Bilde av Uhlin-Hansen, Lars
Bilde av Uhlin-Hansen, Lars
Rettsgenetisk senter lars.uhlin-hansen@uit.no

Lars Uhlin-Hansen


Professor

Stillingsbeskrivelse

Lars Uhlin-Hansen er professor i rettsmedisin og patologi.


  • Anna Maria Wirsing, Inger-Heidi Bjerkli, Sonja Eriksson Steigen, Oddveig G Rikardsen, Synnøve Norvoll Magnussen, Beate Hegge m.fl.:
    Validation of Selected Head and Neck Cancer Prognostic Markers from the Pathology Atlas in an Oral Tongue Cancer Cohort
    Cancers 2021 ARKIV / DOI
  • Sushma Pandey, Tarig Al-Hadi Osman, Sunita Sharma, Evan Michael Vallenari, Aboulghassem Shahdafar, Chin B. Pun m.fl.:
    Loss of S100A14 expression at the tumor-invading front correlates with poor differentiation and worse prognosis in oral squamous cell carcinoma
    Head and Neck 2020 ARKIV / DOI
  • Inger-Heidi Bjerkli, Olav Jetlund, Gunnhild Karevold, Åsa Karlsdottir, Ellen A. Andreassen Jaatun, Lars Uhlin-Hansen m.fl.:
    Characteristics and prognosis of primary treatment-naïve oral cavity squamous cell carcinoma in Norway, a descriptive retrospective study
    PLOS ONE 2020 ARKIV / DOI
  • Inger-Heidi Bjerkli, Elin Synnøve Hadler-Olsen, Elisabeth Sivy Nginamau, Helene Laurvik, Tine Merete Søland, Daniela Elena Costea m.fl.:
    A combined histo-score based on tumor differentiation and lymphocytic infiltrate is a robust prognostic marker for mobile tongue cancer
    Virchows Archiv 30. juni 2020 ARKIV / DOI
  • Inger-Heidi Bjerkli, Helene Laurvik, Elisabeth Sivy Nginamau, Tine Merete Søland, Daniela Elena Costea, Håkon Hov m.fl.:
    Tumor budding score predicts lymph node status in oral tongue squamous cell carcinoma and should be included in the pathology report
    PLOS ONE 25. september 2020 ARKIV / DOI
  • Sonja Eriksson Steigen, Tine Merete Søland, Elisabeth Sivy Nginamau, Helene Laurvik, Daniela Elena Costea, Anne Christine Johannessen m.fl.:
    Grading of oral squamous cell carcinomas – Intra and interrater agreeability: Simpler is better?
    Journal of Oral Pathology & Medicine 2020 ARKIV / DOI
  • Anna Maria Wirsing, Ida Korsnes Ervik, Marit Seppola, Lars Uhlin-Hansen, Sonja Eriksson Steigen, Elin Synnøve Hadler-Olsen :
    Presence of high-endothelial venules correlates with a favorable immune microenvironment in oral squamous cell carcinoma
    Modern Pathology 2018 ARKIV / DOI
  • Synnøve Magnussen, Elin Synnøve Hadler-Olsen, Daniela Elena Costea, Eli Berg, Cristiane de Albuquerque Cavalcanti Jacobsen, Bente Mortensen m.fl.:
    Cleavage of the urokinase receptor (uPAR) on oral cancer cells: Regulation by transforming growth factor - beta1 (TGF-beta1) and potential effects on migration and invasion
    BMC Cancer 2017 ARKIV / DOI
  • Elin Synnøve Hadler-Olsen, Ann Iren Solli, Anne Dragøy Hafstad, Jan-Olof Winberg, Lars Uhlin-Hansen :
    Intracellular MMP-2 Activity in Skeletal Muscle is Associated with Type II Fibers
    Journal of Cellular Physiology 2015 ARKIV / DOI
  • Oddveig G Rikardsen, Synnøve Magnussen, Gunbjørg Svineng, Elin Synnøve Hadler-Olsen, Lars Uhlin-Hansen, Sonja Eriksson Steigen :
    Plectin as a prognostic marker in non-metastatic oral squamous cell carcinoma
    BMC Oral Health 2015 ARKIV / DOI
  • Anna Maria Wirsing, Oddveig G Rikardsen, Sonja Eriksson Steigen, Lars Uhlin-Hansen, Elin Synnøve Hadler-Olsen :
    Presence of tumour high-endothelial venules is an independent positive prognostic factor and stratifies patients with advanced-stage oral squamous cell carcinoma
    Tumour Biology 17. september 2015 ARKIV / DOI
  • Emma Pirilä, Otto Väyrynen, Elias Sundquist, Kaisa Päkkilä, Pia Nyberg, Sini Nurmenniemi m.fl.:
    Macrophages modulate migration and invasion of human tongue squamous cell carcinoma
    PLOS ONE 2015 ARKIV / DOI
  • Eystein Skjölsvik, Tor Steensrud, Øystein Dahl-Eriksen, Lars Uhlin-Hansen, Per Lunde :
    Cardiac Perforation Caused by Cement Embolus After Total Hip Replacement
    Circulation 2015 DOI
  • Synnøve Magnussen, Oddveig G Rikardsen, Elin Synnøve Hadler-Olsen, Lars Uhlin-Hansen, Sonja Eriksson Steigen, Gunbjørg Svineng :
