Lars Marius Giske Ytrebø
Stillingsbeskrivelse
Dr. Lars Marius Ytrebø is a professor of Anesthesiology at UIT- The Arctic University of Tromsø and a consultant in anesthesiology and intensive care medicine at the the University Hospital of North Norway (UNN). His primary research interests are perioperative medicine, acute kidney injury, and sepsis. Funding for these activities primarily comes from the University Hospital of North Norway and UIT- The Arctic University of Tromsø.
Vitenskapelige arbeidsområder
Marisa Antunes,
Aleksander Johannes Baumgärtel,
Petter Fosse Gjessing,
Lars Marius Giske Ytrebø
:
Spinal Anaesthesia as an Adjunct to General Anaesthesia for Laparoscopic Abdominoperineal Rectal Amputation
Kjellbjørn Jakobsen,
Bjørn Odvar Eriksen,
Ole Martin Fuskevåg,
Stephen John Hodges,
Lars Marius Giske Ytrebø
:
Continuous Infusion of Iohexol to Monitor Perioperative Glomerular Filtration Rate
Dario Davide Musso,
Øivind Klaastad,
Lars Marius Ytrebø
:
A combination of infraclavicular and suprascapular nerve blocks for total shoulder arthroplasty: A case series
Dmitri Nepogodiev,
Omar M Omar,
James C Glasbey,
Elizabeth Li,
Joana FF Simoes,
Tom EF Abbott
m.fl.:
Elective surgery cancellations due to the COVID-19 pandemic: global predictive modelling to inform surgical recovery plans
Hanne T. Olsen,
Helene K. Nedergaard,
Thomas Strøm,
Jakob Oxlund,
Karl-Andre Wian,
Lars Marius Ytrebø
m.fl.:
Nonsedation or Light Sedation in Critically Ill, Mechanically Ventilated Patients
New England Journal of Medicine 2020 DOI
Marthe Arnes Pettersen,
Trude Ingeborg Smukkestad,
Sidsel Kristiansen,
Aslak Johansen,
Lars Marius Ytrebø
:
Forbruk av opioider ved to kirurgiske sykehusavdelinger
Dario Musso,
Øivind Klaastad,
Tom Wilsgaard,
Lars Marius Ytrebø
:
Brachial plexus block of the posterior and the lateral cord using ropivacaine 7.5 mg/mL
Acta Anaesthesiologica Scandinavica 2018 DOI
Dario Musso,
Sandra Flohr-Madsen,
Khaled Meknas,
Tom Wilsgaard,
Lars Marius Ytrebø,
Øivind Klaastad
:
A novel combination of peripheral nerve blocks for arthroscopic shoulder surgery
Aarne Feldheiser,
Omer Aziz,
Gabriele Baldini,
Boris P.B.W. Cox,
Kenneth Christopher H. Fearon,
Liane S. Feldman
m.fl.:
Enhanced Recovery After Surgery (ERAS) for gastrointestinal surgery, part 2: Consensus statement for anaesthesia practice
Acta Anaesthesiologica Scandinavica 2016 DOI
Sandra Flohr-Madsen,
Lars Marius Ytrebø,
Katrin Valen,
Tom Wilsgaard,
Øivind Klaastad
:
A randomised placebo-controlled trial examining the effect on hand supination after the addition of a suprascapular nerve block to infraclavicular brachial plexus blockade
Geir Ivar Nedredal,
Kjetil Helge Elvevold,
MF Chedid,
Lars Marius Ytrebø,
CF Rose,
S Sen
m.fl.:
Pulmonary vascular clearance of harmful endogenous macromolecules in a porcine model of acute liver failure
Anders Backer-Grøndahl,
Sigurd Lindal,
Merethe Andberg Lorentzen,
Odd Petter Eldevik,
Torgrim Vorren,
Bente Kristiansen
m.fl.:
A new non-craniotomy model of subarachnoid hemorrhage in the pig: A pilot study
