Kristin Andreassen Fenton


Professor

Stillingsbeskrivelse

Jeg er utdannet molekylærbiolog med hovedfag i biokjemi og har en PhD i immunologi. Mitt forskningsområde dekker molekylær biologi innen immunologi og autoimmunitet, Jeg forsker på sykdomsmekanismene som fører til utvikling av den autoimmune sykdommen systemisk lupus erythematosus (SLE) og spesielt utviklingen av lupus nefritt (LN). Vårt mål er å kunne stille diagnosen på et tidligere stadium og utvikle nye pasient spesifikke behandlings strategier.

 

Jeg underviser immunologi og autoimmunitet til BSc og MSc i biomedisin og medisin studenter. Jeg er også ansvarlig for bachelor oppgaven i biomedisin (MBI-2010).

 

Jeg er i tillegg nestleder utdanning ved institutt for medisinsk biologi der jeg har ansvar for alle undervisere og all undervisning som gis av IMB.


  • Kristin Andreassen Fenton, Hege Lynum Pedersen :
    Advanced methods and novel biomarkers in autoimmune diseases ‑ a review of the recent years progress in systemic lupus erythematosus
    Frontiers in medicine 2023 ARKIV / DOI
  • Luis Villegas, Vishesh Kumar Dubey, Mona Nystad, Jean-Claude Tinguely, David Andre Coucheron, Firehun Tsige Dullo m.fl.:
    Chip-based multimodal super-resolution microscopy for histological investigations of cryopreserved tissue sections
    Light: Science & Applications (LSA) 2022 ARKIV / DOI
  • Luis Villegas, Vishesh Kumar Dubey, Jean-Claude Tinguely, David Andre Coucheron, Anish Priyadarshi, Sebastian Andres Acuña Maldonado m.fl.:
    Photonic-chip: a multimodal imaging tool for histopathology.
    Journal of the Optical Society of America. B, Optical physics 2021 ARKIV / DOI
  • Simin Jamaly, Mehrdad Rakaee, Reza Abdi, George tsokos, Kristin Andreassen Fenton :
    Interplay of immune and kidney resident cells in the formation of tertiary lymphoid structures in lupus nephritis
    Autoimmunity Reviews 2021 ARKIV / DOI
  • Seyed Esmaeil Dorraji, Ana Oteiza, Samuel Kuttner, Armas Maria Montserrat Martin, Premasany Kanapathippillai, Sara Garbarino m.fl.:
    Positron emission tomography and single photon emission computed tomography imaging of tertiary lymphoid structures during the development of lupus nephritis
    International Journal of Immunopathology and Pharmacology 2021 ARKIV / DOI
  • Seyed Esmaeil Dorraji, Premasany Kanapathippillai, Aud-Malin Karlsson Hovd, Mikael Ryan Stenersrød, Kjersti Daae Horvei, anita Ursvik m.fl.:
    Kidney tertiary lymphoid structures in Lupus Nephritis develop into large interconnected networks and resemble lymph nodes in gene signature
    American Journal of Pathology 2020 ARKIV / DOI
  • Samuel Kuttner, Kristoffer Knutsen Wickstrøm, Gustav Kalda, Seyed Esmaeil Dorraji, Montserrat Martin-Armas, Ana Oteiza m.fl.:
    Machine learning derived input-function in a dynamic 18F-FDG PET study of mice
    Biomedical Engineering & Physics Express 2020 ARKIV / DOI
  • Stine Figenschau, Erik Knutsen, Ilona Urbarova, Christopher Graham Fenton, Bryan Elston, Maria Perander m.fl.:
    ICAM1 expression is induced by proinflammatory cytokines and associated with TLS formation in aggressive breast cancer subtypes
    Scientific Reports 2018 ARKIV / DOI
  • Seyed Esmaeil Dorraji, Aud-Malin Karlsson Hovd, Premasany Kanapathippillai, Gunnstein Bakland, Gro Østli Eilertsen, Stine Figenschau m.fl.:
    Mesenchymal stem cells and T cells in the formation of Tertiary Lymphoid Structures in Lupus Nephritis
    Scientific Reports 2018 ARKIV / DOI
  • Kristin Andreassen Fenton :
    The effect of cell death in the initiation of lupus nephritis
    Clinical and Experimental Immunology 2015 ARKIV / DOI
  • Stine Linn Figenschau, Silje Fismen, Kristin Andreassen Fenton, Christopher Graham Fenton, Elin Synnøve Mortensen :
    Tertiary lymphoid structures are associated with higher tumor grade in primary operable breast cancer patients
    BMC Cancer 2015 ARKIV / DOI
  • Premasany Kanapathippillai, Annica Hedberg, Christopher Graham Fenton, Kristin Andreassen Fenton :
    Nucleosomes contribute to increase mesangial cell chemokine expression during the development of lupus nephritis
    Cytokine 2013 DOI
  • Annica Hedberg, Premasany Kanapathippillai, Ole Petter Rekvig, Kristin Andreassen Fenton :
    LMW Heparin Prevents Increased Kidney Expression of Proinflammatory Mediators in (NZBxNZW)F1 Mice
    Clinical & Developmental Immunology 2013 ARKIV / DOI
  • Janne erikke Mjelle, Ole Petter Rekvig, Johan van der Vlag, Kristin Andreassen Fenton :
    Nephritogenic antibodies bind in glomeruli through interaction with exposed chromatin fragments and not with renal cross-reactive antigens
    Autoimmunity 2011 DOI
  • Annica Hedberg, Silje Fismen, Kristin Andreassen Fenton, Christopher Graham Fenton, Bjarne Østerud, Elin Mortensen m.fl.:
    Heparin Exerts a Dual Effect on Murine Lupus Nephritis by Enhancing Enzymatic Chromatin Degradation and Preventing Chromatin Binding in Glomerular Membranes
    Arthritis and Rheumatism 2011 DOI
  • Mariann Hellvik Jørgensen, Ole Petter Rekvig, Rasmus S. Jacobsen, Søren Jacobsen, Kristin Andreassen Fenton :
    Circulating levels of chromatin fragments are inversely correlated with anti-dsDNA antibody levels in human and murine systemic lupus erythematosus