    Urokinase Plasminogen Activator Receptor (uPAR) and Plasminogen Activator Inhibitor-1 (PAI-1) are potential predictive biomarkers in early stage Oral Squamous Cell Carcinomas (OSCC)
    PLOS ONE 07. juli 2014 ARKIV / DOI
  • Anna Wirsing, Oddveig G Rikardsen, Sonja Eriksson Steigen, Lars Uhlin-Hansen, Elin Synnøve Hadler-Olsen :
    Characterisation and prognostic value of tertiary lymphoid structures in oral squamous cell carcinoma
    BMC Clinical Pathology 2014 ARKIV / DOI
  • Synnøve Magnussen, Elin Synnøve Hadler-Olsen, Nadezhda Latysheva, Emma Pirila, Sonja Eriksson Steigen, Robert Hanes m.fl.:
    Tumour Microenvironments Induce Expression of Urokinase Plasminogen Activator Receptor (uPAR) and Concomitant Activation of Gelatinolytic Enzymes
    PLOS ONE 2014 ARKIV / DOI
  • Oddveig G Rikardsen, Inger-Heidi Bjerkli, Lars Uhlin-Hansen, Elin Synnøve Hadler-Olsen, Sonja Eriksson Steigen :
    Clinicopathological characteristics of oral squamous cell carcinoma in Northern Norway: a retrospective study
    BMC Oral Health 2014 ARKIV / DOI
  • Ann Iren Solli, Bodil Irene Fadnes, Jan-Olof Winberg, Lars Uhlin-Hansen, Elin Synnøve Hadler-Olsen :
    Tissue- and Cell-Specific Co-localization of Intracellular Gelatinolytic Activity and Matrix Metalloproteinase 2
    Journal of Histochemistry and Cytochemistry 2013 DOI
  • Nabin Malla, Eli Berg, Achilleas D. Theocharis, Gunbjørg Svineng, Lars Uhlin-Hansen, Jan-Olof Winberg :
    Invitro reconstitution of complexes between pro-matrix metalloproteinase-9 and the proteoglycans serglycin and versican
    The FEBS Journal 2013 DOI
  • Elin Synnøve Hadler-Olsen, Jan-Olof Winberg, Lars Uhlin-Hansen :
    Matrix metalloproteinases in cancer: their value as diagnostic and prognostic markers and therapeutic targets
    Tumour Biology 01. august 2013 DOI
  • Bodil Irene Fadnes, Elin Synnøve Hadler-Olsen, Ingebrigt Sylte, Lars Uhlin-Hansen, Jan-Olof Winberg :
    Matrix metalloproteinase complexes and their biological significance
    Walter de Gruyter (De Gruyter) 2012 DOI
  • Bodil Irene Fadnes, Anne Husebekk, Gunbjørg Svineng, Øystein Rekdal, Masaki Yanagishita, Svein Olav Kolset m.fl.:
    The proteoglycan repertoire of lymphoid cells
    Glycoconjugate Journal 2012 ARKIV / DOI
  • Hilde Ljones, Elin Synnøve Hadler-Olsen, Synnøve Magnussen, Oddveig G Rikardsen, sonja eriksson Steigen, elisabeth Sundkvist m.fl.:
    S100A4 Expression in Xenograft Tumors of human carcinoma cell lines is induced by the tumor microenvironment
    American Journal of Pathology 2011 DOI
  • Elin Synnøve Hadler-Olsen, Bodil Irene Fadnes, Ingebrigt Sylte, Lars Uhlin-Hansen, Jan-Olof Winberg :
    Regulation of matrix metalloproteinase activity in health and disease
    The FEBS Journal 2011 DOI
  • Nabin Malla, Eli Berg, Ugo Moens, Lars Uhlin-Hansen, Jan-Olof Winberg :
    Biosynthesis of Promatrix Metalloproteinase-9/Chondroitin Sulphate Proteoglycan Heteromer Involves a Rottlerin-Sensitive Pathway
    PLOS ONE 2011 ARKIV / DOI
  • Bodil Irene Fadnes, Lars Uhlin-Hansen, Inger Lindin, Øystein Rekdal :
    Small lytic peptides escape the inhibitory effect of heparan sulfate on the surface of cancer cells
    BMC Cancer 2011 ARKIV / DOI
  • Elin Synnøve Hadler-Olsen, Jan-Olof Winberg, Finn P. Reinholt, Terje Larsen, Lars Uhlin-Hansen, Trond Geir Jenssen m.fl.:
    Proteases in plasma and kidney of db /db mice as markers of diabetes-induced nephropathy
    ISRN Endocrinology 2011 ARKIV / DOI
  • Elin Synnøve Hadler-Olsen, Hilde Ljones, Chandra Sekhar Ravuri, Ahmad Omair, Oddveig G Rikardsen, Gunbjørg Svineng m.fl.:
    Organ specific regulation of tumour invasiveness and gelatinolytic activity at the invasive front
    European Journal of Cancer 2011 DOI
  • Elin Synnøve Hadler-Olsen, Hilde Ljones, Oddveig G Rikardsen, Sonja Eriksson Steigen, Premasany Kanapathippillai, Reidar Grenman m.fl.:
    Stromal impact on tumor growth and lymphangiogenesis in human carcinoma xenografts
    Virchows Archiv 2010 ARKIV / DOI
  • Elin Synnøve Hadler-Olsen, Premasany Kanapathippillai, Eli Berg, Gunbjørg Svineng, Jan-Olof Winberg, Lars Uhlin-Hansen :
    Gelatin In Situ Zymography on Fixed, Paraffin-embedded Tissue: Zinc and Ethanol Fixation Preserve Enzyme Activity