Laboratory Animals 2016 DOI
Rune Gangsøy Kristiansen,
Christopher F. Rose,
Lars Marius Ytrebø
:
Glycine and hyperammonemia: potential target for the treatment of hepatic encephalopathy
Metabolic brain disease 2016 DOI
Elisabeth Johansen,
Stine-Mari Haustreis,
Ann Storm Mowinckel,
Lars Marius Ytrebø
:
Effects of implementing a clinical pharmacist service in a mixed Norwegian ICU
European Journal of Hospital Pharmacy (EJHP) 2016 DOI
Rune Gangsøy Kristiansen,
Christopher F. Rose,
Ole-Martin Fuskevåg,
Hanne K Mæhre,
Arthur Revhaug,
Rajiv Jalan
m.fl.:
L-Ornithine phenylacetate reduces ammonia in pigs with acute liver failure through phenylacetylglycine formation: A novel ammonia-lowering pathway
American Journal of Physiology - Gastrointestinal and Liver Physiology 2014 DOI
Palle Toft,
Hanne Tanghus Olsen,
Helene Korvenius Jørgensen,
Thomas Strøm,
Helle Lykkeskov Nibro,
Jacob Oxlund
m.fl.:
Non-sedation versus sedation with a daily wake-up trial in critically ill patients receiving mechanical ventilation (NONSEDA Trial): study protocol for a randomised controlled trial
Rune Gangsøy Kristiansen,
Christopher F. Rose,
Ole-Martin Fuskevåg,
Hanne K Mæhre,
Arthur Revhaug,
R Jalan
m.fl.:
L-Ornithine Phenylacetate reduces ammonia in pigs with acute liver failure through phenylacetylglycine formation: a novel ammonia-lowering pathway
American Journal of Physiology - Gastrointestinal and Liver Physiology 2014 DOI
Yannick Cerantola,
Massimo Valerio,
Beata Persson,
Patrice Jichlinski,
Olle Ljungqvist,
Martin Hubner
m.fl.:
Guidelines for perioperative care after radical cystectomy for bladder cancer: Enhanced Recovery After Surgery (ERAS®) society recommendations
Clinical Nutrition 2013 DOI
Sandra Flohr-Madsen,
Lars Marius Ytrebø,
Sylvia Beate Kregnes,
Tom Wilsgaard,
Øivind Klaastad
:
Minimum effective volume of ropivacaine 7.5mg/ml for an ultrasound-guided infraclavicular brachial plexus block
V Sharma,
G Ten Have,
Lars Marius Ytrebø,
S Sen,
C Rose,
RN Dalton
m.fl.:
Nitric oxide and L-arginine metabolism in a devascularized porcine model of acute liver failure
American Journal of Physiology - Gastrointestinal and Liver Physiology 2012 DOI
Rune Gangsøy Kristiansen,
Sigurd Lindal,
Kate Myreng,
Arthur Revhaug,
Lars Marius Ytrebø,
CF Rose
:
Neuropathological changes in the brain of pigs with acute liver failure
Scandinavian Journal of Gastroenterology 2010 DOI
Lars Marius Ytrebø,
Pål Klepstad
:
Intensivbehandling av voksne med leversvikt
Tidsskrift for Den norske legeforening 2010 DOI
Lars marius Ytrebø,
Rune Gangsøy Kristiansen,
Hanne K Mæhre,
Ole-Martin Fuskevåg,
Trine Kalstad,
Arthur Revhaug
m.fl.:
L-Ornithine Phenylacetate Attenuates Increased Arterial and Extracellular Brain Ammonia and Prevents Intracranial Hypertension in Pigs with Acute Liver Failure
Hepatology 2009 DOI
NA Davies,
G Wright,
Lars marius Ytrebø,
V Stadlbauer,
Ole-Martin Fuskevåg,
C Zwingmann
m.fl.:
L-Ornithine and Phenylacetate Synergistically Produce Sustained Reduction in Ammonia and Brain Water in Cirrhotic Rats
Hepatology 2009 DOI
Øyvind Jakobsen,