    Immunology Letters 2011 DOI
  • Idun Grønsberg, Lise Nordgård, Kristin Andreassen Fenton, Beate Hegge, Kaare Magne Nielsen, Susan Bardocz m.fl.:
    Uptake and Organ Distribution of Feed Introduced Plasmid DNA in Growing or Pregnant Rats
    Food and Nutrition Sciences 2011 DOI
  • Kristin Andreassen Fenton, berit TØmmerÅs, Tony Norman Marion, Ole Petter Rekvik :
    Pure anti-dsDNA mAbs need chromatin structures to promote glomerular mesangial deposits in BALB/c mice
    Autoimmunity 2010 DOI
  • Annica Hedberg, Silje Fismen, Kristin Andreassen Fenton, Elin Mortensen, Ole Petter Rekvig :
    Deposition of chromatin-IgG complexes in skin of nephritic MRL-lpr/lpr mice is associated with increased local matrix metalloprotease activities
    Experimental Dermatology 2010 DOI
  • Silje Fismen, Annica Hedberg, Kristin Andreassen Fenton, S Jacobsen, E Krarup, AL Kamper m.fl.:
    Circulating chromatin-anti-chromatin antibody complexes bind with high affinity to dermo-epidermal structures in murine and human lupus nephritis
    Lupus 2009 DOI
  • Kristin Andreassen Fenton, berit TØmmerÅs, Tony Norman Marion, Ole Petter Rekvik :
    Pure anti-dsDNA mAbs need chromatin structures to promote glomerular mesangial deposits in BALB/c mice
    Autoimmunity 2009 DOI
  • Kristin Andreassen Fenton, Silje Fismen, Annica Hedberg, Natalya Seredkina, Christopher Graham Fenton, Elin Mortensen m.fl.:
    Anti-dsDNA Antibodies Promote Initiation, and Acquired Loss of Renal Dnase1 Promotes Progression of Lupus Nephritis in Autoimmune (NZBxNZW)F1 mice
    PLOS ONE 2009 ARKIV / DOI
  • Kristin Andreassen Fenton, Janne erikke Mjelle, Søren Jakobsen, randi Olsen, Ole Petter Rekvik :
    Renal expression of polyomavirus large T antigen is associated with nephritis in human systemic lupus erythematosus
    Molecular Immunology 2008 DOI
  • signy Bendiksen, Elin Mortensen, randi Olsen, Kristin Andreassen Fenton, manar Kalaaji, Leif Jørgensen m.fl.:
    Glomerular expression of large polyomavirus T antigen in binary tet-off regulated transgenic mice induces apoptosis, release of chromatin and initiates a lupus-like nephritis
    Molecular Immunology 2008 DOI
  • Elin Mortensen, Kristin Andreassen Fenton, Ole Petter Rekvik :
    Lupus nephritis - The central role of nucleosomes revealed
    American Journal of Pathology 2008 DOI
  • Casandra C. van Bavel, Kristin Andreassen Fenton, Ole Petter Rekvik, Johan van der Vlag, Jo H. Berden :
    Glomerular targets of nephritogenic autoantibodies in systemic lupus erythematosus
    Arthritis and Rheumatism 2008 DOI
  • Kristin Andreassen Fenton, Ole Petter Rekvik :
    A central role of nucleosomes in lupus nephritis
    Annals of the New York Academy of Sciences 2007 DOI
  • Janne erikke Mjelle, Ole Petter Rekvik, Kristin Andreassen Fenton :
    Nucleosomes possess a high affinity for glomerular laminin and collagen IV and bind nephritogenic antibodies in murine lupus-like nephritis
    Annals of the Rheumatic Diseases 2007 DOI
  • manar Kalaaji, Kristin Andreassen Fenton, Elin Mortensen, randi Olsen, G Sturfelt, P Alm m.fl.:
    Glomerular apoptotic nucleosomes are central target structures for nephritogenic antibodies in human SLE nephritis
    Kidney International 2007 DOI
  • Marit Renee Myhre, Kristin Andreassen Fenton, Julia Friederike Egger, Kaare Magne Nielsen, Terje I Traavik :
    The 35S CaMV plant virus promoter is active in human enterocyte-like cells
    European Food Research and Technology 2006 DOI
  • Luis Villegas, Vishesh Kumar Dubey, Mona Nystad, Kristin Andreassen Fenton, Ganesh Acharya, Jose M. Mateos m.fl.:
    Chip-based multimodal microscopy for histological investigations of cryopreserved tissue sections
    2022
  • Samuel Kuttner, Luigi Tommaso Luppino, Kristoffer Wickstrøm, Nils Thomas Doherty Midtbø, Seyed Esmaeil Dorraji, Ana Oteiza m.fl.:
    Deep learning derived input function in dynamic 18F-FDG PET imaging of mice
    2022
  • Vishesh Kumar Dubey, Luis Enrique Villegas Hernández, Jean-Claude Tinguely, David Andre Coucheron, Anish Priyadarshi, Sebastian Acuña m.fl.:
    Multimodal super-resolution imaging for histopathology applications
    2021
  • Vishesh Kumar Dubey, Luis Enrique Villegas Hernández, Mona Nystad, Jean-Claude Tinguely, David Andre Coucheron, Firehun Tsige Dullo m.fl.:
    Photonic-chip for multimodal super-resolution imaging in histopathology applications
    2021
  • Kristin Andreassen Fenton, Hege Lynum Pedersen :
    Characterising tertiary lymphoid structures in lupus-prone mice
    Research Features Magazine 05. mai 2021 DOI
  • Kristin Andreassen Fenton, Stine Figenschau, Elin Synnøve Mortensen :
    ICAM1 er uttrykt i trippel negative brystkreftceller og vev
    BestPractice Nordic 2018
  • Kristin Andreassen Fenton, Janne erikke Mjelle, R Olsen, manar Kalaaji, Ole Petter Rekvik :
    Electron dense deposits in the GBM of (NZBxNZW)F1 mice constitute chromatin that represents target for in vivo bound autoantibodies
    2006
  • Julia Friederike Eggert, Kristin Andreassen Fenton, olga Goldfain, Beate Hegge, AI Myhr, Lise Nordgård m.fl.:
    Absence of Proof is not a Proof of Absence. Risks of Genetically Modified Organisms
    2002