    Journal of Histochemistry and Cytochemistry 2010 DOI
  • Bodil Irene Fadnes, Øystein Rekdal, lars Uhlin-hansen :
    The anticancer activity of lytic peptides is inhibited by heparan sulfate on the surface of the tumor cells
    BMC Cancer 2009 DOI
  • Nabin Malla, Eli Berg, lars Uhlin-hansen, Jan-Olof Winberg :
    Interaction of pro-matrix metalloproteinase-9/proteoglycan heteromer with gelatin and collagen
    Journal of Biological Chemistry 2008 DOI
  • Nabin Malla, Stian Sjøli, Jan-Olof Winberg, Elin Synnøve Hadler-Olsen, lars Uhlin-hansen :
    Biological and pathobiological functions of gelatinase dimers and complexes
    Connective Tissue Research 2008 DOI
  • Berit Hansen, Inger Øynebråten, Lars Uhlin-Hansen, Bård Smedsrød :
    Endocytosis and degradation of serglycin in liver sinusoidal endothelial cells
    Molecular and Cellular Biochemistry 2006
  • Lars Uhlin Hansen :
    Retinal hemorrhages in an infant with cerebral edema and asphyxia after prolonged cardiopulmonary resuscitation: a case report.
    2024
  • Katrine Holter, Henriette Willix, Lars Uhlin-Hansen :
    Rett og Slett #50: Filleristing: En ny justisskandale?
    22. februar 2023 DATA
  • Lars Uhlin-Hansen :
    Ny utgave av lærebok i rettsmedisin
    Tidsskrift for Den norske legeforening 2021 DOI
  • Sushma Pandey Dhakal, Tarig A. Osman, Sunita Sharma, Lars Uhlin-Hansen, Chin Babadur Pun, Dej K. Gautam m.fl.:
    Oral squamous cell carcinomas expressing higher levels of S100A14 correlate with prognosis
    2019
  • Sonja Eriksson Steigen, Anna Maria Wirsing, Elin Synnøve Hadler-Olsen, Lars Uhlin-Hansen, Marit Seppola, Ida Korsnes Ervik :
    Oral cancer and high endothelial venules (HEV)
    2017
  • Anna Wirsing, Oddveig G Rikardsen, Sonja Eriksson Steigen, Lars Uhlin-Hansen, Elin Synnøve Hadler-Olsen :
    Prognostic relevance of tertiary lymphoid structures in oral squamous cell carcinoma
    2014 ARKIV
  • Gunbjørg Svineng, Synnøve Magnussen, Elin Synnøve Hadler-Olsen, Nadezhda Latysheva, Emma Pirila, Sonja Eriksson Steigen m.fl.:
    Stromal induced expression of uPAR
    2013
  • Ann Iren Solli, Bodil Irene Fadnes, Jan-Olof Winberg, Lars Uhlin-Hansen, Elin Synnøve Hadler-Olsen :
    Intracellular MMP-2 localization and activity
    2013
  • Anna Wirsing, Elin Synnøve Hadler-Olsen, Oddveig G Rikardsen, Lars Uhlin-Hansen :
    Tertiary lymphoid organs in oral squamous cell carcinoma
    2013
  • Elin Synnøve Hadler-Olsen, Ann Iren Solli, Anne Dragøy Hafstad, Jan-Olof Winberg, Lars Uhlin-Hansen :
    Intracellular MMP-2 Activity in Skeletal Muscle is Associated with Type II Fibers
    2013
  • Arne Stray-Pedersen, Sidsel Rogde, Kari Ormstad, Åshild Vege, Gerd Jorunn Delavaris, Marianne Skjerven-Martinsen m.fl.:
    Forensic medical examination after the July 22nd 2011 terror attack
    2012
  • Berit Myhre Dupuy, Dorota Perchla, Gunnar Markussen, Torleiv Ole Rognum, Lars Uhlin-Hansen, Ivar Skjåk Nordrum m.fl.:
    DNA-analysis for DVI or other identification purposes. Evaluation of the COPAN 4N6FLOQSwabs™ for collection of blood or tissue samples from deceased individuals
    2012
  • Elin Synnøve Hadler-Olsen, Ann Iren Solli, Bodil Irene Fadnes, Lars Uhlin-Hansen, Jan-Olof Winberg :
    Tissue localization of intracellular gelatinolytic activity
    The FEBS Journal 2012
  • Elin Synnøve Hadler-Olsen, Chandra Sekhar Ravuri, Hilde Ljones Wetting, Oddveig G Rikardsen, sonja eriksson Steigen, Gunbjørg Svineng m.fl.:
    Stromal Impact on Tumor Invasiveness and Gelatinolytic Activity at the Invasive Front
    2011
  • Elin Synnøve Hadler-Olsen, Chandra Sekhar Ravuri, Hilde Ljones, Oddveig G Rikardsen, sonja eriksson Steigen, Gunbjørg Svineng m.fl.:
    Organ specific stromal influence on tumor invasiveness and proteolytic activity at the invasive front
    European Journal of Cancer 2010 DOI
  • Elin Synnøve Hadler-Olsen, Hilde Ljones, O Rikardsen, sonja eriksson Steigen, Jan-Olof Winberg, Gunbjørg Svineng m.fl.:
    Stromal impact on tumor growth and lymphangiogenesis in human carcinoma xenografts
    APMIS - Journal of Pathologiy, Microbiology and Immunology 2010