Thor Allan Stenberg,
O Losvik,
Sveinung Ekse,
Dag Glen Sørlie,
Lars marius Ytrebø
:
Adenosine instead of supranormal potassium in cardioplegic solution preserves endothelium-derived hyperpolarization factor-dependent vasodilation
European Journal of Cardio-Thoracic Surgery 2008 DOI
Lars marius Ytrebø
:
Forstyrrelser i ammoniakkmetabolismen ved leversvikt
Tidsskrift for Den norske legeforening 2007
Geir Ivar Nedredal,
kjetil helge Elvevold,
Lars marius Ytrebø,
Ole-Martin Fuskevåg,
ingvild Pettersen,
Kjell Bertheussen
m.fl.:
Significant contribution of liver nonparenchymal cells to metabolism of ammonia and lactate and cocultivation augments the functions of a bioartificial liver
American Journal of Physiology - Gastrointestinal and Liver Physiology 2007 DOI
Sveinung Ekse,
Luice H. Clapp,
Arthur Revhaug,
Lars marius Ytrebø
:
Endothelium-derived hyperpolarization factor (EDHF) is up-regulated in a pig model of acute liver failure
Scandinavian Journal of Gastroenterology 2007 DOI
Christopher Rose,
Lars marius Ytrebø,
Nathan A. Davies,
Sambit Sen,
Geir Ivar Nedredal,
Mireille Belanger
m.fl.:
Association of reduced extracellular brain ammonia, lactate, and intracranial pressure in pigs with acute liver failure
Hepatology 2007 DOI
Lars marius Ytrebø,
Arthur Revhaug,
Geir Ivar Nedredal
:
Effect of albumin dialysis on intracranial pressure increase in pigs with acute liver failure: a randomized study
Critical Care Medicine 2006
Lars Marius Giske Ytrebø
:
Risk Factors for Stroke in COVID-19 Patients on Venovenous Extracorporeal Membrane Oxygenation∗
Critical Care Medicine 2023 DOI
Martin Iversen Hagve,
Petter Fosse Gjessing,
Lars Marius Ytrebø,
Øivind Irtun
:
Ernæring hos kritisk syke intensivpasienter
Tidsskrift for Den norske legeforening 2020 DOI
Dario Musso,
Sandra Flohr-Madsen,
Lars Marius Ytrebø,
Øivind Klaastad
:
The Effect of Infraclavicular Brachial Plexus Blocks on the Axillary Nerve
Regional anesthesia and pain medicine 2018 DOI
Håkon Haugaa,
Lars Marius Ytrebø
:
Vasopressin and nitroglycerine may reduce bleeding during liver resection surgery
Acta Anaesthesiologica Scandinavica 2018 DOI
Hitendra R.H. Patel,
Yannick Cerantola,
Massimo Valerio,
Beata Persson,
Patrice Jichlinski,
Olle Ljungqvist
m.fl.:
Enhanced recovery after surgery: are we ready, and can we afford not to implement these pathways for patients undergoing radical cystectomy?
European Urology 2014 SAMMENDRAG / DOI
Lars Marius Ytrebø,
Christopher F. Rose
:
Significant advances towards a reproducible, clinically relevant large animal model of acetaminophen-induced acute liver failure
Liver international (Print) 2013 DOI
Lars Marius Ytrebø
:
Selective decontamination of the oral and digestive tract in surgical versus non-surgical patients in intensive care in a cluster-randomized trial (Br J Surg 2012; 99: 232-237)
British Journal of Surgery 2012 DOI
Lars Marius Ytrebø
:
Stop filling patients against central venous pressure, please!
Critical Care Medicine 2011 DOI
Lars Marius Ytrebø
:
Vascular dysfunction in septic shock-Any ROCKing news?