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    Forskningsinteresser

    Mitt hovedmål er å utvikle nye diagnostiske markører og ikke invasive avbildningsmetoder som kan føre til tidligere påvisning av lupus nefritt hos SLE pasienter.

    SLE er blant annet karakterisert av at autoantistoffer binder seg i nyrene og disse nedslagene fortykker membranene som igjen fører til nyresvikt. Autoantistoffer og kromatin aktiverer nyreceller og er viktige for initieringen av nyrebetennelse (lupus nefritt). Vi kartlegger derfor rollen til spesialiserte celler som endotel- og mesangial celler i nyrene under utviklingen av lupus nefritt. I tillegg er det gjort lite forskning på hvilken rolle andre celler i nyrene som tubuliceller, makrofager og dendrittiske celler, har i interstitiell inflammasjon. Vi fokuserer på hvilken effekt inflammasjon i disse cellene har på utviklingen av nyreaffeksjon i SLE. I tillegg har vi oppdaget nye strukturer som dannes i nyrer som er inflammerte, såkalte tertiære lymfoide strukturer (TLS). Disse har samme oppbygning som lymfeknuter, men mangler kapsel. Ved hjelp av genteknologiske og immunologiske analyser av humant nyrevev karakteriserer vi hvilken rolle de ovennevnte cellene og strukturene har i utviklingen av human lupus nefritt. Vårt må er å etablere og utføre klinisk PET/MRI undersøkelse på SLE pasienter med og uten nyreaffeksjon basert på prekliniske PET/MRI og PET/CT studier på lupus mus.