thor Ueland,
John Bjarne Hansen,
Sigrid Kufaas Brækkan
m.fl.:
Galectin-3-binding protein and future venous thromboembolism
Research and Practice in Thrombosis and Haemostasis (RPTH) 2024 DOI
Steven P. Grover,
Sigrid Kufaas Brækkan,
Nigel Mackman,
John Bjarne Hansen
:
“High plasma levels of C1-inhibitor are associated with lower risk of future venous thromboembolism”: reply
Journal of Thrombosis and Haemostasis 2023 DOI
Steven P. Grover,
Linda Sundler Björkman,
Sigrid Kufaas Brækkan,
Bengt Zöller,
John Bjarne Hansen,
Nigel Mackman
:
“C1-inhibitor levels and Venous Thromboembolism: Results from a Mendelian Randomization Study”: comment from Grover et al
Journal of Thrombosis and Haemostasis 2023 DOI
Sigrid Kufaas Brækkan
:
NRK reportasje blodproppforskning
06. april 2021
Sigrid Kufaas Brækkan
:
Thea (21) fikk blodpropp - etterlyser mer forskning
05. april 2021
Sigrid Kufaas Brækkan
:
Blodproppforskning - kvinnehelse
17. mars 2021
Sigrid Kufaas Brækkan
:
Arvelig blodpropp: Dette sier ekspertene om corona-vaksinering
31. mars 2021
Sigrid Kufaas Brækkan
:
Haga fikk blodpropp under samling: – Det var et sjokk
16. april 2021
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Forskningsinteresser
Klinisk epidemiologi og risikofaktorer for venøs tromboembolisme
Patofysiologi ved venøs tromboembolisme
Medlem i forskningsgruppe
Medlem i prosjekt
PREVENT
Mission-VTE
Milestone VTE
Genetics and VTE
PEPSI-VTE
Obesity-related VTE
Biomarkers of VTE risk
Diagnostic biomarkers of VTE
Cancer-associated VTE (CAT)
Sex-differences in VTE
Arterial and venous thrombosis
Life-style factors and VTE
VTE recurrence
Hypoxia-dependent proteins and VTE
Epidemiology of VTE
Risk of bleeding after VTE
CV
Utdanning/Grad
2010 PhD i Helsefag, Universitetet i Tromsø
2005 Master i Farmasi, Universitetet i Tromsø
Tidligere akademiske stillinger
2012-13 Postdoktor, Dep. of Clinical Epidemiology, Leiden University Medical Center, Nederland
2010-12 Postdoktor, Hematologisk forskningsgruppe, Universitetet i Tromsø (Helse-Nord midler)
2008-09 Universitetslektor, Avd for Farmakologi, Institutt for Farmasi, UiT
2006-08 PhD-student, Center for Atherothrombotic Research in Tromsø, UiT
2005-06 Universitetslektor, Avd for Farmakologi, Institutt for Farmasi, UiT
Publikasjoner
>150 fagfellevurderte originalartikler indeksert i PubMed. Har bidratt til mer enn 200 abstracts presentert og publisert i forbindelse med internasjonale vitenskapelige kongresser.
Priser og utmerkelser
Young Investigator Award ISTH2016 (International Society of Thrombosis and Haemostasis)
Helsefaks pris til yngre forsker 2017
Veiledning av PhD-studenter
Fullførte doktorgrader: Hovedveileder: 4; Biveileder: 20
Pågående doktorgrader: Hovedveileder for 4 og biveileder for 7