Critical Care Medicine 2009 DOI
Geir Ivar Nedredal,
kjetil helge Elvevold,
Lars marius Ytrebø,
Ole-Martin Fuskevåg,
ingvild Pettersen,
kjell h. Bertheussen
m.fl.:
LIVER SINUSOIDAL ENDOTHELIAL CELLS ARE AN IMPORTANT CONTRIBUTOR TO THE INTRAHEPATIC NITROGEN METABOLISM
Hepatology 2008
GA Wright,
NA Davies,
Lars marius Ytrebø,
V Stadlbauer,
OM Fuskevag,
C Zwingmann
m.fl.:
L-ornithine phenylacetate reduces arterial ammonia, improves brain osmolytes and reduces brain water in a bile duct ligated pat model of cirrhosis
Hepatology 2007
Lars marius Ytrebø,
RG Kristiansen,
OM Fuskevag,
Hanne K Mæhre,
Arthur Revhaug,
R Jalan
m.fl.:
L-ornithine phenylacetate attenuates increase in arterial ammonia and intracranial pressure in a devascularised pig model of acute liver failure: A novel ammonia-lowering strategy for hepatic encephalopathy
Hepatology 2007
Lars marius Ytrebø
:
A lowered incidence of severe encephalopathy and cardiovascular dysfunction
Critical Care Medicine 2005
Lars marius Ytrebø
:
A PROSPECTIVE OBSERVATIONAL STUDY OF REGURGITATION AND ASPIRATION DURING ANESTHESIA IN AN UNIVERSITY HOSPITAL
2005
Lars marius Ytrebø
:
THE USE OF NEUROMUSCULAR BLOCKING AGENTS AT INDUCTION OF GENERAL ANESTHESIA - A CRITICAL ASSESSMENT ON THE USE OF SUXAMETHONIUM IN AN UNIVERSITY HOSPITAL
2005
Lars marius Ytrebø,
S Ekse,
Arthur Revhaug
:
ENDOTHELIUM DEPENDENT HYPERPOLARISATION FACTOR (EDHF) CONTRIBUTES TO THE DEVELOPMENT OF HYPERDYNAMIC CIRCULATION IN ACUTE LIVER FAILURE
2005
Lars marius Ytrebø
:
TRAUMATIC THORACIC AORTIC DISRUPTIONS: A CASE REPORT AND LITERATURE REVIEW
2005
Lars marius Ytrebø,
Arthur Revhaug
:
The pathophysiological basis of brain swelling of grey vs white matter in acute liver failure are different: Lessons from a study using MARS
2005
Lars marius Ytrebø,
Arthur Revhaug
:
DERANGED DIMETYLARGININE (NOS INHIBITOR) METABOLISM IS ASSOCIATED WITH PROGRESSIVE ORGAN INJURY IN PIGS WITH ACUTE LIVER FAILURE
2005
Lars marius Ytrebø,
Arthur Revhaug,
Geir Ivar Nedredal
:
Deranged dimethylarginine (NOS inhibitor) metabolism is associated with progressive organ injury in a devascularised pig model of acute liver failure
2005
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Forskningsinteresser
Professor Ytrebø`s broad experience includes experimental studies of acute liver failure in pigs, clinical studies of perioperative medicine including sepsis, pain, nutrition, and peripheral nerve blocks. Current research interests are centered around pathogenesis and pathobiology of acute kidney injury. Specifically focusing on glomerular filtration markers, proximal tubule function, glomerular-tubular feedback systems and renal metabolism.
Top 5 published papers:
- Nonsedation or Light Sedation in Critically Ill, Mechanically Ventilated Patients. DOI: 10.1056/NEJMoa1906759
- Continuous Infusion of Iohexol to Monitor Perioperative Glomerular Filtration Rate. DOI: 10.1155/2022/8267829
- Hydroxyethyl starch 130/0.42 versus Ringer's acetate in severe sepsis. DOI: 10.1056/NEJMoa1204242
- L-ornithine phenylacetate attenuates increased arterial and extracellular brain ammonia and prevents intracranial hypertension in pigs with acute liver failure. DOI: 10.1002/hep.22917
- Enhanced Recovery After Surgery (ERAS) for gastrointestinal surgery, part 2: consensus statement for anaesthesia practice. DOI: 10.1111/aas.12651
Undervisning
Professor Ytrebø teaches medical students at all levels during year 1-6. He is also member of the Exam Commitee in year 4.
Medlem i forskningsgruppe
Vedlegg:
- CV Ytrebø (pdf)