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    Forskningsinteresser

    Kreft, med hovedfokus på munnhulekreft.

    Undervisning

    Underviser i anatomi, patologi og rettsmedisin.



    Medlem i prosjekt


    CV

    Lars Uhlin-Hansen er professor i rettsmedisin og patologi. Han har bred rettsmedisinsk erfaring fra inn- og utland, og har i over 20 år regelmessig blitt benyttet som rettsmedisinsk sakkyndig i straffesaker i hele landet. Han har også hatt oppdrag for Den internasjonale straffedomstolen i Haag. Han er medlem av den nasjonale ID-gruppen og har deltatt i en rekke operasjoner nasjonalt og internasjonalt. Han er medlem av Den rettsmedisinske kommisjon, og er leder for Rettsgenetisk senter ved UiT. Hans forskningsaktivitet har i hovedsak vært kreftrelatert og de siste årene har han spesielt fokusert på munnhulekreft. Han er leder for Norwegian Oral Cancer (NOROC) studien, en tverrfaglig studie på munnhulekreft hvor alle universitetssykehusene i Norge er involvert. Uhlin-Hansen har bistilling som overlege på avdeling for Klinisk patologi, Universitetssykehuset Nord-Norge hvor han blant annet har et ansvar for diagnostikk av lymfeknutekreft (lymfom).


    Utdanning
    1982: Cand.med. (MD), Universitetet i Tromsø
    1990: Dr. med. (PhD), Universitetet i Tromsø
    2003: Spesialist i patologi.

    Yrkespraksis
    1985-1987: Stipendiat, Institutt for medisinsk biologi, UiT
    1987-2006: Amanuensis/førsteamanuensis, Institutt for medisinsk biologi
    1991-1992: Visiting scientist, National Institutes of Health, Bethesda, USA
    1996-2001: Assistentlege, Patologisk anatomisk avdeling, UNN
    1997-1998: Visiting scientist, US Food and Drug Administration, Bethesda, USA
    2001-d.d.: Overlege, Patologisk anatomisk avdeling/Klinisk patologi, UNN
    2003: Visiting pathologist, Hotel Dieu, Paris
    2004: Visiting pathologist, Medical examiners department, Miami
    2006-d.d.: Professor i rettsmedisin og patologi, Institutt for medisinsk biologi, UiT
    2010-2011: Visiting scientist, Retsmedicinsk institut, Københavns universitet1